المؤلفون: Pirjo Nummela, Colin Nixon, William C. Clark, Ella Gilchrist, Simon J. Leedham, Michael C. Hodder, Nalle Pentinmikko, Arafath Kaja Najumudeen, Nathalie Sphyris, E. Yvonne Jones, Jean-Paul Vincent, Hans Clevers, Nicky J. Willis, Alexander Raven, Kristina Kirschner, Dustin J. Flanagan, Paul V. Fish, Emma Minnee, Pekka Katajisto, Ville Hietakangas, Owen J. Sansom, Christine Perret, Lynn McGarry, Nadia Nasreddin, Rachel A. Ridgway, Ann C. Williams, Kathryn Gilroy, Kalle Luopajärvi, Sandra Scharaw, Béatrice Romagnolo, Marianne Lähde, Ari Ristimäki, Johanna Englund, Anna Taylor Webb, Kari Alitalo, Ann Hedley

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Institute of Biotechnology (-2009), University of Helsinki, CAN-PRO - Translational Cancer Medicine Program, Centre of Excellence in Stem Cell Metabolism, Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, Juha Klefström / Principal Investigator, Research Programs Unit, Department of Pathology, Doctoral Programme in Biomedicine, ATG - Applied Tumor Genomics, Doctoral Programme in Integrative Life Science, HUSLAB, Kari Alitalo / Principal Investigator, Molecular and Integrative Biosciences Research Programme, Biosciences, Nutrient sensing laboratory

المصدر: Nature, 594(7863), 430-435. Nature Publishing Group
Flanagan, D J, Williams, A C, Katajisto, P K, Sampson, O J & al., E 2021, ' NOTUM from Apc-mutant cells biases clonal competition to initiate cancer ', Nature, vol. 594, pp. 430–435 (2021) . https://doi.org/10.1038/s41586-021-03525-z

مصطلحات موضوعية: 0301 basic medicine, Male, HOMEOSTASIS, Cell, medicine.disease_cause, Cell Transformation, Inbred C57BL, Ligands, BETA-CATENIN, ACTIVATION, PATHWAY, Mice, 0302 clinical medicine, Conditioned, INTESTINE, Stem Cells/cytology, Wnt Signaling Pathway, Cell Competition/genetics, Esterases/antagonists & inhibitors, Mutation, Multidisciplinary, biology, Stem Cells, Cell Transformation, Neoplastic/genetics, Wnt signaling pathway, Esterases, Cell Differentiation, Neoplastic/genetics, Cell biology, Organoids, POLYPOSIS, medicine.anatomical_structure, Cell Transformation, Neoplastic, 030220 oncology & carcinogenesis, Disease Progression, Organoids/cytology, Female, Stem cell, Colorectal Neoplasms, STEM-CELLS, BONE-FORMATION, Adenoma, Beta-catenin, Genes, APC, 3122 Cancers, Crypt, Adenomatous Polyposis Coli Protein, WNT, 03 medical and health sciences, Cancer stem cell, Wnt Proteins/metabolism, medicine, Animals, Humans, Adenomatous Polyposis Coli Protein/genetics, Cell Proliferation, Adenoma/genetics, Colorectal Neoplasms/genetics, Notum, Culture Media, APC, Wnt Proteins, Mice, Inbred C57BL, 030104 developmental biology, Genes, Cell Competition, Culture Media, Conditioned, biology.protein, 1182 Biochemistry, cell and molecular biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5733edf6d5fc44fd62aea7978eb694e
https://pure.knaw.nl/portal/en/publications/69a3582f-fc29-4f40-bc5f-17ba7825a11a

المؤلفون: Roos, E, Soer, E C, Klompmaker, S, Meijer, Laura, Besselink, M G, Giovannetti, E, Heger, M, Kazemier, G, Klümpen, H J, Takkenberg, R B, Wilmink, H, Würdinger, T, Dijk, F, van Gulik, T M, Verheij, J, van de Vijver, M J, Afd Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Pharmaceutics

المساهمون: Afd Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Pharmaceutics

المصدر: Critical Reviews in Oncology/Hematology, 140, 8. Elsevier Ireland Ltd.
Roos, E, Soer, E C, Klompmaker, S, Meijer, L L, Besselink, M G, Giovannetti, E, Heger, M, Kazemier, G, Klümpen, H J, Takkenberg, R B, Wilmink, H, Würdinger, T, Dijk, F, van Gulik, T M, Verheij, J & van de Vijver, M J 2019, ' Crossing borders: A systematic review with quantitative analysis of genetic mutations of carcinomas of the biliary tract ', Critical Reviews in Oncology/Hematology, vol. 140, pp. 8-16 . https://doi.org/10.1016/j.critrevonc.2019.05.011

