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المؤلفون: Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, P.O. Box 33516, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia St., Alexandria 21648, Egypt. Electronic address: wagdy2000@gmail.com., Elsayed ZM; Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt., Ammara A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Firenze, Italy., El Hassab MA; Department of Medicinal Chemistry, Faculty of Pharmacy, King Salman International University (KSIU), South Sinai, Egypt., Almahli H; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK., Fares M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, ERU, Badr City, Cairo 11829, Egypt., Nocentini A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Firenze, Italy., Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Firenze, Italy. Electronic address: claudiu.supuran@unifi.it., Abou-Seri SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, P.O. Box 11562, Egypt. Electronic address: sahar.shaarawy@pharma.cu.edu.eg.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 Aug 26; Vol. 279 (Pt 2), pp. 135010. Date of Electronic Publication: 2024 Aug 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

المؤلفون: Abdelaal HI; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, Egypt., Mohamed AR; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 11829, Egypt. Electronic address: abdallaharafa@eru.edu.eg., Abo-Ashour MF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, El Saleheya El Gadida University, El Saleheya El Gadida, Egypt., Giovannuzzi S; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019, Sesto Fiorentino, Firenze, Italy., Fahim SH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt. Electronic address: samer.mohamed@pharma.cu.edu.eg., Abdel-Aziz HA; Department of Applied Organic Chemistry, National Research Center, Dokki, Cairo 12622, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pahros University in Alexandria, Canal El Mahmoudia Street, Alexandria 21648, Egypt., Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019, Sesto Fiorentino, Firenze, Italy. Electronic address: claudiu.supuran@unifi.it., Abou-Seri SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Nov; Vol. 152, pp. 107759. Date of Electronic Publication: 2024 Aug 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Carbonic Anhydrase Inhibitors*/pharmacology , Carbonic Anhydrase Inhibitors*/chemistry , Carbonic Anhydrase Inhibitors*/chemical synthesis , Coumarins*/pharmacology , Coumarins*/chemistry , Coumarins*/chemical synthesis , Carbonic Anhydrase IX*/antagonists & inhibitors , Carbonic Anhydrase IX*/metabolism , Doxorubicin*/pharmacology , Carbonic Anhydrases*/metabolism , Drug Screening Assays, Antitumor* , Dose-Response Relationship, Drug* , Cell Proliferation*/drug effects, Humans ; MCF-7 Cells ; Structure-Activity Relationship ; Molecular Structure ; Antigens, Neoplasm/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Drug Resistance, Neoplasm/drug effects ; Cell Hypoxia/drug effects

المؤلفون: Elgohary MK; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt., Abo-Ashour MF; Pharmaceutical Chemistry Department, Faculty of Pharmacy, El Saleheya El Gadida University, Egypt., Abd El Hadi SR; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt. Electronic address: soha-ramadan@eru.edu.eg., El Hassab MA; Department of Medicinal Chemistry, Faculty of Pharmacy, King Salman International University (KSIU), South Sinai, Egypt., Abo-El Fetoh ME; Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt., Afify H; Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt., Abdel-Aziz HA; Applied Organic Chemistry Department, National Research Center, Dokki, Cairo 12622, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia St., Alexandria 21648, Egypt. Electronic address: ha.abdel-aziz@nrc.sci.eg., Abou-Seri SM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo P.O. Box 11562, Egypt. Electronic address: sahar.shaarawy@pharma.cu.edu.eg.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Nov; Vol. 152, pp. 107727. Date of Electronic Publication: 2024 Aug 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Cyclooxygenase 2 Inhibitors*/pharmacology , Cyclooxygenase 2 Inhibitors*/chemical synthesis , Cyclooxygenase 2 Inhibitors*/chemistry , Rats, Wistar* , Cyclooxygenase 2*/metabolism , Edema*/drug therapy , Edema*/chemically induced , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal*/chemistry, Animals ; Male ; Rats ; Structure-Activity Relationship ; Molecular Structure ; Acetates/chemistry ; Acetates/pharmacology ; Acetates/chemical synthesis ; Molecular Docking Simulation ; Humans ; Dose-Response Relationship, Drug ; Formaldehyde ; Pharmacophore

المؤلفون: El Hassab MA; Department of Medicinal Chemistry, Faculty of Pharmacy, King Salman International University (KSIU), Ras Sudr, South Sinai, Egypt., El-Hafeez AAA; Cancer Biology Department, Pharmacology and Experimental Oncology Unit, National Cancer Institute, Cairo University, Cairo, Egypt., Almahli H; Department of Chemistry, University of Cambridge, Cambridge, UK., Elsayed ZM; Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt., Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.; School of Biotechnology, Badr University in Cairo, Badr City, Egypt., Hassan GS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Pharmaceutical Chemistry Department, School of Pharmacy, Badr University in Cairo (BUC), Badr City, Egypt., Abou-Seri SM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

المصدر: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Mar; Vol. 357 (3), pp. e2300599. Date of Electronic Publication: 2023 Dec 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

مواضيع طبية MeSH: Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology , Isatin*, Male ; Humans ; Structure-Activity Relationship ; Phthalimides/pharmacology ; Cell Line, Tumor

المؤلفون: Elsayed ZM; Scientific Research and Innovation Support Unit, Kafrelsheikh University, Kafrelsheikh, Egypt., Almahli H; Department of Chemistry, University of Cambridge, Cambridge, UK., Nocentini A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy., Ammara A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy., Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy., Eldehna WM; Department of Pharmaceutical Chemistry, Kafrelsheikh University, Kafrelsheikh, Egypt.; School of Biotechnology, Badr University in Cairo, Badr City, Cairo, Egypt., Abou-Seri SM; Department of Pharmaceutical Chemistry, Cairo University, Cairo, Egypt.

