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المؤلفون: Brett Hamilton, Paul F. Alewood, Yanni K.-Y. Chin, Jennifer J. Smith, Ben Cristofori-Armstrong, Eivind A. B. Undheim, Jan Tytgat, Zoltan Dekan, Sónia Troeira Henriques, Bruno Madio, Steve Peigneur, Glenn F. King, Berin A. Boughton
المصدر: Cellular and Molecular Life Sciences
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Folding, Protein Conformation, 060109 Proteomics and Intermolecular Interactions (excl. Medical Proteomics), Venom, Sea anemone, 3D structure, Evolution, Molecular, Mass spectrometry imaging, 03 medical and health sciences, Cellular and Molecular Neuroscience, Cnidarian Venoms, Protein structure, Gene duplication, Animals, Gene family, Amino Acid Sequence, 14. Life underwater, Molecular Biology, Peptide sequence, Gene, Pharmacology, Concerted evolution, biology, 060303 Biological Adaptation, Cell Biology, biology.organism_classification, Extreme resolution mass spectrometry imaging, Sea Anemones, 030104 developmental biology, 030406 Proteins and Peptides, Potassium Channels, Voltage-Gated, Evolutionary biology, Molecular Medicine, 060101 Analytical Biochemistry, Peptides, Transcriptome, Ion channel, Neurotoxin, On-tissue reduction alkylation
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المؤلفون: Neha S. Gandhi, Pilar Blancafort, Ricardo L. Mancera
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, iPeps, Peptide, 010402 general chemistry, Engrailed homeodomain, 01 natural sciences, 03 medical and health sciences, Molecular dynamics, breast cancer, Hox gene, Transcription factor, transcription factor, chemistry.chemical_classification, Chemistry, 030402 Biomolecular Modelling and Design, Rational design, Biological activity, engrailed, molecular dynamics, 0104 chemical sciences, 030104 developmental biology, Oncology, 030406 Proteins and Peptides, Biophysics, Homeobox, 060112 Structural Biology (incl. Macromolecular Modelling), iPep, Research Paper
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92cf07e9b3588ed293a18589ac78968
http://europepmc.org/articles/PMC5976472 -
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المؤلفون: Imala Alwis, Jorge Ripoll-Rozada, Pedro Pereira, Choy-Theng Loh, Mike Wu, Robert E. Thompson, Gottfried Otting, Shaun P. Jackson, Emma E. Watson, Xuyu Liu, Richard J. Payne, Benjamin L. Parker, Alessandro Gori
المساهمون: Instituto de Investigação e Inovação em Saúde
المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Central Science, Vol 4, Iss 4, Pp 468-476 (2018)
ACS Central Scienceمصطلحات موضوعية: 0301 basic medicine, Tyrosine sulfation, biology, Chemistry, General Chemical Engineering, Anopheles gambiae, Anopheles, General Chemistry, biology.organism_classification, 3. Good health, 03 medical and health sciences, 030104 developmental biology, Thrombin, Sulfation, Biochemistry, Anopheles albimanus, In vivo, 030406 - Proteins and Peptides [FoR], medicine, Tyrosine, 030405 - Molecular Medicine [FoR], QD1-999, Research Article, medicine.drug
وصف الملف: application/pdf
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المصدر: Neuropharmacology
مصطلحات موضوعية: 0301 basic medicine, 060110 Receptors and Membrane Biology, 030403 Characterisation of Biological Macromolecules, Lipid Bilayers, Pain, Spider Venoms, Drug design, Gating, Cell membrane, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Surface plasmon resonance, medicine, Animals, Rational drug design, Lipid bilayer, POPC, Ion channel, Pharmacology, Binding Sites, Sodium channel, Chemistry, Cell Membrane, Spider toxin, 030104 developmental biology, medicine.anatomical_structure, 030406 Proteins and Peptides, Biochemistry, Biophysics, Model membranes, 060112 Structural Biology (incl. Macromolecular Modelling), 060101 Analytical Biochemistry, Peptides, Disulfide-rich peptides, Ion Channel Gating
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المؤلفون: David J. Craik, Alysha G. Elliott, Yen-Hua Huang, Nicole Lawrence, Mark E. Cooper, Aurélie H. Benfield, Stephanie Chaousis, Olivier Cheneval, Sónia Troeira Henriques, Lai Yue Chan, Angela M. Kavanagh, Anjaneya S. Ravipati
المصدر: ACS Chemical Biology
