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المؤلفون: Charles F Wright, Theodore E. Liston, Rosalina Destito, Alexander V. Kuperman, Lawrence A. Reiter, Kelvin Cooper, Deborah Malloy, Fiese Eugene F, Anthony Michael Campeta, David Young Mitchell, Wayne E. Barth, Sheri L. Shamblin, Fred C. Falkner, John J. Martin, Frank W. Rusek, Diane Lynn Johnson, Ralph P. Robinson, B. J. Cronin, Kathleen M. Donahue
المصدر: Journal of Medicinal Chemistry. 61:3237-3237
مصطلحات موضوعية: Aqueous solution, Ether, Nuclear magnetic resonance spectroscopy, Prodrug, Chemical synthesis, Combinatorial chemistry, Bioavailability, chemistry.chemical_compound, chemistry, Drug Discovery, Molecular Medicine, Organic chemistry, Oxindole, Chemical stability
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المؤلفون: Diane Lynn Johnson, Anthony Michael Campeta, David Young Mitchell, Ralph P. Robinson, Lawrence A. Reiter, Alexander V. Kuperman, Kelvin Cooper, Fiese Eugene F, Sheri L. Shamblin, Wayne E. Barth, John J. Martin, Theodore E. Liston, C. F. Wright, R. Destito, Frank W. Rusek, Fred C. Falkner, B. J. Cronin, Kathleen M. Donahue, D. Malloy
المصدر: ChemInform. 27
مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Group (periodic table), Oxindole, Ether, General Medicine, Prodrug, Medicinal chemistry
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3
المؤلفون: T.C. Liston, Anthony Marfat, G.W. Antognoli, John B. Cheng, J.S. Pillar, Alexander V. Kuperman, J.T. Shirley, R. J. Chambers, Brian S. Owens, John W. Watson
المصدر: ChemInform. 30
مصطلحات موضوعية: Chemistry, medicine, General Medicine, Zafirlukast, Pharmacology, Receptor, Pranlukast, medicine.drug, Cyslt1 receptor
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4
المؤلفون: Hang T. Nguyen, Alexander V. Kuperman, Michael A. Letavic, Kirk R. Henne, Frederick Kosea, Edna F. Choo, Timothy J. Taylor, Kim F. McClure, Heather L. Hatch, Amit S. Kalgutkar, Mark A. Dombroski
المصدر: Biopharmaceuticsdrug disposition. 27(8)
مصطلحات موضوعية: Male, Cell Membrane Permeability, Pyridines, Metabolite, Anti-Inflammatory Agents, Drug Evaluation, Preclinical, Pharmaceutical Science, Administration, Oral, Biological Availability, Biology, Pharmacology, In Vitro Techniques, Hydroxylation, Mitogen-Activated Protein Kinase 14, Rats, Sprague-Dawley, chemistry.chemical_compound, Dogs, Pharmacokinetics, Cytochrome P-450 Enzyme System, In vivo, Predictive Value of Tests, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Pharmacology (medical), Intestinal Mucosa, Oxazoles, Protein Kinase Inhibitors, Active metabolite, Biotransformation, ADME, CYP3A4, CYP1A2, General Medicine, Recombinant Proteins, Rats, Isoenzymes, Macaca fascicularis, chemistry, Intestinal Absorption, Injections, Intravenous, Microsome, Microsomes, Liver, Female, Caco-2 Cells, Protein Binding
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المؤلفون: Thomas J. Carty, Nancy C. Elliott, Hang T. Nguyen, Franco Lombardo, Kendra Louise Nelson, Christopher A. Gabel, Kathleen M. Donahue, Jun Zhou, Jennifer M. McCoy, Mark A. Dombroski, Laurent P. Audoly, John F. Braganza, Brian M. Naiman, Ronald E. Laliberte, Amit S. Kalgutkar, Jeff M. Labasi, Walter A. Volberg, Kevin M. Peese, Kim F. McClure, Timothy J. Taylor, John T. Barberia, Ellen R. Laird, Colleen P. Gibbons, Catherine E. Trebino, Crystal K. Jordan, Francis J. Sweeney, Alexander V. Kuperman, Yuriy A. Abramov, Santo R. Cortina, Demetrius Carter, Michael A. Letavic, Justin Bach
المصدر: Bioorganicmedicinal chemistry letters. 16(16)
مصطلحات موضوعية: Pyridines, Chemistry, Pharmaceutical, Clinical Biochemistry, Triazole, Pharmaceutical Science, Biochemistry, Chemical synthesis, p38 Mitogen-Activated Protein Kinases, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Drug Discovery, Structure–activity relationship, Humans, Enzyme Inhibitors, Molecular Biology, Oxazoles, Oxazole, biology, Organic Chemistry, Triazoles, Kinetics, chemistry, Models, Chemical, Solubility, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Triazolopyridine, Identification (biology)
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المؤلفون: G.W. Antognoli, C. Mebus, T.C. Liston, David B. Damon, R. J. Chambers, J. W. Watson, J.T. Shirley, A. Marfat, John B. Cheng, J.S. Pillar, Alexander V. Kuperman
المصدر: Bioorganicmedicinal chemistry letters. 9(18)
مصطلحات موضوعية: Clinical Biochemistry, Guinea Pigs, Pharmaceutical Science, Biological Availability, Pharmacology, Biochemistry, Pranlukast, Pharmacokinetics, In vivo, Oral administration, Drug Discovery, medicine, Animals, Benzopyrans, Zafirlukast, Receptor, Molecular Biology, Receptors, Leukotriene, Leukotriene, Sulfonamides, Chemistry, Organic Chemistry, Membrane Proteins, Haplorhini, Rats, Liver, Drug Design, Toxicity, Molecular Medicine, Leukotriene Antagonists, medicine.drug, Half-Life
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المؤلفون: R. J. Chambers, Brian S. Owens, G.W. Antognoli, T.C. Liston, J.S. Pillar, Anthony Marfat, J.T. Shirley, John B. Cheng, Alexander V. Kuperman, John W. Watson
المصدر: Bioorganicmedicinal chemistry letters. 8(24)
مصطلحات موضوعية: Leukotriene D4, Magnetic Resonance Spectroscopy, Clinical Biochemistry, Guinea Pigs, Pharmaceutical Science, Biological Availability, Pharmacology, Biochemistry, Pranlukast, Cyslt1 receptor, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Anti-Asthmatic Agents, Zafirlukast, Receptor, Molecular Biology, Receptors, Leukotriene, Leukotriene, Chemistry, Organic Chemistry, Antagonist, Membrane Proteins, Stereoisomerism, U937 Cells, Rats, Thiazoles, Quinolines, Molecular Medicine, Leukotriene Antagonists, medicine.drug
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