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1دورية أكاديمية
المؤلفون: Louis H; Department of Thoracic and vascular Surgery, AZ Groeninge, Kortrijk, Belgium., Philip L; Department of Thoracic and vascular Surgery, AZ Groeninge, Kortrijk, Belgium.
المصدر: Acta chirurgica Belgica [Acta Chir Belg] 2024 Aug; Vol. 124 (4), pp. 316-324. Date of Electronic Publication: 2024 Apr 02.
نوع المنشور: Journal Article; Case Reports; Review
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 0370571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0001-5458 (Print) Linking ISSN: 00015458 NLM ISO Abbreviation: Acta Chir Belg Subsets: MEDLINE
مواضيع طبية MeSH: Femoral Artery*/surgery , Cysts*/surgery , Adventitia*/surgery , Saphenous Vein*/transplantation, Humans ; Female ; Middle Aged ; Intermittent Claudication/etiology ; Intermittent Claudication/surgery
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2دورية أكاديمية
المؤلفون: Hinloopen JH; Department of Surgery, Groene Hart Ziekenhuis, Gouda, The Netherlands., Blok JJ; Department of Surgery, Groene Hart Ziekenhuis, Gouda, The Netherlands. Electronic address: joris.blok@ghz.nl.
المصدر: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery [Eur J Vasc Endovasc Surg] 2024 Oct; Vol. 68 (4), pp. 547. Date of Electronic Publication: 2024 May 15.
نوع المنشور: Case Reports; Journal Article
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9512728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2165 (Electronic) Linking ISSN: 10785884 NLM ISO Abbreviation: Eur J Vasc Endovasc Surg Subsets: MEDLINE
مواضيع طبية MeSH: Adventitia*/diagnostic imaging , Adventitia*/surgery , Cysts*/diagnostic imaging , Cysts*/complications , Cysts*/surgery, Humans ; Male ; Ischemia/etiology ; Ischemia/surgery ; Ischemia/diagnosis ; Ischemia/diagnostic imaging ; Middle Aged
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3دورية أكاديمية
المؤلفون: Wu Y; Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China., Li X; Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China., Wang Z; Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China., Zhang S; Department of Ultrasound, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China., Feng Y; Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China., Sun L; Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China. sunlitao@hmc.edu.cn.
المصدر: Translational stroke research [Transl Stroke Res] 2024 Jun; Vol. 15 (3), pp. 545-555. Date of Electronic Publication: 2023 Feb 20.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101517297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-601X (Electronic) Linking ISSN: 18684483 NLM ISO Abbreviation: Transl Stroke Res Subsets: MEDLINE
مواضيع طبية MeSH: Adventitia*/diagnostic imaging , Adventitia*/pathology , Elasticity Imaging Techniques*/methods , Plaque, Atherosclerotic*/diagnostic imaging , Plaque, Atherosclerotic*/pathology , Early Diagnosis* , Contrast Media*, Animals ; Rabbits ; Male ; Disease Models, Animal ; Ultrasonography/methods ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/pathology
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4دورية أكاديمية
المؤلفون: Chen J; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China., Wei JQ; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China., Hong MN; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China., Zhang Z; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China., Zhou HD; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China., Lu YY; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China., Zhang J; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China., Guo YT; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China., Chen X; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China., Wang JG; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China., Gao PJ; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China., Li XD; Department of Cardiovascular Medicine, Department of Hypertension, Ruijin Hospital and State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, China. flylxd@163.com.
