المؤلفون: da Cruz AT; Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Hunger A; Laboratório de Vetores Virais, Centro de Investigação Translacional em Oncologia/LIM24, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil; Current address: Cristalia, Biotecnologia Unidade 1, Rodoviária SP 147, Itapira, SP, Brasil., de Melo FHM; Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, São Paulo, SP, Brazil., Monteiro AC; Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil; Department of Pathology, Friedrich-Alexander Universität, Erlangen, Bavaria, Germany., Paré GC; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada., Lai D; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada., Alves-Fernandes DK; Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Ayub ALP; Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Cordero EM; Microbiology, Immunology and Parasitology Department, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Filho JFDS; Microbiology, Immunology and Parasitology Department, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Schneider-Stock R; Department of Pathology, Friedrich-Alexander Universität, Erlangen, Bavaria, Germany., Strauss BE; Laboratório de Vetores Virais, Centro de Investigação Translacional em Oncologia/LIM24, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil., Tron V; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada; Microbiology, Immunology and Parasitology Department, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Jasiulionis MG; Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address: mjasiulionis@gmail.com.

المصدر: Neoplasia (New York, N.Y.) [Neoplasia] 2021 Aug; Vol. 23 (8), pp. 823-834. Date of Electronic Publication: 2021 Jul 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic* , RNA Interference*, Melanoma/*genetics , Melanoma/*mortality , MicroRNAs/*genetics , Tumor Suppressor Protein p53/*genetics, 3' Untranslated Regions ; Animals ; Cell Line, Tumor ; Humans ; Melanoma/pathology ; Mice ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Survival Analysis

المؤلفون: Branco PC; Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, 05508-900, Sao Paulo, SP, Brazil., Pontes CA; Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, 05508-900, Sao Paulo, SP, Brazil., Rezende-Teixeira P; Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, 05508-900, Sao Paulo, SP, Brazil., Amengual-Rigo P; Department of Life Sciences, Barcelona Supercomputing Center, 08034, Barcelona, Spain., Alves-Fernandes DK; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, 05508-000, São Paulo, SP, Brazil., Maria-Engler SS; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, 05508-000, São Paulo, SP, Brazil., da Silva AB; Department of Organic and Inorganic Chemistry, Federal University of Ceará, 60021, Fortaleza, CE, Brazil., Pessoa ODL; Department of Organic and Inorganic Chemistry, Federal University of Ceará, 60021, Fortaleza, CE, Brazil., Jimenez PC; Institute of Marine Sciences, Institute of Marine Sciences, Federal University of São Paulo, 11.070-100, Santos, SP, Brazil., Mollasalehi N; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 85721-0207, Tucson, USA., Chapman E; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 85721-0207, Tucson, USA., Guallar V; Department of Life Sciences, Barcelona Supercomputing Center, 08034, Barcelona, Spain., Machado-Neto JA; Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, 05508-900, Sao Paulo, SP, Brazil., Costa-Lotufo LV; Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, 05508-900, Sao Paulo, SP, Brazil. Electronic address: costalotufo@usp.br.

المصدر: European journal of pharmacology [Eur J Pharmacol] 2020 Dec 05; Vol. 888, pp. 173465. Date of Electronic Publication: 2020 Aug 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Melanoma/*metabolism , Prodigiosin/*analogs & derivatives , Prodigiosin/*pharmacology , Survivin/*antagonists & inhibitors , Survivin/*biosynthesis, Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/physiology ; DNA Damage/drug effects ; DNA Damage/physiology ; Dose-Response Relationship, Drug ; Down-Regulation/drug effects ; Down-Regulation/physiology ; Humans ; Melanoma/drug therapy ; Prodigiosin/therapeutic use ; Survivin/genetics

المؤلفون: Alves-Fernandes DK; Skin Biology Group, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Oliveira ÉA; Skin Biology Group, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Hastreiter AA; Laboratory of Hematology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Faião-Flores F; Skin Biology Group, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Felipe-Silva AS; Department of Pathology, Faculdade de Medicina (FMUSP), Universidade de São Paulo, São Paulo, Brazil., Turato W; Skin Biology Group, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Fock RA; Laboratory of Hematology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Maria-Engler SS; Skin Biology Group, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: silvya@usp.br., Barros SBM; Skin Biology Group, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: smbarros@usp.br.

