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المؤلفون: Zhu Qiang, Shailaja Panduga, Kassoum Nacro, Rashmi Pathak, Venkateswara R. Narreddula, Alan J. Henderson, Kai Xiang, Ming Min Hsia, Bharat Shimpukade, Matthew Isherwood, Jagjit Kaur, Animesh Ghosh, Valentina Tan, Peter R. Guzzo
المصدر: Isherwood, M, Guzzo, P R, Henderson, A J, Hsia, M M, Kaur, J, Nacro, K, Narreddula, V R, Panduga, S, Pathak, R, Shimpukade, B, Tan, V, Xiang, K, Qiang, Z & Ghosh, A 2012, ' An efficient synthesis of (7S,10R)-2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole: application in the preparation and structural confirmation of a potent 5-HT6 antagonist ', Tetrahedron: Asymmetry, vol. 23, no. 22, pp. 1522-1527 . https://doi.org/10.1016/j.tetasy.2012.10.012
مصطلحات موضوعية: Indole test, Sulfonyl, chemistry.chemical_classification, Chiral auxiliary, Trifluoromethyl, Chemistry, Stereochemistry, Organic Chemistry, 5-HT6, Enantioselective synthesis, Diastereomer, Catalysis, Chiral resolution, Inorganic Chemistry, chemistry.chemical_compound, GPCR, Physical and Theoretical Chemistry, Enantiomer, Asymmetric Synthesis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7307be23988970a045095b21d4ee86ac
https://doi.org/10.1016/j .tetasy.2012.10.012 -
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المؤلفون: Alan J. Henderson, Sargent Bruce J
المصدر: Current Opinion in Pharmacology. 11:52-58
مصطلحات موضوعية: Pharmacology, Serotonin, medicine.medical_specialty, Mechanism (biology), Biology, Ligand (biochemistry), Serotonin Receptor Agonists, Endocrinology, Receptors, Serotonin, Internal medicine, Drug Discovery, Knockout mouse, medicine, Anorectic, Animals, Humans, Molecular Targeted Therapy, Obesity, Serotonin Antagonists, Antagonism, Receptor, 5-HT receptor
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المؤلفون: Guowei Jiang, Mark Hadden, Jean Viggers, Xiaowu May Jiang, Matthew David Surman, Sharon C. Cheetham, Peter R. Guzzo, Michele Luche, Steven P Vickers, Emily Freeman, Alan J. Henderson, Yuri L. Khmelnitsky, James F. Grabowski
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7015-7019
مصطلحات موضوعية: Indazoles, Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Obesity, Receptors, Pituitary Hormone, Molecular Biology, biology, Organic Chemistry, Antagonist, Combinatorial chemistry, Ether-A-Go-Go Potassium Channels, Potassium channel, chemistry, Cardiovascular Diseases, biology.protein, Lactam, Molecular Medicine, Anti-Obesity Agents
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المؤلفون: Sharon C. Cheetham, Alan J. Henderson, Steven P Vickers, Michele Luche, Matthew David Surman, Jean Viggers, Peter R. Guzzo, Mark Hadden, Dustin M. Deering, Yuri L. Khmelnitsky
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7020-7023
مصطلحات موضوعية: Indazole, Pyridines, Stereochemistry, Aryl, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Suzuki reaction, Drug Discovery, Lactam, Animals, Molecular Medicine, Structure–activity relationship, Anti-Obesity Agents, Obesity, Receptors, Pituitary Hormone, Antagonism, Molecular Biology, Trifluoromethanesulfonate
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المؤلفون: Marc L. Reitman, Cheng Guo, Theresa M. Kelly, Constantin Tamvakopoulos, Joseph M. Metzger, Tianying Jian, Howard Y. Chen, Arthur A. Patchett, Oksana C. Palyha, Alison M. Strack, Allan J. Goodman, Ravi P. Nargund, Peter H. Dobbelaar, Yanqing Kan, Mark Hadden, Larry Yet, Peter R. Guzzo, Qianping Peng, Linus S. Lin, Shuwen He, Lauren P. Shearman, Alan J. Henderson, Carina P. Tan, Sargent Bruce J, Xiao-Ming Guan, Scott D. Feighner, Iyassu K. Sebhat, Jie Pan, Jian Liu, Donald J. Marsh, Matthew J. Wyvratt, Andrew D. Howard, Megan Ruenz
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1913-1917
