المؤلفون: Francesco Bavo, Marco Pallavicini, Rebecca Appiani, Cristiano Bolchi

المصدر: Molecules, Vol 26, Iss 12, p 3603 (2021)

مصطلحات موضوعية: (S)-nicotine, nAChR, N-methyl-pyrrolidinyl, selectivity, alpha4beta2, alpha3beta4, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/26/12/3603; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/92948bab41844f2c9c2aa4b0446d9fe9

المؤلفون: D’Agostino, Massimo, Crespi, Arianna, Polishchuk, Elena, Generoso, Serena, Martire, Gianluca, Colombo, Sara Francesca, Bonatti, Stefano

المصدر: The Journal of Membrane Biology. November 2014 247(11):1149-1159

المؤلفون: Francesco Bavo, Marco Pallavicini, Cristiano Bolchi, Rebecca Appiani

المصدر: Bavo, F, Pallavicini, M, Appiani, R & Bolchi, C 2021, ' Determinants for α4β2 vs. α3β4 subtype selectivity of pyrrolidine-based nachrs ligands : A computational perspective with focus on recent cryo-em receptor structures ', Molecules, vol. 26, no. 12, 3603 . https://doi.org/10.3390/molecules26123603
Molecules
Molecules, Vol 26, Iss 3603, p 3603 (2021)
Volume 26
Issue 12

مصطلحات موضوعية: Alpha3beta4, Pyrrolidines, Pyridines, Pharmaceutical Science, N-methyl-pyrrolidinyl, Receptors, Nicotinic, Ligands, 01 natural sciences, Synaptic Transmission, Pyrrolidine, Analytical Chemistry, Docking, chemistry.chemical_compound, QD241-441, alpha4beta2, Drug Discovery, Databases, Genetic, Alpha4beta2, Selectivity, Nicotinic Agonists, Receptor, Cryo-EM, 0303 health sciences, NAChR, Molecular Docking Simulation, Nicotinic agonist, Chemistry (miscellaneous), docking, Molecular Medicine, benzodioxane, Agonist, medicine.drug_class, Structural similarity, Stereochemistry, Benzodioxane, Ether, (S)-nicotine, nAChR, Article, 03 medical and health sciences, Structure-Activity Relationship, medicine, Animals, Humans, Physical and Theoretical Chemistry, 030304 developmental biology, Binding Sites, 010405 organic chemistry, Organic Chemistry, Cryoelectron Microscopy, selectivity, 0104 chemical sciences, Rats, chemistry, Docking (molecular), cryo-EM, alpha3beta4

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512c7f5ba85f13f25e44ad6f04bd9fa1
https://curis.ku.dk/ws/files/285447571/molecules_26_03603_v2.pdf

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المؤلفون: Wu J; Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, USA., Perry DC; Department of Pharmacology & Physiology, George Washington University, 2300 Eye St NW, Washington, DC 20037, USA., Bupp JE; SRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA., Jiang F; Astraea Therapeutics, 320 Logue Avenue, Suite 142, Mountain View, CA 94043, USA., Polgar WE; SRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA., Toll L; Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St. Lucie, FL 34987, USA., Zaveri NT; Astraea Therapeutics, 320 Logue Avenue, Suite 142, Mountain View, CA 94043, USA. Electronic address: nurulain@astraeatherapeutics.com.

المصدر: Neuropharmacology [Neuropharmacology] 2014 Feb; Vol. 77, pp. 193-9. Date of Electronic Publication: 2013 Oct 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

مواضيع طبية MeSH: Ligands*, Aniline Compounds/*pharmacology , Receptors, Nicotinic/*chemistry , Receptors, Nicotinic/*metabolism , Tropanes/*pharmacology, Aniline Compounds/chemistry ; Animals ; Autoradiography ; Female ; HEK293 Cells ; Humans ; Male ; Protein Binding ; Radioligand Assay ; Rats ; Rats, Sprague-Dawley ; Tropanes/chemistry