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المؤلفون: Ahmed A. Samatar, Lata Jayaraman, Leigh Zawel, Stephen Fawell, Alan Cooper, Anthony Mannarino, Nathaniel L. Elsen, Stuart Black, Priya Dayananth, Clifford R. Restaino, Daniel McMasters, Jaren Arbanas, Gottfried K. Schroeder, My Sam Mansueto, Alan Hruza, Erick J. Morris, Sharda Jha
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a41d041f5824e4e438c00c030ecb53b
https://doi.org/10.1158/1535-7163.22509012.v1 -
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المؤلفون: Ahmed A. Samatar, Lata Jayaraman, Leigh Zawel, Stephen Fawell, Alan Cooper, Anthony Mannarino, Nathaniel L. Elsen, Stuart Black, Priya Dayananth, Clifford R. Restaino, Daniel McMasters, Jaren Arbanas, Gottfried K. Schroeder, My Sam Mansueto, Alan Hruza, Erick J. Morris, Sharda Jha
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3185945c7ae768bd2e93b8d986a09ade
https://doi.org/10.1158/1535-7163.22508997 -
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المؤلفون: Ahmed A. Samatar, Stephen Fawell, Leigh Zawel, Lata Jayaraman, D. Gary Gilliland, Daniel Hicklin, W. Robert Bishop, Paul Kirschmeier, David Witter, Phieng Siliphaivanh, Ulrike Philippar, Marc R. Pelletier, Bart A. Lutterbach, Ling Zhang, Pierre Daublain, Liang Zhu, Boga Sobhana Babu, Xiaolei Gao, Sunil Paliwal, Joe Kelly, James Wang, Alan Hruza, Gerald Shipps, Li Xiao, Jagdish Desai, Elaine M. Pinheiro, Minilik H. Angagaw, Shuxia Zhao, Rumin Zhang, William Windsor, Edward DiNunzio, Jenny Liu, Brian Long, Stuart Black, Weihong Jin, Yongi Deng, Donna Carr, Alan Cooper, Hugh Zhu, Priya Dayananth, Clifford R. Restaino, Sharda Jha, Erick J. Morris
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043d9dc9ddac3082860a77d7c7fbd235
https://doi.org/10.1158/2159-8290.22530809 -
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المؤلفون: Ahmed A. Samatar, Lata Jayaraman, Leigh Zawel, Stephen Fawell, Alan Cooper, Anthony Mannarino, Nathaniel L. Elsen, Stuart Black, Priya Dayananth, Clifford R. Restaino, Daniel McMasters, Jaren Arbanas, Gottfried K. Schroeder, My Sam Mansueto, Alan Hruza, Erick J. Morris, Sharda Jha
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae21590fd6fe473ad9f65db7f2896fb
https://doi.org/10.1158/1535-7163.22509000.v1 -
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المؤلفون: Ian M. Bell, Steve S. Carroll, Paula J. Hancock, Richard J. O. Barnard, M. Katharine Holloway, David M. Tellers, Alan Hruza, Gregory C. Adam, Christopher D. Cox, Peter S. Kutchukian, Matthew Tudor, Jing Li, B. Wesley Trotter, Anthony W. Shaw, Corey Strickland, Marina Bukhtiyarova, Scott E. Wolkenberg, David A. Powell, Erica M. Cook, Ivan Cornella-Taracido, Philip M. McKenna
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: business.industry, Chemistry, medicine.drug_class, Phenotypic screening, Organic Chemistry, Farnesyltransferase inhibitor, Histone deacetylase inhibitor, Human immunodeficiency virus (HIV), medicine.disease_cause, Biochemistry, Text mining, Drug Discovery, Proteome, medicine, Cancer research, Latency (engineering), business, Vorinostat, medicine.drug
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المؤلفون: Charles Lee Jayne, Santhosh Neelamkavil, Alan Hruza, Richard N. Ingram, Samuel Chackalamannil, Mariappan V. Chelliah, Keith Eagen, Teresa Andreani, William J. Greenlee, Kartik M. Keertikar, Steve Fried, Brian Hawes, Yan Xia, Zhuyan Guo, Michael P. Dwyer, Tin-Yau Chan, Paul Reichert, Martin C. Clasby
المصدر: Bioorganicmedicinal chemistry letters. 30(15)
