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1دورية أكاديمية
المؤلفون: Elias Zgheib, Alice Limonciel, Xiaoqi Jiang, Anja Wilmes, Steven Wink, Bob van de Water, Annette Kopp-Schneider, Frederic Y. Bois, Paul Jennings
المصدر: Frontiers in Genetics, Vol 10 (2019)
مصطلحات موضوعية: transcriptomics, Nrf2, AhR, ATF4, toxicity pathways, toxicogenomic, Genetics, QH426-470
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Alice Limonciel, Simone G. van Breda, Xiaoqi Jiang, Gregory D. Tredwell, Anja Wilmes, Lydia Aschauer, Alexandros P. Siskos, Agapios Sachinidis, Hector C. Keun, Annette Kopp-Schneider, Theo M. de Kok, Jos C. S. Kleinjans, Paul Jennings
المصدر: Frontiers in Genetics, Vol 9 (2018)
مصطلحات موضوعية: recovery, persistence, epigenomics, stress responses, ochratoxin A, potassium bromate, Genetics, QH426-470
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Elias Zgheib, Alice Limonciel, Xiaoqi Jiang, Anja Wilmes, Steven Wink, Bob van de Water, Annette Kopp-Schneider, Frederic Y. Bois, Paul Jennings
المصدر: Frontiers in Genetics, Vol 9 (2018)
مصطلحات موضوعية: transcriptomics, Nrf2, AhR, ATF4, toxicity pathways, toxicogenomic, Genetics, QH426-470
وصف الملف: electronic resource
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4دورية أكاديمية
المؤلفون: Alice Limonciel, Paul Jennings
المصدر: Toxins, Vol 6, Iss 1, Pp 371-379 (2014)
مصطلحات موضوعية: proximal tubule, ochratoxin, oxidative, Nrf2, Medicine
وصف الملف: electronic resource
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المؤلفون: Alejandro Aguayo-Orozco, Liliana Capinha, Nazanin Golbamaki, Enrico Mombelli, Matthias Wehr, Bart van der Burg, Daria Goldmann, Nanette G Vrijenhoek, Thomas Exner, Richard Maclennan, Katharina Brotzmann, Ulf Norinder, Oliver Hatley, Alice Limonciel, Thomas Braunbeck, Sylvia Escher, Barbara Zdrazil, Frédéric Y. Bois, Paul Jennings, Emilio Benfenati, Domenico Gadaleta, Jose Castel, Ciarán Fisher, Sankalp Jain, Anthony Long, Rabea Graepel, Laia Tolosa, Andrew White, Bob van de Water, Barbara M.A. van Vugt-Lussenburg, Paul Walker, Annette Bitsch, Olivier Taboureau, Iain Gardner
المساهمون: AIMMS, Molecular and Computational Toxicology, Publica
المصدر: Toxicology in Vitro, 79:105269, 1-16. Elsevier Limited
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269, pp. 1-16 . https://doi.org/10.1016/j.tiv.2021.105269
Escher, S E, Aguayo-Orozco, A, Benfenati, E, Bitsch, A, Braunbeck, T, Brotzmann, K, Bois, F, van der Burg, B, Castel, J, Exner, T, Gadaleta, D, Gardner, I, Goldmann, D, Hatley, O, Golbamaki, N, Graepel, R, Jennings, P, Limonciel, A, Long, A, Maclennan, R, Mombelli, E, Norinder, U, Jain, S, Capinha, L S, Taboureau, O T, Tolosa, L, Vrijenhoek, N G, van Vugt-Lussenburg, B M A, Walker, P, van de Water, B, Wehr, M, White, A, Zdrazil, B & Fisher, C 2022, ' Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action ', Toxicology in Vitro, vol. 79, 105269 . https://doi.org/10.1016/j.tiv.2021.105269
Toxicology in Vitro
Toxicology In Vitro, 79مصطلحات موضوعية: Test strategy, Mechanistic hazard assessment, Adverse Outcome Pathways, Computer science, In silico, Gene Expression Profiling, Liver steatosis, Carboxylic Acids, General Medicine, Computational biology, Toxicology, AOP-network, Fatty Liver, Differentially expressed genes, Workflow, Action (philosophy), NAM, Read-across, Adverse Outcome Pathway, Animals, Humans, Computer Simulation, Zebrafish
وصف الملف: application/pdf
