المؤلفون: Suryamohan K; Research and Development Department, MedGenome Inc, Foster City, CA, USA., Diwanji D; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Stawiski EW; Research and Development Department, MedGenome Inc, Foster City, CA, USA., Gupta R; MedGenome Labs Ltd., Bangalore, Karnataka, India., Miersch S; Department of Molecular Genetics, and the Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Liu J; ModMab Therapeutics, Foster City, CA, USA., Chen C; Department of Molecular Genetics, and the Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Jiang YP; ModMab Therapeutics, Foster City, CA, USA., Fellouse FA; ModMab Therapeutics, Accelerator for Donnelly Collaboration, University of Toronto, Toronto, ON, Canada., Sathirapongsasuti JF; Research and Development Department, MedGenome Inc, Foster City, CA, USA., Albers PK; Wellcome Sanger Institute, Cambridge, UK., Deepak T; MedGenome Labs Ltd., Bangalore, Karnataka, India., Saberianfar R; ModMab Therapeutics, Accelerator for Donnelly Collaboration, University of Toronto, Toronto, ON, Canada., Ratan A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Washburn G; Research and Development Department, MedGenome Inc, Foster City, CA, USA., Mis M; Research and Development Department, MedGenome Inc, Foster City, CA, USA., Santhosh D; ModMab Therapeutics, Foster City, CA, USA., Somasekar S; Midwestern University, Glendale, AZ, USA., Hiranjith GH; Research and Development Department, MedGenome Inc, Foster City, CA, USA., Vargas D; Research and Development Department, MedGenome Inc, Foster City, CA, USA., Mohan S; Department of Molecular Biology, SciGenom Labs Pvt Ltd, Kochi, Kerala, India., Phalke S; Department of Molecular Biology, SciGenom Labs Pvt Ltd, Kochi, Kerala, India., Kuriakose B; AgriGenome Labs Private Ltd, Kochi, Kerala, India., Antony A; Department of Molecular Biology, SciGenom Labs Pvt Ltd, Kochi, Kerala, India., Ustav M Jr; Department of Molecular Genetics, and the Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Schuster SC; Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore., Sidhu S; Department of Molecular Genetics, and the Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Junutula JR; ModMab Therapeutics, Foster City, CA, USA., Jura N; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA. natalia.jura@ucsf.edu.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA. natalia.jura@ucsf.edu., Seshagiri S; ModMab Therapeutics, Foster City, CA, USA. sekar@sgrf.org.; SciGenom Research Foundation, Bangalore, Karnataka, India. sekar@sgrf.org.

المصدر: Communications biology [Commun Biol] 2021 Apr 12; Vol. 4 (1), pp. 475. Date of Electronic Publication: 2021 Apr 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

مواضيع طبية MeSH: Polymorphism, Genetic*, Angiotensin-Converting Enzyme 2/*genetics , COVID-19/*genetics , Genetic Predisposition to Disease/*genetics , Mutation, Missense/*genetics , Receptors, Virus/*genetics, Amino Acid Sequence ; Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/metabolism ; COVID-19/virology ; Host-Pathogen Interactions ; Humans ; Models, Molecular ; Protein Binding ; Protein Domains ; Receptors, Virus/chemistry ; Receptors, Virus/metabolism ; SARS-CoV-2/metabolism ; SARS-CoV-2/physiology ; Sequence Homology, Amino Acid ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization

