نتائج البحث - "Allen M. Spiegel"

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دورية أكاديمية

Distribution of Menin-Occupied Regions in Chromatin Specifies a Broad Role of Menin in Transcriptional Regulation

المؤلفون: Sunita K. Agarwal, Soren Impey, Shannon McWeeney, Peter C. Scacheri, Francis S. Collins, Richard H. Goodman, Allen M. Spiegel, Stephen J. Marx

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 2, Pp 101-107 (2007)

مصطلحات موضوعية: MEN1, multiple endocrine neoplasia, SACO, chromatin immunoprecipitation, ChIP, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S147655860780039X; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002

URL الوصول: https://doaj.org/article/f16c8661832a4cf6a35396742dcfd5ab

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Data from Recapitulation of Pancreatic Neuroendocrine Tumors in Human Multiple Endocrine Neoplasia Type I Syndrome via Pdx1-Directed Inactivation of Men1

المؤلفون: Steven K. Libutti, Allen M. Spiegel, Stephen J. Marx, Stephen M. Hewitt, Kris Ylaya, Amelia C. Grover, Charles Heller, Dominique Lorang, Asha Adem, Anathea Powell, Mei He, H.-C. Jennifer Shen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::decca3fe3cb36ed963911092cb4ca616
https://doi.org/10.1158/0008-5472.c.6499364.v1

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Supplementary Data from Recapitulation of Pancreatic Neuroendocrine Tumors in Human Multiple Endocrine Neoplasia Type I Syndrome via Pdx1-Directed Inactivation of Men1

المؤلفون: Steven K. Libutti, Allen M. Spiegel, Stephen J. Marx, Stephen M. Hewitt, Kris Ylaya, Amelia C. Grover, Charles Heller, Dominique Lorang, Asha Adem, Anathea Powell, Mei He, H.-C. Jennifer Shen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1959477c097c3018daac59b78381ce21
https://doi.org/10.1158/0008-5472.22379810

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THE JEREMIAH METZGER LECTURE: A BRIEF HISTORY OF EUGENICS IN AMERICA: IMPLICATIONS FOR MEDICINE IN THE 21

المؤلفون: Allen M, Spiegel

المصدر: Transactions of the American Clinical and Climatological Association. 130

مصطلحات موضوعية: Gene Editing, Fetal Therapies, Eugenics, Genetic Carrier Screening, Infant, Newborn, High-Throughput Nucleotide Sequencing, Fertilization in Vitro, Genetic Therapy, Sequence Analysis, DNA, Emigration and Immigration, History, 20th Century, History, 21st Century, United States, Neonatal Screening, National Socialism, Prenatal Diagnosis, Humans, Sterilization, Involuntary, Preimplantation Diagnosis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::5bedf159cdb059c9192c1845969eead4
https://pubmed.ncbi.nlm.nih.gov/31516187

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A double negative: inhibition of hepatic Gi signaling improves glucose homeostasis

المؤلفون: Allen M. Spiegel

المصدر: The Journal of clinical investigation. 128(2)

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, medicine.medical_specialty, Hepatic glucose, Camp production, Double negative, Glucagon binding, GTP-Binding Protein alpha Subunits, Gi-Go, Glucagon, 03 medical and health sciences, Mice, Phosphatidylinositol 3-Kinases, Internal medicine, medicine, Receptors, Glucagon, Glucose homeostasis, Animals, Humans, Homeostasis, Phosphorylation, Receptor, Extracellular Signal-Regulated MAP Kinases, Mice, Knockout, Chemistry, Gene Expression Profiling, Gluconeogenesis, General Medicine, Mice, Inbred C57BL, Oxygen, 030104 developmental biology, Endocrinology, Glucose, Liver, Commentary, Hepatocytes, Female, Reactive Oxygen Species, Signal Transduction, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2e71a9c9ec5095f3c757284f73a46e
https://pubmed.ncbi.nlm.nih.gov/29337301

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Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders

المؤلفون: Nigel Rust, Fadil M. Hannan, Rajesh V. Thakker, M. Andrew Nesbit, Caroline M Gorvin, Allen M. Spiegel, Valerie N. Babinsky, Sarah A. Howles, Jianxin Hu, Aylin C. Hanyaloglu

