المؤلفون: Yang T; The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China., Li J; Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China; Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, China., Cheng X; The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China., Lu Q; Institute for Biological Electron Microscopy, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China; Department of Chemical Biology, School of Life Southern University of Science and Technology, Shenzhen, Guangdong 518055, China., Farooq Z; William Harvey Research Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Fu Y; The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China., Lv S; The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China., Nan W; The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China., Yu B; Human Aging Research Institute (HARI), School of Life Sciences, Nanchang University, Nanchang, Jiangxi 330031, China., Duan J; Human Aging Research Institute (HARI), School of Life Sciences, Nanchang University, Nanchang, Jiangxi 330031, China., Zhang Y; Shenzhen Crystalo Biopharmaceutical Co., Ltd, Shenzhen, Guangdong 518118, China., Fu Y; School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China., Jiang H; The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China. Electronic address: haihaijiang2020@ncu.edu.cn., McCormick PJ; William Harvey Research Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L69 3GE, UK. Electronic address: P.mccormick@qmul.ac.uk., Li Y; Institute for Biological Electron Microscopy, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China; Department of Chemical Biology, School of Life Southern University of Science and Technology, Shenzhen, Guangdong 518055, China. Electronic address: liyy6@sustech.edu.cn., Zhang J; The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China. Electronic address: zhangxiaokong@hotmail.com.

المصدر: Journal of structural biology [J Struct Biol] 2024 Sep; Vol. 216 (3), pp. 108117. Date of Electronic Publication: 2024 Aug 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9011206 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8657 (Electronic) Linking ISSN: 10478477 NLM ISO Abbreviation: J Struct Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cryoelectron Microscopy*/methods , Receptor, Anaphylatoxin C5a*/chemistry , Receptor, Anaphylatoxin C5a*/metabolism , Complement C5a*/chemistry , Complement C5a*/metabolism, Humans ; Binding Sites ; Protein Binding ; Signal Transduction ; Protein Conformation ; Models, Molecular

المؤلفون: Gupta PK; Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha, India., Das A; Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha, India., Singh A; Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha, India., Rana S; Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha, India.

المصدر: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 Sep; Vol. 42 (14), pp. 7190-7206. Date of Electronic Publication: 2023 Jul 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

مواضيع طبية MeSH: Receptor, Anaphylatoxin C5a*/metabolism , Receptor, Anaphylatoxin C5a*/chemistry , beta-Arrestin 1*/metabolism , beta-Arrestin 1*/chemistry , Protein Binding* , Molecular Dynamics Simulation* , Complement C5a*/chemistry , Complement C5a*/metabolism, Humans ; Models, Molecular ; Lipid Bilayers/chemistry ; Lipid Bilayers/metabolism ; Protein Conformation ; Binding Sites

المؤلفون: Ghosh M; Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha 752050, India., Gupta PK; Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha 752050, India., Behera LM; Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha 752050, India., Rana S; Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha 752050, India.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14110-14124. Date of Electronic Publication: 2024 Jul 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Receptor, Anaphylatoxin C5a*/metabolism , Receptor, Anaphylatoxin C5a*/chemistry , Receptor, Anaphylatoxin C5a*/antagonists & inhibitors , Complement C5a*/metabolism , Complement C5a*/chemistry , Peptides*/chemistry , Peptides*/pharmacology , Peptides*/metabolism , Signal Transduction*/drug effects, Humans ; Protein Binding ; Antibodies/chemistry ; Antibodies/metabolism ; Antibodies/immunology ; Drug Design

المؤلفون: Beach C, MacLean D, Majorova D, Melemenidis S, Nambiar DK, Kim RK, Valbuena GN, Guglietta S, Krieg C, Darvish-Damavandi M, Suwa T, Easton A, Hillson LV, McCulloch AK, McMahon RK, Pennel K, Edwards J, O'Cathail SM, Roxburgh CS, Domingo E, Moon EJ, Jiang D, Jiang Y, Zhang Q, Koong AC, Woodruff TM, Graves EE, Maughan T, Buczacki SJ, Stucki M, Le QT, Leedham SJ, Giaccia AJ, Olcina MM

المصدر: The Journal of clinical investigation [J Clin Invest] 2024 Aug 15; Vol. 134 (16). Date of Electronic Publication: 2024 Aug 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Receptor, Anaphylatoxin C5a*/metabolism , Receptor, Anaphylatoxin C5a*/immunology , Receptor, Anaphylatoxin C5a*/genetics, Humans ; Animals ; Mice ; Tumor Microenvironment/immunology ; Neoplasms/radiotherapy ; Neoplasms/immunology ; Neoplasms/metabolism