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, Factor IXa, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Structure–activity relationship, Humans, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Plasma levels, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Pyrimidines, Molecular Medicine, Selectivity, Factor Xa Inhibitors
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المؤلفون: Corey Strickland, Bridget Carragher, Winifred W. Prosise, Theresa M. Kelly, Clinton S. Potter, Alan Hruza, Venkata P. Dandey, Todd Mayhood, Zhening Zhang, Giovanna Scapin
المصدر: Nature
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, medicine.medical_treatment, Crystallography, X-Ray, Article, 03 medical and health sciences, medicine, Humans, Insulin, Glucose homeostasis, Binding site, Multidisciplinary, biology, Chemistry, Cryoelectron Microscopy, Receptor, Insulin, Single Molecule Imaging, Cell biology, Insulin receptor, Transmembrane domain, 030104 developmental biology, Ectodomain, biology.protein, Protein Multimerization, Signal transduction, Apoproteins, Tyrosine kinase, Signal Transduction
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8دورية أكاديمية
المؤلفون: Giovanna Scapin, Venkata P. Dandey, Zhening Zhang, Winifred Prosise, Alan Hruza, Theresa Kelly, Todd Mayhood, Corey Strickland, Clinton S. Potter, Bridget Carragher
المصدر: Nature, Nature. 556(7699):122-125
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المؤلفون: Marlene C. Hinton, Hua Zhou, Dongyu Sun, Ulrike Philippar, Peter Spacciapoli, Hongmin Chen, Shruti D. Raut, G. Naumov, Joey L. Methot, Alessia Petrocchi, Alan Hruza, My Sam Mansueto, Jongwon Lim, Joon Jung, Elizabeth Helen Kelley, Susan E. Hill, Phieng Siliphaivanh, John Maclean
المصدر: Journal of Medicinal Chemistry. 59:6501-6511
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, MAPK/ERK pathway, Pyridines, Antineoplastic Agents, Crystallography, X-Ray, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Urea, Structure–activity relationship, Extracellular Signal-Regulated MAP Kinases, Protein Kinase Inhibitors, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Drug discovery, Chemistry, Melanoma, Neoplasms, Experimental, medicine.disease, Dose–response relationship, 030104 developmental biology, Biochemistry, Cell culture, Cancer research, Molecular Medicine, Experimental pathology, Drug Screening Assays, Antitumor
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المؤلفون: Harold B. Wood, Kunal Desai, Daming Feng, Jamie McCabe-Dunn, Yi-Heng Chen, Edward C. Sherer, Jane Y. Wu, Marc Poirier, Hong Li, Dongfang Meng, Ting Zhang, Kenneth P. Ellsworth, Liangqin Guo, Teruyuki Nishimura, Jiayi Xu, Tomokazu Hirabayashi, Sunita V. Dewnani, Patrick Andre, Louis-Charles Campeau, Richard Tschirret-Guth, Isao Sakurada, Paul Reichert, Cameron J. Smith, Robert K. Orr, Lisa M. Sonatore, Wayne M. Geissler, Thomas Bateman, Kazuto Araki, Joe Metzger, Alan Hruza, Richard A. Berger, Dann L. Parker, Tianying Jian
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:5437-5443
مصطلحات موضوعية: Drug, media_common.quotation_subject, Clinical Biochemistry, High selectivity, Administration, Oral, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Thrombin generation, Factor IXa, Pharmacokinetics, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, media_common, chemistry.chemical_classification, Molecular Structure, Chemistry, Organic Chemistry, Rats, Enzyme Activation, Human plasma, Drug Design, Pharmacodynamics, Molecular Medicine, Coagulation factor IXa, Heterocyclic Compounds, 3-Ring, Tricyclic