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1
المؤلفون: Daniel G. Shore, Andrew D. Medhurst, Zachary Kevin Sweeney, Xingrong Liu, Andrew W. Gill, Edward G. McIver, John Moffat, Jason Drummond, Alan Beresford, Bryan K. Chan, Tracy Kleinheinz, Haitao Zhu, Huifen Chen, Anthony A. Estrada
المصدر: Bioorganicmedicinal chemistry letters. 29(4)
مصطلحات موضوعية: Parkinson's disease, Indazoles, Clinical Biochemistry, Pharmaceutical Science, Leucine-rich repeat, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 01 natural sciences, Biochemistry, Drug Discovery, medicine, Potency, Kinase activity, Molecular Biology, 010405 organic chemistry, Kinase, Hydrogen bond, Chemistry, Organic Chemistry, Hydrogen Bonding, medicine.disease, LRRK2, nervous system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Intramolecular force, Molecular Medicine
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2
المؤلفون: John Atherall, Bryan K. Chan, Tracy Kleinheinz, Daniel G. Shore, Andrew D. Medhurst, Huifen Chen, Haitao Zhu, Anthony A. Estrada, Sara L. Dominguez, Kimberly Scearce-Levie, Jason Drummond, Alan Beresford, Kevin M. Nash, Zejuan Sheng, Mark Stuart Chambers, Zachary Kevin Sweeney, Andrew Gill, Claire E. Le Pichon, Shuo Zhang, Charles Baker-Glenn, John Moffat, Hervé Van de Poël, Daniel J. Burdick, Xingrong Liu
المصدر: ACS Medicinal Chemistry Letters. 4:85-90
مصطلحات موضوعية: business.industry, Drug discovery, Organic Chemistry, CYP1A2, Pharmacology, Highly selective, Biochemistry, Small molecule, LRRK2, nervous system diseases, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Medicine, Kinase activity, business, Penetrant (biochemical)
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3
المؤلفون: Gordon K. Wilcock, Margaret M. Esiri, Mitchell K.P. Lai, Andrew D. Medhurst, Jasinda H. Lee, Peter T.-H. Wong, Yuan Sheng, Christopher Chen
المصدر: Journal of the Neurological Sciences. 315:110-114
مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Frontal cortex, Symptomatic treatment, Hippocampus, Histamine h, Pharmacology, Brain Ischemia, Neurochemical, medicine, Humans, Receptors, Histamine H3, Receptor, Aged, Aged, 80 and over, Cerebral Cortex, Neocortex, Dementia, Vascular, medicine.anatomical_structure, Neurology, Dementia, Female, Neurology (clinical), Histamine H3 receptor, Psychology, Follow-Up Studies, Protein Binding
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4
المؤلفون: Andrew D. Medhurst, Maria Grazia Giovannini, Laura Della Corte, Patrizia Giannoni, Chiara Ballini, Patrizio Blandina, Maria Beatrice Passani
المصدر: Journal of Pharmacology and Experimental Therapeutics. 332:164-172
مصطلحات موضوعية: Pharmacology, 0303 health sciences, Chemistry, Histaminergic, Striatum, Histamine H1 receptor, Nucleus accumbens, 3. Good health, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine.anatomical_structure, medicine, Molecular Medicine, Histamine H3 receptor, Tuberomammillary nucleus, 030217 neurology & neurosurgery, Acetylcholine, Histamine, 030304 developmental biology, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fd2229c42b85137dd75fe7bf6d862f5d
https://doi.org/10.1124/jpet.109.158444 -
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المؤلفون: Andrew D. Medhurst, Ciaran M. Regan, Claire Barry, Darren Scully, Alison Prendergast, Andrew G. Foley, Neil Upton
المصدر: Neuropsychopharmacology. 34:2585-2600
مصطلحات موضوعية: Male, Niacinamide, Time Factors, Cell Survival, Neurogenesis, Scopolamine, Water maze, Neuropsychological Tests, Hippocampal formation, Discrimination Learning, Memory, Perirhinal cortex, Neuroplasticity, medicine, Animals, Rats, Wistar, Maze Learning, Prefrontal cortex, Neural Cell Adhesion Molecules, Neurons, Pharmacology, Neuronal Plasticity, Dose-Response Relationship, Drug, Brain, Benzazepines, Olfactory Perception, Rats, Psychiatry and Mental health, medicine.anatomical_structure, nervous system, Neural cell adhesion molecule, Memory consolidation, Amnesia, Psychology, Neuroscience, Histamine H3 Antagonists
