يعرض 1 - 10 نتائج من 18 نتيجة بحث عن '"Alastair C Keen"', وقت الاستعلام: 1.03s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

    المؤلفون: J Robert Lane, Ara M Abramyan, Pramisha Adhikari, Alastair C Keen, Kuo-Hao Lee, Julie Sanchez, Ravi Kumar Verma, Herman D Lim, Hideaki Yano, Jonathan A Javitch, Lei Shi

    المصدر: eLife, Vol 9 (2020)

    مصطلحات موضوعية: dopamine d2 receptor, na+ sensitivity, inverse agonism, molecular dynamics, Medicine, Science, Biology (General), QH301-705.5

    وصف الملف: electronic resource

    Relation: https://elifesciences.org/articles/52189; https://doaj.org/toc/2050-084X

    URL الوصول: https://doaj.org/article/22ae5702392642ec91760a357236acbd

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  2. 2
    دورية أكاديمية
    New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling

    المؤلفون: Anika Mann, Alastair C. Keen, Hanka Mark, Pooja Dasgupta, Jonathan A. Javitch, Meritxell Canals, Stefan Schulz, J. Robert Lane

    المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

    مصطلحات موضوعية: Medicine, Science

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2045-2322

    URL الوصول: https://doaj.org/article/ca749480bcc9489bb045eb4ed1f42bf3

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  3. 3
    دورية أكاديمية
    Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

    المؤلفون: Maxine J. Roberts, Lauren T. May, Alastair C. Keen, Bonan Liu, Terrance Lam, Steven J. Charlton, Elizabeth M. Rosethorne, Michelle L. Halls

    المصدر: Frontiers in Pharmacology, Vol 12 (2021)

    مصطلحات موضوعية: G protein-coupled receptor, cAMP, prostacyclin receptor, localised signalling, extracellular signal-regulated kinase, Therapeutics. Pharmacology, RM1-950

    وصف الملف: electronic resource

    Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.669227/full; https://doaj.org/toc/1663-9812

    URL الوصول: https://doaj.org/article/5c85396c76d64dc79fc084910f1ff65a

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  4. 4
    Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

    المؤلفون: Yong-Gang Chang, Christopher J. Lupton, Charles Bayly-Jones, Alastair C. Keen, Laura D’Andrea, Christina M. Lucato, Joel R. Steele, Hari Venugopal, Ralf B. Schittenhelm, James C. Whisstock, Michelle L. Halls, Andrew M. Ellisdon

    المصدر: Nature Structural & Molecular Biology. 29:767-773

    مصطلحات موضوعية: Structural Biology, Molecular Biology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4933da63b86a93b7d7d691f3041d1107
    https://doi.org/10.1038/s41594-022-00804-9

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  5. 5
    The application of targeted protein degradation technologies to G protein‐coupled receptors

    المؤلفون: Alastair C. Keen, Manuela Jörg, Michelle L. Halls

    المصدر: British Journal of Pharmacology.

    مصطلحات موضوعية: Pharmacology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8b4773334d2333b69b0dc5dcd739a79e
    https://doi.org/10.1111/bph.16079

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  6. 6
    New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling

    المؤلفون: Anika Mann, Hanka Mark, Alastair C. Keen, J. Robert Lane, Stefan Schulz, Pooja Dasgupta, Jonathan A. Javitch, Meritxell Canals

    المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

    مصطلحات موضوعية: G protein-coupled receptor kinase, Multidisciplinary, biology, Kinase, Chemistry, Beta adrenergic receptor kinase, Science, Cell biology, Dopamine receptor D2, biology.protein, Phosphorylation, Medicine, Antibody, Intracellular, G protein-coupled receptor

    وصف الملف: PDF

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2797f88d9daed5cce550cb4cef0e26c

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  7. 7
    OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz

    المؤلفون: Alastair C. Keen, Maria Hauge Pedersen, Laura Lemel, Daniel J. Scott, Meritxell Canals, Dene R. Littler, Travis Beddoe, Yuki Ono, Lei Shi, Asuka Inoue, Jonathan A. Javitch, J. Robert Lane

    المصدر: Keen, A C, Pedersen, M H, Lemel, L, Scott, D J, Canals, M, Littler, D R, Beddoe, T, Ono, Y, Shi, L, Inoue, A, Javitch, J A & Lane, J R 2022, ' OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα z ', Communications Biology, vol. 5, no. 1, 256 . https://doi.org/10.1038/s42003-022-03191-5

    مصطلحات موضوعية: Medicine (miscellaneous), General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, Uncategorized

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6d048327180212bf772a72413b8ec2
    https://curis.ku.dk/ws/files/302198266/s42003_022_03191_5.pdf

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  8. 8
    Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

    المؤلفون: Michelle L. Halls, Elizabeth M. Rosethorne, Maxine J. Roberts, Alastair C. Keen, Lauren T. May, Steven J. Charlton, Bonan Liu, Terrance Lam

    المصدر: Frontiers in Pharmacology
    Frontiers in Pharmacology, Vol 12 (2021)

    مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, medicine.medical_treatment, RM1-950, 03 medical and health sciences, 0302 clinical medicine, cAMP, medicine, Pharmacology (medical), G protein-coupled receptor, Fibroblast, Receptor, Prostacyclin receptor, extracellular signal-regulated kinase, Original Research, Pharmacology, biology, Chemistry, Growth factor, prostacyclin receptor, 030104 developmental biology, medicine.anatomical_structure, localised signalling, Second messenger system, biology.protein, Cancer research, Therapeutics. Pharmacology, 030217 neurology & neurosurgery, Platelet-derived growth factor receptor

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789dec86fe33a91a9b182bd928dee627
    https://pubmed.ncbi.nlm.nih.gov/33995100

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  9. 9
    OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα

    المؤلفون: Alastair C, Keen, Maria Hauge, Pedersen, Laura, Lemel, Daniel J, Scott, Meritxell, Canals, Dene R, Littler, Travis, Beddoe, Yuki, Ono, Lei, Shi, Asuka, Inoue, Jonathan A, Javitch, J Robert, Lane

    المصدر: Communications biology. 5(1)

    مصطلحات موضوعية: Pertussis Toxin, GTP-Binding Protein alpha Subunits, Gi-Go, Heterotrimeric GTP-Binding Proteins, Receptors, G-Protein-Coupled, Signal Transduction

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::cdefd2c8a21c0a0b34fdc8d7a0460625
    https://pubmed.ncbi.nlm.nih.gov/35322196

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  10. 10
    New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D

    المؤلفون: Anika, Mann, Alastair C, Keen, Hanka, Mark, Pooja, Dasgupta, Jonathan A, Javitch, Meritxell, Canals, Stefan, Schulz, J, Robert Lane

    المصدر: Scientific Reports

    مصطلحات موضوعية: Arrestins, Receptors, Dopamine D2, Parkinson Disease, G-Protein-Coupled Receptor Kinases, Molecular neuroscience, Antibodies, Article, HEK293 Cells, Receptor pharmacology, Schizophrenia, Humans, Molecular Targeted Therapy, Phosphorylation, Signal Transduction

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::41fa9615f8af87293d0984e42d7ebb2d
    https://pubmed.ncbi.nlm.nih.gov/33859231

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