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المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2
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2Manganese promotes α-synuclein amyloid aggregation through the induction of protein phase transition
المؤلفون: Bingkuan Xu, Shuai Huang, Yinghui Liu, Chun Wan, Yuanyuan Gu, Dianliang Wang, Haijia Yu
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Amyloid, animal diseases, α-Syn, α-synuclein, Amyloidogenic Proteins, Protein Aggregation, Pathological, Biochemistry, condensate, Protein Aggregates, α-synuclein, ThT, thioflavin T, Humans, heterocyclic compounds, Molecular Biology, PD, Parkinson’s disease, Manganese, ThS, thioflavin S, aggregation, FRAP, fluorescence recovery after photobleaching, Parkinson Disease, Amyloidosis, Cell Biology, nervous system diseases, LLPS, liquid–liquid phase separation, IDR, intrinsically disordered region, nervous system, phase transition, health occupations, alpha-Synuclein, liquid–liquid phase separation (LLPS), Lewy Bodies, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d4e4b1349f879b0af226bdc274af50
https://doi.org/10.1016/j.jbc.2021.101469 -
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المؤلفون: Diana Alarcón-Arís, Mireia Galofré, Analía Bortolozzi, Verónica Paz, Lluís Miquel-Rio, Rubén Pavia-Collado, Andrés Montefeltro, Valentín Coppola-Segovia, Miquel Vila, Raquel Revilla, Francesc Artigas, Albert Ferrés-Coy, Leticia Campa, Esther Ruiz-Bronchal, Jeffrey H. Kordower
المساهمون: Ministerio de Economía y Competitividad (España), European Commission, Michael J. Fox Foundation for Parkinson's Research, Centro de Investigación Biomédica en Red Salud Mental (España), Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España)
المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
EBioMedicine, Vol 59, Iss, Pp 102944-(2020)
EBioMedicineمصطلحات موضوعية: 0301 basic medicine, Parkinson's disease, Research paper, lcsh:Medicine, PD, Parkinson's disease, 0302 clinical medicine, DAT, dopamine transporter, Monoaminergic, ASO, antisense oligonucleotides, Antisense oligonucleotide, CPU, caudate-putamen, h-α-synuclein, wild-type human α-synuclein, α-Synuclein, lcsh:R5-920, Antisense oligonucleotides, α-syn, α-synuclein, biology, Neurodegeneration, Dopamine neurotransmission, General Medicine, 030220 oncology & carcinogenesis, shRNA, short hairpin RNA, lcsh:Medicine (General), siRNA, small interfering RNAs, medicine.drug, TH, tyrosine hydroxylase, SNc, substantia nigra pars compacta, VTA, ventral tegmental area, General Biochemistry, Genetics and Molecular Biology, SERT, serotonin transporter, AAV-EV, adeno-associated virus empty vector, 03 medical and health sciences, Dopamine, Mouse and monkey models, medicine, Dopamine transporter, Synucleinopathies, lcsh:R, Neurotoxicity, mPFC, medial prefrontal cortex, NET, norepinephrine transporter, medicine.disease, nervous system diseases, AAV5, adeno-associated virus serotype 5, 030104 developmental biology, Monoamine neurotransmitter, nervous system, Axonal neurodegeneration, biology.protein, DA, dopamine, Neuroscience
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb35670fac82578dfae34af3da951ee
http://hdl.handle.net/10261/223696 -
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المؤلفون: Haruka Yamada, Fumio Sakane, Fumi Hoshino, Qiang Lu
المصدر: Biochemistry and Biophysics Reports, Vol 22, Iss, Pp-(2020)
