المؤلفون: Lars Harbaum, Christopher J. Rhodes, John Wharton, Allan Lawrie, Jason H. Karnes, Ankit A. Desai, William C. Nichols, Marc Humbert, David Montani, Barbara Girerd, Olivier Sitbon, Mario Boehm, Tatyana Novoyatleva, Ralph T. Schermuly, H. Ardeschir Ghofrani, Mark Toshner, David G. Kiely, Luke S. Howard, Emilia M. Swietlik, Stefan Gräf, Maik Pietzner, Nicholas W. Morrell, Martin R. Wilkins, L Southgate, RD Machado, J Martin, WH Ouwehand, MW Pauciulo, A Arora, K Lutz, F Ahmad, SL Archer, R Argula, ED Austin, D Badesch, S Bakshi, C Barnett, R Benza, N Bhatt, CD Burger, M Chakinala, J Elwing, T Fortin, RP Frantz, A Frost, JGN Garcia, J Harley, H He, NS Hill, R Hirsch, D Ivy, J Klinger, T Lahm, K Marsolo, LJ Martin, SD Nathan, RJ Oudiz, Z Rehman, I Robbins, DM Roden, EB Rosenzweig, G Saydain, R Schilz, RW Simms, M Simon, H Tang, AY Tchourbanov, T Thenappan, F Torres, AK Walsworth, RE Walter, RJ White, J Wilt, D Yung, R Kittles, J Aman, J Knight, KB Hanscombe, H Gall, A Ulrich, HJ Bogaard, C Church, JG Coghlan, R Condliffe, PA Corris, C Danesino, CG Elliott, A Franke, S Ghio, JSR Gibbs, AC Houweling, G Kovacs, M Laudes, RV MacKenzie Ross, S Moledina, M Newnham, A Olschewski, H Olschewski, AJ Peacock, J Pepke-Zaba, L Scelsi, W Seeger, CM Shaffer, O Sitbon, J Suntharalingam, C Treacy, A Vonk Noordegraaf, Q Waisfisz, SJ Wort, RC Trembath, M Germain, I Cebola, J Ferrer, P Amouyel, S Debette, M Eyries, F Soubrier, DA Trégouët

المساهمون: Harbaum, Lars [0000-0002-9422-6195], Lawrie, Allan [0000-0003-4192-9505], Montani, David [0000-0002-9358-6922], Sitbon, Olivier [0000-0002-1942-1951], Gräf, Stefan [0000-0002-1315-8873], Wilkins, Martin R [0000-0003-3926-1171], Apollo - University of Cambridge Repository, British Heart Foundation, The Academy of Medical Sciences

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Pulmonary Arterial Hypertension, Proteome, case-control studies, Hypertension, Pulmonary, Respiratory System, Blood Proteins, Critical Care and Intensive Care Medicine, Mendelian randomization, Humans, Familial Primary Pulmonary Hypertension, Netrins, Pathology, Molecular, Mendelian randomisation, protein quantitative trait loci, Thrombospondins, genome, 11 Medical and Health Sciences

وصف الملف: application/octet-stream

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f363dc083e705c01eb9c6d70a4b67afd
https://www.repository.cam.ac.uk/handle/1810/340465

