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1
المؤلفون: Alexander M. Taylor, Chris Bailey, Lisa D. Belmont, Robert Campbell, Nico Cantone, Alexandre Côté, Terry D. Crawford, Richard Cummings, Kevin DeMent, Martin Duplessis, Megan Flynn, Andrew C. Good, Hon-Ren Huang, Shivangi Joshi, Yves Leblanc, Jeremy Murray, Christopher G. Nasveschuk, Adrianne Neiss, Florence Poy, F. Anthony Romero, Peter Sandy, Yong Tang, Vickie Tsui, Laura Zawadzke, Robert J. Sims, James E. Audia, Steven F. Bellon, Steven R. Magnuson, Brian K. Albrecht, Andrea G. Cochran
المصدر: Journal of medicinal chemistry. 65(16)
مصطلحات موضوعية: DNA-Binding Proteins, Protein Domains, Drug Discovery, DNA Helicases, Molecular Medicine, Humans, Nuclear Proteins, Transcription Factors
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2
المؤلفون: Shumei Wang, Peter Sandy, Christopher G. Nasveschuk, Terry Crawford, Brian K. Albrecht, Andrea G. Cochran, Steffan Vartanian, Hon-Ren Huang, Vickie Tsui, David Stokoe, Steve Bellon, Yong Tang, E. Megan Flynn, Jian Wang, James R. Kiefer, Jeremy Murray, F. Anthony Romero, Laura Zawadzke, Michael C. Hewitt, Martin Duplessis, Alexander M. Taylor, Eneida Pardo, Alexandre Côté, Steven Magnuson
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3534-3541
مصطلحات موضوعية: 0301 basic medicine, Pyridones, Clinical Biochemistry, Population, Drug Resistance, Pharmaceutical Science, Drug resistance, Pharmacology, Biochemistry, Aldehyde Dehydrogenase 1 Family, Epigenesis, Genetic, Small Molecule Libraries, 03 medical and health sciences, Drug tolerance, Cell Line, Tumor, Drug Discovery, Gene expression, Humans, Epigenetics, education, Molecular Biology, education.field_of_study, biology, Chemistry, Organic Chemistry, Retinal Dehydrogenase, Aldehyde Dehydrogenase, Chromatin, Bromodomain, Molecular Docking Simulation, 030104 developmental biology, Histone, Drug Resistance, Neoplasm, Drug Design, biology.protein, Cancer research, Molecular Medicine, Transcription Factors
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3
المؤلفون: Arianne Neiss, Martin Duplessis, Hariharan Jayaram, Shumei Wang, F. Anthony Romero, Christopher G. Nasveschuk, Daniel J. Burdick, James E. Audia, Terry Crawford, Steve Bellon, Hon-Ren Huang, Zhaowu Xu, Yongyun Wang, Ying Jiang, Michael C. Hewitt, Jeremy Murray, Andrea G. Cochran, Peter Sandy, Yong Tang, Brian K. Albrecht, E. Megan Flynn, James R. Kiefer, Archana Bommi-Reddy, Jian Wang, Laura Zawadzke, Shivangi Joshi, Vickie Tsui, Xiaoqin Zhu, Alexander M. Taylor, Robert J. Sims, Eneida Pardo, Alexandre Côté, Steven Magnuson, Richard T. Cummings
المصدر: ACS Medicinal Chemistry Letters. 8:737-741
مصطلحات موضوعية: 0301 basic medicine, Genetics, Organic Chemistry, Lysine, Transcription inhibitor, Biology, Biochemistry, In vitro, Bromodomain, 03 medical and health sciences, 030104 developmental biology, Acetylation, Drug Discovery, Cancer research, Epigenetics, Cat eye syndrome chromosome region
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4
المؤلفون: Shumei Wang, Vickie Tsui, Terry D. Crawford, James E. Audia, Daniel J. Burdick, Maureen H. Beresini, Alexandre Côté, Richard Cummings, Martin Duplessis, E. Megan Flynn, Michael C. Hewitt, Hon-Ren Huang, Hariharan Jayaram, Ying Jiang, Shivangi Joshi, Jeremy Murray, Christopher G. Nasveschuk, Eneida Pardo, Florence Poy, F. Anthony Romero, Yong Tang, Alexander M. Taylor, Jian Wang, Zhaowu Xu, Laura E. Zawadzke, Xiaoyu Zhu, Brian K. Albrecht, Steven R. Magnuson, Steve Bellon, Andrea G. Cochran
المصدر: Journal of medicinal chemistry. 61(20)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, 010405 organic chemistry, Protein Conformation, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, Protein Domains, Drug Design, Molecular Probes, Drug Discovery, Molecular Medicine, Humans, Benzimidazoles, Transcription Factor TFIID