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المؤلفون: Anja Wilmes, Tobias Strassfeld, Harry Vrieling, Manoj Kumar, Balázs Mihalik, Costanza Rovida, Giorgia Pallocca, Nanette G Vrijenhoek, Ciarán Fisher, Bart van der Burg, Thomas Braunbeck, Xenia Dolde, Alice Krebs, Zofia Janstova, Béla Z. Schmidt, Wiebke Albrecht, Jan G. Hengstler, Tim Brecklinghaus, David A. Fluri, J. J. W. A. Boei, Thomas Exner, Marcel Leist, Tanja Waldmann, Jaffar Kisitu, Anna-Katharina Holzer, Manuel Pastor, Joh Dokler, Andrea Paola Cediel Ulloa, Paul Jennings, Barbara M.A. van Vugt-Lussenburg, Bas ter Braak, Bob van de Water, Anna Forsby, Maja Brajnik, Wolfgang Moritz, Catherine M. Verfaillie, Johannes P Schimming, Rebecca von Hellfeld, Alice Limonciel, Francois Busquet, Julianna Kobolák, Ugis Sarkans, Regina Stöber, Jessica Lundqvist, Andras Dinnyes
المساهمون: Molecular and Computational Toxicology, AIMMS
المصدر: Archives of Toxicology
Archives of Toxicology, 94(7), 2435-2461. Springer Verlag
Archives of Toxicology, 94(7), 2435-2461. SPRINGER HEIDELBERG
Krebs, A, van Vugt-Lussenburg, B M A, Waldmann, T, Albrecht, W, Boei, J, Ter Braak, B, Brajnik, M, Braunbeck, T, Brecklinghaus, T, Busquet, F, Dinnyes, A, Dokler, J, Dolde, X, Exner, T E, Fisher, C, Fluri, D, Forsby, A, Hengstler, J G, Holzer, A-K, Janstova, Z, Jennings, P, Kisitu, J, Kobolak, J, Kumar, M, Limonciel, A, Lundqvist, J, Mihalik, B, Moritz, W, Pallocca, G, Ulloa, A P C, Pastor, M, Rovida, C, Sarkans, U, Schimming, J P, Schmidt, B Z, Stöber, R, Strassfeld, T, van de Water, B, Wilmes, A, van der Burg, B, Verfaillie, C M, von Hellfeld, R, Vrieling, H, Vrijenhoek, N G & Leist, M 2020, ' The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods ', Archives of Toxicology, vol. 94, no. 7, pp. 2435-2461 . https://doi.org/10.1007/s00204-020-02802-6
Archives of Toxicology, 94(7), 2435-2461
Archives of toxicology, 94:2435-2461مصطلحات موضوعية: 0301 basic medicine, Test data generation, Computer science, Health, Toxicology and Mutagenesis, Data validation, HAZARD ASSESSMENT, Toxicology, CELL-CULTURE PRACTICE, Documentation, Policy Making, Cells, Cultured, Zebrafish, media_common, EPITHELIAL-CELLS, General Medicine, data processing, GIVIMP, in vitro toxicology, metadata, nuclear receptor, Test (assessment), Strategy implementation, Europe, Data processing, In Vitro Systems, NEURAL CREST MIGRATION, Life Sciences & Biomedicine, REPRODUCTIVE TOXICITY, Risk Assessment, 03 medical and health sciences, SDG 17 - Partnerships for the Goals, ddc:570, Terminology as Topic, Toxicity Tests, media_common.cataloged_instance, Animals, Humans, European union, Retrospective Studies, In vitro toxicology, Electronic Data Processing, Metadata, Science & Technology, business.industry, 030111 toxicology, Reproducibility of Results, CALUX METHOD, IN-VITRO, Pipeline (software), DRUG DISCOVERY, 030104 developmental biology, Nuclear receptor, DEVELOPMENTAL NEUROTOXICITY DNT, Government Regulation, Software engineering, business, EMBRYONIC STEM-CELLS
وصف الملف: application/pdf; Print-Electronic
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المؤلفون: Alberto Mantovani, Tanja Waldmann, Bob van de Water, Cristina Cadenas, Hennicke Kamp, Thomas Braunbeck, Annemarie H. Meijer, Mathieu Vinken, Sylvia Escher, Domenico Gadaleta, Patricio Godoy, Anna Forsby, Stefan Schildknecht, Chris T. Evelo, Stefan Höhme, Rosemarie Marchan, Gerhard F. Ecker, Harry Vrieling, Susanne Hougaard Bennekou, Ciarán Fisher, Alice Limonciel, Enrico Mombelli, Rabea Graepel, Marcel Leist, Ahmed Ghallab, Michael Schwarz, Joost B. Beltman, Jens M. Kelm, Albert Braeuning, Olivier Taboureau, Bart van der Burg, Andrea Terron, Ferran Sanz, Frédéric Y. Bois, Steven Dooley, Dinant Kroese, Jan G. Hengstler, Paul Jennings, Egon Willighagen, Barbara Zdrazil, Barry Hardy, Erik H.J. Danen, Bjørn E. V. Koch, David A. Fluri, Christoph van Thriel, Dirk Drasdo, Ben van Ravenzwaay, Iain Gardner, Franz Oesch, Reham Hassan, Raymond Reif, Marvin Martens, Thomas Hartung