Biochemistry and Biophysics Reportsمصطلحات موضوعية: 0301 basic medicine, PABD, phosphatidic acid-binding domain, α-Syn-N, N-terminal region of α-Syn, Neurite, animal diseases, Lysine, Diacylglycerol kinase, Biophysics, α-Syn, α-synuclein, Myr, myristoylated, Biochemistry, LPAAT, LPA acyltransferase, lcsh:Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, PC, phosphatidylcholine, 0302 clinical medicine, Phosphatidic acid, Phospholipase D, Lipid sensor, heterocyclic compounds, lcsh:QD415-436, PA, phosphatidic acid, Growth cone, PLD, phospholipase D, lcsh:QH301-705.5, Phagosome, α-Synuclein, DMEM, Dulbecco's modified Eagle's medium, FIPI, 5-fluoro-2-indolyl deschlorohalopemide, Cell biology, nervous system diseases, Glutamine, F-actin, filamentous actin, 030104 developmental biology, DGK, diacylglycerol kinase, chemistry, nervous system, lcsh:Biology (General), 030220 oncology & carcinogenesis, LPA, lysophosphatidic acid, Research Article
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المؤلفون: Qingshan Wang, Xuefei Wu, Caixia Zang, Yuning Che, Dan Zhang, Liyan Hou, Fuqiang Sun, Hanyu Yang, Shao Li, Xiu-Qi Bao
المصدر: Redox Biology
Redox Biology, Vol 14, Iss, Pp 600-608 (2018)مصطلحات موضوعية: Male, rho GTP-Binding Proteins, 0301 basic medicine, RHOA, animal diseases, Aβ, β-amyloid, Clinical Biochemistry, α-Syn, α-synuclein, PD, Parkinson's disease, Biochemistry, Mice, chemistry.chemical_compound, 0302 clinical medicine, Receptor, lcsh:QH301-705.5, Cells, Cultured, α-Synuclein, lcsh:R5-920, CD11b Antigen, NADPH oxidase, SN, subsantia nigra, Superoxide, Cell biology, Integrin alpha M, TLR2, toll-like receptor 2, NADPH Oxidase 2, alpha-Synuclein, cardiovascular system, LPS, lipopolysaccharide, Microglia, lcsh:Medicine (General), HMGB1, high-mobility group box 1, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, Research Paper, circulatory and respiratory physiology, Integrin αMβ2, Integrin, RAC1, DPI, diphenyliodonium, Biology, Synucleinopathy, Mac1, macrophage antigen complex-1, 03 medical and health sciences, Iba-1, ionized calcium binding adaptor molecule 1, SOD, superoxide dismutase, Animals, Humans, Inflammation, Synucleinopathies, ERK, extracellular regulated protein kinases, CD11b, Organic Chemistry, NOX2, NADPH oxidase, nervous system diseases, Mice, Inbred C57BL, 030104 developmental biology, lcsh:Biology (General), nervous system, chemistry, Cancer research, biology.protein, rhoA GTP-Binding Protein, DHE, dihydroethidium, 030217 neurology & neurosurgery
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المؤلفون: Jordi Pujols, Anita Carija, Tiago F. Outeiro, Susanna Navarro, Inês Caldeira Brás, Rita Grandori, Carlo Santambrogio, Salvador Ventura, Francisca Pinheiro, Diana F. Lázaro
المساهمون: Carija, A, Pinheiro, F, Pujols, J, Bras, I, Lazaro, D, Santambrogio, C, Grandori, R, Outeiro, T, Navarro, S, Ventura, S
المصدر: Redox Biology
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Redox Biology, Vol 22, Iss, Pp-(2019)مصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Spectroscopy, α-synCC, disulfide bridge-containing variant, Protein Conformation, Parkinson's disease, Clinical Biochemistry, Amino Acid Motifs, Druggability, Protein aggregation, NAC, non-amyloid β-component, Biochemistry, PD, Parkinson's disease, 0302 clinical medicine, Disulfides, lcsh:QH301-705.5, CD, circular dichroism, Neurons, lcsh:R5-920, education.field_of_study, DOPC, dioleoylphosphatidylcholine, α-syn, α-synuclein, Chemistry, Parkinson Disease, BIO/10 - BIOCHIMICA, Covalent bond, Amino Acid Motif, alpha-Synuclein, lcsh:Medicine (General), Hydrophobic and Hydrophilic Interactions, Human, Research Paper, Amyloid, Population, FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA), Fibril, Protein Aggregation, Pathological, DMPS, dimyristoylphosphatidylserine, Disulfide, Hydrophobic