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1
المؤلفون: BinQing Wei, Kirk Robarge, Sharada S. Labadie, Jinhua Chen, Laura B. Corson, Antonio DiPasquale, Peter S. Dragovich, Charles Eigenbrot, Marie Evangelista, Benjamin P. Fauber, Anna Hitz, Rebecca Hong, Kwong Wah Lai, Wenfeng Liu, Shuguang Ma, Shiva Malek, Thomas O'Brien, Jodie Pang, David Peterson, Laurent Salphati, Deepak Sampath, Steven Sideris, Mark Ultsch, Zijin Xu, Ivana Yen, Dong Yu, Qin Yue, Aihe Zhou, Hans E. Purkey
المصدر: Bioorganicmedicinal chemistry letters. 59
مصطلحات موضوعية: Dose-Response Relationship, Drug, L-Lactate Dehydrogenase, Lactams, Molecular Structure, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Cell Line, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Microsomes, Liver, Molecular Medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology
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2
المؤلفون: Charles Z. Ding, Laurent Salphati, Hans E. Purkey, HongXiu Ge, Qin Yue, Antonio G. DiPasquale, Charles Eigenbrot, Qunh Ho, Kwong Wah Lai, Thomas O'Brien, Sharada Labadie, Zhongguo Chen, David A. Peterson, Shiva Malek, Laura Corson, Wenfeng Liu, Mark Ultsch, Jinhua Chen, Anna Hitz, Yajing Liu, Kirk Robarge, Jodie Pang, Chiho Li, Peter S. Dragovich, Binqing Wei, Shuguang Ma, Huihui Zhang, Steve Sideris, Zhenting Gao, Marie Evangelista, Ivana Yen, Aihe Zhou, Benjamin Fauber
المصدر: ACS Medicinal Chemistry Letters. 7:896-901
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Organic Chemistry, Cell, Biology, Pharmacology, Biochemistry, Bioavailability, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Enzyme, chemistry, Cell culture, 030220 oncology & carcinogenesis, Lactate dehydrogenase, Drug Discovery, medicine, Glycolysis, IC50
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3
المؤلفون: Gary Salmon, Harvey Wong, Maxine Norman, Adrian Barnard, Aihe Zhou, Julie Hawkins, Benjamin Fauber, Adam R. Johnson, Arunima Ganguli, Yuzhong Deng, Susan Summerhill, Kirk Robarge, Celine Eidenschenk, Wenjun Ouyang, Christine Everett, Jianhua Cao, Wei Tang, Hank La, Alberto Gobbi
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:2907-2912
مصطلحات موضوعية: Pyrimidine, Pyridines, medicine.medical_treatment, Clinical Biochemistry, Retinoic acid, Chemical biology, Pharmaceutical Science, Biochemistry, Autoimmune Diseases, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, RAR-related orphan receptor gamma, Drug Discovery, medicine, Animals, Humans, Inverse agonist, Molecular Biology, Cells, Cultured, Orphan receptor, Interleukin-17, Organic Chemistry, Imidazoles, Nuclear Receptor Subfamily 1, Group F, Member 3, Rats, HEK293 Cells, Pyrimidines, Cytokine, Liver, chemistry, Nuclear receptor, Molecular Medicine
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4
المؤلفون: Binqing Wei, Erica VanderPorten, Mark Ultsch, Jason Boggs, Peter S. Dragovich, S. Sideris, Jinhua Chen, Huihui Zhang, Sharada Labadie, Qin Yue, Charles Z. Ding, Kirk Robarge, David Peterson, Shuguang Ma, Hans E. Purkey, Benjamin Fauber, HongXiu Ge, Aihe Zhou, Kwong Wah Lai, Qunh Ho, Shiva Malek, Xuying Zhang, Ivana Yen, Laura Corson, Charles Eigenbrot, Qing Xu, Laurent Salphati
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:75-82
