المؤلفون: Aldfer MM; School of Infection and Immunity, Sir Graeme Davies Building, 120 University Place, University of Glasgow, GlasgowG12 8TA, UK., Hulpia F; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, 9000 Gent, Belgium., van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, 9000 Gent, Belgium., De Koning HP; School of Infection and Immunity, Sir Graeme Davies Building, 120 University Place, University of Glasgow, GlasgowG12 8TA, UK. Electronic address: Harry.de-Koning@glasgow.ac.uk.

المصدر: Molecular and biochemical parasitology [Mol Biochem Parasitol] 2024 Jun; Vol. 258, pp. 111616. Date of Electronic Publication: 2024 Feb 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8006324 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9428 (Electronic) Linking ISSN: 01666851 NLM ISO Abbreviation: Mol Biochem Parasitol Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma cruzi*/metabolism , Trypanosoma cruzi*/genetics , Trypanosoma cruzi*/chemistry , Guanine*/metabolism , Hypoxanthine*/metabolism, Protozoan Proteins/metabolism ; Protozoan Proteins/genetics ; Protozoan Proteins/chemistry ; Nucleobase Transport Proteins/metabolism ; Nucleobase Transport Proteins/genetics ; Nucleobase Transport Proteins/chemistry ; Biological Transport ; Substrate Specificity ; Protein Binding ; Nucleosides/metabolism

المؤلفون: Ungogo MA; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.; Department of Veterinary Pharmacology and Toxicology, Ahmadu Bello University, Zaria 810107, Kaduna State, Nigeria.; Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, UK., Aldfer MM; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Natto MJ; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Zhuang H; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Chisholm R; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Walsh K; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., McGee M; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Ilbeigi K; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, B-2610 Wilrijk, Belgium., Asseri JI; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Burchmore RJS; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, B-2610 Wilrijk, Belgium., Van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, B-9000 Gent, Belgium., De Koning HP; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 05; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosomiasis, African*/parasitology , Trypanosoma congolense*, Animals ; Nucleosides/therapeutic use ; Tubercidin/therapeutic use ; Adenosine/therapeutic use ; Cloning, Molecular

المؤلفون: Fiuza LFA; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, Rio de Janeiro 21040-360, Brazil., Batista DGJ; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, Rio de Janeiro 21040-360, Brazil., Girão RD; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, Rio de Janeiro 21040-360, Brazil., Hulpia F; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium., Finamore-Araújo P; Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro 20000-000, Brazil., Aldfer MM; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow 62694, UK., Elmahallawy EK; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow 62694, UK.; Department of Zoonoses, Faculty of Veterinary Medicine, Sohag University, Sohag 82524, Egypt., De Koning HP; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow 62694, UK., Moreira O; Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro 20000-000, Brazil., Van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium., Soeiro MNC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, 4365 Manguinhos, Rio de Janeiro 21040-360, Brazil.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2022 Nov 21; Vol. 27 (22). Date of Electronic Publication: 2022 Nov 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Trypanocidal Agents*/pharmacology , Trypanocidal Agents*/therapeutic use , Trypanocidal Agents*/chemistry , Chagas Disease*/drug therapy , Trypanosoma cruzi*, Mice ; Animals ; Nucleosides/pharmacology ; Nucleosides/therapeutic use ; Parasitemia/drug therapy ; Mammals

المؤلفون: Aldfer MM; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Alfayez IA; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Elati HAA; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Gayen N; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK., Elmahallawy EK; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.; Department of Zoonoses, Faculty of Veterinary Medicine, Sohag University, Sohag 82524, Egypt., Milena Murillo A; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil., Marsiccobetre S; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil., Van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, B-9000 Gent, Belgium., Silber AM; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil., de Koning HP; School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2022 Nov 19; Vol. 27 (22). Date of Electronic Publication: 2022 Nov 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma cruzi* , Chagas Disease*/drug therapy, Humans ; Nucleoside Transport Proteins ; Tubercidin ; Biological Transport ; Deoxyuridine

المؤلفون: Aldfer MM; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., AlSiari TA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Elati HAA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Natto MJ; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Alfayez IA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Campagnaro GD; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Sani B; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Burchmore RJS; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK., Diallinas G; Department of Biology, National and Kapodistrian University of Athens, Panepistimioupolis, 15784 Athens, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, 70013 Heraklion, Greece., De Koning HP; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Jul 23; Vol. 23 (15). Date of Electronic Publication: 2022 Jul 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Leishmania mexicana*/genetics, Biological Transport ; Equilibrative Nucleoside Transport Proteins/metabolism ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Nucleosides/metabolism ; Purines/metabolism ; Pyrimidines/metabolism ; Uracil/metabolism

المؤلفون: Cisneros D; Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain., Cueto-Díaz EJ; Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain., Medina-Gil T; Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain., Chevillard R; Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain., Bernal-Fraile T; Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain., López-Sastre R; Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain., Aldfer MM; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom., Ungogo MA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom., Elati HAA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom., Arai N; Graduate School of Science and Technology, Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan., Otani M; Graduate School of Science and Technology, Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan., Matsushiro S; Graduate School of Science and Technology, Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan., Kojima C; Graduate School of Science and Technology, Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan., Ebiloma GU; Graduate School of Science and Technology, Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan.; School of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BX, United Kingdom., Shiba T; Graduate School of Science and Technology, Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan., de Koning HP; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom., Dardonville C; Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, E-28006 Madrid, Spain.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Jan 28; Vol. 13 (2), pp. 312-318. Date of Electronic Publication: 2022 Jan 28 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Robertson J; Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK., Ungogo MA; Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Aldfer MM; Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Lemgruber L; Glasgow Imaging Facility, Institute of Infection, Immunity, and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., McWhinnie FS; Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK., Bode BE; EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK., Jones KL; GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK., Watson AJB; EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK., de Koning HP; Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Burley GA; Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.

المصدر: ChemMedChem [ChemMedChem] 2021 Nov 19; Vol. 16 (22), pp. 3396-3401. Date of Electronic Publication: 2021 Sep 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Development*, Amidines/*pharmacology , Antiparasitic Agents/*pharmacology , Leishmania mexicana/*drug effects , Pentamidine/*pharmacology, Amidines/chemistry ; Antiparasitic Agents/chemical synthesis ; Antiparasitic Agents/chemistry ; Dose-Response Relationship, Drug ; Drug Resistance/drug effects ; Molecular Structure ; Parasitic Sensitivity Tests ; Pentamidine/chemical synthesis ; Pentamidine/chemistry ; Structure-Activity Relationship