المساهمون: University of Konstanz, Department of Forensic Medicine and Veterinary Toxicology [Qena], Faculty of Veterinary Medicine [Qena], South Valley University [Qena]-South Valley University [Qena], Universiteit Leiden, Leibniz Research Centre for Working Environment and Human Factors [Dortmund] (IFADO), Technische Universität Dortmund [Dortmund] (TU), The Danish Epidemiology Science Centre, Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Vrije Universiteit Brussel (VUB), BASF [Ludwigshafen], SimCYP Ltd, Institut National de l'Environnement Industriel et des Risques (INERIS), Bundesinstitut für Risikobewertung - Federal Institute for Risk Assessment (BfR), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Modelling and Analysis for Medical and Biological Applications (MAMBA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universität Leipzig, Medical University Graz, Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), University of Heidelberg, Medical Faculty, Universitat Pompeu Fabra [Barcelona] (UPF), Karolinska Institutet [Stockholm], Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), InSphero [Schlieren], University of Vienna [Vienna], Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), BioDetection Systems, Universität Mannheim, Maastricht University [Maastricht], Institut National de la Santé et de la Recherche Médicale (INSERM), IT University of Copenhagen (ITU), Istituto Superiore di Sanità (ISS), Douglas Connect GmbH, Fraunhofer Institute for Toxicology and Experimental Medicine (Fraunhofer ITEM), Fraunhofer (Fraunhofer-Gesellschaft), Carl Zeiss SMT AG, Carl Zeiss, Oberkochen, Faculty of Biology, Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University [Austria] (IMU), BASF, DRC/VIVA/METO, Institut National de l'Environnement Industriel et des Risques, Department of Experimental and Clinical Pharmacology andToxicology [Tübingen], Eberhard Karls Universität Tübingen, Interdisciplinary Centre for Bioinformatics [Leipzig] (IZBI), Universität Leipzig [Leipzig], Institute for Health and Consumer Protection, European Commission - Joint Research Centre, Université Grenoble Alpes - UFR Médecine [ ?-2019] (UGA UFRM [ ?-2019]), Molecular Hepatology - Alcohol Associated Diseases, Department of Medicine II, University of Heidelberg, Medical Faculty of Mannheim-University of Heidelberg, Medical Faculty of Mannheim, BigCat - Bioinformatics and Systems Biology Research Group, UMR-S973, MTi, Université Paris Diderot - Paris 7 (UPD7), Department of Immunology and Cell Biology, Mario Negri Institute, Leiden University, Vrije Universiteit [Brussels] (VUB), Universiteit Leiden [Leiden], BASF SE, 67056 Ludwigshafen, Johannes Gutenberg - University of Mainz (JGU), Centre for Alternatives to Animal Testing (CAAT EU), Universitat Pompeu Fabra [Barcelona], European Food Safety Authority = Autorité européenne de sécurité des aliments, Université Grenoble Alpes (UGA), Universität Mannheim [Mannheim], Istituto Superiore di Sanita [Rome], Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Johannes Gutenberg - Universität Mainz (JGU), IT University of Copenhagen, Molecular and Computational Toxicology, AIMMS, Bioinformatica, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - R4 - Gene-environment interaction, Promovendi NTM, RS: FHML MaCSBio, Publica, Pharmaceutical and Pharmacological Sciences, Connexin Signalling Research Group, Liver Connexin and Pannexin Research Group, Experimental in vitro toxicology and dermato-cosmetology
