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1دورية أكاديمية
المؤلفون: Laura Cucinotta, Deborah Mannino, Alessia Filippone, Adele Romano, Emanuela Esposito, Irene Paterniti
المصدر: Frontiers in Pharmacology, Vol 15 (2024)
مصطلحات موضوعية: Parkinson’s disease, gender differences, autophagy, ATG (autophagy-related) proteins, leucin rich repeat kinase 2 (LRRK2), Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Claudio Daniel Gonzalez, Roxana Resnik, Maria Ines Vaccaro
المصدر: Frontiers in Endocrinology, Vol 11 (2020)
مصطلحات موضوعية: unconventional protein secretion, IL-1β, aggregate-prone proteins, macroautophagy, ATG (autophagy-related) proteins, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
وصف الملف: electronic resource
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المؤلفون: Po Hu, Hongzheng Wang, Xiaoxuan Yu, Wenzhuo Sun, Hui Hui, Hui Li, Mengyuan Zhu, Zhanyu Wang, Jingyan Xu, Qinglong Guo, Yingjie Qing
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3178-3192 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: NPC, Niemann-Pick type disease C, Cathepsin D, ATG, autophagy related, NH4Cl, ammonium chloride, Lysosomal damage, Calcium in biology, Hematological malignancies, 0302 clinical medicine, RAB7A, RAS-related protein RAB-7a, K48, lysine 48, LC3, microtubule-associated protein 1 light chain 3, TFEB, transcription factor EB, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, RT-qPCR, real time quantitative PCR, Chemistry, LCD, lysosome-dependent cell death, CaN, calcineurin, P62/SQSTM1, sequestosome 1, Cell biology, TRPML1, transient receptor potential mucolipin 1, medicine.anatomical_structure, Cholesterol, 030220 oncology & carcinogenesis, shRNA, short hairpin RNA, Original Article, CsA, cyclosporine A, DAPI, 4′,6-diamidino-2-phenylindole dihydrochloride, Programmed cell death, AO, acridine orange, CTSD, cathepsin D, LW-218, PBS, phosphate-buffered saline, CTSB, cathepsin B, LMP, lysosome membrane permeabilization, EGTA, ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid, RM1-950, Lysosome-dependent cell death, 03 medical and health sciences, Dex, dexamethasone, ROS, reactive oxygen species, FBS, fetal bovine serum, Lysosome, NPC1, NPC intracellular cholesterol transporter 1, medicine, BAF A1, bafilomycin A1, 030304 developmental biology, Cathepsin, PBMCs, peripheral blood mononuclear cells, Lysosomal membrane permeabilization, K63, lysine 63, Cell growth, DCFH-DA, 2,7-dichlorodi-hydrofluorescein diacetate, Autophagy, BID, BH3-interacting domain death agonist, Lysophagy, OD, optical density, TFEB, CCK8, Cell Counting Kit, Therapeutics. Pharmacology, LAMPs, lysosomal-associated membrane proteins
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المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2
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5دورية أكاديمية
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المؤلفون: Yang An, Jin Zhang, Xiaoxi Zeng, Yuqian Zhao, Shouyue Zhang, Ziyi Qin, Heng Xu, Bo Liu
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1227-1245 (2021)مصطلحات موضوعية: Druggable target, Programmed cell death, Candidate gene, CNA, copy number alteration, Regulator, Druggability, RM1-950, Biology, Autophagic regulator, TNBC, triple-negative breast cancer, SIRT3, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, BRCA, invasive breast carcinoma, ATG, autophagy-related gene, GO, Gene Ontology, Gene expression, medicine, General Pharmacology, Toxicology and Pharmaceutics, Migration, SNF, similarity network fusion, 030304 developmental biology, 0303 health sciences, LASSO, least absolute shrinkage and selection operator, Autophagy, SF3B3, medicine.disease, Multi-omics approach, PFS, progression-free survival, Invasive breast carcinoma, MET, DNA methylation, Anti-proliferation, EXP, gene expression, 030220 oncology & carcinogenesis, DNA methylation, Cancer research, TCGA, The Cancer Genome Atlas, Original Article, Therapeutics. Pharmacology
