نتائج البحث - "ADG Lawson"

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Preparation and preclinical evaluation of humanised A33 immunoconjugates for radioimmunotherapy

المؤلفون: DJ King, P Antoniw, RJ Owens, JR Adair, AMR Haines, APH Farnsworth, H Finney, ADG Lawson, A Lyons, TS Baker, D Baldock, J Mackintosh, C Gofton, GT Yarranton, W McWilliams, D Shochat, PK Leichner, S Welt, LJ Old, A Mountain

المصدر: British Journal of Cancer

مصطلحات موضوعية: Cancer Research, DNA, Complementary, Immunoconjugates, medicine.drug_class, medicine.medical_treatment, Molecular Sequence Data, Transplantation, Heterologous, Gene Expression, Mice, Nude, CHO Cells, Monoclonal antibody, Immunoglobulin G, chemistry.chemical_compound, Mice, Antigen, Cricetinae, medicine, Tumor Cells, Cultured, DOTA, Animals, Humans, Avidity, Tissue Distribution, Yttrium Radioisotopes, Amino Acid Sequence, Cloning, Molecular, Immunoglobulin Fragments, Hybridomas, biology, Genes, Immunoglobulin, Indium Radioisotopes, Molecular biology, Immunoconjugate, Transplantation, Oncology, chemistry, Radioimmunotherapy, Immunology, biology.protein, Drug Screening Assays, Antitumor, Colorectal Neoplasms, Multiple Myeloma, Neoplasm Transplantation, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff814f55777341f412a91c8568934a0
http://ora.ox.ac.uk/objects/uuid:7021430e-1ee7-44ea-bd89-23a20d7b4b27

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دورية أكاديمية

Crystal Structure of Bimekizumab Fab Fragment in Complex with IL-17F Provides Molecular Basis for Dual IL-17A and IL-17F Inhibition.

المؤلفون: Adams R; UCB Pharma, Slough, United Kingdom. Electronic address: ralph.adams@ucb.com., Bunick CG; Department of Dermatology, Yale School of Medicine, Yale University, New Haven, Connecticut, USA; Program in Translational Biomedicine, Yale School of Medicine, Yale University, New Haven, Connecticut, USA., Lawson ADG; UCB Pharma, Slough, United Kingdom., Gomez B; UCB Pharma, Smyrna, Georgia, USA., Shaw S; UCB Pharma, Slough, United Kingdom.

المصدر: The Journal of investigative dermatology [J Invest Dermatol] 2024 Apr 16. Date of Electronic Publication: 2024 Apr 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE

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دورية أكاديمية

Modular design of bi- and multi-specific knob domain fusions.

المؤلفون: Kuravsky M; UK Research, UCB Biopharma UK, Slough, United Kingdom., Gibbons GF; UK Research, UCB Biopharma UK, Slough, United Kingdom., Joyce C; UK Research, UCB Biopharma UK, Slough, United Kingdom., Scott-Tucker A; UK Research, UCB Biopharma UK, Slough, United Kingdom., Macpherson A; UK Research, UCB Biopharma UK, Slough, United Kingdom., Lawson ADG; UK Research, UCB Biopharma UK, Slough, United Kingdom.

المصدر: Frontiers in immunology [Front Immunol] 2024 Mar 27; Vol. 15, pp. 1384467. Date of Electronic Publication: 2024 Mar 27 (Print Publication: 2024).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Bispecific*/chemistry, Animals ; Cattle ; Humans ; Peptides ; Nucleocapsid Proteins

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دورية أكاديمية

Identification and characterisation of anti-IL-13 inhibitory single domain antibodies provides new insights into receptor selectivity and attractive opportunities for drug discovery.

