المؤلفون: Amatngalim, GD, Rodenburg, LW, Delpiano, L., Smits, SMA, Aalbers, BL, van der Ent, CK, Gray, MA, Beekman, JM

المصدر: In Journal of Cystic Fibrosis June 2022 21 Supplement 1:S32-S32

المؤلفون: Bierlaagh MC; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., van Mourik P; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., Vonk AM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., Pott J; HUB Organoids B.V. (HUB), Utrecht, the Netherlands., Muilwijk D; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., Berkers G; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG., Aalbers BL; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., Vleggaar FP; Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands., Michel S; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG., Boj SF; HUB Organoids B.V. (HUB), Utrecht, the Netherlands., Vries RGJ; HUB Organoids B.V. (HUB), Utrecht, the Netherlands., Beekman JM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG; Regenerative Medicine Center (UMCU), Utrecht University, Utrecht, the Netherlands., van der Ent CK; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, UMCU, Utrecht, the Netherlands, member of ERN-LUNG. Electronic address: K.vanderEnt@umcutrecht.nl.

مؤلفون مشاركون: HIT-CF organoid study group

المصدر: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2024 Jul; Vol. 23 (4), pp. 703-706. Date of Electronic Publication: 2024 May 18.

نوع المنشور: Journal Article; Multicenter Study

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5010 (Electronic) Linking ISSN: 15691993 NLM ISO Abbreviation: J Cyst Fibros Subsets: MEDLINE

مواضيع طبية MeSH: Precision Medicine*/methods , Organoids* , Cystic Fibrosis*/therapy, Humans ; Europe ; Adult ; Biopsy/methods ; Male ; Female ; Feasibility Studies ; Intestines

المؤلفون: Aalbers BL; Department of Pulmonology, UMC Utrecht, Utrecht University, Utrecht, The Netherlands., Mohamed Hoesein FAA; Department of Radiology, UMC Utrecht, Utrecht University, Utrech, The Netherlands., Hofland RW; Department of Pulmonology, UMC Utrecht, Utrecht University, Utrecht, The Netherlands., Bronsveld I; Department of Pulmonology, UMC Utrecht, Utrecht University, Utrecht, The Netherlands., Kruijswijk MA; Department of Pulmonology, UMC Utrecht, Utrecht University, Utrecht, The Netherlands., Schotman S; Department of Pulmonology, UMC Utrecht, Utrecht University, Utrecht, The Netherlands., Slingerland CW; Department of Pulmonology, UMC Utrecht, Utrecht University, Utrecht, The Netherlands., Panhuis H; Department of Pediatric pulmonology, UMC Utrecht location Wilhelmina Childrens Hospital, Utrecht University, Utrech, The Netherlands., van der Ent CK; Department of Pediatric pulmonology, UMC Utrecht location Wilhelmina Childrens Hospital, Utrecht University, Utrech, The Netherlands., Heijerman HGM; Department of Pulmonology, UMC Utrecht, Utrecht University, Utrecht, The Netherlands.

المصدر: Pediatric pulmonology [Pediatr Pulmonol] 2023 Aug; Vol. 58 (8), pp. 2317-2322. Date of Electronic Publication: 2023 May 24.

نوع المنشور: Clinical Trial; Journal Article

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8510590 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0496 (Electronic) Linking ISSN: 10990496 NLM ISO Abbreviation: Pediatr Pulmonol Subsets: MEDLINE

مواضيع طبية MeSH: Cystic Fibrosis*/complications , Cystic Fibrosis*/drug therapy , Cystic Fibrosis*/genetics, Humans ; Aminophenols/therapeutic use ; Benzodioxoles/therapeutic use ; Chloride Channel Agonists/therapeutic use ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/therapeutic use ; Lung ; Mutation ; Quality of Life

