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1
المؤلفون: Palucki Brenda, Patrick G. Pollard, Liangqin Guo, Tung M. Fong, Matthew J. Wyvratt, Randy R. Miller, Shuwen He, Constantin Tamvakopoulos, Iyassu K. Sebhat, Qianping Peng, Ravi P. Nargund, Zhixiong Ye, Airu S. Chen, Doreen E. Cashen, David H. Weinberg, Min K. Park, Raman K. Bakshi, D. Euan MacIntyre, Howard Y. Chen, Rui Tang, Tanya MacNeil, Qingmei Hong, Alison M. Strack, Ralph A. Stearns, Jian Liu, William J. Martin
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2330-2334
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmaceutical Science, Carboxamide, Pharmacology, Biochemistry, Partial agonist, Piperazines, Rats, Sprague-Dawley, Eating, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, In vivo, Drug Discovery, medicine, Animals, Urea, Obesity, Receptor, Molecular Biology, Organic Chemistry, Haplorhini, Rats, Disease Models, Animal, Piperazine, chemistry, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin
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2
المؤلفون: Yingjie Lai, Ralph A. Stearns, Qianping Peng, Ravi P. Nargund, Qingmei Hong, Jian Liu, Rui Tang, Matthew J. Wyvratt, Raman K. Bakshi, Randy R. Miller, Tianying Jian, Alison M. Strack, Tanya MacNeil, Liangqin Guo, Howard Y. Chen, James Dellureficio, Iyassu K. Sebhat, Peter H. Dobbelaar, Airu S. Chen, Constantin Tamvakopoulos, David H. Weinberg, Tung M. Fong, Christopher L. Franklin, Shuwen He, Zhixiong Ye
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4399-4405
مصطلحات موضوعية: Agonist, medicine.medical_specialty, Pyrrolidines, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Anti-Obesity Agents, Internal medicine, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Spiro Compounds, Obesity, Molecular Biology, Mice, Knockout, Chemistry, Body Weight, Organic Chemistry, Amides, Rats, Endocrinology, Drug development, Anorectic, Receptor, Melanocortin, Type 4, Molecular Medicine
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3
المؤلفون: Howard Y. Chen, William J. Martin, D. Euan MacIntyre, Zhixiong Ye, Raman K. Bakshi, Alison M. Strack, Doreen E. Cashen, Jian Liu, Yingjie Lai, Tianying Jian, Constantin Tamvakopoulos, Nancy N. Tsou, Shuwen He, James Dellureficio, Tung M. Fong, Peter H. Dobbelaar, David H. Weinberg, Airu S. Chen, Qingmei Hong, Iyassu K. Sebhat, Tanya MacNeil, Christopher L. Franklin, Ravi P. Nargund, Ralph A. Stearns, Rui Tang, Richard G. Ball, Matthew J. Wyvratt, Randy R. Miller, Liangqin Guo, Qianping Peng
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2106-2110
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Cricetulus, Dogs, Erectile Dysfunction, Cricetinae, Drug Discovery, medicine, Animals, Humans, Spiro Compounds, Receptor, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Haplorhini, Rats, Bioavailability, Indans, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding
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4
المؤلفون: Paolo Grieco, Airu S. Chen, Connie W. Lam, Mauro Perretti, Stephen J. Getting
المصدر: The FASEB Journal. 20:2234-2241
مصطلحات موضوعية: Male, medicine.medical_specialty, Chemokine, medicine.medical_treatment, Inflammation, Biology, Pharmacology, Biochemistry, Rats, Sprague-Dawley, Mice, In vivo, Internal medicine, Genetics, medicine, Animals, Receptor, Molecular Biology, Mice, Knockout, Arthritis, Gouty, Receptors, Melanocortin, Interleukin, Macrophage Activation, Arthritis, Experimental, Rats, Uric Acid, Mice, Inbred C57BL, CXCL1, Disease Models, Animal, Endocrinology, Cytokine, Gene Expression Regulation, Macrophages, Peritoneal, biology.protein, medicine.symptom, Melanocortin, Receptor, Melanocortin, Type 3, Biotechnology
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5
المؤلفون: Doreen E. Cashen, Constantin Tamvakopoulos, Qianping Peng, William J. Martin, David H. Weinberg, Charles Rosenblum, Arthur A. Patchett, Tanya MacNeil, Patrick G. Pollard, Zhixiong Ye, Raman K. Bakshi, Ralph A. Stearns, Rubana N. Kalyani, Palucki Brenda, Joseph M. Metzger, Alison M. Strack, Lex H.T. Van der Ploeg, D. Euan MacIntyre, Iyassu K. Sebhat, Aurawan Vongs, Airu S. Chen, Ravi P. Nargund, Liangqin Guo, Matthew J. Wyvratt, Randy R. Miller, Rui Tang, Howard Y. Chen, Khaled J. Barakat
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3501-3505
مصطلحات موضوعية: Male, Agonist, Quinuclidines, Time Factors, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Rodentia, Carboxamide, Biochemistry, Chemical synthesis, Piperazines, Rats, Sprague-Dawley, Eating, Structure-Activity Relationship, Piperidines, In vivo, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Aza Compounds, Bicyclic molecule, Chemistry, Penile Erection, digestive, oral, and skin physiology, Organic Chemistry, Small molecule, Rats, Microsomes, Liver, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding
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6
المؤلفون: George R. Breese, Donald J. Marsh, Montserrat Navarro, Todd E. Thiele, Darin J. Knapp, Airu S. Chen, Inmaculada Cubero, Howard Y. Chen
