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المؤلفون: Miyake, Shuntarou
المساهمون: 片山, 高嶺, 高田, 穣, 原田, 浩
مصطلحات موضوعية: ピリミジン, poly(A)+ RNA, DHODH, ミトコンドリア呼吸酵素複合体III, ATM(Ataxia Telangiectasia Mutated)
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=jairo_______::3a02d2206ef46820c108b7a1c834c46a
http://hdl.handle.net/2433/283872 -
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المؤلفون: Hao Wang, Lei Wang, Keyi Jia, Yu Liu, Sha Zhao, Wei Li, Caicun Zhou, Minlin Jiang, Bin Chen, Yayi He
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2983-2994 (2021)مصطلحات موضوعية: Genome instability, PD-L1, programmed death ligand 1, BRCA, breast cancer susceptibility gene, ICI, immune checkpoint inhibitor, medicine.medical_treatment, MUTYH, MutY homolog, cGAS, cyclic GMP–AMP synthase, Review, DNA damage response, Malignant transformation, ORR, objective response rate, PCR, polymerase chain reaction, 0302 clinical medicine, SCNAs, somatic copy number alterations, FDA, United State Food and Drug Administration, Cancer immunotherapy, MGMT, O6-methylguanine methyltransferase, PD-1, RB1, retinoblastoma 1, General Pharmacology, Toxicology and Pharmaceutics, BER, base excision repair, RAD51C, RAD51 homolog C, 0303 health sciences, TME, tumor microenvironment, TP53, tumor protein P53, cGAS–STING, MSI, microsatellite instability, TRIF, Toll-interleukin 1 receptor domain-containing adaptor inducing INF-β, PFS, progression-free survival, STAT, signal transducer and activator of transcription, NEK1, NIMA-related kinase 1, Tumor microenvironment, PALB2, partner and localizer of BRCA2, RSR, replication stress response, 030220 oncology & carcinogenesis, Immunotherapy, PARP, poly-ADP ribose polymerase, JAK, Janus kinase, IHC, immunohistochemistry, Genomic instability, PD-L1, DSBs, double-strand breaks, DNA repair, DNA damage, CHK1, checkpoint kinase 1, IRF1, interferon regulatory factor 1, MLH1, MutL homolog 1, RM1-950, MMR, mismatch repair, STING, stimulator of interferon genes, Biology, MNT, MAX network transcriptional repressor, DDR, DNA damage response, MSH2/6, MutS protein homologue-2/6, OS, overall survival, RPA, replication protein A, 03 medical and health sciences, GSK3β, glycogen synthase kinase 3β, NER, nucleotide excision repair, NSCLC, non-small cell lung cancer, MyD88, myeloid differentiation factor 88, ssDNA, single-stranded DNA, medicine, DAMP, damage-associated molecular patterns, DR, direct repair, 030304 developmental biology, BAP1, BRCA1-associated protein 1, BRAF, v-RAF murine sarcoma viral oncogene homologue B, TLR4, Toll-like receptor 4, Cancer, NGS, next generation sequencing, ATM, ataxia-telangiectasia mutated, NIMA, never-in-mitosis A, medicine.disease, CHEK, cell-cycle checkpoint kinase, PD-1, programmed death 1, MAD1, mitotic arrest deficient-like 1, body regions, IFNγ, interferon gamma, TILs, tumor-infiltrating lymphocytes, TBK1, TANK-binding kinase 1, ATR, ataxia telangiectasia and Rad3 related, Cancer research, NHEJ, nonhomologous end-joining, Therapeutics. Pharmacology, HMGB1, high mobility group box-1, HRR, homologous recombination repair, XRCC4, X-ray repair cross complementing protein 4, TMB, tumor mutational burden
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المصدر: Advanced Drug Delivery Reviews