المؤلفون: Lv M; Osteonecrosis and Joint Reconstruction Ward, Honghui Hospital, Xi'an Jiaotong University, China., Cai Y; Osteonecrosis and Joint Reconstruction Ward, Honghui Hospital, Xi'an Jiaotong University, China., Hou W; Osteonecrosis and Joint Reconstruction Ward, Honghui Hospital, Xi'an Jiaotong University, China., Peng K; Osteonecrosis and Joint Reconstruction Ward, Honghui Hospital, Xi'an Jiaotong University, China., Xu K; Osteonecrosis and Joint Reconstruction Ward, Honghui Hospital, Xi'an Jiaotong University, China., Lu C; Osteonecrosis and Joint Reconstruction Ward, Honghui Hospital, Xi'an Jiaotong University, China., Yu W; Osteonecrosis and Joint Reconstruction Ward, Honghui Hospital, Xi'an Jiaotong University, China., Zhang W; Osteonecrosis and Joint Reconstruction Ward, Honghui Hospital, Xi'an Jiaotong University, China., Liu L; Osteonecrosis and Joint Reconstruction Ward, Honghui Hospital, Xi'an Jiaotong University, China. Electronic address: shiyourongshi654@163.com.

المصدر: Experimental cell research [Exp Cell Res] 2024 Aug 15; Vol. 441 (2), pp. 114195. Date of Electronic Publication: 2024 Aug 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0373226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2422 (Electronic) Linking ISSN: 00144827 NLM ISO Abbreviation: Exp Cell Res Subsets: MEDLINE

مواضيع طبية MeSH: Ferroptosis*/drug effects , Proto-Oncogene Proteins c-akt*/metabolism , Phosphatidylinositol 3-Kinases*/metabolism , Chondrocytes*/metabolism , Chondrocytes*/pathology , Chondrocytes*/drug effects , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , Osteoarthritis*/metabolism , Osteoarthritis*/pathology , Osteoarthritis*/genetics , Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics , Rats, Sprague-Dawley* , Receptor, Anaphylatoxin C5a*/metabolism , Receptor, Anaphylatoxin C5a*/genetics, Animals ; Rats ; Male ; Signal Transduction ; Heme Oxygenase-1/metabolism ; Heme Oxygenase-1/genetics ; Heme Oxygenase (Decyclizing)

المؤلفون: Schartz ND; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA, USA., Liang HY; Department of Developmental & Cell Biology, University of California, Irvine, Irvine, CA, USA., Carvalho K; Department of Developmental & Cell Biology, University of California, Irvine, Irvine, CA, USA., Chu SH; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA, USA., Mendoza-Arvilla A; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA, USA., Petrisko TJ; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA, USA., Gomez-Arboledas A; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA, USA., Mortazavi A; Department of Developmental & Cell Biology, University of California, Irvine, Irvine, CA, USA., Tenner AJ; Department of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, CA, USA. atenner@uci.edu.; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA. atenner@uci.edu.; Department of Pathology and Laboratory Medicine, University of California, Irvine, School of Medicine, Irvine, CA, USA. atenner@uci.edu.

المصدر: Nature communications [Nat Commun] 2024 Aug 15; Vol. 15 (1), pp. 7028. Date of Electronic Publication: 2024 Aug 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Receptor, Anaphylatoxin C5a*/antagonists & inhibitors , Receptor, Anaphylatoxin C5a*/metabolism , Receptor, Anaphylatoxin C5a*/genetics , Alzheimer Disease*/metabolism , Alzheimer Disease*/drug therapy , Alzheimer Disease*/pathology , Alzheimer Disease*/genetics , Disease Models, Animal* , Signal Transduction*/drug effects , Microglia*/drug effects , Microglia*/metabolism , Hippocampus*/metabolism , Hippocampus*/pathology , Hippocampus*/drug effects, Animals ; Mice ; Female ; Male ; Neuroglia/drug effects ; Neuroglia/metabolism ; Astrocytes/drug effects ; Astrocytes/metabolism ; Mice, Transgenic ; Humans ; Mice, Inbred C57BL

المؤلفون: Wu Z; Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, 266071, China., Zang S; Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, 266071, China., Wang W; Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, 266071, China., Tan S; Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, 266071, China., Xu Q; Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, 266071, China., Chen X; Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, China., Han S; Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, 266071, China., Ma J; Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, 266071, China., Shi K; Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, 266071, China., Wang N; Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, 266071, China; College of Basic Medicine, Qingdao University, Qingdao, 266071, China., Cheng J; Engineering and Technology Center for Flatfish Aquaculture of Tangshan, Tangshan Weizhuo Aquaculture Co., Ltd., Tangshan, 063202, China., Sha Z; Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao, 266071, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China. Electronic address: shazhenxia@163.com.