مصطلحات موضوعية: Agonist, medicine.drug_class, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Molecular Biology, Biphenyl, Chemistry, Drug discovery, fungi, Organic Chemistry, Imidazoles, Rats, Bombesin receptor, Bioavailability, Receptors, Bombesin, Molecular Medicine, Bombesin Receptor Subtype-3
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المؤلفون: Mark R. Hellberg, Colene Drace, Mark Hadden, Raj Patil, Marsha A. McLaughlin, Andrew Rusinko, Cheng Guo, Alan J. Henderson, N.A. Sharif, Decornez Helene, Neema Douglas
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1137-1140
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Glaucoma, Biochemistry, In vivo, Drug Discovery, medicine, Animals, Humans, Protein Kinase Inhibitors, Molecular Biology, Rho-associated protein kinase, chemistry.chemical_classification, rho-Associated Kinases, biology, Organic Chemistry, Haplorhini, medicine.disease, In vitro, Enzyme, chemistry, Enzyme inhibitor, Pyrazines, Microsomes, Liver, biology.protein, Cancer research, Molecular Medicine, Rabbits, A kinase, Signal transduction
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المؤلفون: Iyassu K. Sebhat, Christopher Franklin, Michael M.-C. Lo, David Chen, James P. Jewell, Randy Miller, Jianmei Pang, Oksana Palyha, Yanqing Kan, Theresa M. Kelly, Xiao-Ming Guan, Donald J. Marsh, Jennifer A. Kosinski, Joseph M. Metzger, Kathryn Lyons, Jasminka Dragovic, Peter R. Guzzo, Alan J. Henderson, Marc L. Reitman, Ravi P. Nargund, Matthew J. Wyvratt, Linus S. Lin
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5863fccb14ec5b50660a4b1a9d17c4
https://europepmc.org/articles/PMC4018145/ -
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المؤلفون: Yuri L. Khmelnitsky, Sharon C. Cheetham, James F. Grabowski, Michele Luche, Jean Viggers, Steven P Vickers, Peter R. Guzzo, Mark Hadden, Dustin M. Deering, Xiaowu Jiang, Alan J. Henderson, Matthew David Surman
المصدر: Bioorganicmedicinal chemistry letters. 20(23)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, Pharmacokinetics, In vivo, Oral administration, Drug Discovery, Structure–activity relationship, Animals, Obesity, Receptors, Pituitary Hormone, Molecular Biology, Chemistry, Organic Chemistry, Body Weight, Antagonist, Biological activity, In vitro, Molecular Medicine, Anti-Obesity Agents, Carbolines
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المؤلفون: Andrew R. Mount, John Parkinson, Malcolm R. Banks, Ian Gosney, Wesley G. Kerr, Patrick R. R. Langridge-Smith, Andreas Kerth, Paul Thornburn, Alan Taylor, J. I. G. Cadogan, Alan J. Henderson, John R. A. Millar, Philip K. G. Hodgson
المصدر: ChemInform. 27
مصطلحات موضوعية: Acetic acid, chemistry.chemical_compound, Fullerene, chemistry, Reductive cleavage, chemistry.chemical_element, General Medicine, Zinc, Ring (chemistry), Nitrogen, Medicinal chemistry, Derivative (chemistry), Juncture
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المؤلفون: Iyassu K. Sebhat, Ravi P. Nargund, Mark Hadden, Qianping Peng, Shuwen He, Larry Yet, Linus S. Lin, Allan J. Goodman, Cheng Guo, Theresa M. Kelly, Marc L. Reitman, Peter R. Guzzo, Jian Liu, Constantin Tamvakopoulos, Megan Ruenz, Kevin Pattamana, Xiao-Ming Guan, Alan J. Henderson, Sargent Bruce J, Yanqing Kan, Brian Swenson, Joseph M. Metzger, Oksana C. Palyha
المصدر: Bioorganicmedicinal chemistry letters. 20(9)
مصطلحات موضوعية: Agonist, medicine.drug_class, Carboxylic acid, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biochemistry, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Obesity, Molecular Biology, chemistry.chemical_classification, fungi, Organic Chemistry, Imidazoles, Brain, Bombesin receptor, Bioavailability, Rats, Receptors, Bombesin, chemistry, Molecular Medicine, Bombesin Receptor Subtype-3, Anti-Obesity Agents
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