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1
المؤلفون: Peng Gao, Paolo Vincetti, Fabio Maria Sabbatini, Holly J. Carlisle, Luisa Mengatto, Stéphane De Lombaert, Anna Sava, Kerry Zobel, Xinying Liu, Claudia Beato, Jessica M. Bright, Alyssa M. A. Toda, Elena Serra, Federica Budassi, Marco Migliore, Laura Caberlotto, Cristiana Griffante, Silvia Bernardi, Mingliang Zhang, Albert W. Garofalo, Daniele Andreotti
المصدر: Journal of Medicinal Chemistry. 63:14821-14839
مصطلحات موضوعية: Indazoles, Tetrazoles, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 01 natural sciences, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, Animals, Humans, Kinase activity, Protein Kinase Inhibitors, Gene, 030304 developmental biology, 0303 health sciences, Molecular Structure, Chemistry, Kinase, Highly selective, LRRK2, High-Throughput Screening Assays, nervous system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Pyrimidines, Mutation, Cancer research, Molecular Medicine
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2
المؤلفون: Romas Alvydas Kudirka, Robyn M. Barfield, David Rabuka, Albert W. Garofalo, Penelope M. Drake, Wes Zmolek, Adam Carlson, Jesse M. McFarland, Stefanie Bañas
المصدر: ACS Medicinal Chemistry Letters. 7:994-998
مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Pyrazolone, 010402 general chemistry, 01 natural sciences, Biochemistry, Aldehyde, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Drug Discovery, Michael reaction, medicine, Moiety, Knoevenagel condensation, Chemical ligation, Ligation, Enone, medicine.drug
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3
المؤلفون: Robyn M. Barfield, Gregory W. de Hart, Jesse M. McFarland, David Rabuka, Albert W. Garofalo, Penelope M. Drake, Stefanie Bañas, Patrick G. Holder, Lesley C. Jones, Romas Alvydas Kudirka, Aaron Edward Albers
المصدر: Chemistry & Biology. 22:293-298
مصطلحات موضوعية: Immunoconjugates, Cell Survival, Clinical Biochemistry, Antineoplastic Agents, 010402 general chemistry, 01 natural sciences, Biochemistry, Aldehyde, Catalysis, Nucleophile, Cell Line, Tumor, Drug Discovery, Humans, Organic chemistry, Neutral ph, Molecular Biology, Brentuximab Vedotin, Pharmacology, chemistry.chemical_classification, Bioconjugation, 010405 organic chemistry, technology, industry, and agriculture, Proteins, Regioselectivity, General Medicine, Hydrogen-Ion Concentration, Trastuzumab, Combinatorial chemistry, Carbon, 0104 chemical sciences, chemistry, Pyrazoles, Molecular Medicine, Bioorthogonal chemistry, Ligation, Conjugate
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4
المؤلفون: Penelope M. Drake, Jeanne Baker, Stefanie Bañas, Aaron Edward Albers, Robyn M. Barfield, David Rabuka, Romas Alvydas Kudirka, Gregory W. de Hart, Albert W. Garofalo
المصدر: European Journal of Medicinal Chemistry. 88:3-9
مصطلحات موضوعية: Antibody-drug conjugate, Immunoconjugates, Molecular Conformation, Antineoplastic Agents, Context (language use), Mice, SCID, Conjugated system, Antibodies, Mice, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Animals, Humans, Potency, Cell Proliferation, Pharmacology, Organic Chemistry, Mammary Neoplasms, Experimental, General Medicine, Combinatorial chemistry, Small molecule, chemistry, Aldehyde tag, Drug Screening Assays, Antitumor, Linker, Conjugate
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5
المؤلفون: Jeanne Baker, David Rabuka, Wes Zmolek, Jesse M. McFarland, Penelope M. Drake, Robyn M. Barfield, Lesley C. Jones, Abhijit Bhat, Albert W. Garofalo, Gregory W. de Hart, Stefanie Bañas, Romas Alvydas Kudirka, Aaron Edward Albers, Patrick G. Holder
المصدر: Bioconjugate Chemistry