المصدر: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Jul; Vol. 141, pp. 111371. Date of Electronic Publication: 2020 Apr 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Antineoplastic Agents/*pharmacology , Catechols/*pharmacology , GTP Phosphohydrolases/*genetics , Melanoma/*pathology , Membrane Proteins/*genetics , Skin Neoplasms/*pathology, Animals ; Antineoplastic Agents/toxicity ; Catechols/toxicity ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Endoplasmic Reticulum Stress/drug effects ; Female ; Humans ; Melanoma/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Skin Neoplasms/genetics ; Toxicity Tests, Subacute ; Xenograft Model Antitumor Assays

المؤلفون: Alves-Fernandes DK; Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil., Jasiulionis MG; Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil. mjasiulionis@gmail.com.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2019 Jun 28; Vol. 20 (13). Date of Electronic Publication: 2019 Jun 28.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: DNA Damage* , Epigenesis, Genetic*, Neoplasms/*genetics , Sirtuin 1/*metabolism, Animals ; DNA Repair ; Humans ; Sirtuin 1/genetics

المؤلفون: Alves-Fernandes DK; Skin Biology and Melanoma Lab, Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Oliveira ÉA; Skin Biology and Melanoma Lab, Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Faião-Flores F; Skin Biology and Melanoma Lab, Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; The Department of Tumor Biology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Alicea-Rebecca G; Co-Program Leader, Immunology, Microenvironmental and Metastasis, Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA., Weeraratna AT; Co-Program Leader, Immunology, Microenvironmental and Metastasis, Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA., Smalley KSM; The Department of Tumor Biology, The Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL, USA., Barros SBM; Skin Biology and Melanoma Lab, Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Maria-Engler SS; Skin Biology and Melanoma Lab, Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: silvya@usp.br.

المصدر: Pharmacological research [Pharmacol Res] 2019 Mar; Vol. 141, pp. 63-72. Date of Electronic Publication: 2018 Dec 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Catechols/*pharmacology , Drug Resistance, Neoplasm/*drug effects , Endoplasmic Reticulum Stress/*drug effects , Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors , Protein Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins B-raf/*antagonists & inhibitors, Apoptosis/drug effects ; Cell Line, Tumor ; Humans ; Melanoma/drug therapy ; Skin Neoplasms/drug therapy

المؤلفون: Oliveira ÉA; Skin Biology Group, Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, University of Sao Paulo, FCF/USP, Sao Paulo, Brazil., Lima DS; Computational Systems Biology Laboratory, School of Pharmaceutical Sciences, University of Sao Paulo, FCF/USP, Sao Paulo, Brazil., Cardozo LE; Computational Systems Biology Laboratory, School of Pharmaceutical Sciences, University of Sao Paulo, FCF/USP, Sao Paulo, Brazil., Souza GF; Laboratory of Organic Synthesis, Anhanguera University of São Paulo, UNIAN, Sao Paulo, Brazil., de Souza N; Skin Biology Group, Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, University of Sao Paulo, FCF/USP, Sao Paulo, Brazil., Alves-Fernandes DK; Skin Biology Group, Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, University of Sao Paulo, FCF/USP, Sao Paulo, Brazil., Faião-Flores F; Skin Biology Group, Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, University of Sao Paulo, FCF/USP, Sao Paulo, Brazil., Quincoces JAP; Laboratory of Organic Synthesis, Anhanguera University of São Paulo, UNIAN, Sao Paulo, Brazil., Barros SBM; Skin Biology Group, Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, University of Sao Paulo, FCF/USP, Sao Paulo, Brazil., Nakaya HI; Computational Systems Biology Laboratory, School of Pharmaceutical Sciences, University of Sao Paulo, FCF/USP, Sao Paulo, Brazil., Monteiro G; Biochemical Pharmaceutical Technology Department, School of Pharmaceutical Sciences, University of Sao Paulo, FCF/USP, Sao Paulo, Brazil., Maria-Engler SS; Skin Biology Group, Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, University of Sao Paulo, FCF/USP, Sao Paulo, Brazil. Electronic address: silvya@usp.br.

