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المؤلفون: Ulrike Glaenzel, Ad Roffel, Hubert Borell, Gian Camenisch, Yan Ji, Cyrille Marvalin, Hilmar Schiller, Yi Jin, Alexander David James
المصدر: Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 8, Iss 3, Pp n/a-n/a (2020)مصطلحات موضوعية: Male, Metabolite, Placenta, ADME Study, Administration, Oral, Aminopyridines, Antineoplastic Agents, Urine, RM1-950, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Species Specificity, In vivo, Pregnancy, Ribociclib, preclinical, Animals, Humans, Lactation, Tissue Distribution, human, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, ADME, CYP3A4, Chemistry, Cyclin-Dependent Kinase 4, Original Articles, Cyclin-Dependent Kinase 6, Kisquali, Rats, Neurology, Purines, 030220 oncology & carcinogenesis, Renal physiology, Original Article, Female, Therapeutics. Pharmacology, Rabbits, Drug metabolism
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المؤلفون: Axel Meissner, Ulrike Glaenzel, Gian Camenisch, Eric Legangneux, Sjoerd Peter van Marle, Hubert Borell, Robert Nufer, Kirsten Schroer, Alexander David James, Yi Jin, Wenkui Li, Sylvie Adam-Stitah, Anne Gardin
المصدر: Drug Metabolism and Disposition. 46:1001-1013
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, biology, CYP3A4, Metabolite, Glucuronidation, Pharmaceutical Science, Cytochrome P450, Metabolism, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Siponimod, chemistry, Microsome, biology.protein, 030217 neurology & neurosurgery, ADME
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::03d15a91303385d4488bb9542e37609d
https://doi.org/10.1124/dmd.117.079574 -
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المؤلفون: Cornelis E. C. A. Hop, Swapan Chowdhury, Douglas K. Spracklin, Simone Schadt, Christoph Funk, W. Griffith Humphreys, Angus N. R. Nedderman, Fumihiko Igarashi, Josh Yuan, Chandra Prakash, Frank Runge, Holger Scheible, Mark Kagan, S. Cyrus Khojasteh, Piet Swart, R. Scott Obach, Bojan Bister, Alexander David James, Susanna Tse
المصدر: BASE-Bielefeld Academic Search Engine
مصطلحات موضوعية: 0301 basic medicine, Drug Industry, Metabolite, Pharmaceutical Science, Human metabolism, Computational biology, 030226 pharmacology & pharmacy, Food and drug administration, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Animals, Humans, Medicine, Drug Interactions, Safety testing, Pharmaceutical industry, Pharmacology, United States Food and Drug Administration, business.industry, United States, 030104 developmental biology, Pharmaceutical Preparations, chemistry, Drug development, Inactivation, Metabolic, Experimental methods, business, Drug metabolism
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c0739606a23742034a3be6254e08fa
https://doi.org/10.1124/dmd.117.079848 -
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المصدر: Drug Metabolism and Disposition. 45:900-907
مصطلحات موضوعية: Pharmacology, Chromatography, Chemistry, Balance study, Absolute quantification, 010401 analytical chemistry, ADME Study, Analytical chemistry, Late stage, Pharmaceutical Science, Fluorine-19 NMR, Mass spectrometry, 030226 pharmacology & pharmacy, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, 0302 clinical medicine, Metabolite profiling, ADME
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eb43168c156aca0c45787e92caf0f1b3
https://doi.org/10.1124/dmd.117.075424 -
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مصطلحات موضوعية: Pharmacology, Delta, Chemistry, Kinase, Health, Toxicology and Mutagenesis, General Medicine, Fluorine-19 NMR, Metabolism, Absorption (skin), Toxicology, 030226 pharmacology & pharmacy, Biochemistry, Excretion, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, 030220 oncology & carcinogenesis, Phosphatidylinositol, PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed72ab5aa1cb1ac6d3e216ef06705de2
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المؤلفون: Alexander David, James, Cyrille, Marvalin, Alexandre, Luneau, Axel, Meissner, Gian, Camenisch
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 45(8)
مصطلحات موضوعية: Male, Thiazoles, Magnetic Resonance Spectroscopy, Humans, Carbon Radioisotopes, Fluorine, Magnetic Resonance Imaging, Mass Spectrometry, Chromatography, Liquid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::8ae3b5ff20d43cb4a28131f272e48086
https://pubmed.ncbi.nlm.nih.gov/28566285 -
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المؤلفون: Lars Blumenstein, Alexander David James, Regine Hansen, Katharine Hazell, Ulrike Glaenzel, Lucia Trandafir, Arnold Demailly, Piet Swart, Yi Jin, Anuradha Mehta, Annamaria Jakab
المصدر: Cancer chemotherapy and pharmacology. 76(4)
مصطلحات موضوعية: Adult, Male, Cancer Research, Adolescent, Metabolic Clearance Rate, Metabolite, Glucuronidation, Antineoplastic Agents, Urine, Pharmacology, Toxicology, Intestinal absorption, Excretion, chemistry.chemical_compound, Feces, Young Adult, Pharmacokinetics, Intestinal Elimination, Humans, Pharmacology (medical), Tissue Distribution, Carbon Radioisotopes, Enzyme Inhibitors, Biotransformation, ADME, Phosphoinositide-3 Kinase Inhibitors, Chemistry, Hydrolysis, Primary metabolite, Middle Aged, Renal Elimination, Thiazoles, Oncology, Intestinal Absorption, Follow-Up Studies, Half-Life
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المؤلفون: Alexander-David James, Bernd Rosenkranz, Pius S. Fasinu, Patrick J. Bouic, Hilmar Schiller, Heike Gutmann
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 41(2)
مصطلحات موضوعية: Male, Organic anion transporter 1, Swine, Pharmaceutical Science, Organic Anion Transporters, Pharmacology, Organic Anion Transporters, Sodium-Independent, Madin Darby Canine Kidney Cells, Substrate Specificity, Hydroxylation, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, ATP Binding Cassette Transporter, Subfamily G, Member 2, Cytochrome P-450 Enzyme Inhibitors, Testosterone, Enzyme Inhibitors, Biotransformation, biology, Liver-Specific Organic Anion Transporter 1, Fabaceae, Neoplasm Proteins, Organic anion-transporting polypeptide, Isoenzymes, Dose–response relationship, Microsomes, Liver, Female, ATP Binding Cassette Transporter, Subfamily B, Midazolam, Herb-Drug Interactions, Transfection, Solute Carrier Organic Anion Transporter Family Member 1B3, Dogs, Membrane Transport Modulators, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Plants, Medicinal, CYP3A4, Dose-Response Relationship, Drug, CYP1A2, Membrane Transport Proteins, Biological Transport, biology.organism_classification, Plant Leaves, Kinetics, HEK293 Cells, chemistry, Sutherlandia frutescens, Microsome, biology.protein, Hepatocytes, LLC-PK1 Cells, ATP-Binding Cassette Transporters, Plant Preparations
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca64aa2594f850d18b056dcf71d2111
https://pubmed.ncbi.nlm.nih.gov/23209194