مصطلحات موضوعية: 0301 basic medicine, Phosphofructokinase-2/genetics, Biliary Tract Neoplasms/genetics, Chromogranins/genetics, Phosphofructokinase-2, Cell of origin, Isocitrate Dehydrogenase/genetics, Phosphoric Monoester Hydrolases/genetics, Receptor, Transforming Growth Factor-beta Type II/genetics, Cholangiocarcinoma, 0302 clinical medicine, Neoplasm Proteins/genetics, GTP-Binding Protein alpha Subunits, Gs, Medicine, biology, Hematology, GTP-Binding Protein alpha Subunits, Isocitrate Dehydrogenase, Neoplasm Proteins, medicine.anatomical_structure, Biliary Tract Neoplasms, Oncology, Biliary tract, 030220 oncology & carcinogenesis, Cholangiocarcinoma/genetics, Receptor, GTP-Binding Protein alpha Subunits, Gs/genetics, IDH1, Adenomatous Polyposis Coli Protein, Genomics, IDH2, Transforming Growth Factor-beta Type II/genetics, 03 medical and health sciences, GNAS complex locus, Chromogranins, Humans, Adenomatous Polyposis Coli Protein/genetics, Membrane Proteins/genetics, Gene, business.industry, Gallbladder, Receptor, Transforming Growth Factor-beta Type II, Membrane Proteins, Phosphoric Monoester Hydrolases, Gs/genetics, 030104 developmental biology, Mutation, Cancer research, biology.protein, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64563fc2213fbeca1732853fe1f43b9
https://pubmed.ncbi.nlm.nih.gov/31158800

المؤلفون: Jeanine J. Houwing-Duistermaat, Rolf H. Sijmons, Cora M. Aalfs, Nicoline Hoogerbrugge, Marry H. Nieuwenhuis, E. B. Gomez Garcia, Carli M. J. Tops, T. van Wezel, Senno Verhoef, Zeinab Ghorbanoghli, Fred H. Menko, Frederik J. Hes, Tom G.W. Letteboer, Hans F. A. Vasen, Shantie Jagmohan-Changur, Anja Wagner, Juul T. Wijnen

المساهمون: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Human Genetics, Clinical Genetics, Faculty of Medicine and Pharmacy, Clinical sciences, Faculty of Economic and Social Sciences and Solvay Business School, Faculty of Psychology and Educational Sciences, Promovendi NTM, RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA KG Polikliniek (9), Klinische Genetica

المصدر: Familial Cancer, 15(4), 563-570. SPRINGER
Familial Cancer, 15(4), 563–570. Springer Netherlands
Familial cancer, 15(4), 563-570. Springer Netherlands
Familial Cancer
Familial Cancer, 15(4), 563-570. Springer Netherlands
Familial Cancer, 15, 4, pp. 563-70
Familial Cancer, 15, 563-70
Familial Cancer, 15(4), 563-570. Springer, Cham

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Genome-wide association study, 0302 clinical medicine, Gene Frequency, GENETIC-VARIANTS, Genotype, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], Genetics(clinical), Cancer genetics, Genetics (clinical), Medicine(all), Genetics, Familial adenomatous polyposis, REFINEMENT, LYNCH SYNDROME, Adenomatous Polyposis Coli/genetics, Lynch syndrome, Adenomatous Polyposis Coli, Oncology, 030220 oncology & carcinogenesis, Original Article, Colorectal Neoplasms, Chromosomes, Human, Pair 8, Adenoma, Adult, SUSCEPTIBILITY LOCI, Adenomatous Polyposis Coli Protein, Single-nucleotide polymorphism, Genetic polymorphisms, Polymorphism, Single Nucleotide, 03 medical and health sciences, Germline mutation, SDG 3 - Good Health and Well-being, MODIFIER GENES, medicine, Journal Article, Humans, Genetic Predisposition to Disease, Adenomatous Polyposis Coli Protein/genetics, Allele, GENOME-WIDE ASSOCIATION, Allele frequency, business.industry, Chromosomes, Human, Pair 11, FAP, ALLELES, medicine.disease, Adenoma/genetics, Colorectal Neoplasms/genetics, digestive system diseases, 030104 developmental biology, SEVERITY, Mutation, Colonic adenomas, business, Genome-Wide Association Study

وصف الملف: image/pdf; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b02251738806fa5aa1f1a8ee1d1856
https://dspace.library.uu.nl/handle/1874/346538

المؤلفون: Fransén, Karin, Dimberg, Jan, Osterström, Anna, Olsson, Anneli, Söderkvist, Peter, Sirsjö, Allan