مصطلحات موضوعية: ICAM1, Intercellular adhesion molecule–1, PLA, Poly(lactide), GEMM, Genetically modified mouse model, RAG, Rag-deficient, 02 engineering and technology, Metastasis, CCPM, Core-crosslinked block copolymer micelle, TME, Tumor microenvironment, TAM, Tumor-associated macrophages, Breast cancer, NIR, Near-infrared, Th2, Type 2 T helper, NK, Natural killer, AGM, Aminoglutethimide, Medicine, NF1, Neurofibromin 1, BRCA1, Breast cancer type 1 susceptibility protein, SPIO, Superparamagnetic iron oxide nanoparticle, 0303 health sciences, education.field_of_study, ERS1, Estrogen receptor gene, BRCA2, Breast cancer type 2 susceptibility protein, Organoids, CHEK2, Checkpoint kinase 2, Patient-derived xenografts, Nanomedicine, PTBPC, Poly(2‐((tert‐butoxycarbonyl)amino)‐3‐propyl carbonate, DOX, Doxorubicin, 0210 nano-technology, PDOX, Patient-derived organoid-derived xenograft, TNBC, Triple negative breast cancer, NOG, NOD/Shi-scid/γc−/− null, FITC, Fluorescein isothiocyanate, Antineoplastic Agents, 2D, Two-dimensional, MMDOX, Doxorubicin-loaded mixed micelles, Article, NOD-SCID, non-obese diabetic-severe combined immunodeficient, WHO, World Health Organization, FA, Folic acid, PyMT, Polyoma middle tumor-antigen, 03 medical and health sciences, HPMA, Hydroxypropyl methacrylamide, Drug Development, NMU, N-methyl-n-nitrosourea, Humans, SCID, Severe combined immunodeficient, education, WAP, Whey acidic protein, Immune status, MDR1, Multidrug resistance protein 1, PTEN, Phosphatase and tensin homolog, pDNA, Plasmid desoxyribonucleic acid, AuNR, Gold nanorod, medicine.disease, NP, Nanoparticle, VIP, Vasoactive intestinal peptide, Clinical trial, PLGA, poly(lactide-co-glycolide), Nanoparticles, HER2, Epidermal growth factor receptor 2, MMP, Metallopeptidases, Th1, Type 1 T helper, PGA, Poly-L-glutamic acid, Biomarkers, ROS, Reactive oxygen species, IHC, Immunohistochemistry, MMTV, Mouse mammary tumor virus, IO, Iron oxide, IONP, Iron oxide nanoparticle, Pharmaceutical Science, TP53, tumor protein p53, Bioinformatics, ATM, Ataxia-telangiectasia mutated, PALB2, Partner and localizer of BRCA2, Drug Delivery Systems, NSG, NOD scid gamma, uPAR, Urokinase plasminogen activator receptor, PDNA, Plasmid DNA, GSH, Glutathione, LTR, Long terminal repeat, Drug Carriers, EPR, Enhanced permeability and retention, PPTT, Plasmonic photothermal therapy, TPGS, D-α-tocopheryl polyethylene glycol 1000 succinate, DC, Dendritic cells, HIF1α, Hypoxia-inducible factor 1 alpha, MEF, Mouse embryonic fibroblasts, CAF, Cancer-associated fibroblasts, PR, Progesterone receptor, 021001 nanoscience & nanotechnology, Nanomedicines, Animal models, ER, Estrogen receptor, Nude, Athymic nude, DMBA, 7,12-dimethylbenzantracene, PEG, Polyethylene glycol, Female, MUC1, Mucin 1, QbD, Quality by design, 3D, Three-dimensional, PDX, Patient-derived xenograft, Population, Breast Neoplasms, Enhanced permeability and retention effect, Pre-clinical models, CSC, Cancer stem cells, ALOX5, Arachidonate 5-lipoxygenase, iPSC, induced pluripotent stem cells, ECM, Extracellular matrix, ComputingMethodologies_COMPUTERGRAPHICS, 030304 developmental biology, PI3KCA, Phosphatidylinositol 3-kinase, business.industry, SSMM, Sterically-stabilized mixed phospholipid nanomicelle, Cancer, FDA, Food and Drug Administration, PIMs, Porcine pulmonary intravascular macrophages, EGFR, Epithelial growth factor receptor, CDX, Cell-derived xenograft, STK11, Serine/Threonine Kinase 11, business
