المؤلفون: Julia A. Kaye, Malcolm Casale, Ping H Wang, Steven Finkbeiner, Yumay Chen, Ryan G. Lim, Ernest Fraenkel, Min Wu, Alvin R. King, Leslie M. Thompson, Jennifer Stocksdale, Marcy E. MacDonald, Virginia B. Mattis, Nicolas Arbez, Tamara Ratovitski, Clive N. Svendsen, Christopher A. Ross, Amanda J. Kedaigle, James F. Gusella, Colton M Tom, Ranjit Singh Atwal, Sergey S Akimov

المصدر: Human Molecular Genetics

مصطلحات موضوعية: 0301 basic medicine, AcademicSubjects/SCI01140, Bioenergetics, Induced Pluripotent Stem Cells, Oxidative phosphorylation, Biology, Mitochondrion, Proteomics, Oxidative Phosphorylation, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Adenosine Triphosphate, Huntington's disease, Genetics, medicine, Humans, Glycolysis, Molecular Biology, Genetics (clinical), chemistry.chemical_classification, Neurons, Cell Differentiation, General Medicine, Metabolism, medicine.disease, Corpus Striatum, Cell biology, Mitochondria, 030104 developmental biology, Enzyme, Huntington Disease, chemistry, Metabolome, General Article, Energy Metabolism, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ba2a92baf49dc7f08b70392e7573cf
https://pubmed.ncbi.nlm.nih.gov/30768179

المؤلفون: Carlos Cepeda, Alvin R. King, Joshua Barry, Dane P. Coleal‐Bergum, Jack C. Reidling, Gerhard Bauer, Alice Lau, Andrew H. Tran, Talia Kamdjou, Sandra M. Holley, Sylvia Y. Yeung, Brian Fury, Asa Hatami, Chunni Zhu, Charles K. Meshul, Joseph Ochaba, Delaram Salamati, Mathew Blurton-Jones, Frank M. LaFerla, Aroa Relano-Gines, Marie-Françoise Chesselet, Nicholas R. Franich, Cynthia Moore, Michael S. Levine, Joan S. Steffan, Leslie M. Thompson

المصدر: Reidling, JC; Relaño-Ginés, A; Holley, SM; Ochaba, J; Moore, C; Fury, B; et al.(2018). Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice. Stem Cell Reports, 10(1), 58-72. doi: 10.1016/j.stemcr.2017.11.005. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5hr4z9ww
Stem Cell Reports, Vol 10, Iss 1, Pp 58-72 (2018)
Stem Cell Reports

مصطلحات موضوعية: 0301 basic medicine, Huntingtin, Human Embryonic Stem Cells, Striatum, Motor Activity, Biology, Biochemistry, Article, Cell Line, Mice, 03 medical and health sciences, neural stem cell, Cognition, 0302 clinical medicine, Neural Stem Cells, Huntington's disease, Neurotrophic factors, Genetics, medicine, Animals, Humans, lcsh:QH301-705.5, lcsh:R5-920, R6/2 mice, Recovery of Function, Cell Biology, embryonic stem cells, medicine.disease, Embryonic stem cell, Neural stem cell, Q140 mice, Transplantation, Disease Models, Animal, Huntington Disease, 030104 developmental biology, lcsh:Biology (General), Heterografts, Stem cell, lcsh:Medicine (General), Neuroscience, 030217 neurology & neurosurgery, Developmental Biology, transplantation

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345a4660b599a733418cbc09d735bdc6
http://www.escholarship.org/uc/item/5hr4z9ww

المؤلفون: Azar Ghomian, Alessio Lodola, Alvin R. King, Kwang-Mook Jung, Jin Fu, Emmanuel Y. Dotsey, Yan Qiu, Daniele Piomelli, Marco Mor

المصدر: King, AR; Dotsey, EY; Lodola, A; Jung, KM; Ghomian, A; Qiu, Y; et al.(2009). Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors. Chemistry and Biology, 16(10), 1045-1052. doi: 10.1016/j.chembiol.2009.09.012. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/76n7n5r5