المصدر: Archives of Toxicology
Archives of Toxicology, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, Springer Verlag, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, 91(11), 3477-3505. Springer Verlag
Archives of Toxicology, 91(11), 3477-3505
Archives of Toxicology, 91(11), 3477-3505. Springer
Archives of Toxicology, 11, 91, 3477-3505
Leist, M, Ghallab, A, Graepel, R, Marchan, R, Hassan, R, Bennekou, S H, Limonciel, A, Vinken, M, Schildknecht, S, Waldmann, T, Danen, E H J, van Ravenzwaay, B, Kamp, H, Gardner, I, Godoy, P, Bois, F Y, Braeuning, A, Reif, R, Oesch, F, Drasdo, D, Höhme, S, Schwarz, M, Hartung, T, Braunbeck, T, Beltman, J, Vrieling, H, Sanz, F, Forsby, A, Gadaleta, D, Fisher, C, Kelm, J, Fluri, D, Ecker, G F, Zdrazil, B, Terron, A, Jennings, P, van der Burg, B, Dooley, S, Meijer, A H, Willighagen, E, Martens, M, Evelo, C T, Mombelli, E, Taboureau, O, Mantovani, A, Hardy, B, Koch, B, Escher, S, van Thriel, C, Cadenas, C, Kroese, D, van de Water, B & Hengstler, J G 2017, ' Adverse outcome pathways : opportunities, limitations and open questions ', Archives of Toxicology, vol. 91, no. 11, pp. 3477-3505 . https://doi.org/10.1007/s00204-017-2045-3مصطلحات موضوعية: CCl4, 0301 basic medicine, Proof of non-toxicity, Health, Toxicology and Mutagenesis, CCl, RAPID - Risk Analysis for Products in Development, Biomedical Innovation, Signal transduction, Ecotoxicology, Toxicology, NATURAL-KILLER-CELLS, Prioritization of compounds, Life, Adverse Outcome Pathway, ACTIVATED STELLATE CELLS, ComputingMilieux_MISCELLANEOUS, Risk assessment, TUMOR-NECROSIS-FACTOR, Event (computing), EVIDENCE-BASED TOXICOLOGY, ENVIRONMENTAL CHEMICALS, General Medicine, Toxicokinetics, Multiple hit events Proof of non-toxicity, Evidence-based toxicology, Identification (information), Paracetamol, Risk analysis (engineering), Vinyl acetate, RISK-ASSESSMENT, Systems biology, Construct (philosophy), Healthy Living, Human, Quality Control, READ-ACROSS, Vinyl Compounds, Plasticity, Liver fibrosis, Nanotechnology, Harmonization, Multiple hit events, Biology, History, 21st Century, Risk Assessment, Binning of events, Adverse outcome, 03 medical and health sciences, Adverse outcome pathway, SDG 3 - Good Health and Well-being, ddc:570, Tumor promotion, Journal Article, Animals, Humans, Vinyl acetate Tumor promotion, Regulatory toxicology, Set (psychology), Epidemiological data, Adverse Outcome Pathways, Interspecies extrapolation, 030111 toxicology, SYSTEMS TOXICOLOGY, Nonhuman, Toxicity assay, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Mice, Inbred C57BL, Multi-scale integration, Metabolism, 030104 developmental biology, DEVELOPMENTAL NEUROTOXICITY, Computational toxicology, ELSS - Earth, Life and Social Sciences, Pathway unidirectionality
وصف الملف: application/pdf
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المؤلفون: Frédéric Y. Bois, Annette Kopp-Schneider, Anja Wilmes, Steven Wink, Alice Limonciel, Xiaoqi Jiang, Bob van de Water, Paul Jennings, Elias Zgheib
المصدر: Frontiers in Genetics, Vol 10 (2019)
Frontiers in Genetics, 10, 517
Frontiers in Genetics
Zgheib, E, Limonciel, A, Jiang, X, Wilmes, A, Wink, S, Van De Water, B, Kopp-Schneider, A, Bois, F Y & Jennings, P 2019, ' Corrigendum: Investigation of Nrf2, AhR and ATF4 activation in toxicogenomic databases ', Frontiers in Genetics, vol. 10, no. JUNE, 517 . https://doi.org/10.3389/fgene.2019.00517مصطلحات موضوعية: lcsh:QH426-470, In kind, Toxicogenomic, Public administration, Nrf2, 03 medical and health sciences, 0302 clinical medicine, SDG 17 - Partnerships for the Goals, Political science, Genetics, media_common.cataloged_instance, European commission, ATF4, European union, Transcriptomics, Genetics (clinical), Original Research, 030304 developmental biology, media_common, 0303 health sciences, Toxicity pathways, AhR, 3. Good health, lcsh:Genetics, Work (electrical), Oxidative stress, 030220 oncology & carcinogenesis, Molecular Medicine