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المؤلفون: Robert M. Campbell, Yves Leblanc, James E. Audia, Jennifer A. Mertz, Brian K. Albrecht, Michael R. Cooper, Jeffrey G. Supko, Emmanuel Normant, Florence Poy, Christopher G. Nasveschuk, Richard T. Cummings, Michael C. Hewitt, Adrianne Neiss, Victor S. Gehling, Louise Bergeron, Jean-Christophe Harmange, Peter Sandy, Michael O'Meara, Alexander M. Taylor, Robert J. Sims, Nico Cantone, Eneida Pardo, Alexandre Côté, Shivangi Joshi, Hariharan Jayaram, Rishi G. Vaswani, Steve Bellon
المصدر: Journal of Medicinal Chemistry. 59:1330-1339
مصطلحات موضوعية: 0301 basic medicine, Genes, myc, Antineoplastic Agents, Cell Cycle Proteins, Biology, Proto-Oncogene Proteins c-myc, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, In vivo, Cell Line, Tumor, Drug Discovery, Gene expression, Animals, Humans, Nuclear protein, Transcription factor, Gene, Clinical Trials as Topic, Nuclear Proteins, hemic and immune systems, Azepines, Xenograft Model Antitumor Assays, Molecular biology, Rats, Bromodomain, Chromatin, Gene Expression Regulation, Neoplastic, Leukemia, Myeloid, Acute, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Transcription Factors
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المؤلفون: Terry Crawford, F. Anthony Romero, Alexander M. Taylor, Alexandre Côté, Steven Magnuson, Vickie Tsui
المصدر: Journal of Medicinal Chemistry. 59:1271-1298
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein family, Chromosomal Proteins, Non-Histone, Cell Cycle Proteins, Nerve Tissue Proteins, Computational biology, Protein Serine-Threonine Kinases, DNA-binding protein, Histones, Small Molecule Libraries, 03 medical and health sciences, Drug Discovery, Animals, Humans, CREB-binding protein, Adaptor Proteins, Signal Transducing, Adenosine Triphosphatases, biology, Chemistry, Drug discovery, Lysine, DNA Helicases, Nuclear Proteins, RNA-Binding Proteins, Acetylation, Antigens, Nuclear, hemic and immune systems, Epigenome, CREB-Binding Protein, Bromodomain, DNA-Binding Proteins, 030104 developmental biology, Histone, Biochemistry, biology.protein, ATPases Associated with Diverse Cellular Activities, Molecular Medicine, Carrier Proteins, Protein Processing, Post-Translational, Transcription Factors
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7
المؤلفون: Jane L. Grogan, Ruina Li, Edna F. Choo, Sarah M. Bronner, Maureen Beresini, Jonathan Maher, Patrick Cyr, Yingjie Li, Thomas Hunsaker, Brian K. Albrecht, Colin Masui, Kevin R Clark, Yingqing Ran, Jeremy Murray, Terry Crawford, Xiaorong Liang, Fei Wang, F. Anthony Romero, Xiaocang Wei, Alexander M. Taylor, Georgia Hatzivassiliou, Kyle Clagg, Kwong Wah Lai, Karen E. Gascoigne, Le An, Steven Magnuson, Mark Merchant, John S. Wai, Zhongguo Chen, Jiangpeng Liao, Vickie Tsui, Emily Chan, Kevin X. Chen, Wenfeng Liu, Wei Huang, Dong Yu, Stefan G. Koenig, Susan Kaufman, Xiaoyu Zhu, Gladys de Leon Boenig, Justin Ly, Denise E. de Almeida Nagata, Bing-Yan Zhu
المصدر: Journal of medicinal chemistry. 60(22)
مصطلحات موضوعية: 0301 basic medicine, Male, Pyridines, Protein domain, Response element, Antineoplastic Agents, Proto-Oncogene Proteins c-myc, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, Protein Domains, In vivo, Drug Discovery, Structure–activity relationship, Animals, Humans, Cyclic adenosine monophosphate, IC50, Chemistry, Binding protein, Forkhead Transcription Factors, CREB-Binding Protein, Xenograft Model Antitumor Assays, Bromodomain, Macaca fascicularis, 030104 developmental biology, HEK293 Cells, Biochemistry, Molecular Medicine, Pyrazoles, RNA, Female
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8
