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1دورية أكاديمية
المؤلفون: Ngoc Anh Thu Nguyen, Pascal Auquier, Any Beltran Anzola, Roseline D’oiron, Thierry Lambert, Céline Falaise, Christine Biron, Anne Lienhart, Jenny Goudemand, Antoine Rauch, Bénédicte Wibaut, Sabine Marie Castet, Dominique Desprez, Annie Harroche, Natalie Stieltjes, Annie Borel-Derlon, Marc Trossaërt, Amandine Celli, Benoît Guillet, Sophie Bayart, Marie-Anne Bertrand, Alexandra Fournel, Guillaume Mourey, Valérie Gay, Pierre Chamouni, Emmanuelle DE Raucourt, Birgit Frotscher, Michèle Martin, Mathieu Puyade, Brigitte Tardy, Stéphane Vanderbecken, Fabienne Genre-Volot, Philippe Nguyen, Benoît Polack, Caroline Oudot-Challard, Stéphane Girault, Annelise Voyer, Aurélien Lebreton, Abel Hassoun, Philippe Moreau, Pierre-Simon Rohrlich, Karine Baumstarck, Mohamed Boucekine, Vanessa Milien, Natacha Rosso, Clemence Tabele, Marie Viprey, Nicolas Giraud, Thomas Sannie, Hervé Chambost, Noémie Resseguier
المصدر: HemaSphere, Vol 7, p e623777c (2023)
مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5
وصف الملف: electronic resource
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المؤلفون: Jerzy Windyga, Benoît Guillet, Lucia Rugeri, Alexandra Fournel, Ewa Stefanska-Windyga, Valérie Chamouard, Sonia Pujol, Céline Henriet, Françoise Bridey, Claude Négrier
المساهمون: Instytut Hematologii i Transfuzjologii - Institute of Hematology and Transfusion Medicine (IHT), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire français du Fractionnement et des Biotechnologies (LFB), Chard-Hutchinson, Xavier
المصدر: Thrombosis and Haemostasis
Thrombosis and Haemostasis, 2022, 122 (8), pp.1304-1313. ⟨10.1055/a-1865-6978⟩مصطلحات موضوعية: Adult, [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, von Willebrand Diseases, Factor VIII, von Willebrand Factor, Humans, hemophilia A, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, coagulation factor, Hematology, von Willebrand disease, Hemostatics, surgical procedures
وصف الملف: application/pdf; charset=UTF-8
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece6fdb9a5dab758d938aeccc3b9e123
https://doi.org/10.1055/a-1865-6978 -
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المؤلفون: Philippe Gautier, Benoit Guillet, Marianne Sigaud, Ségolène Claeyssens, Fabienne Genre Volot, Pierre Chamouni, Anne Lienahrt, Birgit Frotscher, Alexandra Fournel, Sabine Castet, Catherine Poumayou, Valérie Gay, Rodolphe Thuret, Bénédicte Wibaut, Christine Biron‐Andreani
المصدر: Haemophilia. 28:437-444
مصطلحات موضوعية: Male, Biopsy, Prostate, Prostatic Neoplasms, Hemorrhage, Hematology, General Medicine, Middle Aged, Hemophilia A, Humans, Deamino Arginine Vasopressin, Genetics (clinical), Aged, Hematuria, Retrospective Studies
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المؤلفون: Alexandra Fournel, Guillaume Mourey, Rui Vilar, Marguerite Neerman-Arbez, Alessandro Casini
المصدر: Thrombosis Research, Vol. 193 (2020) pp. 5-8
مصطلحات موضوعية: ddc:616, Genetics, business.industry, Hematology, 030204 cardiovascular system & hematology, Hypofibrinogenemia, Severe hemophilia A, Congenital hypofibrinogenemia, Frameshift mutation, 03 medical and health sciences, 0302 clinical medicine, ddc:590, Mutation (genetic algorithm), Medicine, ddc:576.5, business, 030215 immunology
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المؤلفون: Alexandra Fournel, Jérôme Rollin, Claire Pouplard, Thomas Geeraerts, Guillaume Mourey, Gilles Pernod, Sophie Susen, Hubert Galinat, Vincent Mémier, Yves Gruel, Caroline Vayne, Olivier Huet, Raphaël Marlu, Charlotte Cordonnier
المصدر: The New England Journal of Medicine
مصطلحات موضوعية: Laboratory methods, 2019-20 coronavirus outbreak, medicine.diagnostic_test, Coronavirus disease 2019 (COVID-19), business.industry, General Medicine, Heparin, 030204 cardiovascular system & hematology, medicine.disease, Thrombosis, Vaccination, 03 medical and health sciences, 0302 clinical medicine, Immune system, hemic and lymphatic diseases, Immunoassay, Immunology, Correspondence, medicine, 030212 general & internal medicine, business, medicine.drug
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المؤلفون: Marie-Christine Alessi, Jan Rosing, Guillaume Mourey, Pierre-Emmanuel Morange, Marjorie Poggi, Elisabetta Castoldi, M. Christella L. G. D. Thomassen, Tilman M. Hackeng, Manal Ibrahim-Kosta, Alexandra Fournel, Catherine P.M. Hayward, Nathalie Hezard, Kanin Wichapong