المصدر: Pharmacological research [Pharmacol Res] 2017 Nov; Vol. 125 (Pt B), pp. 178-187. Date of Electronic Publication: 2017 Sep 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

مواضيع طبية MeSH: Curcumin/*analogs & derivatives , Curcumin/*pharmacology , Gene Expression Regulation, Fungal/*drug effects , Melanoma/*genetics , Saccharomyces cerevisiae/*genetics, Cell Line, Tumor ; Computational Biology ; Humans ; Mutation ; Toxicogenetics

المؤلفون: Massaro RR; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Faião-Flores F; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Rebecca VW; The Department of Tumor Biology, The Moffitt Cancer Center & Research Institute, Tampa, USA., Sandri S; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Alves-Fernandes DK; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Pennacchi PC; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Smalley KSM; The Department of Tumor Biology, The Moffitt Cancer Center & Research Institute, Tampa, USA., Maria-Engler SS; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: silvya@usp.br.

المصدر: Pharmacological research [Pharmacol Res] 2017 May; Vol. 119, pp. 242-250. Date of Electronic Publication: 2017 Feb 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Cell Proliferation/*drug effects , Estradiol/*analogs & derivatives , Melanoma/*drug therapy , Neoplasm Invasiveness/*prevention & control , Skin/*drug effects , Skin Neoplasms/*drug therapy, 2-Methoxyestradiol ; Apoptosis/drug effects ; Cell Cycle ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Estradiol/pharmacology ; Humans ; Melanoma/pathology ; Neoplasm Invasiveness/pathology ; Skin/pathology ; Skin Neoplasms/pathology

المؤلفون: Faião-Flores F; Department of Clinical Chemistry and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Alves-Fernandes DK; Department of Clinical Chemistry and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Pennacchi PC; Department of Clinical Chemistry and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Sandri S; Department of Clinical Chemistry and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Vicente AL; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil., Scapulatempo-Neto C; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.; Department of Pathology, Barretos Cancer Hospital, Barretos, Brazil., Vazquez VL; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.; Department of Surgery Melanoma/Sarcoma, Barretos Cancer Hospital, Barretos, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.; 3B's - PT Government Associate Laboratory, Braga/Guimarães, Guimarães, Portugal., Chauhan J; Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, UK., Goding CR; Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, UK., Smalley KS; The Department of Tumor Biology, The Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Maria-Engler SS; Department of Clinical Chemistry and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

المصدر: Oncogene [Oncogene] 2017 Mar 30; Vol. 36 (13), pp. 1849-1861. Date of Electronic Publication: 2016 Oct 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

مواضيع طبية MeSH: Drug Resistance, Neoplasm*, Antineoplastic Agents/*pharmacology , Indoles/*pharmacology , Kruppel-Like Transcription Factors/*antagonists & inhibitors , Melanoma/*metabolism , Sulfonamides/*pharmacology , Zinc Finger Protein GLI1/*antagonists & inhibitors, Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cellular Senescence/genetics ; Gene Expression ; Gene Knockdown Techniques ; Hedgehog Proteins/metabolism ; Humans ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Melanoma/drug therapy ; Melanoma/genetics ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Signal Transduction/drug effects ; Vemurafenib ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein GLI1/metabolism ; Zinc Finger Protein Gli2

المؤلفون: Sandri S; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Faião-Flores F; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Tiago M; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Pennacchi PC; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Massaro RR; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Alves-Fernandes DK; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Berardinelli GN; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Evangelista AF; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., de Lima Vazquez V; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil; Department of Surgery Melanoma/Sarcoma, Barretos Cancer Hospital, Barretos, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal; 3B's ⿿ PT Government Associate Laboratory, Braga, Guimarães, Portugal., Maria-Engler SS; Department of Clinical Chemistry & Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: silvya@usp.br.

المصدر: Pharmacological research [Pharmacol Res] 2016 Sep; Vol. 111, pp. 523-533. Date of Electronic Publication: 2016 Jul 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Indoles/*pharmacology , Matrix Metalloproteinase 2/*metabolism , Melanoma/*pathology , Protein Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins B-raf/*antagonists & inhibitors , Sulfonamides/*pharmacology, Cell Line, Tumor ; Drug Resistance, Neoplasm/physiology ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Humans ; Interleukin-8/metabolism ; Matrix Metalloproteinase 14/genetics ; Matrix Metalloproteinase 14/metabolism ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Melanoma/genetics ; Melanoma/metabolism ; Neoplasm Invasiveness ; Proto-Oncogene Proteins B-raf/genetics ; Tissue Inhibitor of Metalloproteinase-2/genetics ; Tissue Inhibitor of Metalloproteinase-2/metabolism ; Tumor Microenvironment/drug effects ; Up-Regulation ; Vemurafenib