المؤلفون: Monique Jänsch, Lubomir T. Lubomirov, Maximilian Trum, Tatjana Williams, Joachim Schmitt, Kai Schuh, Fatimunnisa Qadri, Lars S. Maier, Michael Bader, Oliver Ritter

المصدر: FEBS Open Bio, Vol 13, Iss 1, Pp 118-132 (2023)

مصطلحات موضوعية: APD90, L‐type calcium channel, NOS1AP, QT interval duration, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2211-5463

URL الوصول: https://doaj.org/article/8069512204c84c57aff6a458cf969748

المؤلفون: Hongwei Cheng, Ian Charles, Andrew F. James, Ana P. Abdala, Jules C. Hancox

المصدر: Physiological Reports, Vol 10, Iss 19, Pp n/a-n/a (2022)

مصطلحات موضوعية: action potential, APD90, eleclazine, GS‐6615, MECP2, QT interval, Physiology, QP1-981

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2051-817X

URL الوصول: https://doaj.org/article/f05ecb1cad914724ab07bd42c5bb7a28

المؤلفون: Abramochkin, Denis V.^Aff1, Makarenko, Ekaterina Yu.^Aff1, Mitrochin, Vadim M.^Aff1, Tian, Bo^Aff1, Kuzmin, Vlad S.^Aff1, Kalugin, Leonid^Aff1, Kovalchuk, Leonid V.^Aff2, Khoreva, Marina V.^Aff3, Nikonova, Anna^Aff3, Lozinsky, Ilya^Aff1, Kamkin, Andre^Aff1

المساهمون: Kamkin, Andre, editor^AffID1, Kiseleva, Irina, editor^AffID2

المصدر: Mechanical Stretch and Cytokines. 5:155-164

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المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez

المصدر: Toxicology and Applied Pharmacology

مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291b9744f97d46ac0f6fd500ad2e1c0f
http://europepmc.org/articles/PMC7322544

المؤلفون: James, Andrew F., Arberry, Lesley A., Hancox, Jules C.

المصدر: Basic Research in Cardiology. May 2004 99(3):183-192

المؤلفون: Erich Wettwer, John Ford, Simone Mueller Loose, Said El Haou, Klaus Matschke, Benoit Tyl, James T. Milnes, Ursula Ravens, Patrick Round

المصدر: Heart Rhythm

مصطلحات موضوعية: 0301 basic medicine, Male, Refractory Period, Electrophysiological, PLT20, plateau potential, that is, mean absolute membrane potential (mV) in the time window between 20% and 30% of APD90, Action Potentials, 030204 cardiovascular system & hematology, APD20, APD50, APD90, action potential duration at 20%, 50%, and 90% of repolarization, DMSO, dimethyl sulfoxide, Human atrial action potentials, Electrocardiography, 0302 clinical medicine, QTc, Atrial Fibrillation, QTcF, Medicine, Sinus rhythm, cAF, chronic atrial fibrillation, ANOVA, analysis of variance, dV/dtmax, maximum upstroke velocity, HR, heart rate, Effective refractory period, Atrial fibrillation, ECG, electrocardiogram/electrocardiographic, pAF, paroxysmal atrial fibrillation, QT, corrected QT, Healthy Volunteers, 3. Good health, Treatment Outcome, Tolerability, Cardiology, QTcF, QT interval corrected by the Fridericia formula, Cardiology and Cardiovascular Medicine, Electrophysiologic Techniques, Cardiac, Anti-Arrhythmia Agents, RMP, resting membrane potential, TMC, time-matched control, Adult, medicine.medical_specialty, AF, atrial fibrillation, QT interval, Article, IKur, ultra-rapidly activating delayed-rectifier potassium current, 03 medical and health sciences, Frequency dependence, Physiology (medical), Internal medicine, Heart rate, Repolarization, Humans, Heart Atria, SR, sinus rhythm, business.industry, APA, action potential amplitude, medicine.disease, 030104 developmental biology, ERP, effective refractory period, IKur inhibitor XEN-D0103, AP, action potential, business, Delayed Rectifier Potassium Channels

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c0db90d1ee3c019f8e6841caef7e71
http://europepmc.org/articles/PMC4768384

المؤلفون: Malcolm Hoshi, Elizabeth S. Kaufman, Haiyan Liu, Isabelle Deschenes

المصدر: HeartRhythm Case Reports, Vol 1, Iss 4, Pp 201-205 (2015)
HeartRhythm Case Reports

مصطلحات موضوعية: WT, wild type, VUS, variant of unknown significance, congenital, hereditary, and neonatal diseases and abnormalities, Lineage (genetic), Long QT syndrome, hERG, Population, LQTS, long QT syndrome, Case Report, QT interval, Sudden death, LQT(2-3), long QT syndrome type (2-3), HEK, human embryonic kidney, APD, action potential duration, medicine, Diseases of the circulatory (Cardiovascular) system, cardiovascular diseases, education, Genetic testing, Genetics, education.field_of_study, biology, medicine.diagnostic_test, business.industry, medicine.disease, Penetrance, 3. Good health, RC666-701, APD90, action potential duration at 90% repolarization, Mutation, biology.protein, ECG, electrocardiogram, LQT, long QT, Cardiology and Cardiovascular Medicine, business, Ion channel, Arrhythmia

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9068055ae9cb8246343dba02542be4b1
http://www.sciencedirect.com/science/article/pii/S2214027115000391

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