المصدر: Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2024 Jun; Vol. 38 (3), pp. 527-538. Date of Electronic Publication: 2023 Jan 18.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Kluwer Academic For The International Society For Cardiovascular Pharmacotherapy Country of Publication: United States NLM ID: 8712220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7241 (Electronic) Linking ISSN: 09203206 NLM ISO Abbreviation: Cardiovasc Drugs Ther Subsets: MEDLINE
مواضيع طبية MeSH: Adventitia*/pathology , Adventitia*/drug effects , Adventitia*/metabolism , Adventitia*/enzymology , Becaplermin*/pharmacology , Cyclin D1*/metabolism , Cyclin D1*/genetics , Fibroblasts*/drug effects , Fibroblasts*/pathology , Fibroblasts*/metabolism , Fibroblasts*/enzymology , Mitogen-Activated Protein Kinases*/metabolism , Neointima*, Animals ; Male ; Rats ; Angioplasty, Balloon/adverse effects ; Carotid Artery Injuries/pathology ; Carotid Artery Injuries/enzymology ; Carotid Artery Injuries/drug therapy ; Carotid Artery Injuries/metabolism ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Disease Models, Animal ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Rats, Sprague-Dawley ; Signal Transduction ; Vascular System Injuries/pathology ; Vascular System Injuries/enzymology ; Vascular System Injuries/metabolism ; Vascular System Injuries/drug therapy
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5دورية أكاديمية
المؤلفون: Roman J; University Hospital Ostrava, Department of Surgery - Ostrava, Czech Republic.; University of Ostrava, Faculty of Medicine, Department of Surgery - Ostrava, Czech Republic., Jalůvka F; University Hospital Ostrava, Department of Surgery - Ostrava, Czech Republic.; University of Ostrava, Faculty of Medicine, Department of Surgery - Ostrava, Czech Republic., Sengul I; Giresun University, Faculty of Medicine, Division of Endocrine Surgery - Giresun, Turkey.; Giresun University, Faculty of Medicine, Department of Surgery - Giresun, Turkey., Sengul D; Giresun University, Faculty of Medicine, Department of Pathology - Giresun, Turkey., Jonszta T; University Hospital Ostrava, Department of Radiology - Ostrava, Czech Republic., Hurník P; University Hospital Ostrava, Institute of Molecular and Clinical Pathology and Medical Genetics - Ostrava, Czech Republic.; University of Ostrava, Institute of Molecular and Clinical Pathology and Medical Genetics, Faculty of Medicine - Ostrava, Czech Republic., Pelikán A; University Hospital Ostrava, Department of Surgery - Ostrava, Czech Republic.; University of Ostrava, Faculty of Medicine, Department of Surgery - Ostrava, Czech Republic.; Tomas Bata University in Zlin, Faculty of Humanities, Department of Health Care Sciences - Zlín, Czech Republic., Procházka V; University Hospital Ostrava, Department of Radiology - Ostrava, Czech Republic.
المصدر: Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2024 Apr 22; Vol. 70 (3), pp. e20231482. Date of Electronic Publication: 2024 Apr 22 (Print Publication: 2024).
نوع المنشور: Journal Article; Case Reports
بيانات الدورية: Publisher: Associação Médica Brasileira Country of Publication: Brazil NLM ID: 9308586 Publication Model: eCollection Cited Medium: Internet ISSN: 1806-9282 (Electronic) Linking ISSN: 01044230 NLM ISO Abbreviation: Rev Assoc Med Bras (1992) Subsets: MEDLINE
مواضيع طبية MeSH: Adventitia*/diagnostic imaging , Adventitia*/pathology , Cysts*/diagnostic imaging , Cysts*/pathology , Popliteal Artery*/diagnostic imaging , Popliteal Artery*/pathology, Humans
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6دورية أكاديمية
المؤلفون: Han S; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Nie C; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Wang C; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Song M; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Li J; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Cui X; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Yang Q; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Li Y; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Chen Y; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Li Q; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Cai W; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Weng X; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Wang Y; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Electronic address: wyj056@126.com., Zhu X; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Electronic address: zhuxx59@163.com.
المصدر: Journal of ethnopharmacology [J Ethnopharmacol] 2024 Feb 10; Vol. 320, pp. 117339. Date of Electronic Publication: 2023 Oct 21.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
مواضيع طبية MeSH: Adventitia* , Atherosclerosis*/genetics, Mice ; Animals ; Lipopolysaccharides/pharmacology ; Cell Proliferation ; Inflammation/drug therapy ; Inflammation/metabolism ; Myocytes, Smooth Muscle ; Cells, Cultured
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7دورية أكاديمية
المؤلفون: Rodríguez H; Facultad de Medicina, Universidad de Chile, Santiago, Chile.; Facultad de Medicina, Universidad de Atacama, Copiapó, Chile., Arriaza C; Facultad de Medicina, Universidad de Chile, Santiago, Chile., Sarabia L; Facultad de Medicina, Universidad de Chile, Santiago, Chile., Espinoza-Navarro O; Departamento de Biología, Facultad de Ciencias, Universidad de Tarapacá, Arica, Chile.
