المؤلفون: Zhang L; State Key Laboratory of Cellular Stress Biology, School of Life Science, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, China., Wu Z; State Key Laboratory of Cellular Stress Biology, School of Life Science, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, China., Qiu X; State Key Laboratory of Cellular Stress Biology, School of Life Science, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, China., Zhang J; State Key Laboratory of Cellular Stress Biology, School of Life Science, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, China., Cheng SC; State Key Laboratory of Cellular Stress Biology, School of Life Science, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, China. jamescheng@xmu.edu.cn.

المصدر: Communications biology [Commun Biol] 2024 Jul 05; Vol. 7 (1), pp. 817. Date of Electronic Publication: 2024 Jul 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

مواضيع طبية MeSH: Macrophages*/immunology , Macrophages*/metabolism , Cell Differentiation* , Mice, Knockout* , Reactive Oxygen Species*/metabolism, Animals ; Mice ; Mice, Inbred C57BL ; Aspartate Aminotransferase, Cytoplasmic/genetics ; Aspartate Aminotransferase, Cytoplasmic/metabolism ; Macrophage Activation/genetics ; Lipopolysaccharides/pharmacology

المؤلفون: Som R; Department of Internal Medicine/Endocrinology and Metabolism, University of Iowa and the Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States., Fink BD; Department of Internal Medicine/Endocrinology and Metabolism, University of Iowa and the Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States., Yu L; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, Iowa, United States.; NMR Core Facility, University of Iowa , Iowa City, Iowa, United States., Sivitz WI; Department of Internal Medicine/Endocrinology and Metabolism, University of Iowa and the Iowa City Veterans Affairs Medical Center, Iowa City, Iowa, United States.

المصدر: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Jun 01; Vol. 326 (6), pp. C1669-C1682. Date of Electronic Publication: 2024 Apr 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Respiration*/drug effects , Membrane Potential, Mitochondrial*/drug effects , Mitochondria, Muscle*/metabolism , Mitochondria, Muscle*/enzymology , Mitochondria, Muscle*/drug effects, Animals ; Mice ; Aspartate Aminotransferase, Mitochondrial/metabolism ; Aspartate Aminotransferase, Mitochondrial/genetics ; Cell Differentiation/drug effects ; Cell Line ; Electron Transport Complex II/metabolism ; Electron Transport Complex II/genetics ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/enzymology ; Oxygen Consumption/drug effects ; Succinate Dehydrogenase/metabolism ; Succinate Dehydrogenase/genetics ; Fatty Acid-Binding Proteins/genetics ; Fatty Acid-Binding Proteins/metabolism

المؤلفون: Kim JH; Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea., Lee J; Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea., Im SS; Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea., Kim B; Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea., Kim EY; Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea., Min HJ; Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea., Heo J; Department of Cell and Genetic Engineering, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea., Chang EJ; Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea., Choi KC; Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea., Shin DM; Department of Cell and Genetic Engineering, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea., Son J; Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea. jaekson@amc.seoul.kr.

المصدر: Experimental & molecular medicine [Exp Mol Med] 2024 Apr; Vol. 56 (4), pp. 1013-1026. Date of Electronic Publication: 2024 Apr 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9607880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2092-6413 (Electronic) Linking ISSN: 12263613 NLM ISO Abbreviation: Exp Mol Med Subsets: MEDLINE

مواضيع طبية MeSH: CASP8 and FADD-Like Apoptosis Regulating Protein*/metabolism , CASP8 and FADD-Like Apoptosis Regulating Protein*/genetics , TNF-Related Apoptosis-Inducing Ligand*/metabolism , Epigenesis, Genetic* , Glutamine*/metabolism , Jumonji Domain-Containing Histone Demethylases*/metabolism , Jumonji Domain-Containing Histone Demethylases*/genetics , Drug Resistance, Neoplasm*/genetics , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/genetics , Pancreatic Neoplasms*/pathology , Gene Expression Regulation, Neoplastic*/drug effects , Apoptosis*/drug effects, Humans ; Cell Line, Tumor ; Ketoglutaric Acids/metabolism ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Aspartate Aminotransferase, Cytoplasmic/metabolism ; Aspartate Aminotransferase, Cytoplasmic/genetics ; Animals ; Promoter Regions, Genetic