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المؤلفون: Grace L. Guo, Xiaoyun Chen, Zheng Dong, Bilon Khambu, Xiao Ming Yin, Shengmin Yan
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 973-997 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Gut Dysbiosis, OST-β, organic solute transporter subunit-β, SQSTM1, sequestosome-1, FGF15, CK19, cytokeratin 19, Gut flora, FEX, fexaramine, SHP, small heterodimer partner, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, AST, aspartate transaminase, MCA, muricholic acid, CYP8B1, cytochrome p450 family 8b1, BLU, Blu-9931, TCDCA, taurochenodeoxycholic acid, Original Research, FGFR4, fibroblast growth factor receptor 4, TBA, total bile acid, Liver injury, CA, cholic acid, biology, Bile acid, Gastroenterology, qRT-PCR, quantitative real-time polymerase chain reaction, Liver, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, NRF2, nuclear factor erythroid 2-related factor 2, BA, bile acid, 030211 gastroenterology & hepatology, TDCA, taurodeoxycholic acid, medicine.drug, medicine.medical_specialty, GM, gut microbiota, ALT, alanine transaminase, medicine.drug_class, TCA, taurocholic acid, PBS, phosphate-buffered saline, IBABP, ileal bile acid-binding protein, OST-α, organic solute transporter subunit-α, Liver Injury, ASBT (SLC10A2), apical sodium–bile acid transporter, CDCA, chenodeoxycholic acid, Bile Acids and Salts, CYP7A1, cytochrome p450 7a1, 03 medical and health sciences, FXR, farnesoid X receptor, ATG, autophagy-related gene, TUDCA, tauroursodeoxycholic acid, Internal medicine, medicine, Autophagy, BAS, bile acid sequestrants, lcsh:RC799-869, Cholestyramine, ALP, alkaline phosphatase, FGF15, fibroblast growth factor 15, SE, standard error, Hepatology, Fibroblast growth factor receptor 4, biology.organism_classification, medicine.disease, Gastrointestinal Microbiome, 030104 developmental biology, Endocrinology, DCA, deoxycholic acid, PCoA, principal coordinates analysis, BSH, bile salt hydrolase, ABX, antibiotics, TLCA, taurolithocholic acid, TMCA, tauromuricholic acid, Farnesoid X receptor, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5847c5c25a4c55b7146f469ae9e2e369
http://www.sciencedirect.com/science/article/pii/S2352345X20301740 -
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المؤلفون: Cristiano Rumio, Fabrizio Marcucci
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 234-245 (2021)مصطلحات موضوعية: 0301 basic medicine, PFKFB3, PFKFB isoform 3, Cancer Research, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, OXPHOS, oxidative phosphorylation, ATG, autophagy related, Apoptosis, Drug resistance, Review Article, TKI, tyrosine kinase inhibitor, Oxidative Phosphorylation, 0302 clinical medicine, Neoplasms, Glycolysis, NADPH, nicotinamide adenine dinucleotide phosphate reduced, media_common, LDH, lactate dehydrogenase, Chemistry, ABC, ATP-binding cassette, mTOR, mechanistic target of rapamycin, EMT, TME, tumor microenvironment, PFKFB, phosphofructo-2-kinase/fructose-2,6-biphosphatase, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cell biology, GLUT, glucose transporter, Mitochondria, HIF, hypoxia-inducible factor, PGK1, PGK isoform 1, ENO, enolase, 030220 oncology & carcinogenesis, Efflux, EMT, epithelial-mesenchymal transition, PI3K, phosphoinositide 3-kinase, Drug, PDK1, PDK isoform 1, ATP, adenosine triphosphate, Epithelial-Mesenchymal Transition, media_common.quotation_subject, DDR, DNA damage repair, HK2, HK isoform 2, PPP, pentose phosphate pathway, Antineoplastic Agents, lcsh:RC254-282, 03 medical and health sciences, ROS, reactive oxygen species, Cell Line, Tumor, PGK, phosphoglycerate kinase, PFKP, PFK platelet type, Animals, Humans, LDHA, LDH isoform A, mAb, monoclonal antibody, Tumors, Tumor microenvironment, Innate immune system, Autophagy, Danger, HK, hexokinase, PDH, pyruvate dehydrogenase, EGFR, epidermal growth factor receptor, Metabolic pathway, 030104 developmental biology, Glucose, Drug Resistance, Neoplasm, PK, pyruvate kinase, PKM2, PK isoform M2, ALDO, fructose biphosphate aldolase, ENO1, ENO isoform 1, Energy Metabolism, PDK, pyruvate dehydrogenase kinase
