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1دورية أكاديمية
المؤلفون: Suk Kyu Ko, Carolin Berner, Alina Kulakova, Markus Schneider, Iris Antes, Gerhard Winter, Pernille Harris, Günther H.J. Peters
المصدر: Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1439-1455 (2022)
مصطلحات موضوعية: Aggregation, Granulocyte stimulating factor, Molecular dynamics, Coarse grained simulations, Small angle X-ray scattering, Biotechnology, TP248.13-248.65
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Alina Kulakova, Sowmya Indrakumar, Pernille Sønderby, Lorenzo Gentiluomo, Werner Streicher, Dierk Roessner, Wolfgang Frieß, Günther H.J. Peters, Pernille Harris
المصدر: Journal of Structural Biology: X, Vol 4, Iss , Pp 100017- (2020)
مصطلحات موضوعية: transferrin, stability, formulation, small angle X-ray scattering, molecular dynamics, Biology (General), QH301-705.5
وصف الملف: electronic resource
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المؤلفون: Alina Kulakova, Dillen Augustijn, Inas El Bialy, Lorenzo Gentiluomo, Maria Laura Greco, Stefan Hervø-Hansen, Sowmya Indrakumar, Sujata Mahapatra, Marcello Martinez Morales, Christin Pohl, Marco Polimeni, Aisling Roche, Hristo L. Svilenov, Andreas Tosstorff, Matja Zalar, Robin Curtis, Jeremy P. Derrick, Wolfgang Frieß, Alexander P. Golovanov, Mikael Lund, Allan Nørgaard, Tarik A. Khan, Günther H. J. Peters, Alain Pluen, Dierk Roessner, Werner W. Streicher, Christopher F. van der Walle, Jim Warwicker, Shahid Uddin, Gerhard Winter, Jens Thostrup Bukrinski, Åsmund Rinnan, Pernille Harris
المصدر: Molecular Pharmaceutics.
مصطلحات موضوعية: Drug Discovery, Pharmaceutical Science, Molecular Medicine
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المؤلفون: Jan Jaehrling, Pernille Harris, Wolfgang Friess, Susumu Uchiyama, Felix Kummer, Martin Domnowski, Kanta Enomoto, Alina Kulakova, Takahiro Maruno
المصدر: Journal of Pharmaceutical Sciences. 110:1979-1988
مصطلحات موضوعية: Viscosity, Mechanism (biology), Scattering, Chemistry, Small-angle X-ray scattering, Pharmaceutical Science, 02 engineering and technology, 021001 nanoscience & nanotechnology, 030226 pharmacology & pharmacy, Antibodies, Dynamic Light Scattering, Infliximab, Characterization (materials science), Analytical Ultracentrifugation, 03 medical and health sciences, 0302 clinical medicine, Dynamic light scattering, medicine, Multi method, 0210 nano-technology, Biological system, Ultracentrifugation, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732abff6c33162e3514f2bc50f195361
https://doi.org/10.1016/j.xphs.2021.02.002 -
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مصطلحات موضوعية: Protein Conformation, Iron, Transferrin, Pharmaceutical Science, Hydrogen-Ion Concentration, Molecular Dynamics Simulation, Sodium Chloride, Excipients, Chlorides, X-Ray Diffraction, Drug Discovery, Scattering, Small Angle, Molecular Medicine, Humans
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31c66671798d9708d9b191ee96dc533
https://doi.org/10.1101/2022.01.28.478130 -
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المؤلفون: Werner Streicher, Sujata Mahapatra, Günther H.J. Peters, Allan Nørgaard, Pernille Harris, Christin Pohl, Alina Kulakova
المصدر: Pohl, C, Mahapatra, S, Kulakova, A, Streicher, W, Peters, G H J, Nørgaard, A & Harris, P 2022, ' Combination of high throughput and structural screening to assess protein stability-A screening perspective ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 171 . https://doi.org/10.1016/j.ejpb.2021.08.018