مصطلحات موضوعية: 0301 basic medicine, Cell Survival, 060110 Receptors and Membrane Biology, anti fungal peptide, 030403 Characterisation of Biological Macromolecules, Lipid Bilayers, Cell, Antineoplastic Agents, Peptide, Pharmacology, Biology, 01 natural sciences, Biochemistry, anticancer peptide, Cell membrane, 03 medical and health sciences, Anti-Infective Agents, Cell Line, Tumor, medicine, Animals, Humans, disulfide-rich peptide, Mode of action, Melanoma, 060502 Infectious Agents, chemistry.chemical_classification, Leukemia, Bacteria, 010405 organic chemistry, Fungi, Spiders, Bacterial Infections, General Medicine, host defence peptide, Antimicrobial, 3. Good health, 0104 chemical sciences, 030104 developmental biology, medicine.anatomical_structure, Mycoses, 030406 Proteins and Peptides, chemistry, Drug development, Cell culture, peptide-lipid interactions, Cancer cell, Molecular Medicine, Antimicrobial Cationic Peptides
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المؤلفون: Charles G. Cranfield, Boris Martinac, Paul Duckworth, Bruce Cornell, Sónia Troeira Henriques, David J. Craik
المصدر: Langmuir
مصطلحات موضوعية: 0301 basic medicine, 060110 Receptors and Membrane Biology, 030403 Characterisation of Biological Macromolecules, model membranes, Lipid Bilayers, Cyclotides, 010402 general chemistry, 01 natural sciences, Surface-Active Agents, 03 medical and health sciences, chemistry.chemical_compound, Pulmonary surfactant, Electrochemistry, General Materials Science, Amino Acid Sequence, Lipid bilayer, Spectroscopy, Ion channel, Phosphatidylethanolamine, Chemical Physics, Bilayer, Surfaces and Interfaces, Condensed Matter Physics, disulfide-rich peptides, phosphatidylethanolamine (PE)-phospholipids, 0104 chemical sciences, 030104 developmental biology, Membrane, 030406 Proteins and Peptides, Biochemistry, chemistry, peptide-lipid interactions, Critical micelle concentration, Biophysics
وصف الملف: application/pdf
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المؤلفون: François-Xavier Cantrelle, Xavier Hanoulle, Ralf Bartenschlager, Marie Dujardin, Guy Lippens, Vanesa Madan, Isabelle Huvent, Hélène Launay, Neha S. Gandhi
المساهمون: Université de Lille, Universität Heidelberg [Heidelberg] = Heidelberg University, School of Mathematical Sciences, Queensland University of Technology, School of Mathematical Sciences [Brisbane], Queensland University of Technology [Brisbane] (QUT)-Queensland University of Technology [Brisbane] (QUT), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Bioénergétique et Ingénierie des Protéines (BIP ), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Department of Molecular Virology (DMV), Toulouse Biotechnology Institute (TBI), Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), ANRS French National Research Agency (ANR) A02014-2, Lille University, German Research Foundation (DFG) 112927078-TRR 83, Research Federation 'structural and functional biochemistry of BIOmolecular Assemblies' (CNRS) FR-3688, ANR-11-JSV8-0005,StruFunc5A5B,Etude des relations structurales et fonctionnelles entre les protéines NS5A et NS5B du virus de l'hépatite C et la Cyclophiline A humaine.(2011), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Universität Heidelberg [Heidelberg], Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Synthèse, structure et fonction des biomolécules (SSFB), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), CNRS, Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF], Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, Université de Lille-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Journal of Biological Chemistry
Journal of Biological Chemistry, 2019, 294 (35), pp.13171-13185. ⟨10.1074/jbc.RA119.009537⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, 294 (35), pp.13171-13185. ⟨10.1074/jbc.RA119.009537⟩