المؤلفون: Rhodes CJ; Department of Medicine, Imperial College London, London, UK., Batai K; Department of Surgery, University of Arizona, Tucson, AZ, USA., Bleda M; Department of Medicine, University of Cambridge, Cambridge, UK., Haimel M; Department of Medicine, University of Cambridge, Cambridge, UK., Southgate L; Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK., Germain M; Sorbonne Universités, UPMC, INSERM, Paris, France., Pauciulo MW; Human Genetics, Cincinnati, OH, USA., Hadinnapola C; Department of Medicine, University of Cambridge, Cambridge, UK., Aman J; Department of Medicine, Imperial College London, London, UK., Girerd B; University Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France., Arora A; Department of Surgery, University of Arizona, Tucson, AZ, USA., Knight J; Data Science Institute, Lancaster University, Lancaster, UK., Hanscombe KB; Genetics and Molecular Medicine, King's College London, London, UK., Karnes JH; Pharmacy Practice and Science, University of Arizona, Tucson, AZ, USA., Kaakinen M; Department of Medicine, Imperial College London, London, UK., Gall H; University of Giessen and Marburg Lung Center, Giessen, Germany., Ulrich A; Department of Medicine, Imperial College London, London, UK., Harbaum L; Department of Medicine, Imperial College London, London, UK., Cebola I; Department of Medicine, Imperial College London, London, UK., Ferrer J; Department of Medicine, Imperial College London, London, UK., Lutz K; Human Genetics, Cincinnati, OH, USA., Swietlik EM; Department of Medicine, University of Cambridge, Cambridge, UK., Ahmad F; University of Iowa, Iowa City, IA, USA., Amouyel P; University of Lille, Lille, France., Archer SL; Queen's University, Kingston, ON, Canada., Argula R; Medical University of South Carolina, Charleston, SC, USA., Austin ED; Vanderbilt University, Nashville, TN, USA., Badesch D; University of Colorado Denver, Denver, CO, USA., Bakshi S; Baylor Research Institute, Plano, TX, USA., Barnett C; Medstar Health, Washington, DC, USA., Benza R; Allegheny-Singer Research Institute, Pittsburgh, PA, USA., Bhatt N; Ohio State University, Columbus, OH, USA., Bogaard HJ; VU University Medical Center, Amsterdam, Netherlands., Burger CD; Mayo Clinic Florida, Jacksonville, FL, USA., Chakinala M; Washington University, St Louis, MO, USA., Church C; Golden Jubilee National Hospital, Glasgow, UK., Coghlan JG; Royal Free Hospital, London, UK., Condliffe R; Royal Hallamshire Hospital, Sheffield, UK., Corris PA; University of Newcastle, Newcastle, UK., Danesino C; University of Pavia, Pavia, Italy., Debette S; University of Bordeaux, Bordeaux, France., Elliott CG; Intermountain Medical Center, Murray, UT, USA., Elwing J; University of Cincinnati, Cincinnati OH, USA., Eyries M; Sorbonne Universités, UPMC, INSERM, Paris, France., Fortin T; Duke University Medical Center, Durham, NC, USA; University of Kiel, Kiel, Germany., Franke A; University of Kiel, Kiel, Germany., Frantz RP; Mayo Clinic, Rochester, MN, USA., Frost A; Houston Methodist Research Institute, Houston, TX, USA., Garcia JGN; Department of Medicine, University of Arizona, Tucson, AZ, USA., Ghio S; Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Ghofrani HA; University of Giessen and Marburg Lung Center, Giessen, Germany., Gibbs JSR; National Heart and Lung Institute, Imperial College London, London, UK., Harley J; CAGE, Cincinnati, OH, USA., He H; Human Genetics, Cincinnati, OH, USA., Hill NS; Tufts-New England Medical Center, Boston, MA, USA., Hirsch R; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; University of Cincinnati, Cincinnati OH, USA., Houweling AC; VU University Medical Center, Amsterdam, Netherlands., Howard LS; National Heart and Lung Institute, Imperial College London, London, UK., Ivy D; Health Sciences Center, University of Colorado, Aurora, CO, USA., Kiely DG; Royal Hallamshire Hospital, Sheffield, UK., Klinger J; Rhode Island Hospital, Providence, RI, USA., Kovacs G; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria., Lahm T; Indiana University, Indianapolis, IN, USA., Laudes M; University of Kiel, Kiel, Germany., Machado RD; University of Lincoln, Lincoln, UK., MacKenzie Ross RV; Royal United Hospitals Bath NHS Foundation Trust, Bath, UK., Marsolo K; Biomedical Informatics, Cincinnati, OH, USA., Martin LJ; Human Genetics, Cincinnati, OH, USA., Moledina S; Great Ormond Street Hospital, London, UK., Montani D; University Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France., Nathan SD; Inova Heart and Vascular Institute, Falls Church, VA, USA., Newnham M; Department of Medicine, University of Cambridge, Cambridge, UK; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria., Olschewski A; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria., Olschewski H; Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria., Oudiz RJ; Harbor-UCLA Medical Center, Torrance, CA, USA., Ouwehand WH; Department of Haematology, University of Cambridge, Cambridge, UK., Peacock AJ; Golden Jubilee National Hospital, Glasgow, UK., Pepke-Zaba J; Papworth Hospital, Papworth, UK., Rehman Z; East Carolina University, Greenville, NC, USA., Robbins I; Vanderbilt University School of Medicine, Nashville, TN, USA., Roden DM; Vanderbilt University School of Medicine, Nashville, TN, USA., Rosenzweig EB; Columbia University, New York, NY, USA., Saydain G; Wayne State University, Detroit, MI, USA., Scelsi L; Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Schilz R; University Hospital of Cleveland, Cleveland, OH, USA., Seeger W; University of Giessen and Marburg Lung Center, Giessen, Germany., Shaffer CM; Vanderbilt University School of Medicine, Nashville, TN, USA., Simms RW; Boston University School of Medicine, Boston, MA, USA., Simon M; University of Pittsburgh, Pittsburgh, PA, USA., Sitbon O; University Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France., Suntharalingam J; Royal United Hospitals Bath NHS Foundation Trust, Bath, UK., Tang H; Department of Medicine, University of Arizona, Tucson, AZ, USA., Tchourbanov AY; Ambry Genetics, Aliso Viejo, CA, USA., Thenappan T; University of Minnesota, Minneapolis, MN, USA., Torres F; University of Texas Southwestern Medical Center, Dallas, TX, USA., Toshner MR; Department of Medicine, University of Cambridge, Cambridge, UK., Treacy CM; Department of Medicine, University of Cambridge, Cambridge, UK., Vonk Noordegraaf A; VU University Medical Center, Amsterdam, Netherlands., Waisfisz Q; VU University Medical Center, Amsterdam, Netherlands., Walsworth AK; Human Genetics, Cincinnati, OH, USA., Walter RE; Louisiana State University Health, Shreveport, LA, USA., Wharton J; Department of Medicine, Imperial College London, London, UK., White RJ; University of Rochester Medical Center, Rochester, NY, USA., Wilt J; Spectrum Health Hospitals, Grand Rapids, MI, USA., Wort SJ; National Heart and Lung Institute, Imperial College London, London, UK., Yung D; Seattle Children's Hospital, Seattle, WA, USA., Lawrie A; University of Sheffield, Sheffield, UK., Humbert M; University Paris-Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France., Soubrier F; Sorbonne Universités, UPMC, INSERM, Paris, France., Trégouët DA; Sorbonne Universités, UPMC, INSERM, Paris, France., Prokopenko I; Department of Medicine, Imperial College London, London, UK., Kittles R; City of Hope, Duarte, CA, USA., Gräf S; Department of Medicine, University of Cambridge, Cambridge, UK., Nichols WC; Human Genetics, Cincinnati, OH, USA., Trembath RC; Genetics and Molecular Medicine, King's College London, London, UK., Desai AA; Indiana University, Indianapolis, IN, USA. Electronic address: ankdesai@iu.edu., Morrell NW; Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address: nwm23@cam.ac.uk., Wilkins MR; Department of Medicine, Imperial College London, London, UK. Electronic address: m.wilkins@imperial.ac.uk.