المساهمون: Hôpital de la Timone [CHU - APHM] (TIMONE), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Department of Biochemistry, Maastricht University [Maastricht], Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Canadian Institutes of Health Research (CIHR)MOP 133474, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté]), Biochemie, RS: Carim - B01 Blood proteins & engineering, RS: Carim - B03 Cell biochemistry of thrombosis and haemostasis
المصدر: Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, 2021, 19 (5), pp.1186-1199. ⟨10.1111/jth.15274⟩
Journal of Thrombosis and Haemostasis, Wiley, 2021, 19 (5), pp.1186-1199. ⟨10.1111/jth.15274⟩
Journal of Thrombosis and Haemostasis, 19(5), 1186-1199. Wileyمصطلحات موضوعية: factor V deficiency, Factor V Deficiency, compared with normal FVa, has both pro- and anticoagulant functions. Objective We investigated an FV-deficient patient (FV:C 3%, 030204 cardiovascular system & hematology, Thrombophilia, but also a lower rate of APC-catalyzed inactivation in the presence of protein S. Conclusions FVBesancon induces a hypercoagulable state via quantitative (markedly decreased FV level) and qualitative (phospholipid-binding defect) effects that affect anticoagulant pathways (anticoagulant activities of FV, Background Coagulation factor V (FV), 03 medical and health sciences, 0302 clinical medicine, Tissue factor pathway inhibitor, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Prothrombinase, V-max) of prothrombin activation, medicine, FVa inactivation, Humans, predicting impaired binding of FV(a) to phospholipids. Recombinant FVBesancon was hardly secreted, Platelet, phospholipids, indicating that this mutation is responsible for the patient's FV deficiency. Model system experiments performed using highly diluted plasma as a source of FV showed that, FVa(Besancon) has slightly (<= 1.5-fold) unfavorable kinetic parameters (K-m, biology, Chemistry, Homozygote, present in plasma and platelets, Factor V, Hematology, medicine.disease, Molecular biology,
FVBesancon) that favors a "closed conformation" of the C2 domain, Mutation, biology.protein, activated protein C resistance, tissue factor pathway inhibitor alpha level) more strongly than the prothrombinase activity of FVa. A possible specific role of platelet FV cannot be excluded, venous thrombosis, Blood Coagulation Tests, Activated protein C resistance, thrombin generation in the patient's platelet-rich plasma (PRP) was higher than in control PRP and extremely resistant to activated protein C (APC). This was partially attributable to the complete abolition of the APC-cofactor activity of FV and a marked reduction of plasma tissue factor pathway inhibitor antigen and activity. The patient was homozygous for a novel missense mutation (Ala2086Asp, Protein C, FV:Ag 4%) paradoxically presenting with recurrent venous thrombosis (11 events) instead of bleeding. Methods/Results Thrombophilia screening revealed only heterozygosity for the F2 20210G>A mutation. Although thrombin generation in the patient's platelet-poor plasma was suggestive of a hypocoagulable state, medicine.drug وصف الملف: application/pdf
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المؤلفون: Guillaume Besch, Guillaume Mourey, Franck Grillet, Sebastien Pili-Floury, Basile Mouhat, Gilles Capellier, Hadrien Winiszewski, Nicolas Meneveau, Julien Behr, Gaël Piton, Emmanuel Samain, Nicolas Mahr, Patricia Dockhorn Costa, Thomas Senot, Thibaud Soumagne, Alexandra Fournel
المصدر: Respiratory Medicine and Research
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Adult, Male, ARDS, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Critical Illness, Comorbidity, Pandemic, medicine, Humans, Intensive care medicine, Letter to the Editor, Pandemics, Aged, Respiratory Distress Syndrome, business.industry, Critically ill, SARS-CoV-2, COVID-19, Middle Aged, medicine.disease, Pulmonary embolism, Acute Disease, Female, business, Pulmonary Embolism
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d680a4ba195fae34c74c95c4ed1d9a3a
https://pubmed.ncbi.nlm.nih.gov/33022510 -
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