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المؤلفون: Sandrine Grosse, Abdellah Tahri, Pierre Raboisson, Yannis Houpis, Bart Stoops, Edgar Jacoby, Jean-Marc Neefs, Marnix Van Loock, Olivia Goethals, Peggy Geluykens, Jean-François Bonfanti, Tim H. M. Jonckers
المصدر: ACS Medicinal Chemistry Letters. 13:1879-1884
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
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2
المؤلفون: Jason S. McLellan, Tim H. M. Jonckers, Sandrine Marie Hele Vendeville, Anil Koul, Dirk Roymans, Abdellah Tahri, Samuel Demin, Leen Kwanten, Joke Van Den Berg, Lili Hu, Pierre Raboisson, Ludwig Cooymans, Michael B. Battles, Ann Vos
المصدر: Journal of Medicinal Chemistry. 63:8046-8058
مصطلحات موضوعية: 0303 health sciences, Chemistry, Fusion inhibitor, Treatment options, Pharmacology, medicine.disease, 01 natural sciences, Virus, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Pneumonia, Bronchiolitis, Drug Discovery, Acute lower respiratory tract infection, medicine, Molecular Medicine, Respiratory system, 030304 developmental biology
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3
المؤلفون: Sandrine, Vendeville, Abdellah, Tahri, Lili, Hu, Samuel, Demin, Ludwig, Cooymans, Ann, Vos, Leen, Kwanten, Joke, Van den Berg, Michael B, Battles, Jason S, McLellan, Anil, Koul, Pierre, Raboisson, Dirk, Roymans, Tim H M, Jonckers
المصدر: Journal of medicinal chemistry. 63(15)
مصطلحات موضوعية: Indoles, Respiratory Syncytial Virus, Human, Drug Discovery, Administration, Oral, Humans, Crystallography, X-Ray, Imidazolidines, Antiviral Agents, Protein Structure, Secondary, HeLa Cells, Viral Fusion Protein Inhibitors
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4
المؤلفون: Leen Vijgen, Lotke Tambuyzer, Bart Stoops, Sophie Lachau-Durand, Abdellah Tahri, Laurent Leclercq, Tse-I Lin, Jan Snoeys, Kenny Simmen, Jan Martin Berke, Tim H. M. Jonckers, Pierre Jean-Marie Bernard Raboisson
المصدر: Journal of Medicinal Chemistry. 59:5790-5798
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Pyrimidine, 010405 organic chemistry, virus diseases, Phosphoramidate, Prodrug, 01 natural sciences, digestive system diseases, Uridine, 0104 chemical sciences, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Biochemistry, RNA polymerase, Drug Discovery, Molecular Medicine, Nucleotide, NS5B, Uridine triphosphate
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5
المؤلفون: Ann Vos, Karen Vergauwen, Geert Rombouts, Fuliang Hou, Jan-Martin Berke, Pierre Raboisson, Bing Huang, Bart Stoops, Wim Gaston Verschueren, Koen Vandyck, Jingmei Yang, Pascale Dehertogh, Abdellah Tahri, Yiming Wu
المصدر: Journal of medicinal chemistry. 61(14)
مصطلحات موضوعية: 0301 basic medicine, Hepatitis B virus, Genotype, Protein Conformation, viruses, Chemistry Techniques, Synthetic, medicine.disease_cause, 01 natural sciences, Antiviral Agents, 03 medical and health sciences, chemistry.chemical_compound, Mice, Protein structure, Capsid, Drug Discovery, Hepatitis B virus HBV, medicine, Animals, Humans, Benzamide, Sulfonamides, 010405 organic chemistry, virus diseases, Viral Load, Virology, Small molecule, digestive system diseases, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, chemistry, Benzamides, Molecular Medicine, Viral load
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6
المؤلفون: Maxwell D. Cummings, Tse-I Lin, Lili Hu, Abdellah Tahri, David McGowan, Katie Amssoms, Stefaan Last, Benoit Devogelaere, Marie-Claude Rouan, Leen Vijgen, Jan Martin Berke, Pascale Dehertogh, Els Fransen, Erna Cleiren, Liesbet van der Helm, Gregory Fanning, Origène Nyanguile, Kenny Simmen, Pieter Van Remoortere, Pierre Raboisson, Sandrine Vendeville
المصدر: Journal of Medicinal Chemistry. 57:1880-1892
مصطلحات موضوعية: Models, Molecular, Simeprevir, Magnetic Resonance Spectroscopy, Hepatitis C virus, Drug Evaluation, Preclinical, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Mass Spectrometry, Virus, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Potency, Enzyme Inhibitors, Polymerase, Sulfonamides, biology, Chemistry, Virology, In vitro, Rats, biology.protein, Molecular Medicine
