المؤلفون: Todesco A; Department of Thoracic Surgery, Diseases of the Esophagus and Lung Transplantation, North Hospital Aix Marseille University, Assistance Publique-Hôpitaux de Marseille Marseille France.; INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis Robinson France., Grynblat J; INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis Robinson France.; M3C-Necker, Hôpital Necker-Enfants malades AP-HP Université de Paris Cité, Cardiologie Congénitale et Pédiatrique Paris France.; Faculty of Medicine Le Kremlin-Bicêtre Université Paris-Saclay Bures-sur-Yvette France., Akoumia KKF; INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis Robinson France., Bonnet D; M3C-Necker, Hôpital Necker-Enfants malades AP-HP Université de Paris Cité, Cardiologie Congénitale et Pédiatrique Paris France., Mendes-Ferreira P; Cardiovascular R&D Centre, UnIC@RISE, Department of Surgery and Physiology Faculty of Medicine of the University of Porto Porto Portugal.; Paris-Porto Pulmonary Hypertension Collaborative Laboratory (3PH), UMR_S 999, INSERM Université Paris-Saclay Paris France., Morisset S; Freelance Biostatistician Pérouges France., Chemla D; INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis Robinson France., Levy M; M3C-Necker, Hôpital Necker-Enfants malades AP-HP Université de Paris Cité, Cardiologie Congénitale et Pédiatrique Paris France., Méot M; M3C-Necker, Hôpital Necker-Enfants malades AP-HP Université de Paris Cité, Cardiologie Congénitale et Pédiatrique Paris France., Malekzadeh-Milani SG; M3C-Necker, Hôpital Necker-Enfants malades AP-HP Université de Paris Cité, Cardiologie Congénitale et Pédiatrique Paris France., Tielemans B; Department of Imaging and Pathology, Biomedical MRI unit/Mosaic KU Leuven Leuven Belgium., Decante B; Preclinical Research Laboratory, Pulmonary Hypertension National Referral Center, Hôpital Marie Lannelongue, Groupe Hospitalier Paris Saint Joseph Paris-Saclay University Le Plessis Robinson France., Vastel-Amzallag C; Paediatric Cardiology, Centre de Spécialités Pédiatriques de l'Est Parisien, CSPEP Créteil France., Habert P; Department of Radiology North Hospital, Assistance Publique-Hôpitaux de Marseille Marseille France.; Aix Marseille Univ, LIIE Marseille France., Ghigna MR; INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis Robinson France.; Department of Pathology Institut Gustave Roussy Villejuif France., Humbert M; INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis Robinson France.; Faculty of Medicine Le Kremlin-Bicêtre Université Paris-Saclay Bures-sur-Yvette France.; AP-HP, Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre DMU 5 Thorinno, Hôpital Bicêtre Le Kremlin-Bicêtre France., Montani D; INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis Robinson France.; Faculty of Medicine Le Kremlin-Bicêtre Université Paris-Saclay Bures-sur-Yvette France.; AP-HP, Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Centre DMU 5 Thorinno, Hôpital Bicêtre Le Kremlin-Bicêtre France., Boulate D; Department of Thoracic Surgery, Diseases of the Esophagus and Lung Transplantation, North Hospital Aix Marseille University, Assistance Publique-Hôpitaux de Marseille Marseille France.; INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis Robinson France.; COMPutational Pharmacology and clinical Oncology (COMPO), INRIA-INSERM Aix Marseille University Marseille France., Perros F; INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis Robinson France.; Paris-Porto Pulmonary Hypertension Collaborative Laboratory (3PH), UMR_S 999, INSERM Université Paris-Saclay Paris France.; CarMeN Laboratory, INSERM U1060, INRAE U1397 Université Claude Bernard Lyon1 Pierre-Bénite France.

المصدر: Journal of the American Heart Association [J Am Heart Assoc] 2024 Jul 16; Vol. 13 (14), pp. e034621. Date of Electronic Publication: 2024 Jul 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE

مواضيع طبية MeSH: Bone Morphogenetic Protein Receptors, Type II*/genetics , Bone Morphogenetic Protein Receptors, Type II*/metabolism , Pulmonary Artery*/physiopathology , Pulmonary Artery*/metabolism , Hemodynamics* , Disease Models, Animal* , Mutation*, Animals ; Female ; Male ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/metabolism ; Rats ; Rats, Sprague-Dawley ; Vascular Remodeling/genetics ; Pulmonary Arterial Hypertension/physiopathology ; Pulmonary Arterial Hypertension/genetics ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Arterial Hypertension/etiology ; Stenosis, Pulmonary Artery/genetics ; Stenosis, Pulmonary Artery/physiopathology ; Stenosis, Pulmonary Artery/metabolism ; Arterial Pressure ; Myocardial Contraction/physiology