مصطلحات موضوعية: Glycerol, Stereochemistry, Clinical Biochemistry, Arachidonic Acids, Molecular Dynamics Simulation, Biology, Biochemistry, MOLNEURO, Article, Lanosterol, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Protein structure, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Rats, Wistar, Binding site, Molecular Biology, Cells, Cultured, 030304 developmental biology, Neurons, Pharmacology, chemistry.chemical_classification, 0303 health sciences, Binding Sites, Serine hydrolase, General Medicine, Endocannabinoid system, Monoacylglycerol Lipases, Triterpenes, Protein Structure, Tertiary, Rats, Monoacylglycerol lipase, CHEMBIO, Enzyme, chemistry, Drug Design, Molecular Medicine, Pentacyclic Triterpenes, 030217 neurology & neurosurgery, HeLa Cells, Cysteine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b4afa994d07064f50c2559e50a3d8b
https://doi.org/10.1016/j.chembiol.2009.09.012

المؤلفون: Marco Bortolato, Sevil Yasar, Zuzana Justinova, Svetlana I. Chefer, Alvin R. King, Jason R. Clapper, Alexey G. Mukhin, Godfrey H. Redhi, Daniele Piomelli, Steven R. Goldberg, Regina A. Mangieri

المصدر: Biological Psychiatry. 64:930-937

مصطلحات موضوعية: Male, Reinforcement Schedule, Cannabinoid receptor, Polyunsaturated Alkamides, 2-Arachidonoylglycerol, Self Administration, Arachidonic Acids, Pharmacology, Article, Amidohydrolases, chemistry.chemical_compound, Cocaine, Fatty acid amide hydrolase, Cannabinoid Receptor Modulators, medicine, Animals, Dronabinol, Rats, Wistar, Tetrahydrocannabinol, Saimiri, Biological Psychiatry, Analysis of Variance, Behavior, Animal, Dose-Response Relationship, Drug, Brain, Anandamide, URB597, Endocannabinoid system, Rats, chemistry, Benzamides, lipids (amino acids, peptides, and proteins), Carbamates, Self-administration, Reinforcement, Psychology, psychological phenomena and processes, Chromatography, Liquid, Endocannabinoids, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6804c06a4f07cd9c3a40626ac6852b56
https://doi.org/10.1016/j.biopsych.2008.08.008

المؤلفون: Vez Repunte-Canonigo, Scott A. Chen, Alvin R. King, Pietro Paolo Sanna, Dusan Lekic, George F. Koob, Laura E. O'Dell, Annika Thorsell

المصدر: Brain. 130:1330-1337

مصطلحات موضوعية: Male, medicine.medical_specialty, Liquid diet, Alcohol Drinking, media_common.quotation_subject, Genetic Vectors, Drinking, Gene Expression, Neuropeptide, Alcohol, Biology, Article, Open field, chemistry.chemical_compound, Transduction, Genetic, Internal medicine, medicine, Animals, Neuropeptide Y, Rats, Wistar, media_common, Ethanol, Body Weight, Abstinence, Amygdala, Neuropeptide Y receptor, medicine.disease, Privation, Diet, Rats, Alcoholism, Endocrinology, Anti-Anxiety Agents, chemistry, Models, Animal, Sindbis Virus, Neurology (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582281af6fbd475ea6556a9a0685deee
https://doi.org/10.1093/brain/awm033

المؤلفون: Erin Watkin, Jian Hong Li, Guo Li Ming, Marco Onorati, Ranjit Singh Atwal, James A. Thomson, Vanessa C. Wheeler, Robert N. Cole, Amanda R. Mason, Woon Roung Kim, Nicholas D. Allen, Tammy Gillis, Gayani Batugedara, Allison D. Ebert, Yu Zhu, Alvin R. King, Jason H. Chiang, Peter J. Donovan, Julia A. Kaye, Jamshid Arjomand, Christopher A. Ross, Junying Yu, Marquis P. Vawter, Sara T. Winokur, Amanda Redfern, Sergey S Akimov, Georgia Makri, Stephen P. Brazier, Alysia Battersby, Xiaoli Chen, Valentina Castiglioni, Aaron C. Daub, Punita Sharma, Elisa Fossale, Clive N. Svendsen, Ihn Sik Seong, James F. Gusella, Malcolm Casale, Tamara Ratovitski, Paul J. Kemp, Nicolas Arbez, Hongjun Song, Elena Cattaneo, Leslie M. Thompson, Jayalakshmi S. Mysore, Virginia B. Mattis, Leslie F. Lock, Russell L. Margolis, Soshana P. Svendsen, David Rushton, Yiping Shen, Chun Zhong, Steven Finkbeiner, Tarja A. Juopperi, Marcy E. MacDonald, Hsui Er Tseng, Alexander William John Harrison, Eka Chighladze

المصدر: Cell stem cell. 11(2)

