يعرض 1 - 10 نتائج من 49 نتيجة بحث عن '"Alaric J, Dyckman"', وقت الاستعلام: 1.09s تنقيح النتائج
  1. 1
    Multiple Sclerosis

    المؤلفون: William J. Pitts, Alaric J. Dyckman

    المصدر: Burger's Medicinal Chemistry and Drug Discovery. :1-43

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::34b67336649fa65a9a6e377f5381c10f
    https://doi.org/10.1002/0471266949.bmc203.pub2

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  2. 2
    Optimization of 4H-pyrrolo[3,2-d]thiazole based antagonists of toll-like receptors 7 and 8 (TLR7/8) for the treatment of lupus

    المؤلفون: Alaric J Dyckman, John Macor, Stefan Ruepp, Schieven Gary, Shailesh Dudhgaonkar, Satyanaraya Reddy BhimiReddy, Srinath Subramaniam, Arvind Mathur, David Critton, Shana Posy, Rushith Kumar Anumula, Raju Barre, Anupama Reddy, Subramanya Hegde, Pasunoori Laxman, Sreekantha Ratna Kumar

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf908c9b46738203425be417fe9b3c6
    https://doi.org/10.1021/scimeetings.2c00255

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  3. 3
    Identification of trisubstituted pyrazoles as potent and selective dual antagonists of toll-like receptors 7 and 8 (TLR 7/8) for the treatment of lupus

    المؤلفون: Alaric J Dyckman, John Macor, Stefan Ruepp, Gary Leonard Schieven, Shailesh Dudhgaonkar, Satyanaraya Reddy BhimiReddy, Mushkin Basha, Ananta Karmakar, Arvind Mathur, David Critton, Shana Posy, Ramesh Sistla, Rushith Kumar Anumula, Anupama KR Reddy, Vikram Bhogadi, Srinivas Pitani, Ratna K. Sreekantha, Laxman Pasunoori

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336f946f4a2474d3af406bf065f5e3bc
    https://doi.org/10.1021/scimeetings.2c00064

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  4. 4
    Bicyclic Ligand-Biased Agonists of S1P1: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles

    المؤلفون: Alaric J. Dyckman, Lois D. Lehman-McKeeman, Huadong Sun, Hong Shi, Mary Ellen Cvijic, Ding Ren Shen, Xiaoxia Yang, Michael Yang, Tracy L. Taylor, Hai-Yun Xiao, Zili Xiao, Luisa Salter-Cid, Jian Pang, Percy H. Carter, Paul Levesque, Arvind Mathur, John L. Gilmore, Jenny Xie, T. G. Murali Dhar, Georgia Cornelius, Anthony M. Marino, Kim W. McIntyre, Bethanne M. Warrack

    المصدر: Journal of Medicinal Chemistry. 64:1454-1480

    مصطلحات موضوعية: Chemistry, Metabolite, Arthritis, Pharmacology, medicine.disease, Ligand (biochemistry), chemistry.chemical_compound, Immune system, Pharmacokinetics, In vivo, Drug Discovery, medicine, Molecular Medicine, Receptor, PK/PD models

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3c93ac373a666f79bb2e7b408fdbd2fc
    https://doi.org/10.1021/acs.jmedchem.0c01109

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  5. 5
    Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles

    المؤلفون: John L. Gilmore, Kim W. McIntyre, Lois D. Lehman-McKeeman, David Marcoux, Hai-Yun Xiao, Georgia Cornelius, Alaric J. Dyckman, Mary Ellen Cvijic, Jenny Xie, Yang Michael G, T. G. Murali Dhar, Zili Xiao, Tracy L. Taylor, Anthony M. Marino, Ding Ren Shen, Percy H. Carter, Paul Levesque, Arvind Mathur, Huadong Sun, Hong Shi

    المصدر: ACS Med Chem Lett

    مصطلحات موضوعية: Bicyclic molecule, 010405 organic chemistry, Stereochemistry, Aryl, Sphingosine-1-phosphate receptor, Organic Chemistry, Ether, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Potency, PK/PD models, ED50

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415fc075f357363f95afa2908797c5ae
    https://doi.org/10.1021/acsmedchemlett.0c00333

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  6. 6
    Identification and Preclinical Pharmacology of ((1R,3S)-1-Amino-3-((S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials

    المؤلفون: Lloyd Lecureux, Elizabeth M. Heimrich, Rochelle Thomas, Lois D. Lehman-McKeeman, Hai-Yun Xiao, Georgia Cornelius, Zheng Yang, Alaric J. Dyckman, Anuradha Gupta, Percy H. Carter, Yu-Wen Li, Paul Levesque, Tracy L. Taylor, Zili Xiao, Mary Ellen Cvijic, Arvind Mathur, John L. Gilmore, Lei Gong, Jenny Xie, Marta Dabros, Ding Ren Shen, Xiaoxia Yang, T. G. Murali Dhar, Xia D. Zhou, Yang Michael G, Bala Pragalathan, Huadong Sun, Anthony M. Marino, Hong Shi, Dauh-Rurng Wu, Richard Rampulla, Kim W. McIntyre, Cliff Chen, Luisa Salter-Cid, Bethanne M. Warrack, Celia D’Arienzo, Virna Borowski