المؤلفون: Rachedi NS; Université Côte d'Azur, CNRS, INSERM, IPMC, IHU-RespirERA, Valbonne, France., Tang Y; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Pittsburgh, PA, USA; Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., Tai YY; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Pittsburgh, PA, USA; Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., Zhao J; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Pittsburgh, PA, USA; Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., Chauvet C; Université Côte d'Azur, CNRS, INSERM, IPMC, IHU-RespirERA, Valbonne, France., Grynblat J; Université Paris-Saclay, AP-HP, INSERM UMR_S 999, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital de Bicêtre, Le Kremlin Bicêtre, France; Pôle Thoracique, Vasculaire et Transplantations, Hôpital Marie Lannelongue, Le Plessis-Robinson, France., Akoumia KKF; Université Paris-Saclay, AP-HP, INSERM UMR_S 999, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital de Bicêtre, Le Kremlin Bicêtre, France., Estephan L; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Pittsburgh, PA, USA; Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., Torrino S; Université Côte d'Azur, CNRS, INSERM, IPMC, IHU-RespirERA, Valbonne, France., Sbai C; Université Côte d'Azur, CNRS, INSERM, IPMC, IHU-RespirERA, Valbonne, France., Ait-Mouffok A; Université Côte d'Azur, CNRS, INSERM, IPMC, IHU-RespirERA, Valbonne, France., Latoche JD; Hillman Cancer Center, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., Al Aaraj Y; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Pittsburgh, PA, USA; Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., Brau F; Université Côte d'Azur, CNRS, INSERM, IPMC, IHU-RespirERA, Valbonne, France., Abélanet S; Université Côte d'Azur, CNRS, INSERM, IPMC, IHU-RespirERA, Valbonne, France., Clavel S; Université Côte d'Azur, CNRS, INSERM, IPMC, IHU-RespirERA, Valbonne, France., Zhang Y; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Pittsburgh, PA, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., Guillermier C; Center for NanoImaging, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Kumar NVG; Aging Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., Tavakoli S; Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA; Department of Radiology, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., Mercier O; Université Paris-Saclay, AP-HP, INSERM UMR_S 999, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital de Bicêtre, Le Kremlin Bicêtre, France; Assistance PubliqueHôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France., Risbano MG; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Pittsburgh, PA, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., Yao ZK; Molecular Pharmacology and Chemistry Program and Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yang G; Molecular Pharmacology and Chemistry Program and Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ouerfelli O; Molecular Pharmacology and Chemistry Program and Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Lewis JS; Molecular Pharmacology and Chemistry Program and Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Montani D; Pôle Thoracique, Vasculaire et Transplantations, Hôpital Marie Lannelongue, Le Plessis-Robinson, France; Assistance PubliqueHôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France., Humbert M; Université Paris-Saclay, AP-HP, INSERM UMR_S 999, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital de Bicêtre, Le Kremlin Bicêtre, France; Assistance PubliqueHôpitaux de Paris (AP-HP), Service de Pneumologie et Soins Intensifs Respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital Bicêtre, 94270 Le Kremlin-Bicêtre, France., Steinhauser ML; Center for NanoImaging, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Aging Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., Anderson CJ; Department of Chemistry, University of Missouri, Columbia, MO, USA., Oldham WM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Perros F; Université Paris-Saclay, AP-HP, INSERM UMR_S 999, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital de Bicêtre, Le Kremlin Bicêtre, France; Laboratoire CarMeN, UMR INSERM U1060/INRA U1397, Université Claude Bernard Lyon1, 69310 Pierre-Bénite, France., Bertero T; Université Côte d'Azur, CNRS, INSERM, IPMC, IHU-RespirERA, Valbonne, France. Electronic address: thomas.bertero@univ-cotedazur.fr., Chan SY; Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Pittsburgh, PA, USA; Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA. Electronic address: chansy@pitt.edu.

المصدر: Cell metabolism [Cell Metab] 2024 Jun 04; Vol. 36 (6), pp. 1335-1350.e8. Date of Electronic Publication: 2024 May 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE

مواضيع طبية MeSH: Glutamine*/metabolism , Serine*/metabolism , Vascular Stiffness*, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Fibroblasts/metabolism ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/pathology ; Humans ; Collagen/metabolism ; Rats