and Hydrophilic Interaction, 03 medical and health sciences, Protein Aggregates, α-synuclein, CHIM/01 - CHIMICA ANALITICA, medicine, PK, proteinase K, Humans, Amino Acid Sequence, education, Kinetic, Synucleinopathies, Disulfide bond, TEM, Transmission electron microscopy, Organic Chemistry, Neurotoxicity, Protein engineering, Neuron, medicine.disease, Lipid Metabolism, Kinetics, 030104 developmental biology, Th-T, Thioflavin-T, lcsh:Biology (General), Solubility, Mutation, Biophysics, Protein Aggregate, CR, Congo Red, 030217 neurology & neurosurgery
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443e55413154d26a3dd1fb43439d4fdb
https://hdl.handle.net/21.11116/0000-0003-6327-221.11116/0000-0003-6329-0 -
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المؤلفون: Keiichi Yamaguchi, Yuji Goto, Hideki Mochizuki, Cesar Aguirre, Yasushi Kawata, Masatomo So, Kensuke Ikenaka
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Amyloid, Circular dichroism, nuclear magnetic resonance (NMR), supersaturation, polyP, polyphosphate, pI, isotropic point, Protein aggregation, Biochemistry, protein aggregation, Protein Aggregates, 03 medical and health sciences, chemistry.chemical_compound, synuclein, Polyphosphates, biophysics, ThT, thioflavin T, Pi, Humans, TEM, transmission electron microscopy, CD, circular dichroism, Molecular Biology, PCA, principal component analysis, α-syn, α-synuclein, 030102 biochemistry & molecular biology, biology, Chemistry, solubility, Polyphosphate, polyphosphate, LS, light scattering, Cell Biology, biology.organism_classification, Phosphate, 030104 developmental biology, alpha-Synuclein, Synuclein, Biophysics, Hydrophobic and Hydrophilic Interactions, Bacteria, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40249ffa854437ae2f17edc91b7f1bcc
https://doi.org/10.1016/j.jbc.2021.100510 -
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المؤلفون: Alexander K. Buell, Luca Groß, Wolfgang Hoyer, Lothar Gremer, Hamed Shaykhalishahi, Michael M. Wördehoff, Dieter Willbold, Matthias Stoldt
المصدر: Journal of Molecular Biology
Journal of molecular biology 429, 3018-3030 (2017). doi:10.1016/j.jmb.2017.09.005مصطلحات موضوعية: 0301 basic medicine, WT, wild type, animal diseases, Parkinson's disease, Protein aggregation, medicine.disease_cause, PD, Parkinson's disease, chemistry.chemical_compound, Structural Biology, oxidative stress, Denaturation (biochemistry), heterocyclic compounds, Tyrosine, α-syn, α-synuclein, amyloid, 3. Good health, Biochemistry, OS, oxidative stress, alpha-Synuclein, Ultraviolet Rays, Substantia nigra, Oxidative phosphorylation, macromolecular substances, IDP, intrinsically disordered protein, UV, ultraviolet (light), Fibril, Protein Aggregation, Pathological, Article, protein aggregation, 03 medical and health sciences, ROS, reactive oxygen species, ddc:570, medicine, ThT, thioflavin T, Humans, Molecular Biology, Alpha-synuclein, DiY, dityrosine, nervous system diseases, AFM, atomic force microscopy, 030104 developmental biology, chemistry, nervous system, SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis, Biophysics, SEC, size exclusion chromatography, Y-to-A, tyrosine to alanine (mutants), intrinsically disordered proteins, Protein Multimerization, Oxidative stress
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المؤلفون: Milica Vucetic, Kari E. Fladmark, Antonio Cuadrado, Irina Milisav, Bilge Debelec, Marta Pajares, Samo Ribarič, Irundika H.K. Dias, Huveyda Basaga, Natalia Jiménez-Moreno