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7
المؤلفون: Tim H M, Jonckers, Abdellah, Tahri, Leen, Vijgen, Jan Martin, Berke, Sophie, Lachau-Durand, Bart, Stoops, Jan, Snoeys, Laurent, Leclercq, Lotke, Tambuyzer, Tse-I, Lin, Kenny, Simmen, Pierre, Raboisson
المصدر: Journal of medicinal chemistry. 59(12)
مصطلحات موضوعية: Dose-Response Relationship, Drug, Administration, Oral, HIV Infections, Hepacivirus, Microbial Sensitivity Tests, Pyrimidinones, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, Mice, Structure-Activity Relationship, Drug Discovery, Hepatocytes, Animals, Humans, Prodrugs, Spiro Compounds
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8
المؤلفون: Liesbet van der Helm, Kenneth Simmen, Origène Nyanguile, Reginald F. Clayton, Tse I. Lin, Pascale Dehertogh, Gregory Fanning, Leen Vijgen, Oliver Lenz, Els Fransen, Pierre Jean-Marie Bernard Raboisson, Benoit Devogelaere, Sandrine Vendeville, Erna Cleiren, Katie Amssoms, Maxwell D. Cummings, Abdellah Tahri, Jan Martin Berke
المصدر: Antimicrobial Agents and Chemotherapy. 56:4676-4684
مصطلحات موضوعية: Hepatitis C virus, Hepacivirus, RNA-dependent RNA polymerase, Viral Nonstructural Proteins, Transfection, Virus Replication, medicine.disease_cause, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Cell Line, chemistry.chemical_compound, Genes, Reporter, Escherichia coli, medicine, Humans, Pharmacology (medical), Protease inhibitor (pharmacology), Cloning, Molecular, Enzyme Inhibitors, Mode of action, NS5B, Pharmacology, Sulfonamides, biology, virus diseases, Drug Synergism, Hepatitis C, Chronic, RNA-Dependent RNA Polymerase, medicine.disease, biology.organism_classification, Virology, Recombinant Proteins, digestive system diseases, Drug Combinations, Infectious Diseases, Viral replication, chemistry, Hepatocellular carcinoma, Plasmids
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8dee5d8bfd6f25c3bfb9a920a7ef6d
https://doi.org/10.1128/aac.00245-12 -
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المؤلفون: Sandrine Vendeville, Tse-I. Lin, Lili Hu, Abdellah Tahri, David McGowan, Maxwell D. Cummings, Katie Amssoms, Maxime Canard, Stefaan Last, Iris Van den Steen, Benoit Devogelaere, Marie-Claude Rouan, Leen Vijgen, Jan Martin Berke, Pascale Dehertogh, Els Fransen, Erna Cleiren, Liesbet van der Helm, Gregory Fanning, Kristof Van Emelen, Origène Nyanguile, Kenny Simmen, Pierre Raboisson
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4437-4443
مصطلحات موضوعية: Indoles, Macrocyclic Compounds, Stereochemistry, Hepatitis C virus, Clinical Biochemistry, Allosteric regulation, Drug Evaluation, Preclinical, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Virus Replication, Ring (chemistry), medicine.disease_cause, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, Allosteric Regulation, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Potency, Enzyme Inhibitors, Molecular Biology, Indole test, Sulfonamides, Chemistry, Organic Chemistry, Rats, Liver, Cell culture, Molecular Medicine
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المؤلفون: Koen Vandyck, Maxwell D. Cummings, Origène Nyanguile, Carlo W. Boutton, Sandrine Vendeville, David McGowan, Benoit Devogelaere, Katie Amssoms, Stefaan Last, Klara Rombauts, Abdellah Tahri, Pedro Lory, Lili Hu, Derek A. Beauchamp, Kenny Simmen, Pierre Raboisson
المصدر: Journal of Medicinal Chemistry. 52:4099-4102
مصطلحات موضوعية: Models, Molecular, Stereochemistry, viruses, Hepatitis C virus, Allosteric regulation, Molecular Conformation, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Benzodiazepines, chemistry.chemical_compound, Allosteric Regulation, RNA polymerase, Drug Discovery, medicine, Transferase, Enzyme Inhibitors, NS5B, chemistry.chemical_classification, Drug discovery, virus diseases, biochemical phenomena, metabolism, and nutrition, RNA-Dependent RNA Polymerase, digestive system diseases, In vitro, Enzyme, chemistry, Biochemistry, Drug Design, Molecular Medicine