نتائج البحث - "Abboud MI"

المؤلفون: Coleman OD; School of Natural and Environmental Sciences - Chemistry, Newcastle University Newcastle NE1 7RU UK akane.kawamura@ncl.ac.uk.; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk.; Radcliffe Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford Roosevelt Drive Old Road Campus Oxford OX3 7BN UK., Macdonald J; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk., Thomson B; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk., Ward JA; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford Old Road Campus Oxford OX3 7FZ UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford Oxford OX3 7FZ UK., Stubbs CJ; Mechanistic and Structural Biology, Discovery Sciences, R&D, AstraZeneca Cambridge CB4 0WG UK., McAllister TE; School of Natural and Environmental Sciences - Chemistry, Newcastle University Newcastle NE1 7RU UK akane.kawamura@ncl.ac.uk.; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk.; Radcliffe Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford Roosevelt Drive Old Road Campus Oxford OX3 7BN UK., Clark S; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk., Amin S; School of Natural and Environmental Sciences - Chemistry, Newcastle University Newcastle NE1 7RU UK akane.kawamura@ncl.ac.uk., Cao Y; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk., Abboud MI; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk., Zhang Y; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk., Sanganee H; Emerging Innovations Unit, Discovery Sciences, R&D, AstraZeneca Cambridge UK., Huber KVM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford Old Road Campus Oxford OX3 7FZ UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford Oxford OX3 7FZ UK., Claridge TDW; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk., Kawamura A; School of Natural and Environmental Sciences - Chemistry, Newcastle University Newcastle NE1 7RU UK akane.kawamura@ncl.ac.uk.; Department of Chemistry, University of Oxford, Chemistry Research Laboratory Mansfield Road Oxford OX1 3TA UK tim.claridge@chem.ox.ac.uk.; Radcliffe Department of Medicine, Wellcome Centre for Human Genetics, University of Oxford Roosevelt Drive Old Road Campus Oxford OX3 7BN UK.

المصدر: Chemical science [Chem Sci] 2023 Apr 17; Vol. 14 (26), pp. 7136-7146. Date of Electronic Publication: 2023 Apr 17 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

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دورية أكاديمية

Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2.

المؤلفون: Liu X; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom., Reinbold R; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom., Liu S; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom., Herold RA; Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom., Rabe P; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom., Duclos S; Evotec (UK) Ltd, Abingdon, United Kingdom., Yadav RB; Evotec (UK) Ltd, Abingdon, United Kingdom., Abboud MI; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom., Thieffine S; Evotec (US) Inc., Princeton, NJ, USA., Armstrong FA; Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom., Brewitz L; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom. Electronic address: lennart.brewitz@chem.ox.ac.uk., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, United Kingdom. Electronic address: christopher.schofield@chem.ox.ac.uk.

المصدر: The Journal of biological chemistry [J Biol Chem] 2023 Feb; Vol. 299 (2), pp. 102873. Date of Electronic Publication: 2023 Jan 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Isocitrate Dehydrogenase*/chemistry , Isocitrate Dehydrogenase*/genetics , Isocitrate Dehydrogenase*/metabolism , Ketoglutaric Acids*/chemistry , Ketoglutaric Acids*/metabolism , Ketoglutaric Acids*/pharmacology, Humans ; Neoplasms/metabolism ; Substrate Specificity ; Protein Binding/drug effects ; Crystallography

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دورية أكاديمية

Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease.

المؤلفون: Liu H; State Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China., Xie Y; State Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.; National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Department of Orthopedics, General Hospital of Chinese PLA, Beijing, China., Wang X; State Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China., Abboud MI; The Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Ma C; Department of Human Anatomy, Histology and Embryology, Neuroscience Center, National Human Brain Bank for Development and Function, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China., Ge W; State Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China., Schofield CJ; The Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.

المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2022 Dec; Vol. 18 (12), pp. 2637-2668. Date of Electronic Publication: 2022 Jul 19.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

مواضيع طبية MeSH: Oxygenases*/metabolism , Alzheimer Disease*/metabolism, Humans ; Ketoglutaric Acids/metabolism ; Oxygen ; Hypoxia

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دورية أكاديمية

Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.

المؤلفون: Reinbold R; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Hvinden IC; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Rabe P; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Herold RA; Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK., Finch A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Wood J; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Morgan M; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Staudt M; Institute of Pharmaceutical Sciences, University of Freiburg, 79104, Freiburg, Germany., Clifton IJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Armstrong FA; Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK., McCullagh JSO; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Redmond J; GlaxoSmithKline, Gunnels Wood Rd, Stevenage, SG1 2NY, UK., Bardella C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Abboud MI; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK. martine.abboud@lau.edu.; Department of Natural Sciences, Lebanese American University, Byblos/Beirut, Lebanon. martine.abboud@lau.edu., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.

المصدر: Nature communications [Nat Commun] 2022 Aug 15; Vol. 13 (1), pp. 4785. Date of Electronic Publication: 2022 Aug 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Drug Resistance, Neoplasm*/genetics , Isocitrate Dehydrogenase*/antagonists & inhibitors , Isocitrate Dehydrogenase*/genetics , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/genetics, Glycine/analogs & derivatives ; Glycine/therapeutic use ; Humans ; Mutation ; Pyridines/therapeutic use

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دورية أكاديمية

Carcinogenic and neurotoxic risks of acrylamide consumed through bread, kaak, toast, and crackers among the Lebanese Population.

المؤلفون: El-Zakhem Naous G; School of Arts and Sciences, Department of Natural Sciences, Lebanese American University, Byblos and Beirut, Lebanon., Merhi A; School of Arts and Sciences, Department of Natural Sciences, Lebanese American University, Byblos and Beirut, Lebanon. Electronic address: areej.merhi@lau.edu.lb., Daher R; School of Arts and Sciences, Department of Natural Sciences, Lebanese American University, Byblos and Beirut, Lebanon., Mroueh M; School of Pharmacy, Department of Pharmaceutical Sciences, Lebanese American University, Byblos, Lebanon., Abboud MI; Department of Chemistry, University of Oxford, Oxford, UK., Taleb RI; School of Arts and Sciences, Department of Natural Sciences, Lebanese American University, Byblos and Beirut, Lebanon.

المصدر: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2022 Jul; Vol. 132, pp. 105192. Date of Electronic Publication: 2022 May 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214983 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0295 (Electronic) Linking ISSN: 02732300 NLM ISO Abbreviation: Regul Toxicol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Acrylamide*/toxicity , Neurotoxicity Syndromes*, Bread/analysis ; Carcinogens/toxicity ; Child ; Chromatography, Liquid ; Food Contamination/analysis ; Humans ; Tandem Mass Spectrometry ; Young Adult

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دورية أكاديمية

Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans.

المؤلفون: Chowdhury R; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Abboud MI; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Wiley J; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Tumber A; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Markolovic S; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.

المصدر: Scientific reports [Sci Rep] 2022 Apr 11; Vol. 12 (1), pp. 6065. Date of Electronic Publication: 2022 Apr 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Drosophila melanogaster*/metabolism , Jumonji Domain-Containing Histone Demethylases*/metabolism, Animals ; Histones/metabolism ; Humans ; Hydroxylation ; Oxygenases/metabolism

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