المؤلفون: Gholami YH, Josephson L, Akam EA, Caravan P, Wilks MQ, Pan XZ, Maschmeyer R, Kolnick A, El Fakhri G, Normandin MD, Kuncic Z, Yuan H

المصدر: International Journal of Nanomedicine, Vol Volume 15, Pp 31-47 (2020)

مصطلحات موضوعية: nanomedicine, radiolabeling, radionuclide therapy, hir, feraheme, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: https://www.dovepress.com/a-chelate-free-nano-platform-for-incorporation-of-diagnostic-and-thera-peer-reviewed-article-IJN; https://doaj.org/toc/1178-2013

URL الوصول: https://doaj.org/article/67d723449f6d4486be25c5ff3986cc30

المؤلفون: Moon BF; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Zhou IY; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Ning Y; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Chen YI; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA., Le Fur M; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Shuvaev S; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Akam EA; Department of Medicine, Division of Cardiology, Massachusetts General Hospital and Harvard Medical School Boston MA USA., Ma H; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Solsona CM; Bruker BioSpin, Preclinical Imaging Billerica MA USA., Weigand-Whittier J; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA., Rotile N; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Hariri LP; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School Boston MA USA., Drummond M; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School Boston MA USA., Boice AT; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Zygmont SE; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Sharma Y; Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA., Warburton RR; Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA., Martin GL; Molecular Cardiology Research Institute, Tufts Medical Center Boston MA USA., Blanton RM; Molecular Cardiology Research Institute, Tufts Medical Center Boston MA USA., Fanburg BL; Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA., Hill NS; Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA., Caravan P; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School Boston MA USA.; Institute for Innovation in Imaging, Massachusetts General Hospital Boston MA USA., Penumatsa KC; Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center Boston MA USA.

المصدر: Journal of the American Heart Association [J Am Heart Assoc] 2024 Jul 16; Vol. 13 (14), pp. e034363. Date of Electronic Publication: 2024 Jul 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE

مواضيع طبية MeSH: Positron-Emission Tomography*/methods , Disease Models, Animal* , Fibrosis* , Ventricular Dysfunction, Left*/diagnostic imaging , Ventricular Dysfunction, Left*/physiopathology , Ventricular Dysfunction, Left*/etiology , Ventricular Dysfunction, Left*/metabolism , Magnetic Resonance Imaging*/methods, Animals ; Mice ; Myocardium/pathology ; Myocardium/metabolism ; Pulmonary Fibrosis/diagnostic imaging ; Pulmonary Fibrosis/physiopathology ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/etiology ; Ventricular Function, Left ; Male ; Lung/diagnostic imaging ; Lung/pathology ; Lung/physiopathology ; Lung/metabolism ; Multimodal Imaging/methods ; Collagen/metabolism ; Ventricular Remodeling ; Lysine/analogs & derivatives

المؤلفون: Ma H; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Zhou IY; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Chen YI; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Rotile NJ; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Ay I; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Akam EA; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Wang H; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Knipe RS; Division of Pulmonary and Critical Care Medicine and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, United States., Hariri LP; Division of Pulmonary and Critical Care Medicine and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, United States.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States., Zhang C; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Drummond M; Division of Pulmonary and Critical Care Medicine and the Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, United States., Pantazopoulos P; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Moon BF; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Boice AT; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Zygmont SE; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Weigand-Whittier J; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States., Sojoodi M; Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States., Gonzalez-Villalobos RA; Cardiovascular and Metabolism Discovery, Janssen Research and Development LLC, Boston, Massachusetts 02115, United States., Hansen MK; Cardiovascular and Metabolism Discovery, Janssen Research and Development LLC, Boston, Massachusetts 02115, United States., Tanabe KK; Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States., Caravan P; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i3), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2023 Sep 27; Vol. 145 (38), pp. 20825-20836. Date of Electronic Publication: 2023 Aug 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Aldehydes* , 2-Aminoadipic Acid*/chemistry, Mice ; Animals ; Magnetic Resonance Imaging ; Lung

المؤلفون: Akam EA, Bergemann D, Ridley SJ, To S, Andrea B, Moon B, Ma H, Zhou Y, Aguirre A, Caravan P, Gonzalez-Rosa JM, Sosnovik DE

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 25. Date of Electronic Publication: 2023 Jul 25.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Gaur K; Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States., Pérez Otero SC; Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States., Benjamín-Rivera JA; Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States., Rodríguez I; Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States., Loza-Rosas SA; Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States., Vázquez Salgado AM; Department of Biology, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States., Akam EA; Department of Chemistry and Biochemistry, The University of Arizona, 1306 E. University Blvd., Tucson, Arizona 85721-0041, United States., Hernández-Matias L; Department of Biology, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States., Sharma RK; Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States., Alicea N; Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States., Kowaleff M; Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States., Washington AV; Department of Biology, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States., Astashkin AV; Department of Chemistry and Biochemistry, The University of Arizona, 1306 E. University Blvd., Tucson, Arizona 85721-0041, United States., Tomat E; Department of Chemistry and Biochemistry, The University of Arizona, 1306 E. University Blvd., Tucson, Arizona 85721-0041, United States., Tinoco AD; Department of Chemistry, University of Puerto Rico Río Piedras Campus, San Juan, Puerto Rico 00931, United States.

