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المؤلفون: Thomas J. Tucker, Nianyu Li, Scott P. Salowe, Harold B. Wood, Danila Branca, Alan S. Bass, Rupesh P. Amin, BethAnn Murphy, Aurash Shahripour, Angela Kerekes, Abbas Walji, Nicole Buist, Jeffrey T. Kuethe, Huaibing He, Rodger Tracy, Kenneth A. Koeplinger, Weixun Wang, Bhavana Bhatt, Candice Alleyne, Sookhee Ha, Douglas G. Johns, Elisabetta Bianchi, Chengwei Wu, Peter Orth, Tjerk Bueters, Yusheng Xiong, Hratch J. Zokian, Michael J. Hafey, Mark W. Embrey, John Higgins
المصدر: Journal of Medicinal Chemistry. 64:16770-16800
مصطلحات موضوعية: chemistry.chemical_classification, Molecular Structure, biology, PCSK9, PCSK9 Inhibitors, Administration, Oral, Biological Availability, Peptide, Pharmacology, Crystallography, X-Ray, Proprotein convertase, Peptides, Cyclic, Rats, Bioavailability, Macaca fascicularis, Structure-Activity Relationship, chemistry, Drug Discovery, biology.protein, Animals, Molecular Medicine, Kexin, Dosing, Antibody, Tricyclic
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المؤلفون: Nicolas Couvreur, Charles Benson, Jean-Michel Guillon, Yoshiko Okai, Armando Lagrutta, Todd Wisialowski, Michael G. Rolf, Ard Teisman, C. Michael Foley, Hugo M. Vargas, Jean-Pierre Valentin, Maki Ito, Michael J. Engwall, Khuram W. Chaudhary, Gary Gintant, David J. Gallacher, Takashi Yoshinaga, Andrea Greiter-Wilke, Corina Dota, Paul Levesque, Katsuyoshi Chiba, Amy Pointon, Stephen Jenkinson, Anthony Bahinski, Martin Traebert, Brian Guth, Eric Martel, Alan S. Bass, Christa Hegele‐Hartung, William E. Achanzar, Ravikumar Peri, Herbert M. Himmel, Yusheng Qu, Derek J. Leishman
المصدر: Clinical Pharmacology and Therapeutics
مصطلحات موضوعية: Drug, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Drug Industry, media_common.quotation_subject, Decision Making, hERG, Drug Evaluation, Preclinical, Reviews, Torsades de pointes, Review, Risk Assessment, 030226 pharmacology & pharmacy, QT interval, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Torsades de Pointes, medicine, Animals, Humans, Repolarization, Pharmacology (medical), cardiovascular diseases, Intensive care medicine, media_common, Pharmacology, biology, Surrogate endpoint, business.industry, Arrhythmias, Cardiac, Drugs, Investigational, medicine.disease, nervous system diseases, Clinical trial, Long QT Syndrome, Drug development, 030220 oncology & carcinogenesis, biology.protein, business
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المؤلفون: Jason D. Katz, François G. Gervais, Lauren Dorosh, Milenko Cicmil, Khamir Mehta, Joey L. Methot, Janice D Woodhouse, Hongshi Yu, Hani Houshyar, Prasanthi Geda, Gretchen A. Baltus, Malgorzata A Gil, Antonio Cabal, Sanjiv J. Shah, Robbie L. McLeod, Dapeng Chen, Alan S. Bass, Stephen E. Alves, Michael Caniga
المصدر: Journal of Pharmacology and Experimental Therapeutics. 369:223-233
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, biology, Chemistry, Area under the curve, Cmax, Basophil, 03 medical and health sciences, Cmin, Ovalbumin, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Pharmacodynamics, Blood plasma, medicine, biology.protein, Molecular Medicine, IC50, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9ae30672ed16800c8692f183b1d4851d
https://doi.org/10.1124/jpet.118.252551 -
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المؤلفون: Alan S. Bass, David Jones, Derek J. Leishman, Siddhartha Bhatt, Martin Traebert, Nils Dragsted, Jean-Pierre Valentin, Theodore J. Baird, Simon Authier, Ninette K. Andersen, Tomas Mow, Carrie Markgraf, Anders B. Lassen, Michael J. Curtis, Morten Laursen
المصدر: Journal of pharmacological and toxicological methods. 105
مصطلحات موضوعية: medicine.medical_specialty, Investigational drug, No-observed-adverse-effect level, Drug-Related Side Effects and Adverse Reactions, Context (language use), 030204 cardiovascular system & hematology, Toxicology, 030226 pharmacology & pharmacy, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Toxicity Tests, medicine, Animals, Humans, Intensive care medicine, Adverse effect, Formal description, Pharmacology, No-Observed-Adverse-Effect Level, business.industry, Safety pharmacology, Rubric, Drugs, Investigational, Risk assessment, business