European journal of pharmaceutics and biopharmaceutics 171, 1-10 (2022). doi:10.1016/j.ejpb.2021.08.018
Pohl, C, Mahapatra, S, Kulakova, A, Streicher, W, Peters, G H J, Nørgaard, A & Harris, P 2022, ' Combination of high throughput and structural screening to assess protein stability – A screening perspective ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 171, pp. 1-10 . https://doi.org/10.1016/j.ejpb.2021.08.018مصطلحات موضوعية: Computer science, High-throughput screening, Pharmaceutical Science, Automated data, Protein stability, Protein-protein interaction, X-Ray Diffraction, High throughput screening, Scattering, Small Angle, Humans, ddc:610, Throughput (business), Small-angle X-ray scattering (SAXS), business.industry, Quality assessment, Protein Stability, Proteins, Reproducibility of Results, General Medicine, Protein engineering, Automation, High-Throughput Screening Assays, Protein–protein interaction, Workflow, Drug screening, Biochemical engineering, Protein aggregation, business, Biotechnology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea860997e4adeb3ebbd6a386757edca3
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المؤلفون: Marina Buyanova, Irina Averina, Alina Kulakova
المصدر: Regionalnaya ekonomika. Yug Rossii. :83-93
مصطلحات موضوعية: business.industry, Mechanical Engineering, Economic security, Energy Engineering and Power Technology, Business, International trade, Management Science and Operations Research
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المؤلفون: Sowmya Indrakumar, Sujata Mahapatra, Alina Kulakova, Werner Streicher, Günther H.J. Peters, Pernille Harris, Pernille Sønderby Tuelung
المصدر: Scientific reports 10(1), 10089 (2020). doi:10.1038/s41598-020-67002-9
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Kulakova, A, Indrakumar, S, Sønderby Tuelung, P, Mahapatra, S, Streicher, W W, Peters, G H J & Harris, P 2020, ' Albumin-neprilysin fusion protein : understanding stability using small angle X-ray scattering and molecular dynamic simulations ', Scientific Reports, vol. 10, no. 1, 10089 . https://doi.org/10.1038/s41598-020-67002-9
Scientific Reportsمصطلحات موضوعية: 0301 basic medicine, Protein Conformation, lcsh:Medicine, Serum Albumin, Human, Molecular Dynamics Simulation, Protein Engineering, 010402 general chemistry, 01 natural sciences, Article, 03 medical and health sciences, Molecular dynamics, Protein structure, X-Ray Diffraction, Albumins, Scattering, Small Angle, lcsh:Science, Multidisciplinary, Protein Stability, Scattering, Chemistry, Small-angle X-ray scattering, lcsh:R, High-throughput screening, SAXS, Hydrogen-Ion Concentration, Fusion power, Fusion protein, 0104 chemical sciences, 030104 developmental biology, Intramolecular force, Volume fraction, Biophysics, Neprilysin, lcsh:Q, Molecular modelling, ddc:600
وصف الملف: application/pdf
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المؤلفون: Marie Skepö, Julia Weikum, Alina Kulakova, Jack C. Leo, Shogo Yoshimoto, J. Preben Morth, Katsutoshi Hori, Giulio Tesei, Pernille Harris, Line Vejby Jægerum, Monika Schütz
المصدر: Weikum, J, Kulakova, A, Tesei, G, Yoshimoto, S, Jægerum, L V, Schütz, M, Hori, K, Skepö, M, Harris, P, Leo, J C & Morth, J P 2020, ' The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action ', Scientific Reports, vol. 10, 21249 . https://doi.org/10.1038/s41598-020-77706-7
Scientific Reports
Weikum, J, Vitaliyivna Kulakova, A, Tesei, G, Yoshimoto, S, Jægerum, L V, Schütz, M, Hori, K, Skepö, M, Harris, P, Leo, J C & Morth, J P 2020, ' The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action ', Scientific Reports, vol. 10, no. 1, 21249 . https://doi.org/10.1038/s41598-020-77706-7