المؤلفون: Amatngalim GD; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands G.D.Amatngalim@umcutrecht.nl.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Rodenburg LW; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Aalbers BL; Department of Pulmonology, University Medical Center Utrecht, Utrecht, The Netherlands., Raeven HH; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Aarts EM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Sarhane D; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Spelier S; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Lefferts JW; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Silva IA; BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Lisboa, Portugal., Nijenhuis W; Department of Biology, Cell Biology, Neurobiology and Biophysics, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Centre for Living Technologies, Eindhoven-Wageningen-Utrecht Alliance, Utrecht, The Netherlands., Vrendenbarg S; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kruisselbrink E; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Brunsveld JE; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van Drunen CM; Department of Otorhinolaryngology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Michel S; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands., de Winter-de Groot KM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands., Heijerman HG; Department of Pulmonology, University Medical Center Utrecht, Utrecht, The Netherlands., Kapitein LC; Department of Biology, Cell Biology, Neurobiology and Biophysics, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Centre for Living Technologies, Eindhoven-Wageningen-Utrecht Alliance, Utrecht, The Netherlands., Amaral MD; BioISI-Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Lisboa, Portugal., van der Ent CK; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands., Beekman JM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherlands.; Regenerative Medicine Center Utrecht, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Centre for Living Technologies, Eindhoven-Wageningen-Utrecht Alliance, Utrecht, The Netherlands.

المصدر: Life science alliance [Life Sci Alliance] 2022 Aug 03; Vol. 5 (12). Date of Electronic Publication: 2022 Aug 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE

مواضيع طبية MeSH: Cystic Fibrosis*/genetics, Cells, Cultured ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Epithelial Cells ; Humans ; Organoids

المؤلفون: Aalbers BL; Department of pulmonology, UMC Utrecht, The Netherlands. Electronic address: b.l.aalbers-2@umcutrecht.nl., Brunsveld JE; Department of pediatric pulmonology, UMC Utrecht, The Netherlands., van der Ent CK; Department of pediatric pulmonology, UMC Utrecht, The Netherlands., van den Eijnden JC; Department of pulmonology, UMC Utrecht, The Netherlands., Beekman JM; Department of pediatric pulmonology, UMC Utrecht, The Netherlands., Heijerman HGM; Department of pulmonology, UMC Utrecht, The Netherlands.

المصدر: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2022 Mar; Vol. 21 (2), pp. 254-257. Date of Electronic Publication: 2022 Jan 31.

نوع المنشور: Case Reports

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5010 (Electronic) Linking ISSN: 15691993 NLM ISO Abbreviation: J Cyst Fibros Subsets: MEDLINE

مواضيع طبية MeSH: Compassionate Use Trials* , Cystic Fibrosis*/diagnosis , Cystic Fibrosis*/drug therapy , Cystic Fibrosis*/genetics, Aminophenols/therapeutic use ; Benzodioxoles/therapeutic use ; Colforsin/pharmacology ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Female ; Genotype ; Humans ; Middle Aged ; Mutation ; Organoids ; Rectum

المؤلفون: Aalbers BL; Department of Pulmonology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands., Bronsveld I; Department of Pulmonology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands., Hofland RW; Department of Pulmonology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands., Heijerman HGM; Department of Pulmonology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

المصدر: Journal of personalized medicine [J Pers Med] 2021 Aug 19; Vol. 11 (8). Date of Electronic Publication: 2021 Aug 19.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE

المؤلفون: Aalbers BL; Department of Pulmonology, University Medical Center Utrecht, the Netherlands. Electronic address: b.l.aalbers-2@umcutrecht.nl., Hofland RW; Department of Pulmonology, University Medical Center Utrecht, the Netherlands., Bronsveld I; Department of Pulmonology, University Medical Center Utrecht, the Netherlands., de Winter-de Groot KM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., Arets HGM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., de Kiviet AC; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., van Oirschot-van de Ven MMM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., Kruijswijk MA; Department of Pulmonology, University Medical Center Utrecht, the Netherlands., Schotman S; Department of Pulmonology, University Medical Center Utrecht, the Netherlands., Michel S; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., van der Ent CK; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., Heijerman HGM; Department of Pulmonology, University Medical Center Utrecht, the Netherlands.

