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المؤلفون: Diana Hide, Jordi Gracia-Sancho, Zoe Boyer-Diaz, Anabel Fernández-Iglesias, Alfred P. Spada, Raquel Maeso-Díaz, Sergi Guixé-Muntet, Nicolò Manicardi, Patricia C. Contreras, Héctor García-Calderó, Martí Ortega-Ribera, Jaime Bosch
المصدر: Hepatology Communications
Hepatology Communications, Vol 3, Iss 7, Pp 987-1000 (2019)
Gracia-Sancho, Jordi; Manicardi, Nicolò; Ortega-Ribera, Martí; Maeso-Díaz, Raquel; Guixé Muntet, Sergi; Fernández-Iglesias, Anabel; Hide, Diana; García-Calderó, Héctor; Boyer-Díaz, Zoe; Contreras, Patricia C; Spada, Alfred; Bosch, Jaime (2019). Emricasan Ameliorates Portal Hypertension and Liver Fibrosis in Cirrhotic Rats Through a Hepatocyte-Mediated Paracrine Mechanism. Hepatology communications, 3(7), pp. 987-1000. 10.1002/hep4.1360 <http://dx.doi.org/10.1002/hep4.1360>مصطلحات موضوعية: Pathology, medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Portal venous pressure, 610 Medicine & health, Original Articles, medicine.disease, Chronic liver disease, medicine.anatomical_structure, Fibrosis, Hepatocyte, medicine, Hepatic stellate cell, Portal hypertension, lcsh:Diseases of the digestive system. Gastroenterology, Original Article, Liver function, lcsh:RC799-869, business
وصف الملف: application/pdf
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المصدر: Toxicological Sciences. 162:396-405
مصطلحات موضوعية: Male, 0301 basic medicine, Primary Cell Culture, Caspase Inhibition and Hepatic Tissue Factor-Mediated Coagulation, Apoptosis, Caspase 3, 030204 cardiovascular system & hematology, Toxicology, Thromboplastin, 03 medical and health sciences, Tissue factor, 0302 clinical medicine, medicine, Animals, fas Receptor, Blood Coagulation, Caspase, Liver injury, biology, Chemistry, Microvesicle, medicine.disease, Caspase Inhibitors, Molecular biology, Microvesicles, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Liver, Hepatocyte, Microvessels, Hepatocytes, biology.protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7628c69efaf4f462e63d4061351c3ce0
https://doi.org/10.1093/toxsci/kfx268 -
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المؤلفون: Alfred P. Spada, Gavin Wright, Gautam Mehta, Matthew C. Cave, Rajiv Jalan, Mark Morris, Catherine Frenette, David T. Hagerty, Sam Rousell, Stuart McPherson, Gary Burgess
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, medicine.disease, Placebo, Gastroenterology, Discontinuation, law.invention, 03 medical and health sciences, Liver disease, 030104 developmental biology, 0302 clinical medicine, Randomized controlled trial, Pharmacokinetics, law, Pharmacodynamics, Internal medicine, Medicine, 030211 gastroenterology & hepatology, Decompensation, Original Article, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f344bbaa5d9064e2d7a69774a5e4b34
https://europepmc.org/articles/PMC6175779/ -
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المؤلفون: Jean L. Chan, Raymond A. Rubin, Alfred P. Spada, Giuseppe Morelli, Matthew C. Cave, Jason T. Cheng, Catherine Frenette, R. Todd Frederick, Saira Khaderi, Mason Yamashita, Michael B. Fallon, James S. Park, David T. Hagerty, James M. Robinson, Nikolaos Pyrsopoulos, Mitchell L. Shiffman, Omar Massoud
المصدر: Clinical Gastroenterology and Hepatology. 17:774-783.e4
مصطلحات موضوعية: Liver Cirrhosis, Male, Serum, medicine.medical_specialty, Cirrhosis, Placebo, Gastroenterology, End Stage Liver Disease, Placebos, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Model for End-Stage Liver Disease, Double-Blind Method, Internal medicine, Clinical endpoint, Humans, Medicine, Pentanoic Acids, Aged, Aged, 80 and over, Keratin-18, Hepatology, business.industry, Hepatitis C, Middle Aged, medicine.disease, Caspase Inhibitors, Treatment Outcome, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Liver function, Steatohepatitis, business
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المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
المصدر: Journal of Medicinal Chemistry. 48:6779-6782
مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
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المؤلفون: Mason Helen J, Karen D. Brown, Valeria Chu, Guyan Liang, Daniel M. Green, Alfred P. Spada, Henry W. Pauls, Ross Bentley, Cuong Ly, Roderick S. Davis, Dennis J. Colussi, Daniel L. Cheney, Michael R. Becker, Y.M. Choi-Sledeski, Christopher T. Dunwiddie, Robert J. Leadley, Ewing William R, John H. Barton