المصدر: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2191163.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Carbonic Anhydrases*/metabolism , Neoplasms*/pathology, Humans ; Carbonic Anhydrase IX ; Molecular Structure ; Structure-Activity Relationship ; Carboxylic Acids/pharmacology ; Carbonic Anhydrase Inhibitors ; Quinazolines/pharmacology ; Antigens, Neoplasm/metabolism

المؤلفون: Elgohary MK; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt., Abd El Hadi SR; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt. Electronic address: Soha-ramadan@eru.edu.eg., Abo-Ashour MF; Pharmaceutical Chemistry Department, Faculty of Pharmacy, El Saleheya El Gadida University, Egypt., Abo-El Fetoh ME; Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt., Afify H; Pharmacology and Toxicology Department, Faculty of Pharmacy, Egyptian-Russian University, Badr City, Cairo 11829, Egypt., Abdel-Aziz HA; Applied Organic Chemistry Department, National Research Center, Dokki, Cairo 12622, Egypt., Abou-Seri SM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo P.O. Box 11562, Egypt. Electronic address: sahar.shaarawy@pharma.cu.edu.eg.

المصدر: Bioorganic chemistry [Bioorg Chem] 2023 Oct; Vol. 139, pp. 106724. Date of Electronic Publication: 2023 Jul 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Inflammatory Agents*/pharmacology , Thiazoles*/pharmacology, Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/pharmacology ; Cyclooxygenase 2 Inhibitors/chemistry ; Drug Design ; Lipoxygenase Inhibitors/pharmacology ; Lipoxygenase Inhibitors/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Thiazolidines/pharmacology ; Pyrazoles/chemistry ; Pyrazoles/pharmacology

المؤلفون: El-Fakharany ZS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, Cairo, 12451, Egypt., Nissan YM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, Cairo, 12451, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt., Sedky NK; Department of Biochemistry, School of Life and Medical Sciences, University of Hertfordshire Hosted By Global Academic Foundation, New Administrative Capital, Cairo, Egypt., Arafa RK; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, October Gardens, 6th of October City, Giza, 12578, Egypt. rkhidr@zewailcity.edu.eg.; Drug Design and Discovery Lab, Zewail City of Science and Technology, Cairo, 12578, Egypt. rkhidr@zewailcity.edu.eg., Abou-Seri SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt. sahar.shaarawy@pharma.cu.edu.eg.

المصدر: Scientific reports [Sci Rep] 2023 Jul 13; Vol. 13 (1), pp. 11346. Date of Electronic Publication: 2023 Jul 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Quinolones*/pharmacology , Antineoplastic Agents*/chemistry, Humans ; Molecular Structure ; Structure-Activity Relationship ; Caspase 7/metabolism ; Sorafenib/pharmacology ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Molecular Docking Simulation ; bcl-2-Associated X Protein ; Protein Kinase Inhibitors/pharmacology ; Drug Screening Assays, Antitumor ; Cell Proliferation ; Drug Design

المؤلفون: Elanany MA; Department of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Industries, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt. mohamed.elanany@buc.edu.eg., Osman EEA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt., Gedawy EM; Department of Pharmaceutical Chemistry, School of Pharmacy and Pharmaceutical Industries, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt., Abou-Seri SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. sahar.shaarawy@pharma.cu.edu.eg.

المصدر: Scientific reports [Sci Rep] 2023 Mar 13; Vol. 13 (1), pp. 4144. Date of Electronic Publication: 2023 Mar 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Fluoroquinolones*/pharmacology , Antineoplastic Agents*/chemistry, Humans ; Molecular Structure ; Structure-Activity Relationship ; Moxifloxacin/pharmacology ; Cell Proliferation ; Cell Cycle Checkpoints ; Cell Line, Tumor ; Ciprofloxacin/pharmacology ; Apoptosis ; Ofloxacin/pharmacology ; Drug Screening Assays, Antitumor ; Cell Cycle

المؤلفون: Akl L; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, P.O. Box 33516, Egypt., Abd El-Hafeez AA; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Pharmacology and Experimental Oncology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. Electronic address: aam002@health.ucsd.edu., Ibrahim TM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, P.O. Box 33516, Egypt., Salem R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, P.O. Box 33516, Egypt., Marzouk HMM; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Department of Biochemistry, Faculty of Medicine, Minia University, El-Minia, 61519, Egypt., El-Domany RA; Department of Microbiology and Immunology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, P.O. Box 33516, Egypt., Ghosh P; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA; Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA; Moores Comprehensive Cancer Center, University of California San Diego, La Jolla, CA, 92093, USA., Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, P.O. Box 33516, Egypt. Electronic address: wagdy2000@gmail.com., Abou-Seri SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, P.O. Box 11562, Egypt. Electronic address: sahar.shaarawy@pharma.cu.edu.eg.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 05; Vol. 243, pp. 114704. Date of Electronic Publication: 2022 Aug 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/pathology , Carcinoma, Pancreatic Ductal*/pathology , Antineoplastic Agents*/pharmacology, Humans ; Phthalazines/pharmacology ; Piperazine/pharmacology ; Cell Line, Tumor ; Cell Proliferation ; Protein Kinase Inhibitors/pharmacology ; Drug Screening Assays, Antitumor ; CDC2 Protein Kinase ; Pancreatic Neoplasms