J Biol Chemمصطلحات موضوعية: 0301 basic medicine, nuclear magnetic resonance (NMR), [SDV]Life Sciences [q-bio], Allosteric regulation, prolyl isomerase, Cypa, nonstructural protein 5A (NS5A), Molecular Dynamics Simulation, Viral Nonstructural Proteins, Virus Replication, Intrinsically disordered proteins, Biochemistry, 03 medical and health sciences, Cyclophilin A, conformer ensemble, Prolyl isomerase, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Structural motif, NS5A, Nuclear Magnetic Resonance, Biomolecular, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Cyclophilin, intrinsically disordered protein, hepatitis C virus (HCV), cyclophilin, allosteric regulation, RNA replication, 030102 biochemistry & molecular biology, biology, Chemistry, 030402 Biomolecular Modelling and Design, Cell Biology, biology.organism_classification, 3. Good health, Cell biology, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, 030104 developmental biology, 030406 Proteins and Peptides, Protein Structure and Folding, RNA, Viral, 060112 Structural Biology (incl. Macromolecular Modelling)
وصف الملف: application/octet-stream; application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a3919ac688f598e1879a01b7a0b54d
https://hal.science/hal-02998113/file/Dujardin_Hanoulle_JBC_NS5A_diagonal_2019.pdf -
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المؤلفون: Rakesh Pandey, Neha S. Gandhi, Bashir Akhlaq Akhoon
المصدر: Biochimie
مصطلحات موضوعية: 0301 basic medicine, 060102 Bioinformatics, Structural similarity, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Molecular dynamics, Ligands, Biochemistry, Immediate-Early Proteins, 03 medical and health sciences, Protein Domains, Catalytic Domain, Humans, Protein kinase A, 030102 biochemistry & molecular biology, biology, urogenital system, Kinase, Chemistry, 030402 Biomolecular Modelling and Design, Active site, General Medicine, Ligand (biochemistry), Small molecule, 030104 developmental biology, 030406 Proteins and Peptides, Helix, Biophysics, biology.protein, Phosphorylation, Homology modelling
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010bbc52cdaa560fcc9b2627e82ef337
https://igi.indrastra.com/items/show/28393 -
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المؤلفون: Kaustav Biswas, Akello J. Agwa, Olivier Cheneval, Christina I. Schroeder, David J. Craik, Sónia Troeira Henriques, Joseph Ligutti, Les P. Miranda, Bin Wu, Aurélie H. Benfield, Nicole Lawrence
المصدر: ACS Chemical Biology
مصطلحات موضوعية: 0301 basic medicine, 060110 Receptors and Membrane Biology, Spider Venoms, Peptide, Gating, Biochemistry, structure−activity relationship, 03 medical and health sciences, 0302 clinical medicine, Potency, Structure–activity relationship, Animals, Humans, 030401 Biologically Active Molecules, chemistry.chemical_classification, Sodium channel, peptide−membrane interactions, General Medicine, Spider toxin, 030104 developmental biology, Membrane, 030406 Proteins and Peptides, voltage gated sodium channels, chemistry, Biophysics, Molecular Medicine, 060112 Structural Biology (incl. Macromolecular Modelling), Gating modifier toxins, Selectivity, Peptides, 030217 neurology & neurosurgery
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المؤلفون: Irina Vetter, Jennifer R. Deuis, Sónia Troeira Henriques, Christina I. Schroeder, Marco Inserra, Zoltan Dekan, David J. Craik, Tzong-Hsien Lee, Richard J. Lewis, Paul F. Alewood, Mehdi Mobli, Marie-Isabel Aguilar
المصدر: Journal of Biological Chemistry
مصطلحات موضوعية: Male, 0301 basic medicine, Magnetic Resonance Spectroscopy, Protein Conformation, 060110 Receptors and Membrane Biology, Crystallography, X-Ray, Biochemistry, Cell membrane, Mice, Neurobiology, lipid-protein interaction, pain, Conotoxin, Lipid bilayer, Analgesics, Liposome, Behavior, Animal, Chemistry, Peptide chemical synthesis, Electrophysiology, NaV1.8, μO-conotoxin MfVIA, Membrane, medicine.anatomical_structure, 060101 Analytical Biochemistry, peptide chemical synthesis, mutagenesis, sodium channel, Molecular Sequence Data, NAV1.8 Voltage-Gated Sodium Channel, 03 medical and health sciences, medicine, Animals, Humans, Potency, Amino Acid Sequence, Molecular Biology, 030401 Biologically Active Molecules, Sequence Homology, Amino Acid, Sodium channel, Cell Membrane, structure-activity relationships, Cell Biology, Mice, Inbred C57BL, HEK293 Cells, 030104 developmental biology, 030406 Proteins and Peptides, Liposomes, Conotoxins
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b3f96b520d204d4b6c4a845490818b
https://doi.org/10.1074/jbc.m116.721662