مصطلحات موضوعية: Gene isoform, Stereochemistry, Lactate dehydrogenase A, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Madin Darby Canine Kidney Cells, chemistry.chemical_compound, Dogs, Oxidoreductase, Lactate dehydrogenase, Drug Discovery, Animals, Humans, Potency, Glycolysis, Enzyme Inhibitors, education, Molecular Biology, chemistry.chemical_classification, education.field_of_study, L-Lactate Dehydrogenase, Organic Chemistry, Madin Darby canine kidney cell, chemistry, Molecular Medicine
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5
المؤلفون: Peter S. Dragovich, Benjamin P. Fauber, Jason Boggs, Jinhua Chen, Laura B. Corson, Charles Z. Ding, Charles Eigenbrot, HongXiu Ge, Anthony M. Giannetti, Thomas Hunsaker, Sharada Labadie, Chiho Li, Yichin Liu, Yingchun Liu, Shuguang Ma, Shiva Malek, David Peterson, Keith E. Pitts, Hans E. Purkey, Kirk Robarge, Laurent Salphati, Steve Sideris, Mark Ultsch, Erica VanderPorten, Jing Wang, BinQing Wei, Qing Xu, Ivana Yen, Qin Yue, Huihui Zhang, Xuying Zhang, Aihe Zhou
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:3764-3771
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Oral administration, Lactate dehydrogenase, Drug Discovery, Animals, Humans, Glycolysis, Sulfhydryl Compounds, Enzyme Inhibitors, Surface plasmon resonance, Molecular Biology, Dose-Response Relationship, Drug, L-Lactate Dehydrogenase, Molecular Structure, Cyclohexanones, Chemistry, Organic Chemistry, High-Throughput Screening Assays, Rats, Molecular Medicine
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6
المؤلفون: Janusz J. Kulagowski, Claire Morris, Leslie Lee, Kathy Barrett, Sean P. Flynn, Richard Pastor, Michael Siu, Charles Eigenbrot, Deepak Sampath, Christine Chang, Jane R. Kenny, Aihe Zhou, Jeremy Murray, Joseph P. Lyssikatos, Christopher A. Hurley, Emily J. Hanan, Jeffrey M. Blaney, Wade S. Blair, Tom Rawson, Paul Gibbons, Steven Magnuson, Mark Ultsch, Anne van Abbema
المصدر: Journal of Medicinal Chemistry. 55:10090-10107
مصطلحات موضوعية: Models, Molecular, Pyrimidine, Somatic cell, Mice, SCID, Pharmacology, Pyrazolopyrimidine, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, hemic and lymphatic diseases, Drug Discovery, STAT5 Transcription Factor, Animals, Humans, Structure–activity relationship, Tissue Distribution, Phosphorylation, Protein Kinase Inhibitors, Janus kinase 2, Molecular Structure, biology, Kinase, food and beverages, Janus Kinase 2, Pyrimidines, chemistry, biology.protein, Molecular Medicine, Female, hormones, hormone substitutes, and hormone antagonists
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7
المؤلفون: John Moffat, Marcia Belvin, Lichuan Liu, Jocelyn Chan, Li Ren, Kirk Robarge, Francis J. Sullivan, Jeffrey Stults, Jonas Grina, David A. Moreno, Ann Qin, Matthew Martinson, Stephen E. Gould, Jacob Schwarz, Kang-Jye Chou, Sheerin K. Shahidi-Latham, Lars Mueller, John Gaudino, Aihe Zhou, James F. Blake, Weiru Wang, Danette Dudley, Christine Orr, Michael Burkard, Thomas Hunsaker, Dolores Diaz, Mark Merchant, Huifen Chen, Jianping Yin, Patricia Pacheco, Kevin Rasor
المصدر: Journal of medicinal chemistry. 59(12)
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Pyridones, Extracellular signal-regulated kinases, Erk signaling, Antineoplastic Agents, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, Acquired resistance, Dogs, Oncogenic signaling, Drug Discovery, Extracellular, Animals, Humans, Protein Kinase Inhibitors, Cell Proliferation, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Chemistry, Neoplasms, Experimental, HCT116 Cells, Small molecule, Rats, 030104 developmental biology, Pyrimidines, Biochemistry, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Drug Screening Assays, Antitumor