المصدر: Surgery. 131(4):384-392

مصطلحات موضوعية: Adenocarcinoma/*genetics/metabolism, Adenomatous Polyposis Coli Protein/*genetics, Colorectal Neoplasms/*genetics/metabolism, Female, Genes, p53, Humans, Loss of Heterozygosity, Male, Mutation, Nitric Oxide Synthase/*genetics/metabolism, Nitric Oxide Synthase Type II, RNA, Messenger/*metabolism

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-4270
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=11935128&dopt=Citation

المؤلفون: Pierre Hutter, V. Membrez, F. Joris, Claudio Soravia, Daniel F. Schorderet, C. D. DeLozier-Blanchet, C. Rey-Berthod, Pierre O. Chappuis, A. Couturier, A. Murphy

المصدر: Human Mutation, Vol. 18, No 6 (2001) P. 550

مصطلحات موضوعية: Adult, Male, DNA, Complementary, Adolescent, Adenomatous Polyposis Coli/genetics/pathology, Adenomatous polyposis coli, media_common.quotation_subject, Adenomatous Polyposis Coli Protein, DNA Mutational Analysis, Nonsense, Biology, medicine.disease_cause, Frameshift mutation, Familial adenomatous polyposis, DNA, Complementary/chemistry/genetics, Germline mutation, Genetics, medicine, Humans, Adenomatous Polyposis Coli Protein/genetics, Child, Gene, Germ-Line Mutation, Genetics (clinical), media_common, ddc:616, Family Health, Mutation, ddc:617, DNA, Middle Aged, medicine.disease, Phenotype, Adenomatous Polyposis Coli, DNA/chemistry/genetics, biology.protein, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48ef8ce57f0316c056e12e78183f843
https://doi.org/10.1002/humu.1242

المصدر: Nature vol.594 (2021) nr.7863 p.430-435 [ISSN 0028-0836]

مصطلحات الفهرس: Adenoma/genetics, Adenomatous Polyposis Coli Protein/genetics, Animals, Cell Competition/genetics, Cell Differentiation, Cell Proliferation, Cell Transformation, Neoplastic/genetics, Colorectal Neoplasms/genetics, Culture Media, Conditioned, Disease Progression, Esterases/antagonists & inhibitors, Female, Genes, APC, Humans, Ligands, Male, Mice, Mice, Inbred C57BL, Mutation, Organoids/cytology, Stem Cells/cytology, Wnt Proteins/metabolism, Wnt Signaling Pathway, Artikel, Article

URL: https://pure.knaw.nl/portal/en/publications/69a3582f-fc29-4f40-bc5f-17ba7825a11a

المصدر: Nature vol.594 (2021) nr.7863 p.430-435 [ISSN 0028-0836]

مصطلحات الفهرس: Adenoma/genetics, Adenomatous Polyposis Coli Protein/genetics, Animals, Cell Competition/genetics, Cell Differentiation, Cell Proliferation, Cell Transformation, Neoplastic/genetics, Colorectal Neoplasms/genetics, Culture Media, Conditioned, Disease Progression, Esterases/antagonists & inhibitors, Female, Genes, APC, Humans, Ligands, Male, Mice, Mice, Inbred C57BL, Mutation, Organoids/cytology, Stem Cells/cytology, Wnt Proteins/metabolism, Wnt Signaling Pathway, Artikel, Article

URL: https://pure.knaw.nl/portal/en/publications/69a3582f-fc29-4f40-bc5f-17ba7825a11a

المصدر: Acta Gastro-Enterologica Belgica (Multilingual Edition), Vol. 74, no. 3, p. 421-426 (2011)

مصطلحات الفهرس: Adenomatous Polyposis Coli - diagnosis, genetics, Adenomatous Polyposis Coli Protein - genetics, DNA Glycosylases - genetics, Genotype, Humans, Phenotype, Genetics of familial adenomatous polyposis, Genetic counseling, APC, MutYH, Genotype-phenotype correlations, info:eu-repo/semantics/article

URL: http://hdl.handle.net/2078.1/109970

مصطلحات الفهرس: Adenocarcinoma/*genetics/metabolism, Adenomatous Polyposis Coli Protein/*genetics, Colorectal Neoplasms/*genetics/metabolism, Female, Genes; p53, Humans, Loss of Heterozygosity, Male, Mutation, Nitric Oxide Synthase/*genetics/metabolism, Nitric Oxide Synthase Type II, RNA; Messenger/*metabolism, Article in journal, info:eu-repo/semantics/article, text

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-4270
Surgery, 0039-6060, 2002, 131:4, s. 384-392