المصدر: Alcoholism: Clinical & Experimental Research. 29:949-957
مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, Alcohol Drinking, Genotype, medicine.drug_class, Medicine (miscellaneous), Toxicology, Peptides, Cyclic, Article, Eating, Mice, Dopamine receptor D1, Dopamine, Internal medicine, Dopamine receptor D2, medicine, Animals, Agouti-Related Protein, Ethanol metabolism, Behavior, Animal, Ethanol, Chemistry, Receptors, Melanocortin, digestive, oral, and skin physiology, Melanotan II, Peptide Fragments, Ventral tegmental area, Psychiatry and Mental health, medicine.anatomical_structure, Endocrinology, alpha-MSH, Receptor, Melanocortin, Type 4, Female, Melanocortin, hormones, hormone substitutes, and hormone antagonists, medicine.drug
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7
المؤلفون: Michael R. Tota, Ravi P. Nargund, Xiao-Ming Guan, Howard Y. Chen, Douglas J. MacNeil, David H. Weinberg, Tanya MacNeil, Euan Macintyre, Alison M. Strack, Charles Rosenblum, Maria A. Bednarek, Andrew D. Howard, Chun-Pyn Shen, Tung M. Fong, Mark T. Goulet, Lex H.T. Van der Ploeg, Airu S. Chen, Donald J. Marsh
المصدر: European Journal of Pharmacology. 440:141-157
مصطلحات موضوعية: endocrine system, medicine.medical_specialty, Gene Expression, Biology, Melanocortin receptor, Proopiomelanocortin, Internal medicine, medicine, Animals, Humans, Melanocyte-Stimulating Hormones, Obesity, Receptor, Melanocortins, Pharmacology, integumentary system, Receptors, Melanocortin, digestive, oral, and skin physiology, Body Weight, Melanocortin 3 receptor, Melanocortin 4 receptor, Endocrinology, Receptors, Corticotropin, biology.protein, Anti-Obesity Agents, Melanocortin, hormones, hormone substitutes, and hormone antagonists, Melanocortin 1 receptor
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8
المؤلفون: Patricia Brown, Anthony Sanfiz, Ann E. Weber, Richard A. Berger, Liping Wang, Katherine L. Villa, Scott D. Edmondson, Christopher Moyes, Amanda L. Hurley, Andra S. Stevenson, Aileen Fitzmaurice, Dong-Ming Shen, Stephen D. Goble, Nina Jochnowitz, Karen H. Dingley, Jerry Di Salvo, Mary Struthers, Loise Gichuru, Randall R. Miller, Hiroshi Nagabukuro, Gino Salituro, Airu S. Chen, Beata Zamlynny, Alka Bansal, Bart Harper, Shruty Mistry
المصدر: Journal of medicinal chemistry. 57(4)
مصطلحات موضوعية: medicine.medical_specialty, AS-19, Magnetic Resonance Spectroscopy, Molecular Conformation, Adrenergic beta-3 Receptor Agonists, CHO Cells, chemistry.chemical_compound, Cricetulus, Internal medicine, Cricetinae, Drug Discovery, medicine, Potency, Animals, Humans, Receptor, Thiazole, Acetanilide, Urinary bladder, biology, Urinary Bladder, Overactive, medicine.disease, biology.organism_classification, medicine.anatomical_structure, Endocrinology, Overactive bladder, chemistry, Drug Design, Molecular Medicine, Acetanilides
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9
المؤلفون: Xiao-Ming Guan, Charles Rosenblum, Hong Yu, Yue Feng, D. Euan MacIntyre, Alison M. Strack, Lex H.T. Van der Ploeg, Christian N. Nunes, Airu S. Chen, Joseph M. Metzger, Linhai Cao, Easter G. Frazier, Jill K. Fisher, Ramon E. Camacho, William Min, Shobhna Gopal-Truter, Aurawan Vongs, Howard Y. Chen, Theodore N. Mellin, Donald J. Marsh, Myrna E. Trumbauer
المصدر: Nature Genetics. 26:97-102
مصطلحات موضوعية: Leptin, Male, Time Factors, Energy homeostasis, Body Temperature, Mice, Insulin, Protein Isoforms, Tissue Distribution, In Situ Hybridization, Mice, Knockout, Recombination, Genetic, Age Factors, Melanocortin 3 receptor, Blotting, Southern, Phenotype, medicine.anatomical_structure, Adipose Tissue, Receptor, Melanocortin, Type 4, Female, medicine.symptom, Melanocortin, Oligopeptides, Receptor, Melanocortin, Type 3, medicine.medical_specialty, Genotype, Receptors, Peptide, Calorimetry, Motor Activity, Biology, Feed conversion ratio, Melanocortin receptor, Central melanocortin system, Hyperinsulinism, Internal medicine, Genetics, medicine, Animals, Humans, Obesity, Models, Genetic, Body Weight, Feeding Behavior, Thyroxine, Glucose, Endocrinology, Receptors, Corticotropin, alpha-MSH, Lean body mass, Corticosterone, Weight gain
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10
المؤلفون: Donald J. Marsh, D. E. Macintyre, Xiao-Ming Guan, Michael J. Forrest, Easter G. Frazier, Airu S. Chen, Theodore N. Mellin, Ramon E. Camacho, Hong Yu, Jill K. Fisher, Van der Ploeg Lh, Joe Metzger, Alison M. Strack, Myrna E. Trumbauer, Howard Y. Chen, Shobhna Gopal-Truter
المصدر: Transgenic Research. 9:145-154
مصطلحات موضوعية: Agonist, medicine.medical_specialty, medicine.drug_class, digestive, oral, and skin physiology, Melanotan II, Biology, medicine.disease, Melanocortin 4 receptor, Endocrinology, Hormone receptor, Internal medicine, Knockout mouse, Basal metabolic rate, Genetics, medicine, Hyperinsulinemia, Animal Science and Zoology, Receptor, Agronomy and Crop Science, Biotechnology, medicine.drug