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المؤلفون: Laura Corson, Thomas Hunsaker, Yingqing Ran, Andrea G. Cochran, Elizabeth Blackwood, Hans-Willi Krell, Leslie Walker, Jun Li, Birong Zhang, Aihe Zhou, Jason Halladay, Thomas E. Rawson, Bing-Yan Zhu, Carter Fields, Brian Safina, Mark Ultsch, Matthias Rüth, Tracy Kleinheinz, Angela McNutt, Dan Burdick, Jun Liang, Jason Drummond, Petra Rüger, Christian Wiesmann, Bernhard Goller, Guy Georges, Gail Lewis Phillips, Anja Limberg, John Moffat, Jenna Dotson
المصدر: Journal of Medicinal Chemistry. 51:4465-4475
مصطلحات موضوعية: Models, Molecular, Lactams, Aurora B kinase, Aurora inhibitor, Administration, Oral, Biological Availability, Protein Serine-Threonine Kinases, Pharmacology, Crystallography, X-Ray, Heterocyclic Compounds, 4 or More Rings, Mice, Dogs, Aurora kinase, Aurora Kinases, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Aurora Kinase B, Humans, Potency, Protein Kinase Inhibitors, IC50, Aurora Kinase A, Molecular Structure, Chemistry, Rats, Biochemistry, embryonic structures, Molecular Medicine, Benzimidazoles, biological phenomena, cell phenomena, and immunity
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المؤلفون: Mark McCleland, David Peterson, Anneleen Daemen, Deepak Sampath, Alexander N. Vanderbilt, Rebecca Hong, Christopher Del Nagro, Simon Williams, Raju V. Pusapati, Binqing Wei, Shuguang Ma, Hans E. Purkey, Tommy Lai, Aihe Zhou, Mandy Kwong, Laurent Salphati, Jodie Pang, Aaron Boudreau, Shiva Malek, Peter K. Jackson, Steve Sideris, Yingjie Li, Ron Firestein, Min Gao, Laura Corson, Charles Eigenbrot, Thomas O'Brien, Kirk Robarge, Sharada Labadie, Anna Hitz, Zhongguo Chen, Marcia Belvin, Marie Evangelista, Ivana Yen, Georgia Hatzivassiliou
المصدر: Nature chemical biology. 12(10)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Pyridones, Cell Plasticity, Oxidative phosphorylation, Thiophenes, Biology, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Acquired resistance, Lactate dehydrogenase, Pancreatic cancer, Cell Line, Tumor, medicine, Humans, Glycolysis, Enzyme Inhibitors, Molecular Biology, Cell Proliferation, Cell Death, Dose-Response Relationship, Drug, L-Lactate Dehydrogenase, Molecular Structure, Cell Biology, medicine.disease, Cell biology, 030104 developmental biology, chemistry, Biochemistry, 030220 oncology & carcinogenesis
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10
المؤلفون: Binqing Wei, Qin Yue, Aihe Zhou, David A. Peterson, Shiva Malek, Peter S. Dragovich, Hans E. Purkey, Benjamin Fauber, Ivana Yen, Sharada Labadie, Steve Sideris, Charles Z. Ding, Laura Corson, Charles Eigenbrot, Mark Ultsch, Jinhua Chen, Kirk Robarge
المصدر: Bioorganicmedicinal chemistry letters. 24(24)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, L-Lactate dehydrogenase, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Oxidoreductase, Lactate dehydrogenase, Drug Discovery, Structure–activity relationship, Potency, Humans, Binding site, Enzyme Inhibitors, Molecular Biology, IC50, chemistry.chemical_classification, Binding Sites, L-Lactate Dehydrogenase, Molecular Structure, Organic Chemistry, chemistry, Pyrones, Molecular Medicine