مصطلحات موضوعية: Programmed cell death, Induced Pluripotent Stem Cells, LINES, METABOLISM, Biology, medicine.disease_cause, Bioinformatics, Article, MUTANT HUNTINGTIN, 03 medical and health sciences, AGE, 0302 clinical medicine, Huntington's disease, LENGTH, Genetics, medicine, Humans, GLUTAMATE TRANSPORT, BRAIN, Induced pluripotent stem cell, Cell adhesion, NEURONS, MUTATION, 030304 developmental biology, 0303 health sciences, Mutation, Cell Biology, medicine.disease, Phenotype, GENE-EXPRESSION CHANGES, 3. Good health, Huntington Disease, Cancer research, Molecular Medicine, Stem cell, Trinucleotide repeat expansion, Trinucleotide Repeat Expansion, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220351e85ee7daa05622d72e75cf00ea
https://pubmed.ncbi.nlm.nih.gov/22748968

المؤلفون: Daniele Piomelli, Alessio Lodola, Caterina Carmi, Marco Mor, Jin Fu, Alvin R. King

المصدر: British journal of pharmacology. 157(6)

مصطلحات موضوعية: Stereochemistry, 2-Arachidonoylglycerol, Molecular Sequence Data, Glycine, Substrate Specificity, chemistry.chemical_compound, Structure-Activity Relationship, Drug Delivery Systems, Animals, Humans, Amino Acid Sequence, Cysteine, Enzyme Inhibitors, Cysteine metabolism, Pharmacology, biology, Active site, Serine hydrolase, Acylglycerol lipase, Research Papers, Monoacylglycerol Lipases, Rats, Monoacylglycerol lipase, Thiazoles, chemistry, Biochemistry, Amino Acid Substitution, Enzyme inhibitor, biology.protein, Mutagenesis, Site-Directed, Thiazolidines, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97881038e1c56f27572a2573e4921a69
https://pubmed.ncbi.nlm.nih.gov/19486005

المؤلفون: Andrea Tontini, Alvin R. King, Francesca Antonietti, Giuseppe Astarita, Daniele Piomelli, Silvia Rivara, Marco Mor, Giorgio Tarzia, Jason R. Clapper, Pietro Traldi, Andrea Duranti

المصدر: Tarzia, G; Antonietti, F; Duranti, A; Tontini, A; Mor, M; Rivara, S; et al.(2007). Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754). Annali di Chimica, 97(9), 887-894. doi: 10.1002/adic.200790073. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2133f3k0

مصطلحات موضوعية: chemistry.chemical_classification, Spectrometry, Mass, Electrospray Ionization, Aniline Compounds, Magnetic Resonance Spectroscopy, Stereochemistry, High-performance liquid chromatography, URB754, Analytical Chemistry, D-1, Chemical library, Benzoxazines, Monoacylglycerol lipase, chemistry.chemical_compound, Enzyme, chemistry, Impurity, IC50, Chromatography, High Pressure Liquid, General Environmental Science

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504c007f85edb1480b35efa3c574b290
https://hdl.handle.net/11576/2300702

المؤلفون: Alvin R. King, Vez Repunte-Canonigo, Lena D. van der Stap, Pietro Paolo Sanna

المصدر: Brain research. Brain research protocols. 15(2)

مصطلحات موضوعية: Neurogenomics, Microarray, General Neuroscience, Gene Expression Profiling, Lasers, Brain, Computational biology, Biology, Proteomics, Molecular biology, Rats, Gene expression profiling, Neuroproteomics, Gene expression, Animals, Microdissection, Laser capture microdissection, Oligonucleotide Array Sequence Analysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fd70920136bf7d0e1f21b961982d2f
https://pubmed.ncbi.nlm.nih.gov/15946894

المؤلفون: Maurizio Cammalleri, Cindy Simpson, Walter Francesconi, Fulvia Berton, Alvin R. King, Pietro Paolo Sanna, Robert Lutjens

مصطلحات موضوعية: Dendritic spine, Time Factors, Long-Term Potentiation, Models, Neurological, Hippocampal formation, In Vitro Techniques, Hippocampus, Animals, Rats, Wistar, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cells, Cultured, Sirolimus, Multidisciplinary, biology, TOR Serine-Threonine Kinases, Glutamate receptor, Ribosomal Protein S6 Kinases, 70-kDa, Long-term potentiation, Dendrites, Biological Sciences, biology.organism_classification, Cell biology, Rats, Enzyme Activation, Aplysia, Synaptic plasticity, Protein Kinases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65d67d207af2b8d43f92fdb2091a492
https://europepmc.org/articles/PMC283598/