المساهمون: Genesis Research Trust

المصدر: Journal of Biological Chemistry
The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Cinacalcet, medicine.disease_cause, Biochemistry, 0302 clinical medicine, drug action, 11 Medical And Health Sciences, Calcium-sensing receptor, Signal transduction, uveal melanoma, Calcium disorder, 03 Chemical Sciences, medicine.drug, Signal Transduction, medicine.medical_specialty, Biochemistry & Molecular Biology, Allosteric regulation, Mutation, Missense, 030209 endocrinology & metabolism, GNA11, familial hypocalciuric hypercalcemia, Biology, Naphthalenes, 03 medical and health sciences, Allosteric Regulation, genetic disease, Internal medicine, medicine, autosomal dominant hypocalcemia, Humans, parathyroid hormone, Molecular Biology, calcium, Familial hypocalciuric hypercalcemia, Hypocalcemia, G protein, Cell Biology, 06 Biological Sciences, medicine.disease, 030104 developmental biology, Endocrinology, HEK293 Cells, Amino Acid Substitution, Cinacalcet Hydrochloride, Cancer research, Hypercalcemia, GTP-Binding Protein alpha Subunits, Gq-G11, Carcinogenesis, Receptors, Calcium-Sensing

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab95fe6248991a7835f10522f5d98ff8

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Recapitulation of Pancreatic Neuroendocrine Tumors in Human Multiple Endocrine Neoplasia Type I Syndrome via Pdx1-Directed Inactivation of Men1

المؤلفون: Steven K. Libutti, Amelia C. Grover, Mei He, Kris Ylaya, Stephen M. Hewitt, Allen M. Spiegel, Stephen J. Marx, H.-C. Jennifer Shen, Charles K. Heller, Asha Adem, Dominique Lorang, Anathea C. Powell

المصدر: Cancer Research. 69:1858-1866

مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, endocrine system, Cancer Research, Pancreatic disease, endocrine system diseases, Biology, Neuroendocrine tumors, medicine.disease, medicine.anatomical_structure, Oncology, Pancreatic tumor, Cancer research, medicine, PDX1, Endocrine system, MEN1, Multiple endocrine neoplasia, Pancreas

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2d2b42427d31523fdbf52b5c51be9fcb
https://doi.org/10.1158/0008-5472.can-08-3662

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Parathyroid tumor development involves deregulation of homeobox genes

المؤلفون: Sharon A. Savage, Lauren M Yang, Settara C. Chandrasekharappa, Sunita K. Agarwal, Stephen J. Marx, A. Lee Burns, Carmen M. Mateo, Jennifer E. Rosen, Francis S. Collins, H-C Jennifer Shen, Allen M. Spiegel, Steven K. Libutti

المصدر: Endocrine Related Cancer. 15:267-275

مصطلحات موضوعية: Adult, Male, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system, Cancer Research, Adolescent, endocrine system diseases, Tumor suppressor gene, Endocrinology, Diabetes and Metabolism, Cellular differentiation, Biology, Article, Endocrinology, Proto-Oncogene Proteins, Multiple Endocrine Neoplasia Type 1, medicine, Humans, Genetic Predisposition to Disease, MEN1, RNA, Messenger, Multiple endocrine neoplasia, Hox gene, Gene, Aged, Reverse Transcriptase Polymerase Chain Reaction, Genes, Homeobox, Cancer, Middle Aged, medicine.disease, Gene Expression Regulation, Neoplastic, Parathyroid Neoplasms, Oncology, Mutation, Cancer research, Homeobox, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b755b56a1c90d7b95449890e95ffb3db
https://doi.org/10.1677/erc-07-0191

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Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators

المؤلفون: Allen M. Spiegel, Jianxin Hu

المصدر: Journal of Cellular and Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2dfa660dfbada479edaa1421d2b848
https://doi.org/10.1111/j.1582-4934.2007.00096.x

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Find this article in full text from ProQuest

10

Distribution of Menin-Occupied Regions in Chromatin Specifies a Broad Role of Menin in Transcriptional Regulation

المؤلفون: Francis S. Collins, Soren Impey, Peter C. Scacheri, Richard H. Goodman, Sunita K. Agarwal, Stephen J. Marx, Shannon K. McWeeney, Allen M. Spiegel

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 2, Pp 101-107 (2007)

مصطلحات موضوعية: Cancer Research, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system, Transcription, Genetic, Brief Article, endocrine system diseases, ChIP, chromatin immunoprecipitation, Biology, Polymerase Chain Reaction, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Proto-Oncogene Proteins, Multiple Endocrine Neoplasia Type 1, Humans, Immunoprecipitation, MEN1, multiple endocrine neoplasia, Promoter Regions, Genetic, Gene, 3' Untranslated Regions, 030304 developmental biology, Gene Library, Regulation of gene expression, Genetics, 0303 health sciences, Gene Expression Profiling, Promoter, DNA, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Chromatin, Gene expression profiling, Gene Expression Regulation, 030220 oncology & carcinogenesis, Human genome, SACO, 5' Untranslated Regions, Chromatin immunoprecipitation, HeLa Cells, Plasmids, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f28e605e7ca178fc4382963126c3dab
http://www.sciencedirect.com/science/article/pii/S147655860780039X

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