مصطلحات موضوعية: Immunoconjugates, Receptor, ErbB-2, Stereochemistry, Biomedical Engineering, Pharmaceutical Science, Antineoplastic Agents, Breast Neoplasms, Bioengineering, Mice, SCID, Conjugated system, Aldehyde, Article, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Tumor Cells, Cultured, Animals, Humans, Structure–activity relationship, Tissue Distribution, Cell Proliferation, Pharmacology, chemistry.chemical_classification, Aldehydes, Molecular Structure, biology, Organic Chemistry, Antibodies, Monoclonal, Xenograft Model Antitumor Assays, Rats, 3. Good health, body regions, chemistry, Aldehyde tag, biology.protein, Female, Antibody, Linker, Biotechnology, Conjugate
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6
المؤلفون: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
المصدر: Journal of Medicinal Chemistry. 56:5261-5274
مصطلحات موضوعية: Trifluoromethyl, biology, Stereochemistry, Quinoline, In vitro, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Chirality (chemistry), Amyloid precursor protein secretase, Semagacestat, medicine.drug
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7
المؤلفون: Kevin P. Quinn, Marc Adler, Gary Probst, Albert W. Garofalo, Anh P. Truong, Danny Tam, Erich Goldbach, Danielle L. Aubele, Maurizio Franzini, David Chian, Grace Kwong, Xiaocong M. Ye, Zhao Ren, Hing L. Sham, Lany Ruslim, Pearl Tanaka, Elizabeth F. Brigham, Ruth Motter
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1974-1977
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, MAP3K7, Biochemistry, MAP2K7, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Mice, Knockout, Dose-Response Relationship, Drug, Molecular Structure, biology, Cyclin-dependent kinase 4, Chemistry, Organic Chemistry, Cyclin-dependent kinase 2, Protein kinase R, nervous system diseases, HEK293 Cells, Mutation, Quinolines, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9
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8
المؤلفون: Anh P. Truong, Shawn Gauby, Pam Santiago, Xiaocong M. Ye, Danielle L. Aubele, Marc Adler, Danny Tam, Albert W. Garofalo, Maurizio Franzini, Hing L. Sham, Erich Goldbach, Gary Probst, Zhao Ren, Kevin P. Quinn
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1967-1973
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Mutant, Pharmaceutical Science, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Kinase, Organic Chemistry, HEK 293 cells, Wild type, LRRK2, nervous system diseases, Pyridazines, HEK293 Cells, Molecular Medicine, Bioisostere
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9
المؤلفون: Colin Lorentzen, Maurizio Franzini, Anh P. Truong, R. Jeffrey Neitz, Marc Adler, Danielle L. Aubele, Pam Santiago, Hing L. Sham, Albert W. Garofalo, Simeon Bowers, Xiaocong M. Ye, Danny Tam, Kevin P. Quinn, Gary Probst, Zhao Ren, Erich Goldbach
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:71-74
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Transfection, Heterocyclic Compounds, 2-Ring, Biochemistry, MAP2K7, Mice, TANK-binding kinase 1, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Binding Sites, biology, Cyclin-dependent kinase 4, Chemistry, Organic Chemistry, Cyclin-dependent kinase 2, Amides, Protein kinase R, Protein Structure, Tertiary, nervous system diseases, Molecular Docking Simulation, HEK293 Cells, Mutation, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9, Protein Binding
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المؤلفون: Jacek Jagodzinski, Raymond A. Ng, Hing L. Sham, Albert W. Garofalo, Semko Christopher M, Minghua Sun, Xiaocong Michael Ye, Andrei W. Konradi
المصدر: Chemical and Pharmaceutical Bulletin. 60:1063-1066
مصطلحات موضوعية: Reaction conditions, chemistry.chemical_classification, Stereochemistry, Nitrilimine, Diastereomer, Alkyne, General Chemistry, General Medicine, Pyrazole, Cycloaddition, chemistry.chemical_compound, chemistry, Intramolecular force, Drug Discovery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b0f7230419daa457434434e47b2e8f6e
https://doi.org/10.1248/cpb.c110498
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