يعرض 1 - 10 نتائج من 21 نتيجة بحث عن '"Aengus Mac Sweeney"', وقت الاستعلام: 1.18s تنقيح النتائج
  1. 1
    دورية أكاديمية
    The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms.

    المؤلفون: Aengus Mac Sweeney, Alain Chambovey, Micha Wicki, Manon Müller, Nadia Artico, Roland Lange, Aleksandar Bijelic, Joscha Breibeck, Annette Rompel

    المصدر: PLoS ONE, Vol 13, Iss 6, p e0199639 (2018)

    مصطلحات موضوعية: Medicine, Science

    وصف الملف: electronic resource

    Relation: http://europepmc.org/articles/PMC6021075?pdf=render; https://doaj.org/toc/1932-6203

    URL الوصول: https://doaj.org/article/f998f584c5c44a2b990db3842d71b04e

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  2. 2
    Inverse agonist efficacy of selatogrel blunts constitutive P2Y12 receptor signaling by inducing the inactive receptor conformation

    المؤلفون: Véronique Pons, Cédric Garcia, Naomi Tidten-Luksch, Aengus Mac Sweeney, Eva Caroff, Céline Galés, Markus A. Riederer

    المصدر: Biochemical pharmacology. 206

    مصطلحات موضوعية: Pharmacology, Blood Platelets, Adenosine Diphosphate, Ticagrelor, Platelet Aggregation, Purinergic P2Y Receptor Antagonists, Humans, Platelet Activation, Biochemistry

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10834c4b2d30ebb1004f17c4db090b6
    https://pubmed.ncbi.nlm.nih.gov/36306820

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  3. 3
    Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

    المؤلفون: Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki, Karen Anderson, Aengus Mac Sweeney, Sha-Mei Liao, Upendra A. Argikar, Keith Jendza, Chun Zhang, James Powers, Daniel W. Klosowski, Maura Crowley, Toshio Kawanami, Jian Ding, Myriam April, Cornelia Forster, Michael Serrano-Wu, Michael Capparelli, Rrezarta Ramqaj, Catherine Solovay, Frederic Cumin, Thomas M. Smith, Luciana Ferrara, Wendy Lee, Debby Long, Melissa Prentiss, Andrea De Erkenez, Louis Yang, Fang Liu, Holger Sellner, Finton Sirockin, Eric Valeur, Paulus Erbel, Daniela Ostermeier, Paul Ramage, Bernd Gerhartz, Anna Schubart, Stefanie Flohr, Nathalie Gradoux, Roland Feifel, Barbara Vogg, Christian Wiesmann, Jürgen Maibaum, Jörg Eder, Richard Sedrani, Richard A. Harrison, Muneto Mogi, Bruce D. Jaffee, Christopher M. Adams

    المصدر: Journal of Medicinal Chemistry. 63:5697-5722

    مصطلحات موضوعية: Drug Discovery, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::161530bd60ced781537b4b5cf97869fc
    https://doi.org/10.1021/acs.jmedchem.9b01870

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  4. 4
    Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo

    المؤلفون: Stefanie Flohr, Simon Rüdisser, Anna Vulpetti, Andrea De Erkenez, Stefan Steinbacher, Olivier Rogel, Laurence Kieffer, Solene Dussauge, Louis Yang, Frederic Cumin, Karen Anderson, Aengus Mac Sweeney, Edwige Lorthiois, Nils Ostermann, Ronald Newton, Viral Kansara, Sha-Mei Liao, Ulrich Hommel, Constanze Hartwieg, Upendra A. Argikar, Stefan Andreas Randl, Laura R. La Bonte, Omar Delgado, Kamal Fettis, Jürgen Maibaum, Bruce D Jaffee

    المصدر: Journal of Medicinal Chemistry. 60:5717-5735

    مصطلحات موضوعية: Male, 0301 basic medicine, Proline, Complement Pathway, Alternative, Administration, Oral, Complement Membrane Attack Complex, Pharmacology, Macular Degeneration, Mice, 03 medical and health sciences, In vivo, Drug Discovery, Atypical hemolytic uremic syndrome, medicine, Animals, Humans, Atypical Hemolytic Uremic Syndrome, biology, Chemistry, Haplorhini, medicine.disease, Complement system, Macaca fascicularis, 030104 developmental biology, Biochemistry, biology.protein, Alternative complement pathway, Paroxysmal nocturnal hemoglobinuria, Molecular Medicine, Complement Factor D, Female, Factor D, Complement membrane attack complex, Ex vivo