Scientific reports 10(1), 21249 (2020). doi:10.1038/s41598-020-77706-7مصطلحات موضوعية: 0301 basic medicine, Virulence Factors, Mathematics and computing, 030106 microbiology, Biophysics, Biochemistry, Protein Structure, Secondary, Article, Virulence factor, Atomic force microscopy, 03 medical and health sciences, Extracellular, Enteropathogenic Escherichia coli, Adhesins, Bacterial, Biological sciences, X-ray crystallography, Juncture, Intimin, Bacterial structural biology, Multidisciplinary, Chemistry, Escherichia coli Proteins, SAXS, Cell biology, 030104 developmental biology, Mitochondrial Membranes, Molecular modelling, Pathogens, Structural biology, ddc:600, Bacterial Outer Membrane Proteins, Autotransporters
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023c209e29fde8baa2495ee27655d3c8
https://curis.ku.dk/portal/da/publications/the-extracellular-juncture-domains-in-the-intimin-passenger-adopt-a-constitutively-extended-conformation-inducing-restraints-to-its-sphere-of-action(e47b40d1-c894-4780-a8ae-3aaf17436d9c).html -
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المؤلفون: Shahid Uddin, Christin Pohl, Christopher F. van der Walle, Inas El Bialy, Jeremy P. Derrick, Andreas Tosstorff, Robin Curtis, Sujata Mahapatra, Werner Streicher, Dillen Augustijn, Aisling Roche, Alina Kulakova, Wolfgang Frieß, Åsmund Rinnan, Hristo L. Svilenov, Dierk Roessner, Lorenzo Gentiluomo, Sowmya Indrakumar, Alain Pluen, Gerhard Winter, Pernille Harris, Allan Nørgaard, Günther H.J. Peters, Maria Laura Greco, Marcello Martinez Morales, Tarik A. Khan
المصدر: Molecular Pharmaceutics
Gentiluomo, L, Svilenov, H L, Augustijn, D, El Bialy, I, Greco, M L, Vitaliyivna Kulakova, A, Indrakumar, S, Mahapatra, S, Morales, M M, Pohl, C, Roche, A, Tosstorff, A, Curtis, R, Derrick, J P, Nørgaard, A, Khan, T A, Peters, G H J, Pluen, A, Rinnan, Å, Streicher, W W, van der Walle, C F, Uddin, S, Winter, G, Roessner, D, Harris, P & Frieß, W 2020, ' Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization ', Molecular Pharmaceutics, vol. 17, no. 2, pp. 426-440 . https://doi.org/10.1021/acs.molpharmaceut.9b00852
Gentiluomo, L, Svilenov, H L, Augustijn, D, El Bialy, I, Greco, M L, Kulakova, A, Indrakumar, S, Mahapatra, S, Morales, M M, Pohl, C, Roche, A, Tosstorff, A, Curtis, R, Derrick, J P, Nørgaard, A, Khan, T A, Peters, G H J, Pluen, A, Rinnan, Å, Streicher, W W, van der Walle, C F, Uddin, S, Winter, G, Roessner, D, Harris, P & Friess, W 2020, ' Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization ', Molecular Pharmaceutics, vol. 17, no. 2, pp. 426-440 . https://doi.org/10.1021/acs.molpharmaceut.9b00852مصطلحات موضوعية: protein characterization, Computer science, Drug Storage, Stability (learning theory), Pharmaceutical Science, Serum Albumin, Human, 02 engineering and technology, Computational biology, Interferon alpha-2, Protein aggregation, 030226 pharmacology & pharmacy, Protein Aggregates, 03 medical and health sciences, 0302 clinical medicine, Protein stability, Drug Discovery, Humans, Amino Acid Sequence, Protein Unfolding, therapeutic proteins, Protein Stability, Osmolar Concentration, Transferrin, Antibodies, Monoclonal, Therapeutic protein, A protein, developability assessment, Hydrogen-Ion Concentration, 021001 nanoscience & nanotechnology, Characterization (materials science), Solubility, Research Design, Immunoglobulin G, Molecular Medicine, protein formulation, 0210 nano-technology
وصف الملف: application/pdf