المؤلفون: Vuckovic D; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK; National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK., Bao EL; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA; Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA, 02142, USA., Akbari P; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, UK; National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Lareau CA; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Mousas A; Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada., Jiang T; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, UK; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK., Chen MH; The Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, MA, 01702, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA, 01702, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA., Tardaguila M; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Huffman JE; Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, 02130, USA., Ritchie SC; Department of Public Health and Primary Care, Cambridge Baker Systems Genomics Initiative, University of Cambridge, Cambridge, CB1 8RN, UK; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria, VIC 3004, Australia; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK., Megy K; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK; National Institute for Health Research (NIHR) BioResource, Cambridge University Hospitals, Cambridge, CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge, CB2 0PT, UK., Ponstingl H; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Penkett CJ; National Institute for Health Research (NIHR) BioResource, Cambridge University Hospitals, Cambridge, CB2 0PT, UK; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK., Albers PK; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Wigdor EM; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Sakaue S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan., Moscati A; Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, 10029, USA., Manansala R; Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA., Lo KS; Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada., Qian H; Department of Statistics and Operation Research, University of North Carolina, Chapel Hill, NC, 27599, USA., Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan; Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8581, Japan., Bartz TM; Department of Biostatistics, University of Washington, Seattle, WA, 98101, USA., Ben-Shlomo Y; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1QU, UK., Beswick A; Translational Health Sciences, Musculoskeletal Research Unit, Bristol Medical School, University of Bristol, Bristol, BS10 5NB, UK., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Bottinger EP; Hasso-Plattner-Institut, Universität Potsdam, Potsdam, 14469, Germany; Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, 10029, USA., Brody JA; Department of Medicine, University of Washington, Seattle, WA, 98101, USA., van Rooij FJA; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, 3015 GE, the Netherlands., Chitrala KN; Laboratory of Epidemiology and Population Science, National Institute on Aging/NIH, Baltimore, MD, 21224, USA., Wilson PWF; Atlanta VA Medical Center, Decatur, GA, 30033, USA., Choquet H; Division of Research, Kaiser Permanente Northern California, Oakland, CA, 94612, USA., Danesh J; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, CB10 1SA, UK; National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, CB1 8RN, UK., Di Angelantonio E; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, CB10 1SA, UK; National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, CB1 8RN, UK., Dimou N; Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, 69008, France; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece., Ding J; Department of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27101, USA., Elliott P; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK; Imperial Biomedical Research Centre, Imperial College London and Imperial College NHS Healthcare Trust, London, W2 1NY, UK; Medical Research Council Centre for Environment and Health, Imperial College London, London, W2 1PG, UK; UK Dementia Research Institute, Imperial College London, London, WC1E 6BT, UK; Health Data Research UK London, London, W2 1PG, UK., Esko T; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Evans MK; Laboratory of Epidemiology and Population Science, National Institute on Aging/NIH, Baltimore, MD, 21224, USA., Felix SB; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, 17475, Germany., Floyd JS; Department of Medicine, University of Washington, Seattle, WA, 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA, 98101, USA., Broer L; Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, 3015 GE, the Netherlands., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Guo MH; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA., Guo Q; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, UK., Greinacher A; Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, 17475, Germany., Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98101, USA., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Howson JMM; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, UK; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK; Novo Nordisk Research Centre Oxford, Oxford, OX3 7FZ, UK., Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI), Shanghai, 201203, China., Jorgenson E; Division of Research, Kaiser Permanente Northern California, Oakland, CA, 94612, USA., Kacprowski T; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany; Chair of Experimental Bioinformatics, Research Group Computational Systems Medicine, Technical University of Munich, Freising-Weihenstephan, 85354, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, 17475, Germany., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, 33521, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, 108-8639, Japan., Kanai M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA., Karthikeyan S; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, UK., Koskeridis F; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece., Lange LA; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, 80045, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, 2000, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Liu Y; Department of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 27701, USA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22903, USA., Matsuda K; Department of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of Tokyo, Tokyo, 108-8639, Japan., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA., Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland., Murakami Y; Division of Molecular Pathology, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan., Nadkarni GN; Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, 10029, USA., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, 33521, Finland; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Preuss M; Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, 10029, USA., Psaty BM; Departments of Epidemiology, University of Washington, Seattle, WA, 98101, USA; Department of Medicine, University of Washington, Seattle, WA, 98101, USA; Department of Health Services, University of Washington, Seattle, WA, 98101, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20521, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22903, USA., Rodriguez BAT; The Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, MA, 01702, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA, 01702, USA., Rosen JD; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, 27599, USA., Rotter JI; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Schubert P; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, 02130, USA., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA, 01002, USA., Surendran P; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, UK; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, CB1 8RN, UK; Health Data Research UK Cambridge, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK; Department of Public Health and Primary Care, Rutherford Fund Fellow, University of Cambridge, Cambridge, CB1 8RN, UK., Tang H; Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305, USA., Tardif JC; Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, 3015 GE, the Netherlands; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran., Völker U; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, 17475, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, 17475, Germany., Watkins NA; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge, CB2 0PT, UK., Weiss S; Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, 17475, Germany., Cai N; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Kundu K; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK., Watt SB; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Walter K; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Zonderman AB; Laboratory of Epidemiology and Population Science, National Institute on Aging/NIH, Baltimore, MD, 21224, USA., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, 02130, USA; Department of Medicine, Division on Aging, Brigham and Women's Hospital, Boston, MA, 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Li Y; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA; Department of Computer Science, University of North Carolina, Chapel Hill, NC, 27599, USA., Loos RJF; Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, 10029, USA., Knight JC; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Georges M; Unit of Animal Genomics, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, B-4000, Belgium., Stegle O; European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, CB10 1SA, UK., Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan; Laboratory of Statistical Immunology, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan., Roberts DJ; BRC Haematology Theme and Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK; NHSBT Blood and Transplant - Oxford Center, John Radcliffe Hospital, Oxford, OX3 9BQ, UK., Inouye M; Department of Public Health and Primary Care, Cambridge Baker Systems Genomics Initiative, University of Cambridge, Cambridge, CB1 8RN, UK; Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria, VIC 3004, Australia; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, UK; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, CB1 8RN, UK; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, CB10 1SA, UK; The Alan Turing Institute, London, NW1 2DB, UK., Johnson AD; The Framingham Heart Study, National Heart, Lung and Blood Institute, Framingham, MA, 01702, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, MA, 01702, USA., Auer PL; Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA., Astle WJ; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK; National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge, CB2 0PT, UK., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, 98109, USA., Butterworth AS; Department of Public Health and Primary Care, British Heart Foundation Cardiovascular Epidemiology Unit, University of Cambridge, Cambridge, CB1 8RN, UK; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, CB10 1SA, UK; National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, CB1 8RN, UK., Ouwehand WH; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge, CB2 0PT, UK; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK; National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, CB1 8RN, UK., Lettre G; Montreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, H3T 1J4, Canada., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. Electronic address: sankaran@broadinstitute.org., Soranzo N; Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK; National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK. Electronic address: ns6@sanger.ac.uk.