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e242e3d44a96036addb2cb8f7ea9cefc
    https://doi.org/10.1021/acs.jmedchem.7b00425

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  5. 5
    Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors

    المؤلفون: Paul Erbel, Bernd Gerhartz, Frederic Cumin, Jürgen Maibaum, Nils Ostermann, Edwige Lorthiois, Claudio Dalvit, Thomas Zoller, Stefan Andreas Randl, Simon Rüdisser, Ulrich Hommel, Anna Vulpetti, Aengus Mac Sweeney, Bahaa Salem

    المصدر: Journal of Medicinal Chemistry. 60:1946-1958

    مصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Spectroscopy, In silico, medicine.medical_treatment, 010402 general chemistry, 01 natural sciences, 03 medical and health sciences, Catalytic Domain, Complement Factor D, Drug Discovery, Hydrolase, medicine, Humans, Protease Inhibitors, Serine protease, Protease, Molecular Structure, biology, Chemistry, 0104 chemical sciences, Complement system, 030104 developmental biology, Biochemistry, Drug Design, biology.protein, Alternative complement pathway, Molecular Medicine, Factor D

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfc49de28df6dccc09e8711c747aed7
    https://doi.org/10.1021/acs.jmedchem.6b01684

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  6. 6
    Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway

    المؤلفون: Anna Vulpetti, Upendra A. Argikar, Stefanie Flohr, Aengus Mac Sweeney, Melissa Prentiss, Edwige Lorthiois, Karen Anderson, David B. Belanger, Sha-Mei Liao, Nan Ji, Christopher M. Adams, Frederic Cumin, Andrea De Erkenez, Nathalie Gradoux, Muneto Mogi, Donglei Liu, Maura Crowley, Keith Jendza, Debby Long, Nello Mainolfi, Catherine Solovay, Ann Brown, Laura R. La Bonte, Rajeshri Ganesh Karki, Omar Delgado, Powers James J, Bruce D Jaffee, Christine F. Gelin

    المصدر: Journal of medicinal chemistry. 62(9)

    مصطلحات موضوعية: Benzylamines, Serine Proteinase Inhibitors, Protein Conformation, Complement Pathway, Alternative, Mice, Transgenic, 01 natural sciences, 03 medical and health sciences, Dogs, Complement Factor D, Drug Discovery, Hydrolase, Animals, Humans, 030304 developmental biology, Serine protease, 0303 health sciences, Innate immune system, Binding Sites, biology, Chemistry, 0104 chemical sciences, Cell biology, Rats, Mice, Inbred C57BL, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Design synthesis, Drug Design, Alternative complement pathway, biology.protein, Molecular Medicine, Factor D, Medical science

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da588cee5e7843ba124041bcbf4f4b5e
    https://pubmed.ncbi.nlm.nih.gov/30995036

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  7. 7
    Structure-based design and optimization of potent inhibitors of the adenoviral protease

    المؤلفون: Samu Melkko, N. Jarousse, David Archer Ellis, Finton Sirockin, A. Bernardi, Aengus Mac Sweeney, Paul Erbel, Paul Ramage, Philipp Grosche, Eva Altmann, Keith D. Combrink, Nicola Hughes

    المصدر: Bioorganic & Medicinal Chemistry Letters. 25:438-443

    مصطلحات موضوعية: Adenain, Drug, Peptidomimetic, medicine.medical_treatment, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Viral Conjunctivitis, Crystallography, X-Ray, Antiviral Agents, Biochemistry, Adenoviridae, Structure-Activity Relationship, Viral Proteins, Drug Discovery, medicine, Humans, Effective treatment, Protease Inhibitors, Molecular Biology, media_common, Binding Sites, Protease, Tetrapeptide, Chemistry, Organic Chemistry, Virology, Protein Structure, Tertiary, Molecular Docking Simulation, Cysteine Endopeptidases, HEK293 Cells, Drug Design, Molecular Medicine, Structure based, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3777095530490cc9447027eeafc558
    https://doi.org/10.1016/j.bmcl.2014.12.057

