المؤلفون: Hannu Raunio, Rabia Jehangir, Moshe Finel, Risto O. Juvonen, Olli Kärkkäinen, Olli T. Pentikäinen, Johanna Troberg, Juhani Huuskonen, Aki T. Heikkinen

مصطلحات موضوعية: entsyymit, Colon, Glucuronidation, Pharmaceutical Science, 02 engineering and technology, liver, 030226 pharmacology & pharmacy, Beagle, koira, 7-hydroxycoumarin derivative, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Glucuronides, Pharmacokinetics, Microsomes, enzyme kinetics, Intestine, Small, medicine, Animals, Humans, Umbelliferones, Glucuronosyltransferase, kumariinit, aineenvaihdunta, chemistry.chemical_classification, Chemistry, glucuronidation, dog, intestine, maksa, Metabolism, lääkeaineet, 021001 nanoscience & nanotechnology, Coumarin, Small intestine, Enzyme, medicine.anatomical_structure, Biochemistry, Liver, farmakokinetiikka, suolisto, Microsome, koe-eläinmallit, 0210 nano-technology

وصف الملف: application/pdf; fulltext

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3337c30bac2dd826b1ef2c625fcabd
http://urn.fi/URN:NBN:fi:jyu-201911054726

المؤلفون: Moshe Finel, Risto O. Juvonen, Juhani Huuskonen, Olli T. Pentikäinen, Sanna Niinivehmas, Johanna Troberg, Sanna Rauhamäki, Aleksanteri Petsalo, Hannu Raunio, Sami Kortet

المساهمون: Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Moshe Finel / Principal Investigator, Pharmaceutical Design and Discovery group, Drug Research Program

مصطلحات موضوعية: 0301 basic medicine, Mutant, Glucuronidation, Pharmaceutical Science, UGT1A10, 030226 pharmacology & pharmacy, Substrate Specificity, 7-hydroxycoumarin derivative, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, CRYSTAL-STRUCTURE, Glucuronosyltransferase, ta116, ta317, AFFINITY, chemistry.chemical_classification, Chemistry, 3. Good health, Molecular Imaging, Molecular Docking Simulation, 7-hydroxycoumarin, 317 Pharmacy, in silico, Molecular Medicine, fluorescence, UDP-glucuronosyltransferase, EXPRESSION, ENZYME, Stereochemistry, In silico, Kinetics, FLUORESCENT-PROBE, Triazole, ta3111, 03 medical and health sciences, Glucuronides, Microsomes, XENOBIOTICS, Humans, Umbelliferones, Fluorescent Dyes, GLUCURONIDATION, ta1182, glucuronidation, fluoresenssi, Substrate (chemistry), drug metabolism, 030104 developmental biology, Enzyme, DRUG-METABOLISM, Drug Design, Molecular Probes, Mutation, Mutagenesis, Site-Directed, ORAL BIOAVAILABILITY, Drug metabolism

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377ce476f5ec0cc73c7cb09d06309193
http://urn.fi/URN:NBN:fi:jyu-201803051654

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