المساهمون: Kidney Research UK, European Cooperation in Science and Technology, UAM. Departamento de Bioquímica, Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ), Instituto de Investigaciones Biomédicas 'Alberto Sols' (IIBM), Ege Üniversitesi
المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox Biology
Biblos-e Archivo. Repositorio Institucional de la UAMمصطلحات موضوعية: GSH, reduced glutathione, Clinical Biochemistry, NOX, nicotinamide adenine dinucleotide phosphate oxidase, Review Article, Aβ, amyloid beta, ASK1, apoptosis signal-regulating kinase 1, Protein oxidation, Biochemistry, HIF-1, hypoxia inducible factor-1, ATG4, autophagy related protein 4, Prion Diseases, Unfolded protein response, 0302 clinical medicine, UPR, unfolded protein response, Ubiquitin, IKKB, inhibitor of nuclear factor kappa-B kinase subunit beta, Trx, thioredoxin, Ub, ubiquitin, 0303 health sciences, biology, GSSG, oxidized glutathione, PI3K, phosphatidylinositol 3-kinase, mTORC1, mammalian target of rapamycin complex 1, Parkinson Disease, Cell biology, CMA, chaperone mediated autophagy, Oxidation-Reduction, Intracellular, Proteasome Endopeptidase Complex, Proteinoxidation, Medicina, Nerve Tissue Proteins, TSC2, tuberous sclerosis complex 2, Protein degradation, PDIs, protein disulfide isomerase, ER, endoplasmic reticulum, 03 medical and health sciences, UPS, ubiquitin proteasome system, NRF1/2, nuclear factor (erythroid-derived 2)-like 1/2, Alzheimer Disease, LC3, microtubule-associated protein light chain 3, Autophagy, Humans, 030304 developmental biology, α-SYN, α-synuclein, ROS, reactive oxygen species (mtROS, mitochondrial ROS), Proteasome, Organic Chemistry, PARP1, poly [ADP-ribose] polymerase 1, PrP, prion protein (PrPc, cellular form, PrPsc, scrapie form), Ubiquitination, ATM, ataxia-telangiectasia mutated, PTEN, phosphatase and tensin homolog, ULK1, unc-51 like autophagy activating kinase 1, Proteostasis, AMPK, AMP activated protein kinase, NFκB, nuclear factor kappa B, PDH, prolyl-4-hydroxylase, Proteolysis, biology.protein, Reactive Oxygen Species, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, BCL-2, B-cell lymphoma 2, JNK1, c-Jun N-terminal kinase
وصف الملف: application/pdf
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المؤلفون: Roberto Cappai, Chi L.L. Pham
المصدر: Bioscience Reports
مصطلحات موضوعية: Cell Membrane Permeability, Dopamine, animal diseases, Plasma protein binding, Biochemistry, Oligomer, oligomer, Cell membrane, chemistry.chemical_compound, 0302 clinical medicine, heterocyclic compounds, Met-ox, methionine-oxidized, Lipid bilayer, Phospholipids, 0303 health sciences, POPS, 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine, α-syn, α-synuclein, Vesicle, CMC, critical micelle concentration, Sodium Dodecyl Sulfate, POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Fluoresceins, Membrane, medicine.anatomical_structure, alpha-Synuclein, SUV, small unilamellar vesicle, Protein Binding, Membrane permeability, Biophysics, S2, DHPS, 1,2-dihexanoyl-sn-glycero-3-phospho-L-serine, Surface-Active Agents, 03 medical and health sciences, α-synuclein, ROS, reactive oxygen species, lipid, PUFA, polyunsaturated fatty acid, medicine, Humans, Molecular Biology, PD, Parkinson’s disease, Fluorescent Dyes, 030304 developmental biology, Alpha-synuclein, Original Paper, Cell Membrane, Cell Biology, nervous system diseases, DHPC, 1,2-dihexanoyl-sn-glycero-3-phosphocholine, nervous system, chemistry, Liposomes, Parkinson’s disease, health occupations, DA, dopamine, LUV, large unilamellar vesicle, Protein Multimerization, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc4affe967e3e50cdc0d8726bc2880c
https://doi.org/10.1042/bsr20130092
