المؤلفون: Steven P. Maher, Amélie Vantaux, Victor Chaumeau, Adeline C. Y. Chua, Caitlin A. Cooper, Chiara Andolina, Julie Péneau, Mélanie Rouillier, Zaira Rizopoulos, Sivchheng Phal, Eakpor Piv, Chantrea Vong, Sreyvouch Phen, Chansophea Chhin, Baura Tat, Sivkeng Ouk, Bros Doeurk, Saorin Kim, Sangrawee Suriyakan, Praphan Kittiphanakun, Nana Akua Awuku, Amy J. Conway, Rays H. Y. Jiang, Bruce Russell, Pablo Bifani, Brice Campo, François Nosten, Benoît Witkowski, Dennis E. Kyle

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/82bd81cce09f483dac02985c053a9b50

المؤلفون: Adeline C. Y. Chua, Jessica Jie Ying Ong, Benoit Malleret, Rossarin Suwanarusk, Varakorn Kosaisavee, Anne-Marie Zeeman, Caitlin A. Cooper, Kevin S. W. Tan, Rou Zhang, Bee Huat Tan, Siti Nurdiana Abas, Andy Yip, Anne Elliot, Chester J. Joyner, Jee Sun Cho, Kate Breyer, Szczepan Baran, Amber Lange, Steven P. Maher, François Nosten, Christophe Bodenreider, Bryan K. S. Yeung, Dominique Mazier, Mary R. Galinski, Nathalie Dereuddre-Bosquet, Roger Le Grand, Clemens H. M. Kocken, Laurent Rénia, Dennis E. Kyle, Thierry T. Diagana, Georges Snounou, Bruce Russell, Pablo Bifani

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/68f08622b7b941e08fb8d5ecab44264a

المؤلفون: Kurt E Ward, Peter Christensen, Annie Racklyeft, Satish K Dhingra, Adeline C Y Chua, Caroline Remmert, Rossarin Suwanarusk, Jessica Matheson, Michael J Blackman, Osamu Kaneko, Dennis E Kyle, Marcus C S Lee, Robert W Moon, Georges Snounou, Laurent Rénia, David A Fidock, Bruce Russell, Pablo Bifani

المصدر: The Journal of Infectious Diseases. 227:1121-1126

مصطلحات موضوعية: Infectious Diseases, Immunology and Allergy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e238afd3c39b602fa01c6f8d778c32
https://doi.org/10.1093/infdis/jiac469

المؤلفون: Adeline C. Y. Chua, Saorin Kim, Bruce Russell, Eakpor Piv, Sivkeng Ouk, Rays H. Y. Jiang, Zaira Rizopoulos, Dennis E. Kyle, Sivchheng Phal, Pablo Bifani, Bros Doeurk, Amélie Vantaux, Julie Péneau, Nana Akua Awuku, Sangrawee Suriyakan, Brice Campo, Benoit Witkowski, Chansophea Chhin, Mélanie Rouillier, Sreyvouch Phen, Chantrea Vong, Praphan Kittiphanakun, Steven P. Maher, François Nosten, Chiara Andolina, Amy J. Conway, Caitlin A. Cooper, Baura Tat, Victor Chaumeau

المساهمون: Center for Tropical and Emerging Global Diseases, University of Georgia [USA], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Shoklo Malaria Research Unit [Mae Sot, Thailand] (SMRU), Mahidol Oxford Tropical Medicine Research Unit (MORU), Wellcome Trust-Mahidol University [Bangkok]-University of Oxford [Oxford]-Wellcome Trust-Mahidol University [Bangkok]-University of Oxford [Oxford], Centre for Tropical Medicine and Global Health [Oxford, UK], Nuffield Department of Medicine [Oxford, UK] (Big Data Institute), University of Oxford [Oxford]-University of Oxford [Oxford], Agency for science, technology and research [Singapore] (A*STAR), University of Otago [Dunedin, Nouvelle-Zélande], Health and Biosecurity [Canberra, ACT, Australia] (CSIRO), Medicines for Malaria Venture (MMV), Université de Genève (UNIGE), University of South Florida [Tampa] (USF), Yong Loo Lin School of Medicine [Singapore], London School of Hygiene and Tropical Medicine (LSHTM), Funding support was provided by the NUHS (WBS R-571-000-040-133 to P.B.), the Bill & Melinda Gates Foundation (OPP1023601 to D.E.K.), and Medicines for Malaria Venture (RD/2017/0042 to B.W. and A.V., RD/16/1082 and RD/15/0022 to S.P.M. and D.E.K.) For the purpose of Open Access, the authors have applied a CC BY public copyright license to any Author Accept Manuscript version arising from this submission., We thank the malaria patients of northwestern Thailand and northeastern Cambodia for participation in this study. We thank Celgene for providing analogs of MMV676121. We thank Irene Hallyburton and Mark Anderson of the Dundee Drug Discovery Unit at Dundee University for providing PfABS data. The Pathogen Box biological activity data produced for Medicines for Malaria Venture27 (https://www.mmv.org/sites/default/files/uploads/docs/mmv_open/Pathogen_Box_Activity_Biological_Data_Smiles.xlsx) is provided, with MMV's permission, as supplemental material in the online version of this report. We thank Dr. Erika Flannery at Novartis Institute for Tropical Diseases and Dr. Jeremy Burrows of Medicines for Malaria Venture for critical review of the manuscript. HCI data from drug studies was produced in part by the Biomedical Microscopy Core at the University of Georgia, supported by the Georgia Research Alliance. The Shoklo Malaria Research Unit is part of the Mahidol Oxford Research Unit, supported by the Wellcome Trust of Great Britain [220211].