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6b3a64215e6e72102b82044535aa89
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المؤلفون: Ghislaine Gayraud, Magdalini Sachana, Alice Limonciel, Cleo Tebby, Elias Zgheib, Wang Gao, Huan Yang, Paul Jennings, Joost B. Beltman, Hristo Aladjov, Frédéric Y. Bois
المساهمون: Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Molecular and Computational Toxicology, AIMMS
المصدر: Computational Toxicology
Zgheib, E, Gao, W, Limonciel, A, Aladjov, H, Yang, H, Tebby, C, Gayraud, G, Jennings, P, Sachana, M, Beltman, J B & Bois, F Y 2019, ' Application of three approaches for quantitative AOP development to renal toxicity ', Computational Toxicology, vol. 11, pp. 1-13 . https://doi.org/10.1016/j.comtox.2019.02.001
Computational Toxicology, 11(August), 1-13
Computational Toxicology, 2019, 11, pp.1-13. ⟨10.1016/j.comtox.2019.02.001⟩
Computational Toxicology, 11, 1-13. Elsevierمصطلحات موضوعية: Calibration (statistics), Computer science, Health, Toxicology and Mutagenesis, Systems biology, Quantitative AOP Systems biology model, 010501 environmental sciences, Hazard analysis, Toxicology, Machine learning, computer.software_genre, 01 natural sciences, Quantitative AOP, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Chronic kidney disease, Predictive toxicology, Adverse Outcome Pathway, SDG 14 - Life Below Water, Systems biology model, Representation (mathematics), ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, business.industry, Bayesian network, Experimental data, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Computer Science Applications, Bayesian networks, Potassium bromate, Artificial intelligence, business, Risk assessment, computer
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المؤلفون: Pascal Phrakonkham, Mireia Vilardell, Rob Stierum, A. Brandenburg, Hans Gmuender, Liesbeth Ceelen, Alice Limonciel, Craig Slattery, Tatyana Y. Doktorova, Christophe Chesne, Edward A. Lock, Robert J. Radford, Michael P. Ryan, Katarzyna M. Bloch, Ralf Herwig, Timo Wittenberger, Jos C. S. Kleinjans, Tara McMorrow, Vera Rogiers, Raffaella Corvi, Paul Jennings, Danyel Jennen, José V. Castell, Reha Yildirimman
المساهمون: Pharmaceutical and Pharmacological Sciences, Experimental in vitro toxicology and dermato-cosmetology, Connexin Signalling Research Group, Toxicogenomics, RS: GROW - R1 - Prevention
المصدر: Archives of Toxikology
Archives of Toxicology, 90(9), 2215-2229. Springerمصطلحات موضوعية: 0301 basic medicine, Laboratory Proficiency Testing, Time Factors, Bioinformatics, Health, Toxicology and Mutagenesis, Alternatives to animal testing, Genome-wide association study, Biology, Toxicology, Risk Assessment, Toxicogenetics, Workflow, Transcriptome, Kidney Tubules, Proximal, 03 medical and health sciences, Inter-laboratory assessment, Cell Line, Tumor, Humans, Oligonucleotide Array Sequence Analysis, Observer Variation, Carcinogenicity, Dose-Response Relationship, Drug, Gene Expression Profiling, Pre-validation, In vitro toxicology, Computational Biology, Reproducibility of Results, General Medicine, Toxicogenomics, 3. Good health, Gene expression profiling, 030104 developmental biology, Gene Expression Regulation, Liver, Carcinogens, In vitro assays, DNA microarray, Genome-Wide Association Study
وصف الملف: application/pdf