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المؤلفون: Joseph A. Ware, John Chen, Xiao Ding, Qin Yue, Jodie Pang, Nicholas Siebers, Lori Joas, S. Cyrus Khojasteh, Sungjoon Cho, Jackson D. Pellet, Shuguang Ma, Laurent Salphati, Alan Deese, Teresa Mulder
المصدر: Xenobiotica; the fate of foreign compounds in biological systems. 51(7)
مصطلحات موضوعية: Indazoles, Class I Phosphatidylinositol 3-Kinases, Health, Toxicology and Mutagenesis, Absorption (skin), Pharmacology, Toxicology, Phosphatidylinositols, 030226 pharmacology & pharmacy, Biochemistry, Excretion, 03 medical and health sciences, chemistry.chemical_compound, Feces, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Dogs, Pharmacokinetics, Oral administration, Animals, Humans, Phosphatidylinositol, Sulfonamides, Chemistry, Kinase, General Medicine, Metabolism, Small molecule, Rats, 030220 oncology & carcinogenesis
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2
المؤلفون: Lewis J. Gazzard, Remy Angelaud, Mark Reynolds, Brian Wong, Alan Deese, Zhigang Cheng, Christine Gu, James Girotti, Andreas Stumpf
المصدر: Organic Process Research & Development. 19:661-672
مصطلحات موضوعية: Aryl, Organic Chemistry, Ether, Cyanation, Chloride, Catalysis, chemistry.chemical_compound, chemistry, Nucleophilic aromatic substitution, medicine, Organic chemistry, Physical and Theoretical Chemistry, Fluoride, Pyrrole, medicine.drug
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3
المؤلفون: Frédéric St-Jean, Scott Savage, Keith Lee Spencer, Alan Deese, Brian Wong, Lane Jonathan W, David Askin, Herbert Yajima, Travis Remarchuk, Srinivasan Babu, Michael W. Dong, Jeffrey Stults, Diane E. Carrera
المصدر: Organic Process Research & Development. 18:1652-1666
مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Total synthesis, Physical and Theoretical Chemistry, Akt inhibitor, Ipatasertib
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4
المؤلفون: Nathaniel L. Segraves, Derrick Yazzie, Alan Deese
المصدر: Magnetic Resonance in Chemistry. 50:256-259
مصطلحات موضوعية: Stereochemistry, Hydrogen bond, Acetal, General Chemistry, Nuclear magnetic resonance spectroscopy, chemistry.chemical_compound, Deuterium, chemistry, Intramolecular force, Hemiacetal, Organic chemistry, Molecule, General Materials Science, Two-dimensional nuclear magnetic resonance spectroscopy
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5
المؤلفون: Peter W. Fan, Cornelis E. C. A. Hop, Jane R. Kenny, Luke Koenigs Lightning, Kevin A. Ford, Hoa Le, Alan Deese, S. Cyrus Khojasteh, Chenghong Zhang, Jason Halladay, James P. Driscoll
المصدر: Chemical Research in Toxicology. 24:1668-1677
مصطلحات موضوعية: inorganic chemicals, Aniline Compounds, Magnetic Resonance Spectroscopy, Halogenation, Molecular Structure, Human liver, Stereochemistry, General Medicine, Glutathione, Toxicology, Combinatorial chemistry, Metabolic Detoxication, Phase II, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, mental disorders, Microsomes, Liver, Microsome, Humans, NADP, Chromatography, Liquid
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6
المؤلفون: Susan Wong, Young G. Shin, Cornelis E. C. A. Hop, C. Gregory Sowell, Alan Deese, Harvey Wong, Kevin S. Currie, Hoa Le, X. Charlene Liao, Matthew Baumgardner, Jason Boggs, S. Cyrus Khojasteh, Jason Halladay, Lichuan Liu, John C. Davis, Wendy B. Young, Peter Kuebler, Hank La, Sashi Gopaul, Joseph W. Lubach, Melis Coraggio
المصدر: Drug Metabolism and Disposition. 39:1840-1849