المصدر: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2021 Jan; Vol. 20 (1), pp. e7-e11. Date of Electronic Publication: 2020 May 21.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5010 (Electronic) Linking ISSN: 15691993 NLM ISO Abbreviation: J Cyst Fibros Subsets: MEDLINE

مواضيع طبية MeSH: Aminophenols/*pharmacology , Aminopyridines/*pharmacology , Benzodioxoles/*pharmacology , Chlorides/*analysis , Cystic Fibrosis/*metabolism , Cystic Fibrosis/*physiopathology , Quinolones/*pharmacology , Sweat/*chemistry , Sweat/*drug effects, Adolescent ; Adult ; Body Mass Index ; Child ; Correlation of Data ; Drug Combinations ; Female ; Forced Expiratory Volume ; Humans ; Male ; Retrospective Studies ; Sex Factors ; Young Adult

المؤلفون: Aalbers BL; Department of Pulmonology, University Medical Center Utrecht, the Netherlands. Electronic address: b.l.aalbers-2@umcutrecht.nl., de Winter-de Groot KM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., Arets HGM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., Hofland RW; Department of Pulmonology, University Medical Center Utrecht, the Netherlands., de Kiviet AC; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., van Oirschot-van de Ven MMM; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., Kruijswijk MA; Department of Pulmonology, University Medical Center Utrecht, the Netherlands., Schotman S; Department of Pulmonology, University Medical Center Utrecht, the Netherlands., Michel S; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., van der Ent CK; Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, Utrecht, the Netherlands., Heijerman HGM; Department of Pulmonology, University Medical Center Utrecht, the Netherlands.

المصدر: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2020 Jul; Vol. 19 (4), pp. 654-658. Date of Electronic Publication: 2020 Jan 07.

نوع المنشور: Journal Article; Observational Study

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5010 (Electronic) Linking ISSN: 15691993 NLM ISO Abbreviation: J Cyst Fibros Subsets: MEDLINE

مواضيع طبية MeSH: Aminophenols*/administration & dosage , Aminophenols*/adverse effects , Aminopyridines*/administration & dosage , Aminopyridines*/adverse effects , Benzodioxoles*/administration & dosage , Benzodioxoles*/adverse effects , Cystic Fibrosis*/diagnosis , Cystic Fibrosis*/drug therapy , Cystic Fibrosis*/genetics , Cystic Fibrosis*/physiopathology , Quinolones*/administration & dosage , Quinolones*/adverse effects, Cystic Fibrosis Transmembrane Conductance Regulator/*genetics , Nutritional Status/*drug effects , Sweat/*chemistry, Child ; Chloride Channel Agonists/administration & dosage ; Chloride Channel Agonists/adverse effects ; Drug Combinations ; Female ; Forced Expiratory Volume/drug effects ; Homozygote ; Humans ; Male ; Respiratory Function Tests/methods ; Retrospective Studies ; Treatment Outcome

المؤلفون: Aalbers BL; Department of Pulmonology, University Medical Center Utrecht, Postbus 85500, 3508, GA, Utrecht, the Netherlands. Electronic address: b.l.aalbers-2@umcutrecht.nl., Yaakov Y; Pediatric Gastroenterology Unit and Cystic Fibrosis Center, Hadassah-Hebrew University Medical Center, Kiryat Hadassah, POB 12000, Jerusalem 91120, Israel., Derichs N; CF Center, Pediatric Pulmonology and Immunology, Charité Universitätsmedizin, Charitépl. 1, 10117 Berlin, Germany., Simmonds NJ; Department of Cystic Fibrosis, Royal Brompton Hospital and Imperial College, Sydney Street, SW3 6NP London, United Kingdom., De Wachter E; Department of Pediatric Pneumology, UZ Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium., Melotti P; Cystic Fibrosis Centre, Azienda Ospedaliera Universitaria Integrata. Piazzale Aristide Stefani 1, 37126 Verona, Italy., De Boeck K; Department of Pediatric Pulmonology, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium., Leal T; Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Place de l'Université 1, B-1348 Louvain-la-Neuve, Brussels, Belgium., Tümmler B; CF Center and Clinical Research Group, Department of Pediatric Pneumology and Neonatology, OE 6710, Medical School Hannover, Carl-Neuberg-Straße 1, 30625 Hannover, Germany., Wilschanski M; Pediatric Gastroenterology Unit and Cystic Fibrosis Center, Hadassah-Hebrew University Medical Center, Kiryat Hadassah, POB 12000, Jerusalem 91120, Israel., Bronsveld I; Department of Pulmonology, University Medical Center Utrecht, Postbus 85500, 3508, GA, Utrecht, the Netherlands.