المصدر: Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.19905. ⟨10.1038/s41598-021-99152-9⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)

مصطلحات موضوعية: Time Factors, Primaquine, Tafenoquine, Plasmodium vivax, Diseases, 030204 cardiovascular system & hematology, Pharmacology, chemistry.chemical_compound, 0302 clinical medicine, Parasitic Sensitivity Tests, Chloroquine, Medicine, 030212 general & internal medicine, 0303 health sciences, Multidisciplinary, Molecular Structure, biology, Drug discovery, Biological techniques, Drug Synergism, 3. Good health, Liver, Drug development, Aminoquinolines, medicine.drug, 8-Aminoquinoline, Science, Article, Antimalarials, 03 medical and health sciences, parasitic diseases, Malaria, Vivax, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, 030304 developmental biology, Liver stage, Life Cycle Stages, Dose-Response Relationship, Drug, 030306 microbiology, business.industry, biology.organism_classification, In vitro, ROC Curve, chemistry, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d351b9c26631b1545f18c69ca7cb66
https://hal-pasteur.archives-ouvertes.fr/pasteur-03491954/document

المؤلفون: Kevin S. W. Tan, Kate Breyer, Georges Snounou, Clemens H. M. Kocken, Anne Elliot, Bruce Russell, Varakorn Kosaisavee, Bryan K. S. Yeung, Bee Huat Tan, Adeline C. Y. Chua, Rossarin Suwanarusk, Siti Nurdiana Abas, Rou Zhang, Anne-Marie Zeeman, Jee Sun Cho, Benoit Malleret, Laurent Rénia, Roger Le Grand, Dennis E. Kyle, Mary R. Galinski, Christophe Bodenreider, Nathalie Dereuddre-Bosquet, Chester J. Joyner, François Nosten, Dominique Mazier, Szczepan W Baran, Pablo Bifani, Amber Lange, Jessica Jie Ying Ong, Thierry T. Diagana, Steven P. Maher, Caitlin A. Cooper, Andy M. Yip

المساهمون: Institut des Maladies Emergentes et des Thérapies Innovantes (IMETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Global Health Division, Menzies School of Health Research, Mahidol Oxford Tropical Medicine Research Unit, University of Oxford [Oxford]-Mahidol University [Bangkok], Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biomedical Primate Research Centre [Rijswijk] (BPRC), Institut Cochin (UMR_S567 / UMR 8104), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Novartis Institute for Tropical Diseases (NITD), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Oxford-Mahidol University [Bangkok], ANR-17-CE13-0025,IMHyp,Recherches sur l'Hypnozoïte du Paludisme(2017)

المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11332-4⟩

مصطلحات موضوعية: 0301 basic medicine, Erythrocytes, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Science, General Physics and Astronomy, 02 engineering and technology, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Malaria transmission, Plasmodium cynomolgi, Anopheles, parasitic diseases, in vitro culture, medicine, Parasite hosting, Model protists, Animals, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, lcsh:Science, Multidisciplinary, Drug discovery, Monkey Diseases, High-throughput screening, Plasmodium falciparum, General Chemistry, 021001 nanoscience & nanotechnology, biology.organism_classification, medicine.disease, Virology, In vitro, 3. Good health, Malaria, 030104 developmental biology, Macaca, lcsh:Q, 0210 nano-technology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fd9b03ad20049d99276309712f02ba
https://hal.archives-ouvertes.fr/hal-02347287

المؤلفون: René Wintjens, Hana L. Haver, Pramila Baban Ghode, Amit Singhal, Adeline C. Y. Chua, Pablo Bifani, Suresh B. Lakshminarayana, Barun Mathema

المصدر: Antimicrobial Agents and Chemotherapy. 59:5316-5323

مصطلحات موضوعية: Pharmacology, Genetics, Mutation, Tuberculosis, biology, Mutant, biology.organism_classification, medicine.disease, medicine.disease_cause, Microbiology, Mycobacterium tuberculosis, chemistry.chemical_compound, Infectious Diseases, chemistry, Genetic marker, Pretomanid, Genotype, medicine, Pharmacology (medical), Gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6730fdaf7982797914c00237bcd82ffd
https://doi.org/10.1128/aac.00308-15

المؤلفون: Siu Kwan Sze, Adeline C. Y. Chua, Bamaprasad Dutta, Laurent Dembele, Devendra Kumar Gupta, Pablo Bifani