مصطلحات موضوعية: Male, Metabolite, Pharmaceutical Science, Pyrimidinones, Thiophenes, Urine, Pharmacology, Rats, Sprague-Dawley, Mice, Hydrolysis, chemistry.chemical_compound, Dogs, Double-Blind Method, Species Specificity, Pharmacokinetics, Agammaglobulinaemia Tyrosine Kinase, Animals, Humans, Bruton's tyrosine kinase, Protein Kinase Inhibitors, Cells, Cultured, Randomized Controlled Trials as Topic, Clinical Trials, Phase I as Topic, biology, Protein-Tyrosine Kinases, Amides, In vitro, Rats, Macaca fascicularis, chemistry, Hepatocytes, Microsomes, Liver, Microsome, biology.protein, Female, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab0859988552390efc705d236910786
https://doi.org/10.1124/dmd.111.040840 -
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المؤلفون: Alan Deese, S. Cyrus Khojasteh, Harvey Wong, Yung-Hsiang Chen, Patrick J. Rudewicz, Eric Solon, Qin Yue, Ryan H. Takahashi, Cornelis E. C. A. Hop, Teresa Mulder, Mark Reynolds
المصدر: Drug Metabolism and Disposition. 39:952-965
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, Glucuronidation, Pharmaceutical Science, Vismodegib, Metabolism, Urine, Biology, Excretion, Endocrinology, Pharmacokinetics, Oral administration, Internal medicine, medicine, Feces, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fc10cecf092996698a46da669582d5f1
https://doi.org/10.1124/dmd.110.037374 -
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المؤلفون: Evan Smith, Sue Zhou, Deepak Dalvie, Alan Deese, James A. Nieman, Ping Kang
المصدر: Drug Metabolism and Disposition. 36:1425-1437
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, medicine.medical_specialty, Magnetic Resonance Spectroscopy, medicine.drug_class, Metabolite, Pharmaceutical Science, Pharmacology, Antiandrogen, Flutamide, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Tandem Mass Spectrometry, Internal medicine, medicine, Humans, Biotransformation, biology, CYP3A4, CYP1A2, Cytochrome P450, Androgen Antagonists, Glutathione, Endocrinology, chemistry, Microsomes, Liver, biology.protein, Microsome, Chromatography, Liquid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fa2eadafe5acf11e473e3be4aa2d61
https://doi.org/10.1124/dmd.108.020370 -
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المؤلفون: Sue Zhou, Deepak Dalvie, Ping Kang, Alan Deese, Evan Smith
المصدر: Drug Metabolism and Disposition. 35:1081-1088
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Antineoplastic Agents, Hormonal, Stereochemistry, Pharmaceutical Science, In Vitro Techniques, Mixed Function Oxygenases, Flutamide, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Cytochrome P-450 CYP1A2, Tandem Mass Spectrometry, Cytochrome P-450 CYP3A, Humans, Biotransformation, Chromatography, High Pressure Liquid, Pharmacology, Molecular Structure, biology, CYP3A4, Chemistry, CYP1A2, Cytochrome P450, Androgen Antagonists, Glutathione, biology.organism_classification, Recombinant Proteins, Cytochrome P-450 CYP2C19, Biochemistry, Microsoma, Microsomes, Liver, biology.protein, Microsome, Aryl Hydrocarbon Hydroxylases, Chemical and Drug Induced Liver Injury, NADP, Conjugate
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809fabe9085a511f60c4f8b03c083e2c
https://doi.org/10.1124/dmd.107.014860 -
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المؤلفون: Paroma Chakravarty, Alan Deese, Joseph W. Lubach, Kothari Sanjeev H
المصدر: Molecular pharmaceutics. 12(7)
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Chemistry, Pharmaceutical, Pharmaceutical Science, Polyvinyl alcohol, Excipients, chemistry.chemical_compound, Differential scanning calorimetry, X-Ray Diffraction, Drug Discovery, Microscopy, Organic chemistry, Dissolution, Active ingredient, Calorimetry, Differential Scanning, Chemistry, Temperature, Esters, Nuclear magnetic resonance spectroscopy, Lipids, Propylene Glycol, Thermogravimetry, Solutions, Solubility, Molecular Medicine, Powder diffraction, Nuclear chemistry