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1دورية أكاديمية
المؤلفون: Werner Neidhart, Tanja Schulz-Gasch, Armin Ruf, Matthias Nettekoven, Hans Peter Märki, Bernd Kuhn, Daniel Hunziker, Aurelia Conte, Kurt Amrein, Jean Ackermann, Alexander V. Mayweg
المصدر: CHIMIA, Vol 69, Iss 7-8 (2015)
مصطلحات موضوعية: Cardiovascular, High-throughput screening, Medicinal chemistry, Metabolic, Molecular design, Chemistry, QD1-999
وصف الملف: electronic resource
Relation: https://www.chimia.ch/chimia/article/view/5774; https://doaj.org/toc/0009-4293; https://doaj.org/toc/2673-2424
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2
المؤلفون: Weixing Zhang, Lei Guo, Haixia Liu, Guolong Wu, Houguang Shi, Mingwei Zhou, Zhisen Zhang, Buyu Kou, Taishan Hu, Zheng Zhou, Zhiheng Xu, Xue Zhou, Yuan Zhou, Xiaojun Tian, Guang Yang, John A. T. Young, Hongxia Qiu, Giorgio Ottaviani, Jianxun Xie, Alexander V. Mayweg, Hong C. Shen, Wei Zhu
المصدر: Journal of Medicinal Chemistry. 66:4253-4270
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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3
المؤلفون: Remo Hochstrasser, Mingwei Zhou, Giorgio Ottaviani, Wenming Chen, Stephan Müller, Alexander V. Mayweg, Benoit Hornsperger, Johannes Aebi, Lisha Wang, Philippe Verry, Dongbo Li, William Riboulet, Hans-Peter Märki, Jian Xin, Andreas Kuglstatter, Yongfu Liu, Zhanguo Wang, Jun Wu, Bernd Kuhn, Susanne Mohr, Jörg Benz, Stephan Kirchner, Hong C. Shen, Kurt Amrein, Xuefei Tan
المصدر: Journal of medicinal chemistry. 63(13)
مصطلحات موضوعية: Aldosterone synthase, Models, Molecular, Pyridines, Molecular Conformation, Administration, Oral, Adrenocorticotropic hormone, Pharmacology, Isoindoles, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Mineralocorticoid receptor, Drug Stability, In vivo, Drug Discovery, medicine, Structure–activity relationship, Animals, Cytochrome P-450 CYP11B2, Cytochrome P-450 Enzyme Inhibitors, Humans, Tissue Distribution, Benzamide, 030304 developmental biology, 0303 health sciences, Kidney, biology, ATP synthase, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, chemistry, Drug Design, biology.protein, Molecular Medicine
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4
المؤلفون: Alexander Flohr, Jie Zhang, Andrei Salomatov, Matthew O'Connor, Darlene Romashko, Elizabeth Buck, Roberto Iacone, Noboru Ishiyama, David Epstein, Sandra Markovic, Alexander V. Mayweg, Theodore Nicolaides
مصطلحات موضوعية: Mutation, Chemistry, Kinase, Epidermal growth factor, Allosteric regulation, medicine, Cancer research, Extracellular, medicine.disease_cause, Carcinogenesis, Small molecule, EGFR inhibitors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6dbe4ae70e10bd14a8f83ce835e6404
https://doi.org/10.1101/810721 -
5
المؤلفون: Darlene Romashko, Matthew O'Connor, Elizabeth Buck, Alexander V. Mayweg, Nigel J. Waters, Alexander Flohr, Giorgio Ottaviani
المصدر: Cancer Research. 81:LB127-LB127
مصطلحات موضوعية: Cancer Research, Physiologically based pharmacokinetic modelling, business.industry, Allosteric regulation, Pharmacology, Oncology, Pharmacokinetics, In vivo, ErbB, Pharmacodynamics, Medicine, Distribution (pharmacology), business, ADME
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2f19c696cb471fd6603dfc963f2a7731
https://doi.org/10.1158/1538-7445.am2021-lb127 -
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المؤلفون: Chungen Liang, Xue Zhou, Zhanling Cheng, Jianping Wang, Hong C. Shen, Xingchun Han, Xin Yu, Zhanguo Wang, Min Wang, Souphalone Luangsay, Chengang Zhou, Song Yang, Jianxun Xie, Wenzhe Lv, Yongguang Wang, Min Jiang, Robert James Weikert, Jianhua Wang, Liu Yongqiang, Hassan Javanbakht, Alexander V. Mayweg
المصدر: Journal of medicinal chemistry. 61(23)