المصدر: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2020 Jul; Vol. 19 (4), pp. 627-631. Date of Electronic Publication: 2019 Jul 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5010 (Electronic) Linking ISSN: 15691993 NLM ISO Abbreviation: J Cyst Fibros Subsets: MEDLINE

مواضيع طبية MeSH: Cystic Fibrosis*/diagnosis , Cystic Fibrosis*/genetics , Cystic Fibrosis*/physiopathology , Membrane Potentials* , Nasal Mucosa*/metabolism , Nasal Mucosa*/physiopathology , Sweat*/chemistry , Sweat*/metabolism, Cystic Fibrosis Transmembrane Conductance Regulator/*genetics, Adult ; Chlorides/analysis ; Correlation of Data ; Female ; Homozygote ; Humans ; Male ; Mutation ; Symptom Assessment/methods

المؤلفون: Geurts MH; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands; Oncode Institute, Hubrecht Institute, 3584 CT Utrecht, the Netherlands., de Poel E; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, the Netherlands., Amatngalim GD; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, the Netherlands., Oka R; Princess Maxima Center, 3584 CS Utrecht, the Netherlands; Oncode Institute, Princess Maxima Center, 3584 CS Utrecht, the Netherlands., Meijers FM; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, the Netherlands., Kruisselbrink E; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, the Netherlands., van Mourik P; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands., Berkers G; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands., de Winter-de Groot KM; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands., Michel S; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands., Muilwijk D; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands., Aalbers BL; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands., Mullenders J; Hubrecht Organoid Technology, 3584 CM, Utrecht, the Netherlands., Boj SF; Hubrecht Organoid Technology, 3584 CM, Utrecht, the Netherlands., Suen SWF; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, the Netherlands., Brunsveld JE; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, the Netherlands., Janssens HM; Department of Pediatrics, division of Respiratory Medicine and Allergology, ErasmusMC-Sophia Children's Hospital, University Hospital Rotterdam, 3015 GD Rotterdam, the Netherlands., Mall MA; Department of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany., Graeber SY; Department of Pediatric Pulmonology, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany., van Boxtel R; Princess Maxima Center, 3584 CS Utrecht, the Netherlands; Oncode Institute, Princess Maxima Center, 3584 CS Utrecht, the Netherlands., van der Ent CK; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands., Beekman JM; Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Center, Utrecht University, 3584 EA Utrecht, the Netherlands; Regenerative Medicine Utrecht, University Medical Center, Utrecht University, 3584 CT Utrecht, the Netherlands. Electronic address: j.beekman@umcutrecht.nl., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands; Oncode Institute, Hubrecht Institute, 3584 CT Utrecht, the Netherlands. Electronic address: h.clevers@hubrecht.eu.

المصدر: Cell stem cell [Cell Stem Cell] 2020 Apr 02; Vol. 26 (4), pp. 503-510.e7. Date of Electronic Publication: 2020 Feb 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Clustered Regularly Interspaced Short Palindromic Repeats* , Cystic Fibrosis*/genetics, Adenine ; Biological Specimen Banks ; CRISPR-Associated Protein 9/genetics ; CRISPR-Cas Systems/genetics ; Codon, Nonsense ; Gene Editing ; Humans ; Organoids/metabolism