المؤلفون: Walker K; Leicester Institute of Structural and Chemical Biology, and Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Baravalle R; Leicester Institute of Structural and Chemical Biology, and Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Holyfield R; Leicester Institute of Structural and Chemical Biology, and Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Kalms J; Leicester Institute of Structural and Chemical Biology, and Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.; UCB Biopharma, UCB Pharma, Slough, United Kingdom., Wright H; Leicester Institute of Structural and Chemical Biology, and Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Seewooruthun C; Leicester Institute of Structural and Chemical Biology, and Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Muskett FW; Leicester Institute of Structural and Chemical Biology, and Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Scott-Tucker A; UCB Biopharma, UCB Pharma, Slough, United Kingdom., Merritt A; LifeArc, Centre for Therapeutics Discovery, Stevenage Bioscience Catalyst, Stevenage, United Kingdom., Henry A; UCB Biopharma, UCB Pharma, Slough, United Kingdom., Lawson ADG; UCB Biopharma, UCB Pharma, Slough, United Kingdom., Hall G; Leicester Institute of Structural and Chemical Biology, and Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Prosser C; Leicester Institute of Structural and Chemical Biology, and Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.; UCB Biopharma, UCB Pharma, Slough, United Kingdom., Carr MD; Leicester Institute of Structural and Chemical Biology, and Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.

المصدر: Frontiers in immunology [Front Immunol] 2023 Jul 06; Vol. 14, pp. 1216967. Date of Electronic Publication: 2023 Jul 06 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-13*/metabolism , Single-Domain Antibodies*, Interleukin-4/metabolism ; Interleukin-13 Receptor alpha1 Subunit/metabolism ; Cytokines

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دورية أكاديمية

Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.

المؤلفون: Shaw DJ; Department of Chemistry and York Biomedical Research Institute, University of York Heslington York YO19 5DD UK neil.hunt@york.ac.uk., Waters LC; Department of Molecular and Cell Biology/Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road Leicester LE1 7RH UK fwm1@leicester.ac.uk., Strong SL; Department of Molecular and Cell Biology/Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road Leicester LE1 7RH UK fwm1@leicester.ac.uk., Schulze MED; UCB Pharma UCB Biopharma UK 216 Bath Road Slough SL1 3WE UK., Greetham GM; Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory Harwell Oxford Didcot Oxon OX11 0QX UK., Towrie M; Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory Harwell Oxford Didcot Oxon OX11 0QX UK., Parker AW; Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory Harwell Oxford Didcot Oxon OX11 0QX UK., Prosser CE; UCB Pharma UCB Biopharma UK 216 Bath Road Slough SL1 3WE UK., Henry AJ; UCB Pharma UCB Biopharma UK 216 Bath Road Slough SL1 3WE UK., Lawson ADG; UCB Pharma UCB Biopharma UK 216 Bath Road Slough SL1 3WE UK., Carr MD; Department of Molecular and Cell Biology/Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road Leicester LE1 7RH UK fwm1@leicester.ac.uk., Taylor RJ; UCB Pharma UCB Biopharma UK 216 Bath Road Slough SL1 3WE UK., Hunt NT; Department of Chemistry and York Biomedical Research Institute, University of York Heslington York YO19 5DD UK neil.hunt@york.ac.uk., Muskett FW; Department of Molecular and Cell Biology/Leicester Institute of Structural and Chemical Biology, University of Leicester, University Road Leicester LE1 7RH UK fwm1@leicester.ac.uk.

المصدر: Chemical science [Chem Sci] 2023 Jun 16; Vol. 14 (27), pp. 7524-7536. Date of Electronic Publication: 2023 Jun 16 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

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دورية أكاديمية

Serum albumin binding knob domains engineered within a V H framework III bispecific antibody format and as chimeric peptides.

المؤلفون: Adams R; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., Joyce C; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., Kuravskiy M; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., Harrison K; School of Chemistry, The University of Sydney, Sydney, NSW, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, NSW, Australia., Ahdash Z; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., Balmforth M; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., Chia K; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., Marceddu C; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., Coates M; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., Snowden J; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., Goursaud E; Early Solutions, UCB Biopharma SA, Braine L'Alleud, Belgium., Ménochet K; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., van den Elsen J; Department of Life Sciences, University of Bath, Bath, United Kingdom., Payne RJ; School of Chemistry, The University of Sydney, Sydney, NSW, Australia.; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, NSW, Australia., Lawson ADG; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., Scott-Tucker A; Early Solutions, UCB Biopharma UK, Slough, United Kingdom., Macpherson A; Early Solutions, UCB Biopharma UK, Slough, United Kingdom.