المؤلفون: Jonathan Maher, F. Anthony Romero, Samir Kharbanda, Mark Merchant, Ivana Yen, Yingjie Li, Edna F. Choo, Jiangpeng Liao, Xiaocang Wei, Kwong Wah Lai, Karen E. Gascoigne, Richard D. Cummings, Hariharan Jayaram, Thomas Hunsaker, Steven F. Bellon, Jian Wang, Cameron L. Noland, Brian K. Albrecht, Ying Jiang, Jeremy Murray, Susan Kaufman, Kerry L. Spillane, Florence Poy, Zhaowu Xu, Fei Wang, James R. Kiefer, Laura Zawadzke, Zhongguo Chen, Alexander M. Taylor, Andrew R. Conery, Xiaoyu Zhu, Wenfeng Liu, Eneida Pardo, Alexandre Côté, Andrea G. Cochran, Vickie Tsui, Steven Magnuson, Terry Crawford, Maureen Beresini, Emily Chan, Kevin X. Chen, Gladys de Leon Boenig, Justin Ly, Tracy Kleinheinz, Zhongya Xu
المصدر: Journal of medicinal chemistry. 59(23)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, BRD4, Pyridones, Mice, Nude, Antineoplastic Agents, P300-CBP Transcription Factors, 01 natural sciences, Madin Darby Canine Kidney Cells, 03 medical and health sciences, Mice, Structure-Activity Relationship, Dogs, In vivo, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Animals, Humans, p300-CBP Transcription Factors, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Drug discovery, Chemistry, Cell growth, 0104 chemical sciences, Cell biology, Bromodomain, 030104 developmental biology, Biochemistry, Acetylation, Molecular Medicine, Pyrazoles, Female, Drug Screening Assays, Antitumor
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9
المؤلفون: Brian K. Albrecht, Laura Zawadzke, F. Anthony Romero, Steve Bellon, Yong Tang, Shumei Wang, Christopher G. Nasveschuk, Jian Wang, James E. Audia, Michael C. Hewitt, Alexander M. Taylor, Eneida Pardo, Alexandre Côté, Daniel J. Burdick, Steven Magnuson, Xiaoyu Zhu, Maureen Beresini, Jeremy Murray, Richard D. Cummings, Ying Jiang, Andrew C. Good, Vickie Tsui, Hariharan Jayaram, Florence Poy, Zhaowu Xu, Terry Crawford, Les A. Dakin, E. Megan Flynn, James R. Kiefer, Martin Duplessis, Hon-Ren Huang, Andrea G. Cochran
المصدر: Journal of medicinal chemistry. 59(11)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, BRD4, Stereochemistry, Pyridones, Molecular Conformation, RNA-binding protein, Cell Cycle Proteins, Ligands, 03 medical and health sciences, Structure-Activity Relationship, Transcription (biology), Drug Discovery, Fluorescence Resonance Energy Transfer, Structure–activity relationship, Humans, Fluorometry, Pyrroles, Histone Acetyltransferases, TATA-Binding Protein Associated Factors, Binding Sites, Dose-Response Relationship, Drug, Chemistry, Nuclear Proteins, Water, Highly selective, Bromodomain, TAF1, 030104 developmental biology, Förster resonance energy transfer, Biochemistry, Molecular Medicine, Transcription Factor TFIID, Transcription Factors
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المؤلفون: Yongyun Wang, Yingjie Li, James E. Audia, F. Anthony Romero, Zhongguo Chen, Alexander M. Taylor, Robert J. Sims, Nico Cantone, Wenfeng Liu, Eneida Pardo, Alexandre Côté, Richard Pastor, Michael C. Hewitt, Steven Magnuson, Jeremy Murray, Steve Bellon, Richard T. Cummings, Jian Wang, Brian K. Albrecht, Hariharan Jayaram, Maureen Beresini, Leslie A. Dakin, Susan Kaufman, Henry Lu, Terry Crawford, Laura Zawadzke, Vickie Tsui, Xiaoqin Zhu, Gladys de Leon Boenig, Xiaoyu Zhu, Christopher G. Nasveschuk, Fen Yan, Yves Leblanc, Jiangpeng Liao, Andrew R. Conery, Zhaowu Xu, E. Megan Flynn, James R. Kiefer, Andrea G. Cochran, Dong Yu, Oscar W. Huang, Jeremy W. Setser, Tommy Lai, Patricia J. Keller
المصدر: ACS medicinal chemistry letters. 7(5)
مصطلحات موضوعية: 0301 basic medicine, 010405 organic chemistry, Chemistry, Organic Chemistry, Cell, Cellular pathways, Target engagement, Computational biology, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, Bromodomain, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Transcription (biology), Drug Discovery, medicine, Cancer research, EP300
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