مؤلفون مشاركون: VA Million Veteran Program

المصدر: Cell [Cell] 2020 Sep 03; Vol. 182 (5), pp. 1214-1231.e11.

نوع المنشور: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease/*genetics , Multifactorial Inheritance/*genetics, Female ; Gene Regulatory Networks/genetics ; Genome-Wide Association Study/methods ; Hematopoiesis/genetics ; Humans ; Male ; Phenotype ; Polymorphism, Single Nucleotide/genetics

المؤلفون: Albers PK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom., McVean G; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom.

المصدر: PLoS biology [PLoS Biol] 2020 Jan 17; Vol. 18 (1), pp. e3000586. Date of Electronic Publication: 2020 Jan 17 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Validation Study

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Speciation* , Polymorphism, Single Nucleotide*, Genetics, Population/*methods , Racial Groups/*genetics, Age Factors ; Alleles ; Computer Simulation ; Datasets as Topic ; Evolution, Molecular ; Gene Frequency ; Genetic Variation ; Genome, Human ; High-Throughput Nucleotide Sequencing ; Humans ; Pedigree ; Phylogeny ; Sequence Analysis, DNA ; Statistics as Topic/methods ; Time Factors

المؤلفون: Cortes A; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK., Albers PK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Dendrou CA; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Fugger L; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK.; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Danish National Research Foundation Centre PERSIMUNE, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., McVean G; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. gil.mcvean@bdi.ox.ac.uk.

المصدر: Nature genetics [Nat Genet] 2020 Jan; Vol. 52 (1), pp. 126-134. Date of Electronic Publication: 2019 Dec 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Biological Specimen Banks* , Genetic Loci* , Genetic Predisposition to Disease* , Genome-Wide Association Study* , Polymorphism, Single Nucleotide* , Quantitative Trait, Heritable*, Genetic Diseases, Inborn/*genetics, Adult ; Aged ; Female ; Gene-Environment Interaction ; Humans ; Male ; Middle Aged ; Phenotype ; Prospective Studies ; Risk Factors ; United Kingdom

المؤلفون: Kelleher J; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. jerome.kelleher@bdi.ox.ac.uk., Wong Y; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Wohns AW; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Fadil C; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Albers PK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., McVean G; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.