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المؤلفون: Junichi Sadoshima, Daniela Zablocki, Jihoon Nah
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Ischemia, 030204 cardiovascular system & hematology, autophagic flux, STATE-OF-THE-ART REVIEW, Na k adenosine triphosphatase, ER, endoplasmic reticulum, 03 medical and health sciences, 0302 clinical medicine, PI3K, phosphatidylinositol 3 kinase, Late phase, ATG, autophagy-related, medicine, rubicon, Na+,K+–adenosine triphosphatase, business.industry, Tat, transactivation of transcription, Autophagy, beclin 1, autosis, PNS, perinuclear space, medicine.disease, I/R, ischemia-reperfusion, HIV, human immunodeficiency virus, 030104 developmental biology, autophagic cell death, Perinuclear space, Cancer research, Molecular mechanism, ATPase, adenosine triphosphatase, Cardiology and Cardiovascular Medicine, business, LBR, lamin B receptor
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المؤلفون: Jifa Zhang, Bo Liu, Liang Ouyang, Honggang Xiang, Congcong Lin, Lan Zhang
المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 569-581 (2020)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: PINK1, PTEN-induced putative kinase 1, Review, PROTAC, proteolysis targeting chimeras, PTMs, post-translational modifications, Protein aggregation, PKCα, protein kinase C alpha type, AKT1, AKT serine/threonine kinase 1, PD, Parkinson's disease, Autophagy-related kinase, DAPK, death associated protein kinase, PKD1, polycystin-1, GAP, GTPase-activating protein, PKACα, a protein kinase cAMP-activated catalytic subunit alpha, 0302 clinical medicine, Human disease, TNBC - Triple-negative breast cancer, Protein kinases, LC3, microtubule-associated protein 1 light chain 3, UVRAG, ultraviolet resistance-associated gene, TFEB, transcription factor EB, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Rheb, the RAS homolog enriched in brain, TAK1, transforming growth factor activated kinase-1, 0303 health sciences, Kinase, mTORC1, mammalian target of rapamycin complex 1, PI3 kinase, phosphoinositide 3-kinase, Cell biology, GSK3α, glycogen synthase kinase 3 alpha, HMGB1, high mobility group protein B1, AMBRA1, autophagy/beclin-1 regulator 1, ULK complex, ULK1–mATG13–FIP200–ATG101 complex, ARF, auxin response factor gene, 030220 oncology & carcinogenesis, TSC1/2, tuberous sclerosis complex proteins 1/2, PIM2, proviral insertion in murine lymphomas 2, LPS, lipopolysaccharide, PI3P, phosphatidylinositol triphosphate, Small-molecule kinase inhibitors/activators, JNK1, C-Jun N-terminal kinase, mTOR, mammalian target of rapamycin, ULK1, unc-51-like kinase 1, Biology, PPIs, protein–protein interactions, PI, phosphatidylinositol, TNBC, triple-negative breast cancer, FIP200, FAK family kinase-interacting protein of 200 kDa, 03 medical and health sciences, 4E-BP1, eukaryotic translation initiation factor 4E-binding protein, Organelle, Autophagy, LRRK2, leucine rich repeat kinase 2, ATG, autophagy-related protein, GO, gene ontology, 030304 developmental biology, PD - Parkinson's disease, lcsh:RM1-950, CaMKK2, calcium/calmodulin-dependent protein kinase kinase 2, Human disease therapy, AMPK, AMP-activated protein kinase, lcsh:Therapeutics. Pharmacology, PIP2, phosphatidylinositol-4,5-bisphosphate, LKB1, serine/threonine-protein kinase stk11
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