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المؤلفون: Melissa Cadena, Roberto Silva Villatoro, Jyoti Shah Gupta, Cody Phillips, Jonathan B. Allen, Hadi D. Arman, Daniel J. Wherritt, Nicholas A. Clanton, Alexander L. Ruchelman, Eric M. Simmons, Albert J. DelMonte, John R. Coombs, Doug E. Frantz
المصدر: ACS Catalysis. 12:10199-10206
مصطلحات موضوعية: General Chemistry, Catalysis
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2
المؤلفون: Alexander L. Ruchelman, Longqin Hu
المصدر: Medicinal Chemistry Research. 31:1621-1622
مصطلحات موضوعية: Organic Chemistry, General Pharmacology, Toxicology and Pharmaceutics
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3
المؤلفون: Kevin Ronald Condroski, Matt Hickman, Wei Liu, Laurie LeBrun, Gilles Carmel, Joshua Hansen, Gang Lu, Afshin Mahmoudi, Frans Baculi, Correa Matthew D, Tim Crea, Hon-Wah Man, George W. Muller, Chin-Chun Lu, Alexander L. Ruchelman, Fan Vocanson, Weihong Zhang
المصدر: Journal of Medicinal Chemistry. 61:492-503
مصطلحات موضوعية: 0301 basic medicine, Quantitative structure–activity relationship, biology, 010405 organic chemistry, Chemistry, Stereochemistry, Cereblon, Glutarimide, Protein degradation, 01 natural sciences, Molecular Docking Simulation, 0104 chemical sciences, Ubiquitin ligase, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Biochemistry, Docking (molecular), Drug Discovery, biology.protein, Molecular Medicine, Ternary complex
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4
المؤلفون: Alexander L. Ruchelman, Jack Houston, Nai-Yu Wang, Lyn'Al Nosaka, Antonia Lopez-Girona, Takumi Ito, Gilles Carmel, Mary E Matyskiela, Wei Fang, Derek Nguyen, Philip P Chamberlain, Thomas O. Daniel, Karen Miller, Chin-Chun Lu, Barbra Pagarigan, Svetlana Gaidarova, Gang Lu, Shuichan Xu, James Carmichael, Tam Tran, Gabriel C. Lander, Mariko Riley, Brian E. Cathers, Hiroshi Handa
المصدر: Nature. 535:252-257
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Ubiquitin-Protein Ligases, Amino Acid Motifs, Antineoplastic Agents, Plasma protein binding, Crystallography, X-Ray, 01 natural sciences, DNA-binding protein, Substrate Specificity, Ikaros Transcription Factor, 03 medical and health sciences, Ubiquitin, Humans, Adaptor Proteins, Signal Transducing, chemistry.chemical_classification, DNA ligase, Binding Sites, Multidisciplinary, biology, 010405 organic chemistry, Chemistry, Phenylurea Compounds, Cereblon, Thalidomide, 0104 chemical sciences, Ubiquitin ligase, Cell biology, DNA-Binding Proteins, 030104 developmental biology, Multiprotein Complexes, Proteolysis, biology.protein, Degron, Peptide Hydrolases, Peptide Termination Factors, Protein Binding
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5
المؤلفون: Alexander L. Ruchelman, Connolly Terrence Joseph
المصدر: Tetrahedron: Asymmetry. 26:553-559
مصطلحات موضوعية: Active ingredient, chemistry.chemical_classification, Ketone, Organic Chemistry, Asymmetric hydrogenation, High selectivity, Enantioselective synthesis, Catalysis, Enamine, Inorganic Chemistry, chemistry.chemical_compound, chemistry, medicine, Organic chemistry, Apremilast, Physical and Theoretical Chemistry, medicine.drug
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6
المؤلفون: Alice Collette, Rama K. Narla, Heather Raymon, Alexander L. Ruchelman, Hon-Wah Man, Roger Shen-Chu Chen, Jim Leisten, George W. Muller, Ling Lu, Ling Zhang, Wei Liu, Dorota Cedzik
المصدر: Bioorganic & Medicinal Chemistry. 19:6356-6374
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Nitrile, Phosphodiesterase Inhibitors, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Alkenes, Molecular Dynamics Simulation, Biochemistry, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Tubulin, Drug Discovery, Benzene Derivatives, Animals, Humans, Structure–activity relationship, Derivatization, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Alkene, Aryl, Organic Chemistry, Nuclear magnetic resonance spectroscopy, HCT116 Cells, Tubulin Modulators, Cyclic Nucleotide Phosphodiesterases, Type 4, Amino acid, chemistry, Molecular Medicine, Pharmacophore, Colorectal Neoplasms
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المؤلفون: John E. Kerrigan, Edmond J. LaVoie, Leroy F. Liu, Tsai-Kun Li, Angela Liu, Nai Zhou, Alexander L. Ruchelman
المصدر: Bioorganic & Medicinal Chemistry. 12:3731-3742
مصطلحات موضوعية: Tertiary amine, Nitrogen, Stereochemistry, Static Electricity, Clinical Biochemistry, Molecular Conformation, Substituent, Nitro compound, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Chemical synthesis, Methylenedioxy, Inhibitory Concentration 50, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Moiety, Enzyme Inhibitors, Naphthyridines, Molecular Biology, Amination, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, DNA, DNA Topoisomerases, Type I, chemistry, Nitro, Lactam, Molecular Medicine, Topoisomerase I Inhibitors
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المؤلفون: Leroy F. Liu, Angela Liu, Sudhir Kumar Singh, Nai Zhou, Alexander L. Ruchelman, Edmond J. La Voie
المصدر: Letters in Drug Design & Discovery. 1:198-202
مصطلحات موضوعية: Stereochemistry, Chemistry, Drug Discovery, medicine, Pharmaceutical Science, Molecular Medicine, Tumor cells, Cytotoxicity, Camptothecin, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bcf9544af73efb4011f700d65aff4483
https://doi.org/10.2174/1570180043399064 -
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المؤلفون: Jin Ming Yang, Angela Liu, Alexander L. Ruchelman, Edmond J. LaVoie, Sudhir K. Singh, Leroy-Fong Liu, Xiaohua Wu, Abhijit Ray, Nai Zhou
المصدر: Bioorganic & Medicinal Chemistry. 12:795-806
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Substituent, Mice, Nude, Pharmaceutical Science, Antineoplastic Agents, Heterocyclic Compounds, 2-Ring, Biochemistry, Chemical synthesis, Methylenedioxy, Cell Line, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Ethyl group, Cytotoxicity, Molecular Biology, Molecular Structure, biology, Chemistry, Topoisomerase, Organic Chemistry, DNA, DNA Topoisomerases, Type I, Enzyme inhibitor, biology.protein, Molecular Medicine, Female, Topoisomerase I Inhibitors, Topotecan, Neoplasm Transplantation
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المؤلفون: Edmond J. LaVoie, Leroy-Fong Liu, Angela Liu, Alexander L. Ruchelman, Sudhir K. Singh, Tsai-Kun Li, Xiao Hua Wu, Jin Ming Yang, Abhijit Ray
المصدر: Bioorganic & Medicinal Chemistry. 11:2061-2073
مصطلحات موضوعية: Male, Tertiary amine, Stereochemistry, Clinical Biochemistry, Substituent, Mice, Nude, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Mice, chemistry.chemical_compound, Drug Delivery Systems, In vivo, Drug Discovery, Animals, Humans, Potency, Ethyl group, Naphthyridines, Cytotoxicity, Molecular Biology, biology, Topoisomerase, Organic Chemistry, Xenograft Model Antitumor Assays, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Female, Topoisomerase I Inhibitors