المؤلفون: Wu Q; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Qixia, Nanjing 210023, Jiangsu, China; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Sun Z; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Life Science and Technology, Harbin Institute of Technology, Harbin 200092, China., Chen Z; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Liu J; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Ding H; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Luo C; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Qixia, Nanjing 210023, Jiangsu, China; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Wang M; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528437, China. Electronic address: wangmingliang@simm.ac.cn., Du D; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Qixia, Nanjing 210023, Jiangsu, China; Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: dhdu@simm.ac.cn.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Oct 01; Vol. 73, pp. 128883. Date of Electronic Publication: 2022 Jul 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Aspartate Aminotransferase, Cytoplasmic*/metabolism , Aspartate Aminotransferase, Cytoplasmic*/pharmacology , High-Throughput Screening Assays*, Cell Line, Tumor ; Cell Proliferation ; Hydralazine/pharmacology

المؤلفون: Li Y; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Li B; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Xu Y; Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China., Qian L; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Xu T; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Meng G; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Li H; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Wang Y; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Zhang L; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Jiang X; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Liu Q; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Xie Y; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Cheng C; Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital, Nanjing University of Chinese Medicine, Nanjing, China., Sun B; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Yu D; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.; Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing, China.; Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital, Nanjing University of Chinese Medicine, Nanjing, China.

المصدر: Cancer research [Cancer Res] 2022 Sep 16; Vol. 82 (18), pp. 3223-3235.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Aspartate Aminotransferase, Mitochondrial*/metabolism , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology, Animals ; Humans ; Mice ; Antioxidants ; Aspartate Aminotransferases/genetics ; Aspartate Aminotransferases/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Glutaminase/genetics ; Glutaminase/metabolism ; Glutamine/metabolism ; Glutathione/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; TOR Serine-Threonine Kinases/metabolism

المؤلفون: Song Z; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Yang Y; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Wu Y; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China., Zheng M; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Sun D; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: sywysdj@163.com., Li H; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: li_hua@hust.edu.cn., Chen L; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: syzyclx@163.com.

المصدر: European journal of pharmacology [Eur J Pharmacol] 2022 Feb 15; Vol. 917, pp. 174754. Date of Electronic Publication: 2022 Jan 08.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Aspartate Aminotransferase, Cytoplasmic*

المؤلفون: Zhao Y; Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin Province, China., Wang Y; Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin Province, China., Miao Z; Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin Province, China., Liu Y; Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin Province, China., Yang Q; Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun, 130021, Jilin Province, China. yangq@jlu.edu.cn.

المصدر: Molecular biology reports [Mol Biol Rep] 2023 Aug; Vol. 50 (8), pp. 6627-6641. Date of Electronic Publication: 2023 Jun 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/metabolism , Ferroptosis*, Humans ; Aspartate Aminotransferase, Cytoplasmic/metabolism ; Aspartate Aminotransferase, Cytoplasmic/therapeutic use ; NF-E2-Related Factor 2/genetics ; Glutamine/pharmacology ; Glutamine/metabolism ; Cell Line, Tumor

المؤلفون: Kremer DM; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Graduate Program in Chemical Biology, University of Michigan, Ann Arbor, MI, USA., Nelson BS; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA., Lin L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Yarosz EL; Immunology Graduate Program, University of Michigan, Ann Arbor, MI, USA., Halbrook CJ; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Kerk SA; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA., Sajjakulnukit P; Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI, USA., Myers A; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Thurston G; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Hou SW; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Carpenter ES; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA., Andren AC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Nwosu ZC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Cusmano N; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Wisner S; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Mbah NE; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Shan M; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Das NK; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Magnuson B; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Little AC; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Savani MR; Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ramos J; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Gao T; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Sastra SA; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA., Palermo CF; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA., Badgley MA; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.; Department of Pathology, Columbia University Medical Center, New York, NY, USA., Zhang L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Asara JM; Division of Signal Transduction and Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., McBrayer SK; Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA., di Magliano MP; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA., Crawford HC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Shah YM; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Olive KP; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA., Lyssiotis CA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.

