المؤلفون: El Gammal RN; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Elmansi H; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., El-Emam AA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Belal F; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Hammouda MEA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt (HUE), New Damietta, Egypt.

المصدر: Luminescence : the journal of biological and chemical luminescence [Luminescence] 2024 Jun; Vol. 39 (6), pp. e4792.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley & Sons Country of Publication: England NLM ID: 100889025 Publication Model: Print Cited Medium: Internet ISSN: 1522-7243 (Electronic) Linking ISSN: 15227235 NLM ISO Abbreviation: Luminescence Subsets: MEDLINE

مواضيع طبية MeSH: Pyrazines*/chemistry , Pyrazines*/metabolism , Amides*/chemistry , Amides*/metabolism , Adenine Nucleotides*/chemistry , Adenine Nucleotides*/metabolism , Antiviral Agents*/chemistry , Antiviral Agents*/pharmacology , Antiviral Agents*/metabolism , Thermodynamics*, Spectroscopy, Fourier Transform Infrared ; Spectrometry, Fluorescence ; Fluorescence Resonance Energy Transfer ; Spectrophotometry, Ultraviolet ; Binding Sites ; Adenine/chemistry ; Adenine/metabolism

المؤلفون: Choi Y; Department of Biomedical Science, Graduate School of Ajou University, Worldcup-ro 164, Yeoungtong-gu, Suwon-si 16499, South Korea. Electronic address: rkddpf1123@naver.com., Kim SH; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Worldcup-ro 164, Yeoungtong-gu, Suwon-si 16499, South Korea. Electronic address: oh4038@naver.com., Jun Shin S; Department of Biomedical Science, Graduate School of Ajou University, Worldcup-ro 164, Yeoungtong-gu, Suwon-si 16499, South Korea. Electronic address: 01075871087t@gmail.com., Park HS; Department of Biomedical Science, Graduate School of Ajou University, Worldcup-ro 164, Yeoungtong-gu, Suwon-si 16499, South Korea; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Worldcup-ro 164, Yeoungtong-gu, Suwon-si 16499, South Korea. Electronic address: hspark@ajou.ac.kr., Seob Shin Y; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Worldcup-ro 164, Yeoungtong-gu, Suwon-si 16499, South Korea. Electronic address: drsys93@naver.com.

المصدر: International immunopharmacology [Int Immunopharmacol] 2024 May 10; Vol. 132, pp. 111903. Date of Electronic Publication: 2024 Apr 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Adenine*/*analogs & derivatives, Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors , Asthma*/drug therapy , Asthma*/immunology , Mice, Inbred BALB C* , Piperidines*/therapeutic use , Piperidines*/pharmacology , Ovalbumin*/immunology , Disease Models, Animal* , Adenine*/therapeutic use , Adenine*/pharmacology , Immunoglobulin E*/blood , Immunoglobulin E*/immunology , Cytokines*/metabolism , Eosinophils*/immunology , Eosinophils*/drug effects , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/therapeutic use, Animals ; Mice ; Pyrimidines/therapeutic use ; Pyrimidines/pharmacology ; Female ; Pyrazoles/therapeutic use ; Pyrazoles/pharmacology ; Bronchoalveolar Lavage Fluid/cytology ; Bronchoalveolar Lavage Fluid/immunology ; Immunoglobulin G/blood ; Anti-Asthmatic Agents/therapeutic use ; Anti-Asthmatic Agents/pharmacology ; Cells, Cultured ; Humans ; Mast Cells/drug effects ; Mast Cells/immunology

المؤلفون: Shadman M; Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA. mshadman@fredhutch.org., Tedeschi A; ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Mohseninejad L; BeiGene, Netherlands B.V., Schiphol, The Netherlands., Yang K; BeiGene USA Inc, San Mateo, CA, USA., Lamanna N; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA., Xu S; BeiGene (Beijing) Co. Ltd., Beijing, China., Cohen A; BeiGene USA Inc, San Mateo, CA, USA., Challagulla S; BeiGene USA Inc, San Mateo, CA, USA., Xue M; BeiGene USA Inc, San Mateo, CA, USA., Williams R; BeiGene USA Inc, San Mateo, CA, USA., O'Brien SM; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA., Brown JR; Dana-Farber Cancer Institute, Boston, MA, USA., Tam C; The Alfred Hospital and Monash University, Melbourne, VIC, Australia.