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المؤلفون: Amy Loughlin, Lisa LaFranco-Scheuch, Heather Vu, Tara Grady Styring, Nianyu Li, Stephen Pacchione, Warren E. Glaab, Alan S. Bass, Nicolas Solban, J. Richard Miller, Ivy Garfinkel, Heather Zhou, Bhavana Bhatt, Amy G. Aslamkhan, Qiuwei Xu, Kara Pearson, Spencer Reynolds
المصدر: Toxicology and applied pharmacology. 406
مصطلحات موضوعية: 0301 basic medicine, Male, Serotonin, Toxicology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Animals, Indoleamine-Pyrrole 2,3,-Dioxygenase, Metabolomics, ortho-Aminobenzoates, Indoleamine 2,3-dioxygenase, Kynurenine, Pharmacology, Mice, Knockout, Nicotinamide, Catabolism, Tryptophan, Wild type, Molecular biology, Tryptophan Oxygenase, 030104 developmental biology, chemistry, Liver, 030220 oncology & carcinogenesis, Knockout mouse, Female, Metabolic Networks and Pathways, Spleen
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المؤلفون: Michael J. Engwall, Simon Authier, Morten Laursen, Michael J. Curtis, Siddhartha Bhatt, Derek J. Leishman, Martin Traebert, Ninette K. Andersen, Alan S. Bass, David K. Jones, Tomas Mow, Carrie G. Markgraf, Theodore J. Baird, Nils Dragsted, Anders B. Lassen, Jean-Pierre Valentin, Zindy Raida
المصدر: Journal of Pharmacological and Toxicological Methods. 93:172-173
مصطلحات موضوعية: Pharmacology, 03 medical and health sciences, 0302 clinical medicine, Safety pharmacology, Engineering ethics, 030204 cardiovascular system & hematology, Toxicology, Psychology, 030226 pharmacology & pharmacy
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المؤلفون: Jean-Pierre Valentin, Takashi Yoshinaga, Alan S. Bass, Frederick Sannajust, Michael K. Pugsley
المصدر: Journal of Pharmacological and Toxicological Methods. 98:106593
مصطلحات موضوعية: Pharmacology, Drug Industry, Drug-Related Side Effects and Adverse Reactions, business.industry, Safety pharmacology, media_common.quotation_subject, Drug Evaluation, Preclinical, 030204 cardiovascular system & hematology, Toxicology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Political science, Service (economics), Financial crisis, Animals, Humans, Engineering ethics, Societies, business, Pharmaceutical industry, media_common
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المؤلفون: Alan S. Bass, Keiji Yamamoto, Hugo M. Vargas, Lewis B. Kinter, Tim Hammond, Peter K. S. Siegl, Rob Wallis, Jean-Pierre Valentin
المصدر: Journal of Pharmacological and Toxicological Methods. 64:7-15
مصطلحات موضوعية: Pharmacology, Societies, Pharmaceutical, Drug-Related Side Effects and Adverse Reactions, business.industry, Safety pharmacology, Drug Evaluation, Preclinical, Guidance documents, Nanotechnology, Toxicology, Risk Assessment, Drug Discovery, Toxicity Tests, Molecular targets, Animals, Humans, Medicine, Engineering ethics, business, Drug toxicity
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المؤلفون: Simon Chivers, J.-P. Valentin, Peter K. S. Siegl, Alan S. Bass, Michael Markert, Richard Briscoe, Brian Guth
المصدر: Journal of Pharmacological and Toxicological Methods. 60:107-116
مصطلحات موضوعية: Risk, medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, hERG, Context (language use), Pharmacology, Toxicology, QT interval, Toxicology studies, Electrocardiography, Heart Rate, Toxicity Tests, medicine, Animals, Humans, cardiovascular diseases, Intensive care medicine, Risk management, biology, business.industry, Safety pharmacology, Long QT Syndrome, Data quality, biology.protein, Safety, business, Risk assessment
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المؤلفون: Craig Mahon, Mark E. Cartwright, Ronald D. Snyder, Paul McNamara, Prudence Bradley, John C. Hunter, Richard Morrison, Ying-Ying Zhou, Alan S. Bass
المصدر: Journal of Pharmacological and Toxicological Methods. 60:69-78
مصطلحات موضوعية: Drug, Drug Industry, Drug-Related Side Effects and Adverse Reactions, Computer science, media_common.quotation_subject, Drug Evaluation, Preclinical, Pharmacology, Toxicology, Drug Discovery, medicine, Animals, Attrition, media_common, Pharmaceutical industry, Safety studies, Drug discovery, business.industry, Safety pharmacology, medicine.disease, Pharmaceutical Preparations, Risk analysis (engineering), Research Design, Identification (biology), business, Genetic Toxicology