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المؤلفون: Clémentine Schilte, Stephen Higgs, Matthew L. Albert, Alain Michault, Kristen Monte, Dana L. Vanlandingham, Deborah J. Lenschow, Arnaud Fontanet, Scott W. Werneke, Fernando Arenzana-Seisdedos, Anjali Rohatgi
المساهمون: Washington University School of Medicine, University of Washington [Seattle], Immunobiologie des Cellules Dendritiques, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Pathogénie Virale Moléculaire, The University of Texas Medical Branch (UTMB), Kansas State University, Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), D.J.L. was supported by a developmental award from NIH grant U54 AI05716007, a Pew Scholar Award, and an award from the Children's Discovery Institute. S.W. was supported by T32 AI00717231. M.L.A. acknowledges the L'Agence nationale de la recherché (ANR) for support of the research. Washington University Hybridoma Core facility and transgenic core facility was supported by NIH P30 AR048335. D.V. and S.H were in part supported by NIH AI R21 AI073389., We thank the Centre d'Immunologie Humaine and the CHIKV Task Force from the Institut Pasteur for support of this work and access to critical reagents. We also acknowledge Olivier Schwartz for helpful suggestions and for the careful review of the manuscript. We thank Kristen Monte and Charlotte Auriau for their outstanding expertise in animal care, and Stéphanie Thomas for support in sample transportation and filing of regulatory procedures., Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Vougny, Marie-Christine
المصدر: PLoS Pathogens, Vol 7, Iss 10, p e1002322 (2011)
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2011, 7 (10), pp. e1002322. ⟨10.1371/journal.ppat.1002322⟩
PLoS Pathogens, 2011, 7 (10), pp. e1002322. ⟨10.1371/journal.ppat.1002322⟩مصطلحات موضوعية: Ubiquitin-Activating Enzymes, MESH: Chikungunya Fever, MESH: Chikungunya virus/physiology, medicine.disease_cause, Mouse models, MESH: Animals, Newborn, Mice, MESH: Alphavirus Infections/diagnosis, Viral load, Conjugated proteins, MESH: Animals, Chikungunya, MESH: Cytokines/immunology, lcsh:QH301-705.5, Recombination, Genetic, 0303 health sciences, virus diseases, MESH: Alphavirus Infections/immunology, 3. Good health, Interferon Type I, Medicine, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH: Recombination, Genetic, Chikungunya infection, Chikungunya virus, medicine.drug, Research Article, Protein Binding, lcsh:Immunologic diseases. Allergy, [SDV.IMM] Life Sciences [q-bio]/Immunology, MESH: Ubiquitins/immunology, Immunology, MESH: Chikungunya virus/pathogenicity, Biology, Microbiology, Virus, Proinflammatory cytokine, MESH: Interferon Type I/immunology, 03 medical and health sciences, Immune system, MESH: Mice, Inbred C57BL, Virology, MESH: Interferon Type I/metabolism, MESH: Ubiquitins/metabolism, Genetics, medicine, Animals, Humans, MESH: Protein Binding, Alphavirus infection, Immune response, Molecular Biology, Ubiquitins, MESH: Mice, 030304 developmental biology, Retrospective Studies, MESH: Ubiquitin-Activating Enzymes/immunology, Innate immune system, MESH: Humans, 030306 microbiology, Alphavirus Infections, Neonates, MESH: Retrospective Studies, MESH: Ubiquitin-Activating Enzymes/metabolism, medicine.disease, Mice, Inbred C57BL, MESH: Alphavirus Infections/metabolism, Disease Models, Animal, Animals, Newborn, lcsh:Biology (General), Chikungunya Fever, Parasitology, Interferons, MESH: Disease Models, Animal, MESH: Cytokines/metabolism, lcsh:RC581-607, Interferon type I
وصف الملف: application/force-download