المصدر: Blood cancer journal [Blood Cancer J] 2024 May 02; Vol. 14 (1), pp. 77. Date of Electronic Publication: 2024 May 02.

نوع المنشور: Letter; Research Support, Non-U.S. Gov't; Comparative Study

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE

مواضيع طبية MeSH: Adenine*/*analogs & derivatives, Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy , Leukemia, Lymphocytic, Chronic, B-Cell*/mortality , Adenine*/therapeutic use , Piperidines*/therapeutic use, Humans ; Male ; Pyrazoles/therapeutic use ; Female ; Pyrimidines/therapeutic use ; Aged ; Treatment Outcome ; Middle Aged

المؤلفون: Konttinen O; Biomolecular Science and Engineering, University of California, Santa Barbara, Santa Barbara, CA, USA., Carmody J; Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, USA., Kurnik M; Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, USA., Johnson KA; Life Sciences Interdisciplinary Graduate Program, Department of Molecular Biosciences, University of Texas, Austin, TX, USA., Reich N; Biomolecular Science and Engineering, University of California, Santa Barbara, Santa Barbara, CA, USA.; Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, USA.

المصدر: Nucleic acids research [Nucleic Acids Res] 2023 Jul 21; Vol. 51 (13), pp. 6883-6898.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Site-Specific DNA-Methyltransferase (Adenine-Specific)*/metabolism , DNA*/chemistry, Humans ; DNA Methylation ; DNA Modification Methylases/genetics ; DNA Modification Methylases/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Adenine/metabolism ; Kinetics ; Substrate Specificity

المؤلفون: Sha W; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China., Gong C; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China., Xiao G; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China., Hou C; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address: chuanlih2199@scut.edu.cn., Ren J; School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China. Electronic address: jyren@scut.edu.cn.

المصدر: Food chemistry [Food Chem] 2024 Aug 01; Vol. 448, pp. 139076. Date of Electronic Publication: 2024 Mar 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE

مواضيع طبية MeSH: Adenine*/chemistry , Adenine*/metabolism , Bayes Theorem* , Monte Carlo Method* , Peptides*/chemistry , Peptides*/metabolism, Molecular Docking Simulation ; Protein Binding ; Hyperuricemia/metabolism ; Humans ; Thermodynamics ; Uric Acid/chemistry ; Uric Acid/metabolism ; Binding Sites

المؤلفون: Zhu T; Department of Critical Care Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310020, China., Yao Y; Department of Neurology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province 310052, China; Department of Pediatrics, Shaoxing People's Hospital, Shaoxing, Zhejiang Province 312300, China., Ding J; Department of Neurology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province 310052, China; Department of Pediatrics, Yiwu Maternal and Child Health Care Hospital, Yiwu, Zhejiang Province 322000, China., Zhang C; Department of Neurology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province 310052, China., Xia N; Department of Neurology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province 310052, China., Tao Y; Department of Neurology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province 310052, China., Zhang W; Department of Neurology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province 310052, China., Qi H; Department of Neurology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province 310052, China., Gong L; Department of Neurology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province 310052, China. Electronic address: 21918475@zju.edu.cn., Jiang P; Department of Neurology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang Province 310052, China. Electronic address: jiangpeifang@zju.edu.cn.

المصدر: International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112744. Date of Electronic Publication: 2024 Jul 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Sepsis-Associated Encephalopathy*/drug therapy , Autophagy*/drug effects , Adenine*/analogs & derivatives , Adenine*/pharmacology , Lipopolysaccharides* , Cognition*/drug effects , Neuroinflammatory Diseases*/drug therapy , Neuroinflammatory Diseases*/immunology, Animals ; Male ; Mice ; Disease Models, Animal ; Mice, Inbred C57BL ; Cytokines/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/pathology ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents/pharmacology

المؤلفون: Sharman JP; Willamette Valley Cancer Center.; Sarah Cannon Research Institute.

المصدر: Blood [Blood] 2024 Sep 26; Vol. 144 (13), pp. 1351-1352.