المصدر: Nature communications [Nat Commun] 2021 Aug 11; Vol. 12 (1), pp. 4860. Date of Electronic Publication: 2021 Aug 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Ferroptosis*/drug effects, Aspartate Aminotransferase, Cytoplasmic/*antagonists & inhibitors , Pancreatic Neoplasms/*metabolism, Animals ; Antioxidants/pharmacology ; Aspartate Aminotransferase, Cytoplasmic/genetics ; Aspartate Aminotransferase, Cytoplasmic/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival/drug effects ; Cystine/metabolism ; Glutathione/biosynthesis ; Humans ; Iron/metabolism ; Mice ; Mitochondria/metabolism ; Pancreatic Neoplasms/pathology

المؤلفون: Wang B; Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China; Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences Jinan, Shandong, China; Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences, Jinan, Shandong, China., Pei J; Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences Jinan, Shandong, China; Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences, Jinan, Shandong, China., Xu S; Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences Jinan, Shandong, China; Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences, Jinan, Shandong, China., Liu J; Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences Jinan, Shandong, China; Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences, Jinan, Shandong, China. Electronic address: linchuangliujie@163.com., Yu J; Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences Jinan, Shandong, China; Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences, Jinan, Shandong, China. Electronic address: sdyujinming@163.com.

المصدر: Computers in biology and medicine [Comput Biol Med] 2023 Oct; Vol. 165, pp. 107415. Date of Electronic Publication: 2023 Aug 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1250250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0534 (Electronic) Linking ISSN: 00104825 NLM ISO Abbreviation: Comput Biol Med Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma of Lung*/genetics , Lung Neoplasms*/genetics , Lung Neoplasms*/therapy, Mice ; Animals ; Humans ; Mice, Inbred C57BL ; Glutamine ; Immunotherapy ; Aspartate Aminotransferase, Cytoplasmic ; Glutamates ; Pyruvates ; Tumor Microenvironment ; Transaminases/genetics

المؤلفون: Dopico-López A; Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Pérez-Mato M; Neuroscience and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address: maria.perez.mato@idipaz.es., da Silva-Candal A; Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Iglesias-Rey R; Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Rabinkov A; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Bugallo-Casal A; Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Sobrino T; Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Mirelman D; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Castillo J; Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain., Campos F; Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. Electronic address: francisco.campos.perez@sergas.es.

المصدر: Translational research : the journal of laboratory and clinical medicine [Transl Res] 2021 Apr; Vol. 230, pp. 68-81. Date of Electronic Publication: 2020 Oct 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101280339 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1810 (Electronic) Linking ISSN: 18781810 NLM ISO Abbreviation: Transl Res Subsets: MEDLINE

مواضيع طبية MeSH: Aspartate Aminotransferase, Cytoplasmic/*antagonists & inhibitors , Aspartate Aminotransferase, Cytoplasmic/*metabolism , Brain Ischemia/*enzymology , Brain Ischemia/*pathology, Animals ; Antibodies ; Aspartate Aminotransferase, Cytoplasmic/cerebrospinal fluid ; Brain/enzymology ; Cloning, Molecular ; Dose-Response Relationship, Immunologic ; Glutamic Acid/blood ; Hep G2 Cells ; Humans ; Immunoglobulin G ; Lactic Acid/blood ; Male ; Rats ; Rats, Sprague-Dawley