    المصدر: Journal of Medicinal Chemistry. 62:2265-2285

    مصطلحات موضوعية: Agonist, 0303 health sciences, medicine.drug_class, Sphingosine-1-phosphate receptor, Metabolite, Pharmacology, 01 natural sciences, Fingolimod, Partial agonist, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Pharmacokinetics, In vivo, Pharmacodynamics, Drug Discovery, medicine, Molecular Medicine, 030304 developmental biology, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::15b124723f06570a19365c4eb5d204b0
    https://doi.org/10.1021/acs.jmedchem.8b01695

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  7. 7
    Bicyclic Ligand-Biased Agonists of S1P

    المؤلفون: John L, Gilmore, Hai-Yun, Xiao, T G Murali, Dhar, Michael, Yang, Zili, Xiao, Xiaoxia, Yang, Tracy L, Taylor, Kim W, McIntyre, Bethanne M, Warrack, Hong, Shi, Paul C, Levesque, Anthony M, Marino, Georgia, Cornelius, Arvind, Mathur, Ding Ren, Shen, Jian, Pang, Mary Ellen, Cvijic, Lois D, Lehman-McKeeman, Huadong, Sun, Jenny, Xie, Luisa, Salter-Cid, Percy H, Carter, Alaric J, Dyckman

    المصدر: Journal of medicinal chemistry. 64(3)

    مصطلحات موضوعية: Lung Diseases, Male, Serine Endopeptidases, Drug Evaluation, Preclinical, Arthritis, Experimental, Autoimmune Diseases, Rats, Bridged Bicyclo Compounds, Chemotaxis, Leukocyte, Structure-Activity Relationship, Rats, Inbred Lew, Animals, Humans, Myocytes, Cardiac, Proprotein Convertases, Phosphorylation, Bronchoalveolar Lavage Fluid, Biotransformation, Half-Life

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::b171f99d63546ff1524adf2df0c96fa6
    https://pubmed.ncbi.nlm.nih.gov/33492963

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  8. 8
    Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9)

    المؤلفون: Shana L. Posy, David A Critton, Stefan Ruepp, Ratna Kumar Sreekantha, Laxman Pasunoori, Dharmpal S. Dodd, Murali Subramanian, Andrew Watson, Percy H. Carter, Honghe Wan, Debarati Mazumder Tagore, Paul Davies, Shailesh Dudhgaonkar, Gary L. Schieven, Ratika Srivastava, Luisa Salter-Cid, Michael A. Poss, Alaric J. Dyckman, Mussari Christopher P

    المصدر: ACS Med Chem Lett

    مصطلحات موضوعية: Autoimmune disease, Toll-like receptor, Innate immune system, 010405 organic chemistry, Organic Chemistry, virus diseases, Context (language use), TLR7, Pharmacology, TLR8, Biology, medicine.disease_cause, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, Autoimmunity, 010404 medicinal & biomolecular chemistry, Drug Discovery, medicine, Receptor

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85418558e63333c915454e108cc2ef6
    https://pubmed.ncbi.nlm.nih.gov/32944143

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  9. 9
    Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P1) Agonists and Future Perspectives

    المؤلفون: Alaric J. Dyckman

    المصدر: Journal of Medicinal Chemistry. 60:5267-5289

    مصطلحات موضوعية: 0301 basic medicine, Sphingosine, Chemistry, Sphingosine-1-phosphate receptor, Sphingosine metabolism, Computational biology, Sphingolipid, Cell biology, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Fingolimod Hydrochloride, Drug Discovery, Molecular Medicine, Sphingosine-1-phosphate, Receptor, Clinical evaluation

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9f35abcdb01b09a1f2d606aee6785d4a
    https://doi.org/10.1021/acs.jmedchem.6b01575

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  10. 10
    Regioselective Epoxide Ring Opening for the Stereospecific Scale-Up Synthesis of BMS-960, A Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist

    المؤلفون: Alaric J. Dyckman, Bang-Chi Chen, Percy H. Carter, Zhiwei Guo, Amarjit Singh, John L. Gilmore, James E. Sheppeck, Animesh Goswami, Huiping Zhang, Xiaoping Hou, Arvind Mathur

    المصدر: Organic Process Research & Development. 21:200-207

    مصطلحات موضوعية: Agonist, Trifluoromethyl, 010405 organic chemistry, medicine.drug_class, Stereochemistry, Organic Chemistry, Epoxide, Regioselectivity, Alcohol, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Benzonitrile, chemistry.chemical_compound, Stereospecificity, chemistry, medicine, Physical and Theoretical Chemistry, Isoxazole

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7f03408f0071ceb43a9b68457e03ff50
    https://doi.org/10.1021/acs.oprd.6b00366

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