المصدر: PROTEOMICS. 19:1900021

مصطلحات موضوعية: Proteomics, Permissiveness, Plasmodium, medicine.medical_specialty, Proteome, Biochemistry, Host-Parasite Interactions, 03 medical and health sciences, Tandem Mass Spectrometry, Molecular genetics, parasitic diseases, medicine, Animals, Humans, Molecular Biology, Cells, Cultured, 030304 developmental biology, 0303 health sciences, biology, Drug discovery, 030302 biochemistry & molecular biology, biology.organism_classification, medicine.disease, Virology, Malaria, Macaca fascicularis, medicine.anatomical_structure, Hepatocyte, Hepatocytes, Asialoglycoprotein receptor, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151cdf0028940883604558938e35d4e1
https://doi.org/10.1002/pmic.201900021

المؤلفون: Abhishek Ananthanarayanan, Silas A. Davidson, François Nosten, Anchalee Tungtaeng, Michael K. McMillian, Ratawan Ubalee, Fan Lee, Chiara Andolina, Adeline C. Y. Chua, Kevin Tan, Hanry Yu, N. Singh, Laurent Dembele, Rawiwan Imerbsin, Yinghua Qu, Andy Yip, Bruce Russell, Bryan K. S. Yeung, Jen Yi Wong, Laurent Rénia, Jessica Jie Ying Ong, Thierry T. Diagana, Kapish Gupta, Pablo Bifani, Amber Lange

المصدر: Biomaterials. 216:119221

مصطلحات موضوعية: Permissiveness, Plasmodium, Plasmodium vivax, Cell Culture Techniques, Biophysics, Bioengineering, 02 engineering and technology, Simian, Cell Line, Biomaterials, Antimalarials, 03 medical and health sciences, Parasitic Sensitivity Tests, Recurrence, Spheroids, Cellular, parasitic diseases, Secondary Prevention, medicine, Animals, Humans, Parasite hosting, Cells, Cultured, 030304 developmental biology, Infectivity, 0303 health sciences, biology, 021001 nanoscience & nanotechnology, biology.organism_classification, medicine.disease, Macaca mulatta, Virology, In vitro, Malaria, Macaca fascicularis, medicine.anatomical_structure, Liver, Sporozoites, Mechanics of Materials, Hepatocyte, Hepatocytes, Ceramics and Composites, 0210 nano-technology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9200adcbb3db03d66d26283e0951c6d6
https://doi.org/10.1016/j.biomaterials.2019.05.032

المؤلفون: Mallika Imwong, Laurent Rénia, Kevin S. W. Tan, Bryan K. S. Yeung, François Nosten, Varakorn Kosaisavee, Ratawan Ubalee, Dennis E. Kyle, Rawiwan Imerbsin, Adeline C. Y. Chua, Bruce Russell, Hugo Sámano-Sánchez, Rou Zhang, Jessica Jie Ying Ong, Rossarin Suwanarusk, Eric Lombardini, Benoit Malleret, Pablo Bifani, Georges Snounou

مصطلحات موضوعية: 0301 basic medicine, Erythrocytes, Reticulocytes, 030231 tropical medicine, Immunology, Plasmodium vivax, Transferrin receptor, Receptors, Cell Surface, Southeast asian, Biochemistry, Tropism, Host-Parasite Interactions, 03 medical and health sciences, Chemokine receptor, 0302 clinical medicine, Red Cells, Iron, and Erythropoiesis, Antigen, Antigens, CD, Zoonoses, parasitic diseases, Receptors, Transferrin, medicine, Animals, Humans, biology, Merozoites, Cell Biology, Hematology, biology.organism_classification, medicine.disease, Virology, 030104 developmental biology, Plasmodium knowlesi, Macaca, Duffy Blood-Group System, Rheology, Malaria, Plasmodium cynomolgi

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6e2d121311bcb03a0a5074854ecfea
https://europepmc.org/articles/PMC5600141/

المؤلفون: Pablo Bifani, Elizabeth A. Winzeler, Victoria C. Corey, David A. Fidock, Christin Reimer, Benoit Malleret, Bianca F Bf Tjahjadi, Bee Huat Tan, Thierry T. Diagana, Marcus C. S. Lee, Laurent Rénia, Bryan K. S. Yeung, Paul Chi-Lui Pc Ho, Liting L. Lim, René Wintjens, Michelle Yi-Xiu Lim, Eric D. Chow, Peter Gedeck, Marie Nachon, Gregory G. LaMonte, Adeline C. Y. Chua, Ghislain M. C. Bonamy

المصدر: Nature microbiology

مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), 030106 microbiology, Immunology, Mutant, Drug resistance, Bioinformatics, Applied Microbiology and Biotechnology, Microbiology, Article, 03 medical and health sciences, parasitic diseases, Genetics, Medicine, CRISPR, Plasmodium berghei, Gene, biology, business.industry, Plasmodium falciparum, Transporter, Cell Biology, biology.organism_classification, 3. Good health, Multiple drug resistance, 030104 developmental biology, Biochemistry, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96c53daeb850f1c4ad21fa8c0ec7572
https://doi.org/10.1038/nmicrobiol.2016.166