المصدر: Nature genetics [Nat Genet] 2019 Nov; Vol. 51 (11), pp. 1660.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Kelleher J; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. jerome.kelleher@bdi.ox.ac.uk., Wong Y; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Wohns AW; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Fadil C; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Albers PK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., McVean G; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.

المصدر: Nature genetics [Nat Genet] 2019 Sep; Vol. 51 (9), pp. 1330-1338. Date of Electronic Publication: 2019 Sep 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Algorithms* , Evolution, Molecular* , Genetics, Population* , Genome, Human* , Pedigree* , Selection, Genetic*, Computer Simulation ; Datasets as Topic ; Haplotypes ; Humans ; Models, Genetic ; Mutation ; Polymorphism, Single Nucleotide ; Population Density

المؤلفون: Valli A; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom. alevalli14@gmail.com alessandro.valli@cardiologicomonzino.it.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Morotti M; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Zois CE; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Albers PK; The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Soga T; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan., Feldinger K; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Fischer R; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Frejno M; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., McIntyre A; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Bridges E; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Haider S; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Buffa FM; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom., Baban D; The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Rodriguez M; Metabolomics Platform, IISPV, Department of Electronic Engineering, Universitat Rovira i Virgili, Tarragona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders-CIBERDEM, Madrid, Spain., Yanes O; Metabolomics Platform, IISPV, Department of Electronic Engineering, Universitat Rovira i Virgili, Tarragona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders-CIBERDEM, Madrid, Spain., Whittington HJ; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Lake HA; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Zervou S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Lygate CA; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Kessler BM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Harris AL; Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

المصدر: Molecular cancer research : MCR [Mol Cancer Res] 2019 Jul; Vol. 17 (7), pp. 1531-1544. Date of Electronic Publication: 2019 Mar 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Colonic Neoplasms/*genetics , Energy Metabolism/*genetics , Glucose Transport Proteins, Facilitative/*genetics , Hypoxia-Inducible Factor 1, alpha Subunit/*genetics, Colonic Neoplasms/pathology ; Creatine/genetics ; Creatine/metabolism ; Fructose-Bisphosphate Aldolase/genetics ; Glucose/metabolism ; Glycolysis/genetics ; HCT116 Cells ; Humans ; Spheroids, Cellular/metabolism ; Tumor Hypoxia/genetics

المؤلفون: Moutsianas L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Agarwala V; Program in Biophysics, Harvard University, Cambridge, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America., Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Flannick J; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America., Rivas MA; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Gaulton KJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Albers PK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., McVean G; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Altshuler D; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America; Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America., McCarthy MI; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom.

مؤلفون مشاركون: GoT2D Consortium

المصدر: PLoS genetics [PLoS Genet] 2015 Apr 23; Vol. 11 (4), pp. e1005165. Date of Electronic Publication: 2015 Apr 23 (Print Publication: 2015).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Diseases, Inborn* , Genetic Variation* , Genome-Wide Association Study* , Models, Theoretical*, Alleles ; Computer Simulation ; Diabetes Mellitus, Type 2/genetics ; Exome/genetics ; Genetic Predisposition to Disease ; Humans ; Linkage Disequilibrium ; Phenotype

المؤلفون: Raposo do Amaral F; Departamento de Genética e Biologia Evolutiva, Universidade de São Paulo, Rua do Matão, 277, Cidade Universitária, São Paulo, SP, CEP 05508-090, Brazil. fabioraposo@gmail.com, Albers PK, Edwards SV, Miyaki CY

المصدر: Molecular ecology [Mol Ecol] 2013 Aug; Vol. 22 (15), pp. 3996-4013. Date of Electronic Publication: 2013 Jun 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9214478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-294X (Electronic) Linking ISSN: 09621083 NLM ISO Abbreviation: Mol Ecol Subsets: MEDLINE

مواضيع طبية MeSH: Biodiversity* , Genetic Variation*, DNA, Mitochondrial/*genetics , Passeriformes/*genetics, Animals ; Ecosystem ; Evolution, Molecular ; Genetic Markers/genetics ; Haplotypes/genetics ; Phylogeography ; Reproductive Isolation ; Sequence Analysis, DNA