مؤلفون مشاركون: UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium

المصدر: The Lancet. Respiratory medicine [Lancet Respir Med] 2019 Mar; Vol. 7 (3), pp. 227-238. Date of Electronic Publication: 2018 Dec 05.

نوع المنشور: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE

مواضيع طبية MeSH: Pulmonary Arterial Hypertension*/diagnosis , Pulmonary Arterial Hypertension*/genetics , Pulmonary Arterial Hypertension*/metabolism , Pulmonary Arterial Hypertension*/mortality, HLA-DP alpha-Chains/*genetics , HLA-DP beta-Chains/*genetics , SOXF Transcription Factors/*genetics, Female ; Genetic Predisposition to Disease ; Genetic Variation ; Genome-Wide Association Study ; Genotyping Techniques/methods ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk Assessment ; Signal Transduction/genetics ; Survival Analysis

المؤلفون: Mascarenhas JB; 1 Department of Medicine, College of Medicine, and., Tchourbanov AY; 2 Arizona Research Laboratories, University of Arizona, Tucson, Arizona., Danilov SM; 1 Department of Medicine, College of Medicine, and.; 3 Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois; and., Zhou T; 4 Department of Physiology and Cell Biology, The University of Nevada, Reno School of Medicine, Reno, Nevada., Wang T; 1 Department of Medicine, College of Medicine, and., Garcia JGN; 1 Department of Medicine, College of Medicine, and.

المصدر: American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2018 May; Vol. 58 (5), pp. 604-613.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Thoracic Society Country of Publication: United States NLM ID: 8917225 Publication Model: Print Cited Medium: Internet ISSN: 1535-4989 (Electronic) Linking ISSN: 10441549 NLM ISO Abbreviation: Am J Respir Cell Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Alternative Splicing*, Calcium-Binding Proteins/*metabolism , Endothelial Cells/*enzymology , Heterogeneous Nuclear Ribonucleoprotein A1/*metabolism , Lung/*blood supply , Myosin-Light-Chain Kinase/*metabolism , Respiratory Distress Syndrome/*enzymology , Ventilator-Induced Lung Injury/*enzymology, Animals ; Binding Sites ; Calcium-Binding Proteins/genetics ; Capillary Permeability ; Disease Models, Animal ; Electric Impedance ; Exons ; HEK293 Cells ; Heterogeneous Nuclear Ribonucleoprotein A1/genetics ; Humans ; Introns ; Mechanotransduction, Cellular ; Mice ; Myosin-Light-Chain Kinase/genetics ; Protein Binding ; Pulmonary Stretch Receptors/metabolism ; Respiratory Distress Syndrome/genetics ; Respiratory Distress Syndrome/physiopathology ; Ventilator-Induced Lung Injury/genetics ; Ventilator-Induced Lung Injury/physiopathology

المؤلفون: Mascarenhas JB; 1 Department of Medicine, and., Tchourbanov AY; 2 Arizona Research Laboratory, University of Arizona, Tucson, Arizona; and., Fan H; 3 Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois., Danilov SM; 1 Department of Medicine, and.; 3 Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois., Wang T; 1 Department of Medicine, and., Garcia JG; 1 Department of Medicine, and.

المصدر: American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2017 Jan; Vol. 56 (1), pp. 29-37.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Thoracic Society Country of Publication: United States NLM ID: 8917225 Publication Model: Print Cited Medium: Internet ISSN: 1535-4989 (Electronic) Linking ISSN: 10441549 NLM ISO Abbreviation: Am J Respir Cell Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Stress, Mechanical*, Alternative Splicing/*genetics , Myosin-Light-Chain Kinase/*genetics , Polymorphism, Single Nucleotide/*genetics, Base Sequence ; Computational Biology ; Computer Simulation ; Consensus Sequence/genetics ; Exons/genetics ; HEK293 Cells ; Humans ; Lymphocytes/metabolism ; RNA Splice Sites/genetics ; Reproducibility of Results