المصدر: JACS Au [JACS Au] 2021 Jun 28; Vol. 1 (6), pp. 865-878. Date of Electronic Publication: 2021 May 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101775714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2691-3704 (Electronic) Linking ISSN: 26913704 NLM ISO Abbreviation: JACS Au Subsets: PubMed not MEDLINE

المؤلفون: Schnetz M; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Meier JK; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Rehwald C; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Mertens C; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Urbschat A; Institute for Biomedicine, Aarhus University, C. F. Møllers Allé 6, 8000 Aarhus, Denmark., Tomat E; Department of Chemistry and Biochemistry, University of Arizona, 1306 E. University Blvd., Tucson, AZ 85721-0041, USA., Akam EA; Department of Chemistry and Biochemistry, University of Arizona, 1306 E. University Blvd., Tucson, AZ 85721-0041, USA., Baer P; Division of Nephrology, Department of Internal Medicine III, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Roos FC; Clinic of Urology, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Brüne B; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), partner site Frankfurt/Mainz, 60590 Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe-University Frankfurt, 60596 Frankfurt am Main, Germany.; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology, 60596 Frankfurt am Main, Germany., Jung M; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

المصدر: Cancers [Cancers (Basel)] 2020 Feb 25; Vol. 12 (3). Date of Electronic Publication: 2020 Feb 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Akam EA; Martinos Center for Biomedical Imaging , Massachusetts General Hospital (MGH) , Boston , USA . Email: caravan@nmr.mgh.harvard.edu.; The Institute for Innovation in Imaging , MGH , Boston , USA.; Harvard Medical School , Boston , USA., Abston E; Martinos Center for Biomedical Imaging , Massachusetts General Hospital (MGH) , Boston , USA . Email: caravan@nmr.mgh.harvard.edu.; Boston University School of Medicine: Pulmonary , Allergy, Sleep & Critical Care Medicine , Boston , USA.; The Division of Thoracic Surgery , MGH , Boston , USA., Rotile NJ; Martinos Center for Biomedical Imaging , Massachusetts General Hospital (MGH) , Boston , USA . Email: caravan@nmr.mgh.harvard.edu.; The Institute for Innovation in Imaging , MGH , Boston , USA., Slattery HR; Martinos Center for Biomedical Imaging , Massachusetts General Hospital (MGH) , Boston , USA . Email: caravan@nmr.mgh.harvard.edu.; The Institute for Innovation in Imaging , MGH , Boston , USA., Zhou IY; Martinos Center for Biomedical Imaging , Massachusetts General Hospital (MGH) , Boston , USA . Email: caravan@nmr.mgh.harvard.edu.; The Institute for Innovation in Imaging , MGH , Boston , USA.; Harvard Medical School , Boston , USA., Lanuti M; Harvard Medical School , Boston , USA.; The Division of Thoracic Surgery , MGH , Boston , USA., Caravan P; Martinos Center for Biomedical Imaging , Massachusetts General Hospital (MGH) , Boston , USA . Email: caravan@nmr.mgh.harvard.edu.; The Institute for Innovation in Imaging , MGH , Boston , USA.; Harvard Medical School , Boston , USA.

المصدر: Chemical science [Chem Sci] 2019 Nov 08; Vol. 11 (1), pp. 224-231. Date of Electronic Publication: 2019 Nov 08 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

المؤلفون: Wei Q; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Beijing 100191 , China., Wang J, Akam EA, Yin D; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Beijing 100191 , China., Ge Z; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Beijing 100191 , China., Cheng T; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Beijing 100191 , China., Wang X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Beijing 100191 , China., Brownell AL, Li R; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences , Peking University , Beijing 100191 , China.

المصدر: The Journal of organic chemistry [J Org Chem] 2019 Feb 01; Vol. 84 (3), pp. 1310-1319. Date of Electronic Publication: 2019 Jan 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE

مواضيع طبية MeSH: Furans/*chemistry , Transition Elements/*chemistry, Amination ; Catalysis ; Oxidation-Reduction

المؤلفون: Akam EA; Department of Chemistry and Biochemistry, The University of Arizona, United States., Utterback RD; Department of Chemistry and Biochemistry, The University of Arizona, United States., Marcero JR; Department of Microbiology and Department of Biochemistry and Molecular Biology, University of Georgia, United States., Dailey HA; Department of Microbiology and Department of Biochemistry and Molecular Biology, University of Georgia, United States., Tomat E; Department of Chemistry and Biochemistry, The University of Arizona, United States. Electronic address: tomat@email.arizona.edu.

المصدر: Journal of inorganic biochemistry [J Inorg Biochem] 2018 Mar; Vol. 180, pp. 186-193. Date of Electronic Publication: 2018 Jan 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Cell Death/*drug effects , Cell Proliferation/*drug effects , Disulfides/*chemistry , Hemoglobins/*biosynthesis , Hydrazones/*chemistry , Hydrazones/*pharmacology , Iron Chelating Agents/*chemistry , Iron Chelating Agents/*pharmacology, Animals ; Cell Line, Tumor ; G1 Phase/drug effects ; Humans ; Mice ; S Phase/drug effects ; Thiosemicarbazones/chemistry

المؤلفون: Mertens C; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Akam EA; University of Arizona, Department of Chemistry and Biochemistry, 1306 E., University Blvd., Tucson, AZ 85721-0041, United States of America., Rehwald C; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Brüne B; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Tomat E; University of Arizona, Department of Chemistry and Biochemistry, 1306 E., University Blvd., Tucson, AZ 85721-0041, United States of America., Jung M; Institute of Biochemistry I, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

المصدر: PloS one [PLoS One] 2016 Nov 02; Vol. 11 (11), pp. e0166164. Date of Electronic Publication: 2016 Nov 02 (Print Publication: 2016).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Culture Media, Conditioned/*pharmacology , Iron/*metabolism , Iron Chelating Agents/*pharmacology , Macrophages/*cytology, Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Gene Expression Regulation/drug effects ; Homeostasis ; Humans ; MCF-7 Cells ; Macrophages/drug effects ; Macrophages/metabolism ; Phenotype ; Spectrophotometry, Atomic ; Tumor Microenvironment/drug effects