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المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez
المصدر: Toxicology and Applied Pharmacology
مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization
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المؤلفون: Malcolm Hoshi, Elizabeth S. Kaufman, Haiyan Liu, Isabelle Deschenes
المصدر: HeartRhythm Case Reports, Vol 1, Iss 4, Pp 201-205 (2015)
HeartRhythm Case Reportsمصطلحات موضوعية: WT, wild type, VUS, variant of unknown significance, congenital, hereditary, and neonatal diseases and abnormalities, Lineage (genetic), Long QT syndrome, hERG, Population, LQTS, long QT syndrome, Case Report, QT interval, Sudden death, LQT(2-3), long QT syndrome type (2-3), HEK, human embryonic kidney, APD, action potential duration, medicine, Diseases of the circulatory (Cardiovascular) system, cardiovascular diseases, education, Genetic testing, Genetics, education.field_of_study, biology, medicine.diagnostic_test, business.industry, medicine.disease, Penetrance, 3. Good health, RC666-701, APD90, action potential duration at 90% repolarization, Mutation, biology.protein, ECG, electrocardiogram, LQT, long QT, Cardiology and Cardiovascular Medicine, business, Ion channel, Arrhythmia