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6
المؤلفون: Lauren Broom, David T. Dexter, Lilia Marinova-Mutafchieva, Andrew D. Medhurst, John B. Davis, Mona Sadeghian
المصدر: Journal of Neurochemistry. 110:966-975
مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Time Factors, Dopamine, Clone (cell biology), Substantia nigra, Biology, Biochemistry, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, medicine, Animals, Parkinson Disease, Secondary, Oxidopamine, Neuroinflammation, Neurons, Microglia, Tyrosine hydroxylase, Pars compacta, Neurodegeneration, medicine.disease, Molecular biology, Rats, Substantia Nigra, Disease Models, Animal, medicine.anatomical_structure, nervous system, Neuroglia
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7
المؤلفون: Andrew D. Medhurst, Patricia Franco, Neil Upton, RX Guo, Jenny C. Roberts, Mei Zhang, JQ Feng, Régis Parmentier, S. H. Brown, Christelle Anaclet, Jean-Pierre Sastre, Jian-Sheng Lin, Colette Buda, G. Guidon
المصدر: British Journal of Pharmacology. 157:104-117
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Sleep disorder, Modafinil, medicine.disease, Orexin, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, medicine, Wakefulness, Dosing, Histamine H3 receptor, Psychology, H3 receptor antagonist, medicine.drug, Narcolepsy
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8
المؤلفون: Andrew D. Medhurst, Jennifer C. Roberts, John B. Davis, David Virley, Marion J. Perren, Sarah Friel, Shilina Roman, Jill C. Richardson, Alex J. Harper
المصدر: Experimental Neurology. 216:459-470
مصطلحات موضوعية: Male, Genetically modified mouse, Pathology, medicine.medical_specialty, Time Factors, Antigens, Differentiation, Myelomonocytic, Hippocampus, Mice, Transgenic, Amyloid beta-Protein Precursor, Mice, Receptors, GABA, Developmental Neuroscience, Alzheimer Disease, Antigens, CD, Ciglitazone, Internal medicine, Acetamides, Presenilin-1, medicine, Translocator protein, Animals, Humans, Aged, Aged, 80 and over, Cerebral Cortex, Brain Mapping, Amyloid beta-Peptides, Pioglitazone, Microglia, biology, GABAA receptor, Age Factors, Isoquinolines, Receptors, GABA-A, Peptide Fragments, Cortex (botany), PPAR gamma, Pyrimidines, medicine.anatomical_structure, Endocrinology, Neurology, biology.protein, Autoradiography, Pyrazoles, Neuroglia, Female, Thiazolidinediones, Protein Binding
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9
المؤلفون: S. H. Brown, Jenny C. Roberts, J. Lee, Shilina Roman, Andrew D. Medhurst, C. P. L.-H. Chen, Mitchell K.P. Lai
المصدر: British Journal of Pharmacology. 157:130-138
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Neocortex, Central nervous system, Hippocampus, Biology, medicine.disease, chemistry.chemical_compound, medicine.anatomical_structure, Endocrinology, chemistry, Cerebral cortex, Internal medicine, medicine, Alzheimer's disease, Histamine H3 receptor, Receptor, H3 receptor antagonist
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المؤلفون: Neil Upton, David Virley, Helen Chapman, Martin P. Vidgeon-Hart, Andrew D. Medhurst, Leann P. Quinn, M E Hows, Barry Crook
المصدر: British Journal of Pharmacology. 154:226-233
مصطلحات موضوعية: Pharmacology, Agonist, medicine.medical_specialty, medicine.drug_class, MPTP, Substantia nigra, chemistry.chemical_compound, Endocrinology, nervous system, chemistry, Dopamine, Internal medicine, medicine, MPTP Poisoning, Neurotoxin, Monoamine oxidase B, Pioglitazone, medicine.drug