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المؤلفون: Guangmei Yan, Ying Liu, Jiankai Liang, Ke Li, Xincheng Liu, Wentao Huang, Cheng Hu, Yuan Lin, Jing Cai, Hao Zhang, Liang Peng, Wenbo Zhu, Jianguang Qiu
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 158-168 (2021)مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Oncolytic virus, ISG, interferon-stimulated genes, viruses, Gene Expression, Apoptosis, CCDC6, Coiled-coil-domain containing 6, Mice, 0302 clinical medicine, Interferon pathway, Neoplasms, DNA-PKI, DNA-PK inhibitor, RNA, Small Interfering, Oncolytic Virotherapy, Gene knockdown, M1 virus, HRP, horseradish peroxidase, Transfection, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Endoplasmic Reticulum Stress, ZAP, zinc finger antiviral protein, Oncolytic Viruses, XBP1, X-box binding protein 1, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, RT, room temperature, Oncolytic Virus Therapy, Female, Original article, DAUCs, area under the curve, PVDF, polyvinylidene fluoride, siRNA, Small interfering RNAs, Genetic Vectors, Alphavirus, Biology, lcsh:RC254-282, Virus, 03 medical and health sciences, DNA-PK, DNA-dependent protein kinase, Cell Line, Tumor, Animals, Humans, Genetic Therapy, biology.organism_classification, Xenograft Model Antitumor Assays, IFNs, Interferons, VCP, valosin-containing protein, Cytoskeletal Proteins, Disease Models, Animal, 030104 developmental biology, CCDC6, Cancer cell, Cancer research, ATM, ataxia telangiectasia-mutated
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المؤلفون: Christina Falkeis-Veits, Victoria Neumeyer, Elisabeth Kremmer, Anna Brutau-Abia, Nicole Pfarr, Michael Allgäuer, Raquel Mejías-Luque, Markus Gerhard, Wilko Weichert, Michael Vieth
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cell. Mol. Gast. Hept. 11, 1071-1094 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1071-1094 (2021)مصطلحات موضوعية: 0301 basic medicine, Male, ATR, ATM-and Rad3-Related, MSI-high, microsatellite instability-high, Carcinogenesis, RNP, ribonucleoprotein, Apoptosis, medicine.disease_cause, Mice, 0302 clinical medicine, Tumor Cells, Cultured, RNF43, RING finger protein 43, PMSS1, pre-mouse SS1, Wnt Signaling Pathway, Original Research, Aged, 80 and over, Mice, Knockout, Mutation, Stomach, Gastroenterology, Wnt signaling pathway, CHK, checkpoint kinase, Middle Aged, Dna Damage Response (ddr), Gastric Cancer, Helicobacter Pylori, Rnf43, ddc, medicine.anatomical_structure, Editorial, Gastritis, RNF43, GC, gastric cancer, 030211 gastroenterology & hepatology, Female, SNP, single-nucleotide polymorphism, medicine.drug, Adult, MSI, microsatellite unstable, SDS, sodium dodecyl sulfate, DNA damage, Ubiquitin-Protein Ligases, H2AX, H2A histone family member X, WNT, Wingless-related integration site, Biology, DDR, DNA damage response, Helicobacter Infections, 03 medical and health sciences, Stomach Neoplasms, medicine, Animals, Humans, DSB, double-strand break, Viability assay, lcsh:RC799-869, Aged, Cell Proliferation, Cisplatin, Hepatology, Helicobacter pylori, D196, deletion at aspartic acid 196, DNA Damage Response (DDR), ATM, ataxia-telangiectasia mutated, shControl, short hairpin control, biology.organism_classification, Xenograft Model Antitumor Assays, WT, wild-type, CRISPR/Cas9, Clustered related interspaced short palindromic repeats/CRISPR associated 9, Mice, Inbred C57BL, body regions, 030104 developmental biology, Case-Control Studies, shRNF43, short hairpin RING finger protein 43, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, Biomarkers, DNA Damage