مصطلحات موضوعية: 0301 basic medicine, Gene Expression Regulation, Viral, Male, Hepatitis B virus, Phenotypic screening, Administration, Oral, Biological Availability, medicine.disease_cause, 01 natural sciences, Virus, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Hepatitis B Surface Antigens, 010405 organic chemistry, RNA, Hep G2 Cells, Virology, 0104 chemical sciences, 030104 developmental biology, Phenotype, Mechanism of action, chemistry, Quinolines, Molecular Medicine, medicine.symptom, Caco-2 Cells, DNA
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7
المؤلفون: Hans Peter Märki, Bernd Kuhn, Kurt Amrein, Robert Britton, Johannes Aebi, Marjorie A. Carnero Corrales, Rainer E. Martin, Alexander V. Mayweg, Mario Lenz, Johannes Lehmann, Thibaut Alzieu
المصدر: Organic & Biomolecular Chemistry. 14:5922-5927
مصطلحات موضوعية: Models, Molecular, Aldosterone synthase, Protein Conformation, Pyridines, Stereochemistry, Chemistry Techniques, Synthetic, Crystal structure, 010402 general chemistry, 01 natural sciences, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Protein structure, Pyridine, Cytochrome P-450 CYP11B2, Cytochrome P-450 Enzyme Inhibitors, Humans, Structure–activity relationship, Physical and Theoretical Chemistry, biology, 010405 organic chemistry, Continuous flow, Organic Chemistry, 0104 chemical sciences, chemistry, biology.protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3022a6d08b79c0f5152e065da24d642b
https://doi.org/10.1039/c6ob00848h -
8
المؤلفون: William Riboulet, André Alker, Dominique Burger, Giorgio Ottaviani, Stephan Müller, Andreas Kuglstatter, Kurt Amrein, Hans-Jakob Krebs, Philippe Verry, Xuefei Tan, Rainer E. Martin, Benoit Hornsperger, Alexander V. Mayweg, Hans Peter Märki, Bernd Kuhn, Johannes Aebi
المصدر: Journal of Medicinal Chemistry. 58:8054-8065
مصطلحات موضوعية: Male, Models, Molecular, Aldosterone synthase, medicine.medical_specialty, Pharmacology, Mice, chemistry.chemical_compound, Mineralocorticoid receptor, In vivo, Tetrahydroisoquinolines, Internal medicine, Drug Discovery, medicine, Animals, Cytochrome P-450 CYP11B2, Humans, Enzyme Inhibitors, Steroid 11-beta-hydroxylase, Aldosterone, Mineralocorticoid Receptor Antagonists, chemistry.chemical_classification, biology, Tetrahydroisoquinoline, In vitro, Rats, Macaca fascicularis, Enzyme, Endocrinology, chemistry, Mice, Inbred DBA, Drug Design, biology.protein, Molecular Medicine
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9
المؤلفون: Rui Niu, Chengang Zhou, Zheng Zhou, Lisha Wang, Alexander V. Mayweg, Zhiheng Xu, Tai-Guang Jin, Min Jiang, Song Yang, Xingchun Han
المصدر: Bioorganicmedicinal chemistry letters. 27(18)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Computational biology, Ligands, Biochemistry, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, Animals, Humans, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Chemistry, Organic Chemistry, Ligand (biochemistry), Cyclin-Dependent Kinase 8, Combinatorial chemistry, Bioavailability, 030104 developmental biology, 030220 oncology & carcinogenesis, Picolines, Molecular Medicine, Cyclin-dependent kinase 8
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المؤلفون: Jean Ackermann, Werner Neidhart, Hans Peter Märki, Bernd Kuhn, Armin Ruf, Tanja Schulz-Gasch, Daniel Hunziker, Alexander V. Mayweg, Aurelia Conte, Matthias Nettekoven, Kurt Amrein
المصدر: CHIMIA, Vol 69, Iss 7-8 (2015)
مصطلحات موضوعية: In silico, Chemistry, Pharmaceutical, Medicinal chemistry, Type 2 diabetes, Biology, Cardiovascular, Drug Delivery Systems, Metabolic Diseases, medicine, Animals, Humans, Conceptual frame, QD1-999, Endothelin Antagonists, Molecular design, Drug discovery, High-throughput screening, Cardiovascular Agents, General Medicine, General Chemistry, medicine.disease, Chemistry, Lipotoxicity, Cardiovascular Diseases, Drug Design, Cardiovascular agent, Metabolic, Metabolic syndrome
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb3f007d3aab3d4854b887b8e02f92f
https://pubmed.ncbi.nlm.nih.gov/28482972