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المؤلفون: David N. Brindley, Frank Wuest, David Murray, Bertrand Heckmann, Alain Monjardet, Jonathan M. Curtis, YuanYuan Zhao, Jennifer Dufour, Matthew G.K. Benesch, Melinda Wuest, Xiaoyun Tang
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15623db6dd34cdaee8d3c634a16c546f
https://doi.org/10.1158/1535-7163.22507225 -
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المؤلفون: David N. Brindley, Frank Wuest, David Murray, Bertrand Heckmann, Alain Monjardet, Jonathan M. Curtis, YuanYuan Zhao, Jennifer Dufour, Matthew G.K. Benesch, Melinda Wuest, Xiaoyun Tang
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77db8e2350f2d37289cadfbeecbc3a02
https://doi.org/10.1158/1535-7163.22507213.v1 -
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المؤلفون: David N. Brindley, Frank Wuest, David Murray, Bertrand Heckmann, Alain Monjardet, Jonathan M. Curtis, YuanYuan Zhao, Jennifer Dufour, Matthew G.K. Benesch, Melinda Wuest, Xiaoyun Tang
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a6654333adefa54bfc627ca0f4251d52
https://doi.org/10.1158/1535-7163.c.6538624.v1 -
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المؤلفون: David N. Brindley, Frank Wuest, David Murray, Bertrand Heckmann, Alain Monjardet, Jonathan M. Curtis, YuanYuan Zhao, Jennifer Dufour, Matthew G.K. Benesch, Melinda Wuest, Xiaoyun Tang
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ee13c61da84ea27eaf34544d2775f5
https://doi.org/10.1158/1535-7163.22507210 -
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المؤلفون: David N. Brindley, Frank Wuest, David Murray, Bertrand Heckmann, Alain Monjardet, Jonathan M. Curtis, YuanYuan Zhao, Jennifer Dufour, Matthew G.K. Benesch, Melinda Wuest, Xiaoyun Tang
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4c37c0afb8d155674c0e34cc27939a
https://doi.org/10.1158/1535-7163.22507231 -
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المؤلفون: David N. Brindley, Frank Wuest, David Murray, Bertrand Heckmann, Alain Monjardet, Jonathan M. Curtis, YuanYuan Zhao, Jennifer Dufour, Matthew G.K. Benesch, Melinda Wuest, Xiaoyun Tang
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416e40858d983ce2277027b0d747a81f
https://doi.org/10.1158/1535-7163.22507228.v1 -
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المؤلفون: David N. Brindley, Frank Wuest, David Murray, Bertrand Heckmann, Alain Monjardet, Jonathan M. Curtis, YuanYuan Zhao, Jennifer Dufour, Matthew G.K. Benesch, Melinda Wuest, Xiaoyun Tang
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f813fa72946e0b9fecd560be0d4669a
https://doi.org/10.1158/1535-7163.22507216 -
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المؤلفون: David N. Brindley, Frank Wuest, David Murray, Bertrand Heckmann, Alain Monjardet, Jonathan M. Curtis, YuanYuan Zhao, Jennifer Dufour, Matthew G.K. Benesch, Melinda Wuest, Xiaoyun Tang
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2569fd2ba42b9191b0bf52a9375f43aa
https://doi.org/10.1158/1535-7163.22507219.v1 -
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المؤلفون: Alain Monjardet, Thierry Christophe, Nicolas Triballeau, Helene Jary, Luke Jonathan Alvey, Romain Luc Marie Gosmini, Frédéric André De Ceuninck, Pierre Deprez, Robert Touitou, Roland Blanque, D. Amantini, Nele Vandervoort, Ellen van der Aar, Philip Leonard, F. Brebion, Patrick Mollat, Natacha Bienvenu, C. Cottereaux, I. Botez, Varin Marie Laurence Claire, Christophe Peixoto
المصدر: Journal of Medicinal Chemistry. 64:2937-2952
مصطلحات موضوعية: Cartilage, Articular, Models, Molecular, Osteoarthritis, Pharmacology, 01 natural sciences, law.invention, Glycosaminoglycan, Mice, 03 medical and health sciences, Dogs, law, Drug Discovery, medicine, Animals, Humans, IC50, Aggrecan, Glycosaminoglycans, 030304 developmental biology, Aggrecanase, 0303 health sciences, Chemistry, Cartilage, ADAMTS, medicine.disease, Rats, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Recombinant DNA, Molecular Medicine, ADAMTS5 Protein
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المؤلفون: Christelle David, Nele Vandervoort, Damien Fleury, Denis Annoot, Laëtitia Cherel, Willem Jan Hengeveld, Thierry Christophe, Sameh H. Soror, Agnès Marie Joncour, Christopher Gaëtan Housseman, Alain Monjardet, R Galien, Patrick Mollat, Reginald Brys, Veronique Roncoroni, Luce Lepissier, Natacha Bienvenu, Lionel Vercheval, Alexandre Wohlkonig, Christophe Peixoto, Jörg Heiermann, Katja Conrath, Mia Jans, Sandrine Le Tallec, Bertrand Heckmann, Robert Touitou, Nicolas Desroy, Jan Steyaert, Virginie Labeguere, Gregor Pilzak, Ellen van der Aar, Xavier Marie Bock, Nicolas Triballeau, Emanuelle Wakselman
المساهمون: Department of Bio-engineering Sciences, Structural Biology Brussels
المصدر: Journal of Medicinal Chemistry. 60:7371-7392
مصطلحات موضوعية: Male, 0301 basic medicine, Phosphodiesterase Inhibitors, Pyridines, Stereochemistry, Inflammation, 01 natural sciences, Cocrystal, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Lysophosphatidic acid, Hydrolase, medicine, Animals, Humans, Structure–activity relationship, chemistry.chemical_classification, Phosphoric Diester Hydrolases, 010405 organic chemistry, Chemistry, Drug discovery, Imidazoles, Lysophosphatidylcholines, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Enzyme, Biochemistry, Molecular Medicine, lipids (amino acids, peptides, and proteins), Lysophospholipids, Autotaxin, medicine.symptom