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المؤلفون: Gavin J. Knott, Jennifer A. Doudna, Mitchell R. O’Connell, Akshay Tambe, Alexandra East-Seletsky
المصدر: Cell reports, vol 24, iss 4
Tambe, Akshay; East-Seletsky, Alexandra; Knott, Gavin J; Doudna, Jennifer A; & O'Connell, Mitchell R. (2018). RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a.. Cell reports, 24(4), 1025-1036. doi: 10.1016/j.celrep.2018.06.105. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/1mv316hnمصطلحات موضوعية: 0301 basic medicine, CRISPR-Cas systems, Cas13a, Base pair, RNA biology, Medical Physiology, CRISPR-Associated Proteins, Computational biology, Cleavage (embryo), Article, General Biochemistry, Genetics and Molecular Biology, Rna regulation, RNA specificity, 03 medical and health sciences, Genetics, Humans, CRISPR, Nucleotide, chemistry.chemical_classification, Nuclease, Cas13, biology, RNA, Endonucleases, 030104 developmental biology, Enzyme, chemistry, C2c2, biology.protein, Biochemistry and Cell Biology, CRISPR-Cas Systems, Carrier Proteins, Guide, RNA, Guide, Kinetoplastida
وصف الملف: application/pdf
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المؤلفون: Spencer C. Knight, David Burstein, Jamie H. D. Cate, Mitchell R. O’Connell, Alexandra East-Seletsky, Jennifer A. Doudna, Robert Tjian
المصدر: Nature. 538:270-273
مصطلحات موضوعية: 0301 basic medicine, RNase P, CRISPR-Associated Proteins, Biology, Article, 03 medical and health sciences, Ribonucleases, 0302 clinical medicine, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, RNase H, Leptotrichia, RNA Cleavage, Genetics, Trans-activating crRNA, CRISPR interference, Multidisciplinary, Base Sequence, Cas9, RNA, Non-coding RNA, Cell biology, RNA, Bacterial, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, CRISPR-Cas Systems, RNA, Guide, Kinetoplastida
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3دورية أكاديمية
المؤلفون: Alexandra East-Seletsky, Mitchell R. O'Connell, Spencer C. Knight, David Burstein, Jamie H. D. Cate, Robert Tjian, Jennifer A. Doudna
المصدر: Nature, Nature. 538(7624):270-273
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المؤلفون: Gavin J. Knott, Akshay Tambe, Mitchell R. O’Connell, Alexandra East-Seletsky, Jennifer A. Doudna
مصطلحات موضوعية: Trans-activating crRNA, Genetics, 0303 health sciences, Nuclease, biology, RNase P, RNA, Nuclease protection assay, Cleavage (embryo), 3. Good health, Cell biology, 03 medical and health sciences, 0302 clinical medicine, biology.protein, CRISPR, Ribonuclease, 030217 neurology & neurosurgery, 030304 developmental biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438b0a58d28fda6a7a0b04165ef897dc
https://doi.org/10.1101/190603 -
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المؤلفون: Mitchell R. O’Connell, Emeric J Charles, Joshua C Cofsky, Alexandra East-Seletsky, James M. Holton, Gavin J. Knott, Jennifer A. Doudna
المصدر: Nature structuralmolecular biology. 24(10)
مصطلحات موضوعية: 0301 basic medicine, Trans-activating crRNA, Clostridiales, biology, Chemistry, Protein Conformation, Ribozyme, RNA, RNA-dependent RNA polymerase, Non-coding RNA, Crystallography, X-Ray, Endonucleases, Article, 03 medical and health sciences, 030104 developmental biology, Biochemistry, Structural Biology, RNA editing, biology.protein, CRISPR, Signal recognition particle RNA, CRISPR-Cas Systems, Molecular Biology, RNA, Guide, Kinetoplastida
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6دورية أكاديمية
المؤلفون: Mitchell R. O'Connell, Benjamin L. Oakes, Samuel H. Sternberg, Alexandra East-Seletsky, Matias Kaplan, Jennifer A. Doudna
المصدر: Nature, Nature. 516(7530):263-266
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المؤلفون: Howard Y. Chang, Rajarshi P. Ghosh, Seung Woo Cho, Ying Shen, Jan Liphardt, William J. Greenleaf, Ulrike M. Litzenburger, Jennifer A. Doudna, Ansuman T. Satpathy, Jason D. Buenrostro, Xingqi Chen, Alexandra East-Seletsky, Ava C. Carter, Will E Draper
المصدر: Nature methods. 13(12)
مصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, Neutrophils, Transposases, Context (language use), Computational biology, Biology, Biochemistry, Genome, Heterocyclic Compounds, 4 or More Rings, Deep sequencing, Article, Cell Line, Epigenesis, Genetic, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Image Processing, Computer-Assisted, Humans, Molecular Biology, Transposase, Epigenomics, Fluorescent Dyes, Genetics, Microscopy, Confocal, Staining and Labeling, Genome, Human, DNA replication, High-Throughput Nucleotide Sequencing, Cell Biology, Chromatin Assembly and Disassembly, Flow Cytometry, Chromatin, 030104 developmental biology, chemistry, DNA Transposable Elements, 030217 neurology & neurosurgery, DNA, Biotechnology
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المؤلفون: Caleb Cassidy-Amstutz, David Quintanilla, Luke M. Oltrogge, David F. Savage, Catherine C. Going, Antony Lee, Evan R. Williams, Alexandra East-Seletsky, Poh Teng
المصدر: Biochemistry. 55(24)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Ideal system, Peptide, Protomer, Biology, In Vitro Techniques, 010402 general chemistry, 01 natural sciences, Biochemistry, 03 medical and health sciences, Bacterial Proteins, Bacterial microcompartment, In vivo, Thermotoga maritima, chemistry.chemical_classification, Circular Dichroism, biology.organism_classification, Ph stability, In vitro, Peptide Fragments, Recombinant Proteins, 0104 chemical sciences, 030104 developmental biology, chemistry, Peroxidases, Biophysics
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المؤلفون: Matias Kaplan, Samuel H. Sternberg, Mitchell R. O’Connell, Alexandra East-Seletsky, Benjamin L. Oakes, Jennifer A. Doudna
المصدر: O'Connell, Mitchell R; Oakes, Benjamin L; Sternberg, Samuel H; East-Seletsky, Alexandra; Kaplan, Matias; & Doudna, Jennifer A. (2014). Programmable RNA recognition and cleavage by CRISPR/Cas9.. Nature, 516(7530), 263-266. doi: 10.1038/nature13769. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/4v49q01n
Nature
Nature, vol 516, iss 7530مصطلحات موضوعية: Cell Extracts, Base pair, General Science & Technology, Messenger, CRISPR-Associated Proteins, Oligonucleotides, Computational biology, Biology, Article, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, MD Multidisciplinary, Genetics, CRISPR, Humans, RNA, Guide, Clustered Regularly Interspaced Short Palindromic Repeats, RNA, Messenger, Kinetoplastida, Nucleotide Motifs, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Base Sequence, Cas9, Oligonucleotide, RNA, DNA, Glyceraldehyde-3-Phosphate Dehydrogenase, DNA binding site, Protospacer adjacent motif, chemistry, Hela Cells, Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating), CRISPR-Cas Systems, Genetic Engineering, 030217 neurology & neurosurgery, Guide, HeLa Cells, RNA, Guide, Kinetoplastida
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b655f2877ff0a91803db94808200562f
http://www.escholarship.org/uc/item/4v49q01n -
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المؤلفون: Gavin J. Knott, David Burstein, Alexandra East-Seletsky, Mitchell R. O’Connell, Jennifer A. Doudna
المصدر: Molecular cell, vol 66, iss 3
مصطلحات موضوعية: 0301 basic medicine, RNA Processing, Protein family, RNA Stability, CRISPR-Associated Proteins, Post-Transcriptional, Medical and Health Sciences, Article, Substrate Specificity, Bacterial genetics, Structure-Activity Relationship, 03 medical and health sciences, Ribonucleases, 0302 clinical medicine, Protein sequencing, Bacterial Proteins, Escherichia coli, RNA Precursors, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, Ribonuclease, RNA Processing, Post-Transcriptional, Molecular Biology, Phylogeny, Trans-activating crRNA, Genetics, biology, Bacterial, RNA, Cell Biology, Biological Sciences, RNA, Bacterial, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Nucleic acid, Nucleic Acid Conformation, CRISPR-Cas Systems, Developmental Biology
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