المصدر: Frontiers in immunology [Front Immunol] 2023 May 12; Vol. 14, pp. 1170357. Date of Electronic Publication: 2023 May 12 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Serum Albumin*/metabolism , Antibodies, Bispecific*, Animals ; Cattle ; Humans ; Immunoglobulin Fab Fragments ; Epitopes ; Cell Surface Display Techniques

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دورية أكاديمية

Chimeric antigens displaying GPR65 extracellular loops on a soluble scaffold enabled the discovery of antibodies, which recognized native receptor.

المؤلفون: Barrett J; UK Research Department, UCB Pharma, Slough, UK.; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Leysen S; UK Research Department, UCB Pharma, Slough, UK., Galmiche C; UK Research Department, UCB Pharma, Slough, UK., Al-Mossawi H; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Bowness P; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Edwards TE; US Research Department, UCB Pharma, Bainbridge Island, WA, USA., Lawson ADG; UK Research Department, UCB Pharma, Slough, UK.

المصدر: Bioengineered [Bioengineered] 2024 Dec; Vol. 15 (1), pp. 2299522. Date of Electronic Publication: 2024 Jan 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101581063 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-5987 (Electronic) Linking ISSN: 21655979 NLM ISO Abbreviation: Bioengineered Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, G-Protein-Coupled*/genetics , Cell Surface Display Techniques*, Technology

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دورية أكاديمية

Phage Display of Bovine Ultralong CDRH3.

المؤلفون: Joyce C; Early Solutions, UCB Biopharma UK, Slough, UK., Speight L; Early Solutions, UCB Biopharma UK, Slough, UK., Lawson ADG; Early Solutions, UCB Biopharma UK, Slough, UK., Scott-Tucker A; Early Solutions, UCB Biopharma UK, Slough, UK. anthony.scott-tucker@ucb.com., Macpherson A; Early Solutions, UCB Biopharma UK, Slough, UK. alex.macpherson@ucb.com.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2681, pp. 83-97.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Surface Display Techniques* , Bacteriophages*/genetics, Animals ; Cattle ; Antigens ; Antibodies, Monoclonal/genetics ; Receptors, Antigen/genetics ; Peptide Library

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دورية أكاديمية

Rings in Clinical Trials and Drugs: Present and Future.

المؤلفون: Shearer J; UCB, 216 Bath Road, SloughSL1 3WE, United Kingdom., Castro JL; UCB, 216 Bath Road, SloughSL1 3WE, United Kingdom., Lawson ADG; UCB, 216 Bath Road, SloughSL1 3WE, United Kingdom., MacCoss M; Bohicket Pharma Consulting Limited Liability Company, 2556 Seabrook Island Road, Seabrook Island, South Carolina29455, United States., Taylor RD; UCB, 216 Bath Road, SloughSL1 3WE, United Kingdom.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Jul 14; Vol. 65 (13), pp. 8699-8712. Date of Electronic Publication: 2022 Jun 22.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: PubMed not MEDLINE; MEDLINE

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دورية أكاديمية

A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers.

المؤلفون: Heads JT; UCB Pharma, 208 Bath Road, Slough SL1 3WE, UK., Kelm S; UCB Pharma, 208 Bath Road, Slough SL1 3WE, UK., Tyson K; UCB Pharma, 208 Bath Road, Slough SL1 3WE, UK., Lawson ADG; UCB Pharma, 208 Bath Road, Slough SL1 3WE, UK.

المصدر: MAbs [MAbs] 2022 Jan-Dec; Vol. 14 (1), pp. 2138092.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

مواضيع طبية MeSH: Immunoglobulin G*/chemistry , Antineoplastic Agents, Immunological*, Antibodies, Monoclonal/chemistry ; Static Electricity ; Hydrophobic and Hydrophilic Interactions

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