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  8. 8
    Discovery and Structure-Based Optimization of Adenain Inhibitors

    المؤلفون: Eva Altmann, A. Bernardi, Paul Erbel, Aengus Mac Sweeney, N. Jarousse, Paul Ramage, Philipp Grosche, Keith D. Combrink, Nicola Hughes, David Archer Ellis, Samu Melkko, Finton Sirockin

    المصدر: ACS Medicinal Chemistry Letters. 5:937-941

    مصطلحات موضوعية: Adenain, Protease, Tetrapeptide, Chemistry, medicine.medical_treatment, Organic Chemistry, Drug Discovery, medicine, Structure based, Biochemistry, Cysteine protease, Combinatorial chemistry, Adenoviral infections

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c6b52f270b5d23e3714c30285f506a
    https://doi.org/10.1021/ml500224t

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  9. 9
    Small-molecule factor D inhibitors targeting the alternative complement pathway

    المؤلفون: Frederic Cumin, Bernd Kinzel, Anna Vulpetti, Antonio M. Risitano, Richard A. Harrison, Kamal Fettis, Aengus Mac Sweeney, Stefan Andreas Randl, Edwige Lorthiois, Fabrice A. Kolb, Nils Ostermann, Solene Dussauge, Corinne Durand, Nicola Hughes, Bernd Gerhartz, Karen Anderson, Samuel Barbieri, Paul Erbel, Omar Delgado, Jörg Eder, Ulrich Hommel, Stefanie Flohr, Simon Rüdisser, Anna Schubart, Ty Gould, Bruce D Jaffee, Jürgen Maibaum, Julia Wagner, Sha-Mei Liao

    المساهمون: Maibaum, Jürgen, Liao, Sha Mei, Vulpetti, Anna, Ostermann, Nil, Randl, Stefan, Rüdisser, Simon, Lorthiois, Edwige, Erbel, Paul, Kinzel, Bernd, Kolb, Fabrice A, Barbieri, Samuel, Wagner, Julia, Durand, Corinne, Fettis, Kamal, Dussauge, Solene, Hughes, Nicola, Delgado, Omar, Hommel, Ulrich, Gould, Ty, Sweeney, Aengus Mac, Gerhartz, Bernd, Cumin, Frederic, Flohr, Stefanie, Schubart, Anna, Jaffee, Bruce, Harrison, Richard, Risitano, ANTONIO MARIA, Eder, Jörg, Anderson, Karen

    المصدر: Nature chemical biology. 12(12)

    مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Models, Molecular, medicine.medical_treatment, Complement Pathway, Alternative, Biology, Small Molecule Libraries, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Protease, Innate immune system, Complement component 3, Dose-Response Relationship, Drug, Molecular Structure, Cell Biology, medicine.disease, Small molecule, Complement system, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, 030220 oncology & carcinogenesis, Alternative complement pathway, Paroxysmal nocturnal hemoglobinuria, biology.protein, Factor D, Complement Factor D

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2c3a47759beca17b7b3f2b775e9551
    https://pubmed.ncbi.nlm.nih.gov/27857140

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  10. 10
    The Crystal Structure of E.coli 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase in a Ternary Complex with the Antimalarial Compound Fosmidomycin and NADPH Reveals a Tight-binding Closed Enzyme Conformation

    المؤلفون: Christian Oefner, Roland Lange, Philip Proteau, Alice Douangamath, Aengus Mac Sweeney, Roberta P.M. Fernandes, Henk Schulz, Glenn E. Dale

    المصدر: Journal of Molecular Biology. 345:115-127

    مصطلحات موضوعية: Models, Molecular, Macromolecular Substances, Protein Conformation, Stereochemistry, Crystallography, X-Ray, Antimalarials, chemistry.chemical_compound, Fosfomycin, Multienzyme Complexes, Structural Biology, Oxidoreductase, Escherichia coli, medicine, Molecular Biology, Ternary complex, Aldose-Ketose Isomerases, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Escherichia coli Proteins, Rational design, Substrate (chemistry), Active site, Fosmidomycin, Enzyme, biology.protein, TCEP, Oxidoreductases, NADP, Protein Binding, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5bbd51bd0a1f4332f4df79588732e7
    https://doi.org/10.1016/j.jmb.2004.10.030

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