نوع المنشور: Letter; Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy , Leukemia, Lymphocytic, Chronic, B-Cell*/pathology , Pyrimidines*/administration & dosage , Pyrimidines*/therapeutic use , Piperidines*/administration & dosage , Piperidines*/therapeutic use , Pyrazoles*/administration & dosage , Pyrazoles*/therapeutic use , Adenine*/analogs & derivatives , Adenine*/administration & dosage , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/administration & dosage, Humans ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/administration & dosage ; Nitriles/administration & dosage ; Nitriles/therapeutic use

المؤلفون: Wulansari D; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; National Research and Innovation Agency, Jakarta, Indonesia., Jeelani G; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Yazaki E; Research Center for Advanced Analysis, National Agriculture and Food Research Organization, Ibaraki, Japan., Nozaki T; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

المصدر: MSphere [mSphere] 2024 Sep 25; Vol. 9 (9), pp. e0034724. Date of Electronic Publication: 2024 Aug 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101674533 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2379-5042 (Electronic) Linking ISSN: 23795042 NLM ISO Abbreviation: mSphere Subsets: MEDLINE

مواضيع طبية MeSH: Entamoeba histolytica*/genetics , Entamoeba histolytica*/enzymology , Entamoeba histolytica*/drug effects , Phylogeny* , Flavin-Adenine Dinucleotide*/metabolism , Archaea*/genetics , Archaea*/enzymology, Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Kinetics ; Antiprotozoal Agents/pharmacology ; Humans ; Nucleotidyltransferases

المؤلفون: Ashar F; Research Scholar, Department of Pharmacy, Annamalai University, Annamalainagar, Chidambaram, Tamil Nadu, India., Mohammed AAS; Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia., Selvamuthukumar S; Research Scholar, Department of Pharmacy, Annamalai University, Annamalainagar, Chidambaram, Tamil Nadu, India.

المصدر: PloS one [PLoS One] 2024 Sep 24; Vol. 19 (9), pp. e0310492. Date of Electronic Publication: 2024 Sep 24 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Adenine*/pharmacokinetics , Adenine*/analogs & derivatives , Adenine*/administration & dosage , Adenine*/chemistry , Piperidines*/pharmacokinetics , Piperidines*/administration & dosage , Piperidines*/chemistry , Biological Availability* , Liposomes*/chemistry , Pyrimidines*/pharmacokinetics , Pyrimidines*/administration & dosage , Pyrimidines*/chemistry , Pyrazoles*/pharmacokinetics , Pyrazoles*/administration & dosage , Pyrazoles*/chemistry, Animals ; Administration, Oral ; Rats ; Male ; Drug Delivery Systems ; Drug Liberation ; Nanoparticles/chemistry ; Rats, Sprague-Dawley ; Silicon Dioxide/chemistry

المؤلفون: Riddler SA; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Kelly CW; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Hoesley CJ; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Department of Medical Education, University of Alabama at Birmingham, Birmingham, Alabama, USA., Ho KS; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Piper JM; Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA., Edick S; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Heard F; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Doncel GF; CONRAD, Eastern Virginia Medical School, Norfolk, Virginia, USA., Johnson S; FHI 360, Durham, North Carolina, USA., Anderson PL; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Brand RM; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA., Kunjara Na Ayudhya RP; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA., Bauermeister JA; Department of Family and Community Health, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA., Hillier SL; Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.; Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hendrix CW; Department of Medicine, Clinical Pharmacology, Johns Hopkins University, Baltimore, Maryland, USA.

المصدر: The Journal of infectious diseases [J Infect Dis] 2024 Sep 23; Vol. 230 (3), pp. 696-705.

نوع المنشور: Journal Article; Clinical Trial, Phase I

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Tenofovir*/pharmacokinetics , Tenofovir*/administration & dosage , Tenofovir*/analogs & derivatives , HIV Infections*/prevention & control , HIV Infections*/drug therapy , Quinolones*/pharmacokinetics , Quinolones*/administration & dosage , Quinolones*/adverse effects , Anti-HIV Agents*/pharmacokinetics , Anti-HIV Agents*/administration & dosage , Anti-HIV Agents*/adverse effects , Alanine*/pharmacokinetics , Alanine*/administration & dosage , Adenine*/analogs & derivatives , Adenine*/pharmacokinetics , Adenine*/administration & dosage , Adenine*/adverse effects , Administration, Rectal*, Humans ; Male ; Adult ; Female ; Middle Aged ; Rectum/virology ; Young Adult ; HIV-1/drug effects ; Drug Combinations