وصف الملف: application/pdf
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المؤلفون: Farah Khashab, May Al-Maghrebi, Nora Al-Kandari, Farah Al-Saleh, Fatemah Fadel
المصدر: Saudi Journal of Biological Sciences, Vol 27, Iss 8, Pp 2174-2184 (2020)
Saudi Journal of Biological Sciencesمصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, O2, molecular oxygen, PERK, pancreatic ER kinase, NADP, nicotinamide adenine dinucleotide phosphate, PCC, protein carbonyl content, DMSO, dimethyl sulfoxide, ST, seminiferous tubule, medicine.disease_cause, 01 natural sciences, ATF, activating transcription factor, eIF2α1, eukaryotic initiation factor 2α1, PVDF, polyvinylidene difluoride, chemistry.chemical_compound, DNA, deoxyribonucleic acid, PCR, polymerase chain reaction, UPR, unfolded protein response, ECL, electrochemiluminescence, TOS, testicular oxidative stress, ASK1, PARP, poly ADP-ribose polymerase, lcsh:QH301-705.5, ANOVA, analysis of variance, ATM, ataxia telangiectasia mutated, NADPH oxidase, RT, reverse transcription, biology, Chemistry, ELISA, enzyme-linked immunosorbent assay, BTB, blood-testis barrier, i.p., intraperitoneal, NOX, NADPH oxidase, JNK, c-Jun N-terminal Kinase, OS, oxidative stress, H2O2, hydrogen peroxide, IAP, inhibitors of apoptosis, p-, phosphorylated, RIPA, radioimmunoprecipitation assay, Germ cell apoptosis, General Agricultural and Biological Sciences, ER stress, kDa, kilodalton, phox, phagocyte oxidase, DNA damage, mRNA, messenger ribonucleic acid, H2AX, histone variant, IRE1, inositol requiring kinase 1, DAPI, diamidino phenylindole, CHOP, CCAAT-enhancer-binding protein homologous protein, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, Article, DDR, DNA damage response, Testicular ischemia Reperfusion Injury, ER, endoplasmic reticulum, Superoxide dismutase, Andrology, cDNA, complementary DNA, 03 medical and health sciences, ROS, reactive oxygen species, SOD, superoxide dismutase, GCA, germ cell apoptosis, medicine, IF, immunofluorescence, MDA, malondialdehyde, GRP78, glucose-related protein 78, medicine.disease, O2−, superoxide anion, Chk, checkpoint kinase, 8-OHdG, 8-hydroxy-2′-deoxyguanosine, 030104 developmental biology, lcsh:Biology (General), Oxidative stress, TRAF-2, tumor-necrosis-factor receptor-associated factor 2, SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis, Apocynin, H&E, hematoxylin and eosin, RNA, ribonucleic acid, γ-H2AX, 139 serine-phosphorylated histone variant, Unfolded protein response, biology.protein, ASK1, apoptosis signaling kinase 1, BSA, bovine serum albumin, gDNA, genomic DNA, SD, standard deviation, Reperfusion injury, 010606 plant biology & botany
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b9b9c3762cf95184a4b635e3a70e69
http://www.sciencedirect.com/science/article/pii/S1319562X20301364 -
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المؤلفون: Emmanuel Skordalakes, Tomas M. Aramburu, Sarah Plucinsky
المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 1939-1946 (2020)مصطلحات موضوعية: Telomerase, Ten1, Telomere Length Regulation Protein, TRF1, Telomere Repeat binding Factor 1, DNA damage, lcsh:Biotechnology, Biophysics, POT1, Protection of telomere 1, Review Article, Biology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Shelterin, 0302 clinical medicine, POT1, Structural Biology, lcsh:TP248.13-248.65, Genetics, TERT, Telomerase Reverse Transcriptase, TRF2, Telomere Repeat binding Factor 2, TIN2, TRF1- and TRF2-Interacting Nuclear Protein 2, RAP1, Repressor/Activator Protein 1, 030304 developmental biology, Ribonucleoprotein, TPP1, CST, CTC1, Stn1 and Ten1, 0303 health sciences, Stn1, Suppressor of Cdc Thirteen, RPA, Replication Protein A, DNA replication, ATR, Ataxia Telangiectasia and Rad3-related Protein, ATM, Ataxia Telangiectasia Mutated protein, USP7, ubiquitin-specific-processing protease 7, Processivity, Computer Science Applications, Telomere, Cell biology, Telomeres, chemistry, TPP1 also known as ACD, Adrenocortical Dysplasia Protein Homolog, 030220 oncology & carcinogenesis, TSPYL5, Testis-specific Y-encoded-like protein 5, TERC, Telomerase RNA, CTC1, Conserved Telomere Capping Protein 1, SMCHD1, Structural Maintenance Of Chromosomes Flexible Hinge Domain Containing 1, DNA, Biotechnology
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المؤلفون: Tetsu Watanabe, Yoichiro Otaki, Harutoshi Tamura, Tetsuro Shishido, Takayuki Sugai, Taro Narumi, Jun Ichi Abe, Chang Hoon Woo, Ken Watanabe, Taku Toshima, Yasuchika Takeishi, Tetsuya Takahashi, Takuya Miyamoto, Hiroki Takahashi, Isao Kubota, Takanori Arimoto, Satoshi Nishiyama, Masafumi Watanabe, Daisuke Kinoshita
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: p-ATM, phosphorylation of ataxia telangiectasia mutated, 0301 basic medicine, CVF, collagen volume fraction, DNA damage, DAMP, damage-associated molecular pattern, Cardiomyocyte hypertrophy, NRCM, neonatal rat cardiomyocyte, chemical and pharmacologic phenomena, 030204 cardiovascular system & hematology, DNA damage response, HMGB1, ERK1/2, extracellular signal-related kinase 1/2, PWd, posterior wall diameter, PRECLINICAL RESEARCH, 03 medical and health sciences, DNA, deoxyribonucleic acid, 0302 clinical medicine, MyD, cardiomyocyte diameter, Fibrosis, LVDd, left ventricular diastolic dimension, Medicine, HMGB1-Tg, high-mobility group box 1 transgenic, HW/TL, heart weight to tibial length, ANP, atrial natriuretic peptide, E/A ratio, ratio of early to atrial wave, Pathological, NF-κB, nuclear factor kappa B, Ang II, angiotensin II, ATM, ataxia telangiectasia mutated, BNP, brain natriuretic peptide, biology, business.industry, medicine.disease, WT, wild-type, LVDs, left ventricular systolic dimension, 030104 developmental biology, High-mobility group, Cardiac hypertrophy, pathological cardiac hypertrophy, cardiovascular system, Cancer research, biology.protein, DDR, deoxyribonucleic acid damage response, IVSd, interventricular septum diameter, Cardiology and Cardiovascular Medicine, business, HMGB1, high-mobility group box 1, Homeostasis
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المؤلفون: Jinquan Cai, Ruijia Wang, Lin Lin, Hengyuan Pang, Magafurov Dinislam, Ziwei Li, Shihong Zhao, Qun Chen, Chuanlu Jiang, Pengfei Wu, Caijun Zha, Chunbin Duan, Xiangqi Meng, Bo Han
المصدر: EBioMedicine