المصدر: Fish & shellfish immunology [Fish Shellfish Immunol] 2024 Aug; Vol. 151, pp. 109706. Date of Electronic Publication: 2024 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: England NLM ID: 9505220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9947 (Electronic) Linking ISSN: 10504648 NLM ISO Abbreviation: Fish Shellfish Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Flatfishes*/immunology , Flatfishes*/genetics , Receptor, Anaphylatoxin C5a*/genetics , Receptor, Anaphylatoxin C5a*/immunology , Fish Diseases*/immunology , Fish Diseases*/microbiology , Fish Proteins*/genetics , Fish Proteins*/immunology , Interleukin-6*/genetics , Interleukin-6*/immunology , Interleukin-6*/metabolism, Animals ; Vibrio Infections/veterinary ; Vibrio Infections/immunology ; Vibrio/physiology ; Inflammation/immunology ; Inflammation/veterinary ; Gene Expression Regulation/immunology ; Immunity, Innate/genetics

المؤلفون: Shen X; Department of Basic Medicine, Jiangsu Vocational College of Medicine, Yancheng, 224005, Jiangsu, China.; Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi, 154000, Heilongjiang, China., Zheng W; Department of Endocrinology, The First Huaian Hospital Affiliated to Nanjing Medical University, Huai'an, 223300, Jiangsu, China., Du X; Department of Basic Medicine, Jiangsu Vocational College of Medicine, Yancheng, 224005, Jiangsu, China., Chen Y; Department of Basic Medicine, Jiangsu Vocational College of Medicine, Yancheng, 224005, Jiangsu, China., Song X; Department of Basic Medicine, Jiangsu Vocational College of Medicine, Yancheng, 224005, Jiangsu, China., Yang L; Department of Basic Medicine, Jiangsu Vocational College of Medicine, Yancheng, 224005, Jiangsu, China. jsyc.ylc@163.com., Yuan Q; Department of Endocrinology, The First Huaian Hospital Affiliated to Nanjing Medical University, Huai'an, 223300, Jiangsu, China. yuanqi_1991@163.com.

المصدر: Scientific reports [Sci Rep] 2024 Jul 26; Vol. 14 (1), pp. 17232. Date of Electronic Publication: 2024 Jul 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Non-alcoholic Fatty Liver Disease*/metabolism , Non-alcoholic Fatty Liver Disease*/pathology , Receptor, Anaphylatoxin C5a*/metabolism , Receptor, Anaphylatoxin C5a*/genetics , Macrophages*/metabolism , Liver*/metabolism , Liver*/pathology , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/genetics , Phagocytosis*, Animals ; Mice ; Humans ; Male ; Disease Models, Animal ; Mice, Inbred C57BL ; Apoptosis ; Alanine Transaminase/blood ; Alanine Transaminase/metabolism ; Aspartate Aminotransferases/blood ; Aspartate Aminotransferases/metabolism ; Efferocytosis

المؤلفون: Zhang T; Department of Pathology The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University, Xi'an 710004, China.; Core Research Laboratory The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University, Xi'an 710004, China., Ma N; Core Research Laboratory The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University, Xi'an 710004, China., Wang J; Institute of Hematology School of Medicine Northwest University, Xi'an 710069, China., Min X; Core Research Laboratory The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University, Xi'an 710004, China., Wei L; Core Research Laboratory The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University, Xi'an 710004, China., Li K; Core Research Laboratory The Second Affiliated Hospital School of Medicine Xi'an Jiaotong University, Xi'an 710004, China.

المصدر: Journal of immunology research [J Immunol Res] 2024 Jul 10; Vol. 2024, pp. 2899154. Date of Electronic Publication: 2024 Jul 10 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 101627166 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-7156 (Electronic) Linking ISSN: 23147156 NLM ISO Abbreviation: J Immunol Res Subsets: MEDLINE

مواضيع طبية MeSH: Macrophages*/immunology , Macrophages*/metabolism , Neutrophils*/immunology , Neutrophils*/metabolism , Peritonitis*/immunology , Receptor, Anaphylatoxin C5a*/metabolism , Receptor, Anaphylatoxin C5a*/genetics, Animals ; Mice ; Complement C5a/metabolism ; Complement C5a/immunology ; Disease Models, Animal ; Immunity, Innate ; Mice, Inbred C57BL ; Mice, Knockout

المؤلفون: Miao S; Amgen Inc., Thousand Oaks, CA, USA., Suso P; Clinical Pharmacology of Miami, Inc., Hialeah, FL, USA., Furst JA; Prosoft Clinical, Chesterbrook, PA, USA., Hudson MG; Prosoft Clinical, Chesterbrook, PA, USA., Trivedi A; Amgen Inc., Thousand Oaks, CA, USA.

المصدر: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2024 Sep; Vol. 13 (9), pp. 1000-1010. Date of Electronic Publication: 2024 Jul 11.

نوع المنشور: Journal Article; Clinical Trial, Phase I

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101572899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2160-7648 (Electronic) Linking ISSN: 2160763X NLM ISO Abbreviation: Clin Pharmacol Drug Dev Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis*/drug therapy , Receptor, Anaphylatoxin C5a*/antagonists & inhibitors, Humans ; Male ; Female ; Middle Aged ; Aged ; Adult ; Area Under Curve ; Severity of Illness Index ; Cytochrome P-450 CYP3A/metabolism ; Administration, Oral ; Liver Diseases/metabolism ; Aniline Compounds ; Nipecotic Acids