المصدر: Microscopy research and technique [Microsc Res Tech] 2024 Feb; Vol. 87 (2), pp. 403-407. Date of Electronic Publication: 2023 Oct 25.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9203012 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0029 (Electronic) Linking ISSN: 1059910X NLM ISO Abbreviation: Microsc Res Tech Subsets: MEDLINE
مواضيع طبية MeSH: Scrotum*/physiology , Adventitia*, Male ; Adult ; Humans ; Biodiversity ; Temperature ; Testis/physiology ; Arteries/physiology ; Body Temperature Regulation/physiology
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8دورية أكاديمية
المؤلفون: Wang Y; Department of Cardiology, State Key Laboratory of Transvascular Implantation Devices, Provincial Key Laboratory of Cardiovascular Research, and., Liu Z; Department of Vascular Surgery, The second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China., Song S; State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Wang J; Department of Cardiology, State Key Laboratory of Transvascular Implantation Devices, Provincial Key Laboratory of Cardiovascular Research, and., Jin C; Department of Cardiology, State Key Laboratory of Transvascular Implantation Devices, Provincial Key Laboratory of Cardiovascular Research, and., Jia L; Department of Cardiology, State Key Laboratory of Transvascular Implantation Devices, Provincial Key Laboratory of Cardiovascular Research, and., Ma Y; Department of Cardiology, State Key Laboratory of Transvascular Implantation Devices, Provincial Key Laboratory of Cardiovascular Research, and., Yuan T; Department of Cardiology, State Key Laboratory of Transvascular Implantation Devices, Provincial Key Laboratory of Cardiovascular Research, and., Cai Z; Department of Cardiology, State Key Laboratory of Transvascular Implantation Devices, Provincial Key Laboratory of Cardiovascular Research, and., Xiang M; Department of Cardiology, State Key Laboratory of Transvascular Implantation Devices, Provincial Key Laboratory of Cardiovascular Research, and.
المصدر: JCI insight [JCI Insight] 2024 Jan 04; Vol. 9 (3). Date of Electronic Publication: 2024 Jan 04.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
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9دورية أكاديمية
المؤلفون: Kohli A; Oral and Maxillofacial Surgery, Department of Dentistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Dave A; Plastic & Reconstructive Surgery, Apollo CBCC Cancer Care, Ahmedabad, India; Department of Plastic Surgery & Burns, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Dixit P; Department of Plastic Surgery & Burns, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Katrolia D; Department of Plastic Surgery & Burns, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Kumar P; Department of Dentistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India., Kala PC; Department of Plastic Surgery & Burns, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India. Electronic address: drpckala@gmail.com.
المصدر: Journal of plastic, reconstructive & aesthetic surgery : JPRAS [J Plast Reconstr Aesthet Surg] 2023 Dec; Vol. 87, pp. 69-77. Date of Electronic Publication: 2023 Sep 15.
نوع المنشور: Randomized Controlled Trial; Journal Article
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101264239 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0539 (Electronic) Linking ISSN: 17486815 NLM ISO Abbreviation: J Plast Reconstr Aesthet Surg Subsets: MEDLINE
مواضيع طبية MeSH: Microsurgery* , Adventitia*, Humans ; Surgical Flaps/blood supply ; Arteries ; Anastomosis, Surgical ; Suture Techniques
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10دورية أكاديمية
المؤلفون: Shirasu T; Division of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA., Yodsanit N; Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, 53715, USA., Li J; Division of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA., Huang Y; Division of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA; The Biomedical Sciences Graduate Program (BIMS), School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA., Xie X; Division of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA., Tang R; Division of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA., Wang Q; Division of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA., Zhang M; Division of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA., Urabe G; Division of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA., Webb A; Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, USA., Wang Y; Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, 53715, USA., Wang X; Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, 53715, USA., Xie R; Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, 53715, USA., Wang B; Division of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA., Kent KC; Division of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA. Electronic address: ck8aq@uvahealth.org., Gong S; Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, 53715, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, 53715, USA. Electronic address: shaoqingong@wisc.edu., Guo LW; Division of Surgical Sciences, Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA, 22908, USA; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, 22908, USA; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, 22908, USA. Electronic address: lg8zr@virginia.edu.
المصدر: Biomaterials [Biomaterials] 2023 Oct; Vol. 301, pp. 122245. Date of Electronic Publication: 2023 Jul 13.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
مواضيع طبية MeSH: Nuclear Proteins*/genetics , Nuclear Proteins*/metabolism , Adventitia*/metabolism, Rats ; Animals ; Humans ; Neointima/drug therapy ; Transcription Factors/metabolism ; Rats, Zucker ; Epigenesis, Genetic ; Endothelium ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Cell Cycle Proteins/genetics