مصطلحات موضوعية: Research paper, DNA Repair, Cellular differentiation, medicine.medical_treatment, ATRX, alpha thalassemia/mental retardation syndrome X-linked, SAA1, serum amyloid A1, Transcriptome, Mice, 0302 clinical medicine, GSEA, gene set enrichment analysis, GME, glioma microenvironment, MEM, Minimum Essential Media, BER, base excision repair, Midkine, TNFSF4, TNF superfamily member 4, NADP, nicotinamide adenine dinucleotide phosphate, General Medicine, DSBR, DNA double-strand break repair, 030220 oncology & carcinogenesis, NHEJ, nonhomologous end joining, Microglia, IHC, immunohistochemistry, γH2AX, phosphorylated on serine 139 on H2A histone family member X, CNV, copy number variation, IL6, interleukin 6, ATM, ataxia telangiectasia-mutated gene, IGV, Integrative Genomics Viewer, MDK, midkine, KEGG, Kyoto Encyclopedia of Genes and Genomes, PI, protease inhibitor, DDR, DNA damage response, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mrc1, mannose receptor C-type 1, NER, nucleotide excision repair, Glioma, Humans, PTEN, IF, immunofluorescence, GCM, glioma-conditioned medium, IDH, isocitrate dehydrogenase (NADP(+)), Tumor microenvironment, SSBR, DNA single-strand break repair, TMZ, temozolomide, Macrophages, medicine.disease, Mice, Inbred C57BL, body regions, 030104 developmental biology, Pen/Strep, penicillin/streptomycin, HR, homologous recombination, DAPI, 4′,6-diamidino-2-phenylindole, p53, 0301 basic medicine, ATR, Ataxia Telangiectasia And Rad3-Related Protein, qRT-PCR, Quantitative real-time reverse transcription-polymerase chain reaction, DAB, Diaminobenzidine, ChIP, Chromatin immunoprecipitation, Tumor Microenvironment, DNA damage repair, FA, Fanconi anemia, MGMT, O6-methylguanine-DNA methyltransferase, biology, LGG, lower grade glioma, TLS, trans-lesion synthesis, TP53, tumor protein P53, HRP, horseradish peroxidase, Cell Differentiation, Fizz1, found in inflammatory zone 1, SNP, single nucleotide polymorphism, TCGA, The Cancer Genome Atlas dataset, Cytokine, TNFA, tumor necrosis factor alpha, Female, Arg1, arginase 1, DNA repair, SWI/SNF, SWItch/Sucrose Non-Fermentable, MMR, mismatch repair, DMEM, Dulbecco's Modified Eagle Medium, AKT, protein kinase B, CCL2, C-C motif chemokine ligand 2, CGGA, The Chinese Glioma Genome Atlas dataset, C5, Complement C5, Cell Line, Glioma microenvironment, VEGFA, vascular endothelial growth factor A, FBS, fetal bovine serum, PBS, phosphate buffered saline, Cell Line, Tumor, medicine, Animals, ELISA, Enzyme-Linked Immunosorbent Assay, DR, direct repair, GO, gene ontology, ssGSEA, single sample gene set enrichment analysis, FC, fold change, PTEN, phosphatase and tensin homolog, EGFR, epidermal growth factor receptor, TBST, Tris-buffered Saline with Tween 20, NFκB, nuclear factor kappa B, biology.protein, Cancer research, GBM, glioblastoma, EM/PM classification, EGFR module / PDGFRA (platelet derived growth factor receptor A) -based molecular classification, Tumor Suppressor Protein p53
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10دورية أكاديمية
المؤلفون: Molly L. Bristol, Dipon Das, Iain M. Morgan
المصدر: Viruses, Vol 9, Iss 10, p 268 (2017)
مصطلحات موضوعية: HPV, human papillomavirus, replication, initiation, life cycle, DNA damage response, TopBP1, E1, E2, ATM (ataxia-telangiectasia mutated), ATR (ataxia telangiectasia and Rad3 related), DNA damage signaling, cervical cancer, head and neck cancer, homologous recombination, MRN (Mre11-Rad50-Nbs1), Microbiology, QR1-502
وصف الملف: electronic resource
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