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:2539-2544
مصطلحات موضوعية: Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Isostere, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Administration, Oral, Pharmaceutical Science, Biochemistry, Chemical synthesis, Benzamidine, Amidine, Serine, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Structure–activity relationship, Molecular Biology, Binding Sites, Organic Chemistry, Isoquinolines, Benzamidines, chemistry, Molecular Medicine, Factor Xa Inhibitors
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المؤلفون: Alfred P. Spada, Robert J. Leadley, Jonathan S. Mason, Dennis J. Colussi, Ewing William R, Mark H. Perrone, Karen D. Brown, Michael R. Becker, Don D. Cha, Daniel M. Green, Ross Bentley, Henry W. Pauls, Christopher T. Dunwiddie, Jean-Pierre Guilloteau, Y.M. Choi-Sledeski, Sebastien Maignan, Mason Helen J, Vincent E. Manetta, Charles Kasiewski, Valeria Chu, Roderick S. Davis, Suzanne Morgan, Daniel L. Cheney, Jeff Bostwick
المصدر: Journal of Medicinal Chemistry. 42:3557-3571
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, medicine.drug_class, Factor Xa Inhibitor, Thiophenes, Crystallography, X-Ray, Amidine, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, In vivo, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Sulfonamides, Molecular Structure, biology, Chemistry, Anticoagulant, Anticoagulants, Stereoisomerism, Thrombosis, Trypsin, Pyrrolidinones, Rats, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Rabbits, Factor Xa Inhibitors, medicine.drug
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المؤلفون: Robert J. Leadley, Charles Kasiewski, Tara Wentz, Glenda E. Bilder, Jeffery Bostwick, Mark H. Perrone, Saul J. Needle, Betsey O’Conner, Christopher T. Dunwiddie, Lisa Byan, Kenneth Page, Helen Galczenski, Linda Merkel, Persons Paul E, Myers Michael R, Alfred P. Spada, Amin Dilip, Cuong Ly
المصدر: Circulation. 99:3292-3299
مصطلحات موضوعية: Pathology, medicine.medical_specialty, Time Factors, Vascular smooth muscle, Platelet-derived growth factor, Swine, Administration, Oral, Coronary Disease, Thiophenes, Pharmacology, chemistry.chemical_compound, Restenosis, Recurrence, Cell surface receptor, Quinoxalines, Physiology (medical), medicine, Animals, Receptors, Platelet-Derived Growth Factor, Angioplasty, Balloon, Coronary, Enzyme Inhibitors, Tyrosine, biology, business.industry, Chemotaxis, Protein-Tyrosine Kinases, medicine.disease, chemistry, biology.protein, Tunica Intima, Tunica Media, Cardiology and Cardiovascular Medicine, business, Tyrosine kinase, Platelet-derived growth factor receptor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d180846942468a5df5011431ca5416
https://doi.org/10.1161/01.cir.99.25.3292 -
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المؤلفون: Ewing William R, Robert J. Leadley, Alfred P. Spada, Mark H. Perrone, Christopher T. Dunwiddie, S. Morgan, Henry W. Pauls, Valeria Chu, Jeffrey S. Bostwick, Karen D. Brown, Ross Bentley
المصدر: Thrombosis and Haemostasis. 81:157-160
مصطلحات موضوعية: Prothrombin time, Pathology, medicine.medical_specialty, medicine.drug_mechanism_of_action, medicine.diagnostic_test, business.industry, Factor Xa Inhibitor, Hematology, Pharmacology, medicine.disease, Venous thrombosis, In vivo, Antithrombotic, Medicine, Thrombus, business, Ex vivo, circulatory and respiratory physiology, Partial thromboplastin time
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f1ed83ecb09809b17f08abe7f2ff8cfa
https://doi.org/10.1055/s-0037-1614434 -
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المؤلفون: Alfred P. Spada, Mark H. Perrone, Fink Cynthia A, Kenneth L. Clark, Bryan F. Cox, Michael F. Jarvis, Glenn J. Smits, Camilo J. Rojas, Linda Merkel
المصدر: Drug Development Research. 45:30-43
مصطلحات موضوعية: Cardioprotection, Agonist, medicine.medical_specialty, Mean arterial pressure, business.industry, medicine.drug_class, Vasodilation, Adenosine, Adenosine receptor, Endocrinology, Internal medicine, Drug Discovery, medicine, Lipolysis, business, Receptor, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8b531c0d378a3a96c5bc770ecb2d6a74
https://doi.org/10.1002/(sici)1098-2299(199809)45:1<30::aid-ddr5>3.0.co;2-5
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